Clinical trials: Critical Ill Patients
Critical Illness, Septic Shock
Evaluation of Intestinal Brush Border Enzyme Function in Critically Ill Patients
The purpose of this study is to evaluate the role of several enzymes of the gut mucosa in preventing invasion of gastrointestinal bacteria.
- Conditions
- Critical Illness, Septic Shock, SIRS
- Trial name
- NCT01585909
- Testing
- Gastroscopy
- Where
- Austria
- Volunteers
- 39 people
- Sponsor
- Medical University of Vienna
Critically Ill
Cardioventilatory Coupling in Critically Ill Patients
This study measures the cardioventilatory coupling in critically ill patients during mechanical ventilation in controlled mode (pressure controlled) and in patient-driven mode (pressure support and neurally adjusted ventilatory…
- Trial name
- NCT02286869
- Testing
- Three different mechanical ventilation modes
- Where
- 2 sites in Italy
- Volunteers
- 22 people
- Sponsor
- ASST Fatebenefratelli Sacco
Sepsis, Respiratory Failure
Use of Lactate-to-Albumin, CRP-to-Albumin, and Procalcitonin-to-Albumin Ratios to Predict Mortality in ICU Patients
This observational study aims to determine whether three blood test ratios - lactate-to-albumin, CRP-to-albumin, and procalcitonin-to-albumin - can predict in-hospital mortality among critically ill adults.
- Conditions
- Sepsis, Respiratory Failure, Cardiac Arrest, Circulatory Failure
- Trial name
- LAR-CAR-PAR (NCT07242027)
- Where
- Poland
- Volunteers
- 212 people
- Sponsor
- Medical University of Silesia
COVID, Acute Kidney Injury
Study of the Treatment and Outcomes in Critically Ill Patients With COVID-19 and High Risk of Acute Kidney Injury
The aim is to describe the epidemiology and determine the independent risk factors for mortality and acute organ injury in AKI and to assess the impact of different treatment strategies on survival.
- Conditions
- COVID, Acute Kidney Injury, Critical Illness
- Trial name
- NCT04445259
- Where
- United Kingdom
- Volunteers
- 300 people
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
Continuous Renal Replacement Therapy (CRRT), Acute Kidney Injury
Insights Into the Continuous Renal Replacement Therapy to Critical Ill Patients
This is a multinational, prospective, observational study designed to characterize patient demographics, prescription parameters, and process measures of continuous renal replacement therapy (CRRT) in intensive care units (ICUs)…
- Conditions
- Continuous Renal Replacement Therapy (CRRT), Acute Kidney Injury, Renal Dialysis, Critical Illness
- Trial name
- iCRRT (NCT07365111)
- Testing
- continuous renal replacement therapy
- Where
- Canada
- Volunteers
- 100,000 people
- Sponsor
- University of Alberta
COVID-19
Tocilizumab to Prevent Clinical Decompensation in Hospitalized, Non-critically Ill Patients With COVID-19 Pneumonitis
Coronavirus disease-2019 (COVID-19) has a quoted inpatient mortality as high as 25%. This high mortality may be driven by hyperinflammation resembling cytokine release syndrome (CRS), offering the hope that therapies targeting…
- Trial name
- COVIDOSE (NCT04331795)
- Testing
- Tocilizumab
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- University of Chicago
Sepsis, Cardiopulmonary Bypass
Multi-omics Study on Gut Microbiota in Critical Ill Patients After Cardiopulmonary Bypass
Using metagenomics as well as metabolomics, the variation of the gut microbiota and host metabolite profiles of patient after undergoing CPB were explored.
- Trial name
- CPB-MUL-GM (NCT04032938)
- Testing
- extracorporeal circulation during cardiac surgery
- Where
- China
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Peking Union Medical College Hospital
Intensive Care
Efficacy and Safety of Three Insulin Protocols in Medical Intensive Care Unit Patients
To evaluate the efficacy and safety of three insulin algorithms in medical ICU patients (MICU).
- Trial name
- NCT00410852
- Testing
- Computer-assisted IV insulin infusion protocol (algorithm A), Leuven Strict glycemic control protocol (Algorithm B), Conventional Intermittent Insulin Protocol (Algorithm C)
- Where
- 5 sites in Brazil
- Volunteers
- 168 people
- Sponsor
- Hospital Israelita Albert Einstein
Critical Illness
Continuous Glucose Monitoring in Critically Ill Patients
The purpose of this study is to determine whether subcutaneous continuous glucose monitoring in critically ill patients is clinically feasible accurate and reliable.
- Trial name
- NCT00494455
- Testing
- continuous subcutaneous glucose monitoring
- Where
- Austria
- Volunteers
- 50 people
- Sponsor
- Medical University of Vienna
Critically Ill
Therapeutic Monitoring of Vancomycin in Critical Ill Patients: a Registry
Vancomycin is a glycopeptide antibiotic that is the first line antibiotics for the treatment of serious gram-positive infections involving methicillin-resistant Staphylococcus aureus (MRSA).
- Trial name
- VCMTDMinCI (NCT02896218)
- Testing
- Pharmacists consultation
- Where
- China
- Volunteers
- 400 people
- Sponsor
- Peking University Third Hospital
Critical Illness, Mechanical Ventilation
Transcutaneous Diaphragm Electrical Stimulation in Critically Ill Patients
This study evaluates the effect of a transcutaneous electrical stimulation in critically ill patients compared to a sham electrical stimulation to decrease the incidence of diaphragm dysfunction before mechanical ventilation…
- Conditions
- Critical Illness, Mechanical Ventilation, Intensive Care Unit
- Trial name
- TESLA (NCT04171024)
- Testing
- Transcutaneous diaphragm electrical stimulation
- Where
- France
- Volunteers
- 66 people
- Sponsor
- Groupe Hospitalier du Havre
Intensive Care (ICU) Myopathy, Intensive Care Unit Acquired Weakness
Effect of Neurophysiological Facilitation Techniques in Intensive Care Patients
The aim of this study was to investigate the effect of neurophysiological facilitation techniques on respiratory and functional levels in intensive care patients.
- Trial name
- NCT05282576
- Testing
- NPF Group, Control Group
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Saglik Bilimleri Universitesi
Critical Illness, Recovery Outcomes
Improving Survivorship for Critically Ill Patients Aged 65 and Over
IMPROVE-65 is a randomised control trial designed specifically for people aged over 65 who have survived critical illness. It aims to support patients and general practitioners by providing timely, personalised information to…
- Conditions
- Critical Illness, Recovery Outcomes, Care Coordination
- Trial name
- IMPROVE-65 (NCT07175961)
- Testing
- Multicomponent telehealth care coordination
- Where
- 2 sites in Australia
- Volunteers
- 300 people
- Sponsor
- Australian and New Zealand Intensive Care Research Centre
Critical Illness, Sepsis
Hyperinflammation and Hyperferritinemia in Critically Ill Patients
Analysing trajectory of critically ill patients with signs of hyperinflammation
- Conditions
- Critical Illness, Sepsis, Hyperferritinemia, Hyperinflammatory Syndrome
- Trial name
- HYFER (NCT06820905)
- Where
- Czechia
- Volunteers
- 1,962 people
- Sponsor
- Charles University, Czech Republic
Critical Illness, Malnutrition
Increasing Enteral Protein Intake in Critically Ill Trauma and Surgical Patients
Published guidelines recommend at least 2 gm/kg/day of protein for critically ill surgical patients. It may not be possible to achieve this level of intake using polymeric enteral nutritional formula and protein or amino acid…
- Conditions
- Critical Illness, Malnutrition, Enteral Nutrition, Protein Supplementation
- Trial name
- NCT03733782
- Testing
- Modular enteral protein - Prosource
- Volunteers
- 118 people
- Sponsor
- University of Washington
COVID-19
Respiratory Function 3 Months After Hospital Discharge in Critically Ill COVID-19 Patients
The objective of this single-center retrospective observational study is to describe spirometric abnormalities and their impact on 6-minute walk test (6MWT) and the physical component summary (PCS) of the SF-36 quality of life…
- Trial name
- NCT05249842
- Testing
- Spirometric evaluation, Physical component summary, 6MWT
- Where
- Brazil
- Volunteers
- 60 people
- Sponsor
- Hospital Sao Domingos
Acute Renal Failure
Furosemide in Early Acute Kidney Injury
Acute renal failure, now referred to as acute kidney injury, is common in intensive care unit patients, contributes to high morbidity and mortality, and has no proven interventions with benefit once established.
- Trial name
- SPARK (NCT00978354)
- Testing
- Furosemide, Normal Saline
- Where
- 4 sites in Australia, Canada
- Volunteers
- 72 people
- Sponsor
- University of Alberta
Drug Resistance
Clinical Characteristics for the Critical Ill Patients With Klebsiella Pneumoniae Infection
The detection of Klebsiella pneumoniae virulence gene and antibiotics resistance gene takes a long time and high cost with equipment requirements. Distinguishing the Klebsiella pneumoniae by gene were late for clinical treatment.
- Trial name
- NCT04404582
- Volunteers
- 546 people
- Sponsor
- Fujian Provincial Hospital
Trauma, Critical Illness
Pilot Study of Targeted Normoxia in Critically Ill Trauma Patients
The objective of this study is to conduct an observational pre/post study to evaluate the clinical impact oxygen guideline implementation on oxygen utilization and oxygenation in critically ill trauma patients.
- Conditions
- Trauma, Critical Illness, Oxygen Toxicity
- Trial name
- NCT03789396
- Testing
- Targeted Normoxia (oxygen saturation 90-96%), Usual Care Oxygenation
- Where
- United States
- Volunteers
- 572 people
- Sponsor
- University of Colorado, Denver
Critical Illness, Cardiac Arrest
Swecrit Biobank - Blood Samples From Critically Ill Patients and Healthy Controls
Blood samples are collected and stored in a biobank for later analysis of circulating substances in peripheral blood and genetic variations in patients with severe critical illness and risk of death.
- Conditions
- Critical Illness, Cardiac Arrest, Sepsis, Influenza
- Trial name
- SWECRIT (NCT04974775)
- Testing
- Blood collection, Blood collection, serial sampling
- Where
- 4 sites in Sweden
- Volunteers
- 8,500 people, healthy volunteers welcome
- Sponsor
- Skane University Hospital