Clinical trials: Critical Ill Patients
Critical Illness
An Assessment of the Feasibility and Safety of Conservative Oxygen Therapy in Critically Ill Patients
The investigators hypothesize that it is feasible and safe to deliver a conservative approach to oxygen therapy in mechanically ventilated critically ill patients (a tiem frame of, on average,10 days).
- Trial name
- NCT01684124
- Testing
- conservative O2 therapy, standard care
- Where
- Australia
- Volunteers
- 105 people
- Sponsor
- Austin Health
Mechanical Ventilation Pressure High, Weaning Failure
Extremes of Respiratory Effort in Weaning Failure From Mechanical Ventilation: a Prospective Observational Study
The presence of high levels of respiratory effort in patients under mechanical ventilation may worsen the adjacent lung injury even after adapting protective ventilation.
- Trial name
- NCT06464224
- Testing
- low respiratory effort, high respiratory effort
- Where
- Brazil
- Volunteers
- 1 people
- Sponsor
- Universidade Federal do Rio de Janeiro
Extubation Success, Craniofacial Pain Syndrome
The Predictive Value of Peak Cough Flow for Endotracheal Extubation of Patients After Craniotomy
In severe cases after craniotomy, tracheal intubation is often required, and the removal of tracheal intubation presents certain risks and challenges.
- Conditions
- Extubation Success, Craniofacial Pain Syndrome, Cough Peak Flow, Endotracheal Tube
- Trial name
- PCFET (NCT04000997)
- Where
- China
- Volunteers
- 785 people
- Sponsor
- Beijing Tiantan Hospital
Sepsis
Procalcitonin-Guided Antimicrobial Discontinuation
The current study aims to validate the diagnostic use of PCT assessing its capability to individualize and shorten the duration of antibiotic therapy in critically ill patients with suspected or confirmed sepsis.
- Trial name
- NCT00250666
- Testing
- PCT measurement
- Where
- Switzerland
- Volunteers
- 70 people
- Sponsor
- University Hospital, Geneva
Hypoalbuminemia, Adult ICU Patient
Acid Base Balance of ICU Patients With Severe Hypoalbuminemia, Before and After an Albumin Infusion, Using Stewart Approach
The primary purpose was to describe the acid base balance of ICU patients with severe hypoalbuminemia using Stewart's approach for acid base disorders, before and after an human albumin perfusion.
- Conditions
- Hypoalbuminemia, Adult ICU Patient, Stewart Approach for Acid Base Disorders, Human Albumin Perfusion
- Trial name
- STEWALB (NCT02288494)
- Testing
- stewart approach
- Where
- France
- Volunteers
- 100 people
- Sponsor
- University Hospital, Clermont-Ferrand
Critically Ill, Ethics
Barriers in the Process of Achieving Informed Consent From Critically Ill Patients
The study will explore barriers in the process of achieving informed consent from critically ill patients
- Conditions
- Critically Ill, Ethics, Informed Consent, Study Recruitment
- Trial name
- NCT03405766
- Where
- Norway
- Volunteers
- 70 people
- Sponsor
- Oslo University Hospital
Critically Ill
Towards RECOVER: Outcomes and Needs Assessment in Intensive Care Unit (ICU) Survivors of Prolonged Mechanical Ventilation and Their Caregivers
Advances in critical care medicine have dramatically improved the survival of critically ill patients requiring prolonged mechanical ventilation.
- Trial name
- RECOVER (NCT00896220)
- Where
- 5 sites in Canada
- Volunteers
- 500 people
- Sponsor
- University Health Network, Toronto
Mechanically Ventilated Patients
Early Directed Physical Therapy in the Management of Mechanically Ventilated Patients in a Medical Intensive Care Unit
To study all ICU patients with an independent baseline functional status, who experience a critical illness requiring intubation and mechanical ventilation, evaluating the role of protocol-directed, early physical and…
- Trial name
- NCT00322010
- Testing
- early PT OT
- Where
- United States
- Volunteers
- 104 people
- Sponsor
- University of Chicago
Multi Organ Failure, Acute Kidney Injury
Serum Vitamin D Levels in Critically Ill Patients Undergoing Regional Citrate Anticoagulation CRRT
Several studies point at a potential relationship between vitamin D deficiency and worse outcome in critically ill patients admitted to the intensive care unit.
- Trial name
- VitDcrrt (NCT02414386)
- Testing
- biospecimen retention
- Where
- 2 sites in Poland
- Volunteers
- 40 people
- Sponsor
- Uniwersytecki Szpital Kliniczny w Opolu
Critical Illness, Enteral Nutrition
Trial of Enteral Glutamine on Clinical Outcomes in Critically Ill Patients
Glutamine supplementation has beneficial effects on morbidity and mortality in critically ill patients, possibly in part through an attenuation of the proinflammatory cytokine response and a Immune function.
- Conditions
- Critical Illness, Enteral Nutrition, Multiple Organ Failure, Infection Complication
- Trial name
- NCT02998931
- Testing
- Glutamin, Maltodextrin
- Where
- 2 sites in Iran
- Volunteers
- 200 people
- Sponsor
- Shahid Beheshti University
Sepsis, Critically Ill
Serum TNF-a in Comparison to Sequential Organ Failure Assessment (SOFA) Score Monitoring in Critically Ill Patients
A total of ninety patients (52men and 38women) were included in the study. Forty five patients developed septic complication during ICU stay (sepsis group).
- Trial name
- NCT01708772
- Where
- Egypt
- Volunteers
- 90 people
- Sponsor
- Tanta University
Oral Cancer, Hypopharyngeal Cancer
Acupuncture Effect on Digestion in Critically Ill Post-Operative Oral and Hypo-pharyngeal Cancer Patients
Background: Head and neck cancer patients are in high risk to suffer from malnourishment, a risk that increase in postoperative condition and with the use of enteral nutrition (EN).
- Trial name
- NCT03934294
- Testing
- Specific acupuncture group, Metoclopramide 10mg, Non-specific acupuncture group
- Where
- Taiwan
- Volunteers
- 28 people
- Sponsor
- China Medical University Hospital
Critical Illness, Kidney Replacement Disorder
Compare Efficacy and Simplicity of Regional Citrate Anticoagulation With Fixed Dose Versus Adjusted Citrate Program
Anticoagulation is required to prevent clotting in the extracorporeal circuit during continuous renal replacement therapy (CRRT). Regional citrate anticoagulation has many advantages regarding bleeding risk and filter survival.
- Conditions
- Critical Illness, Kidney Replacement Disorder, Coagulation; Intravascular
- Trial name
- NCT02663960
- Testing
- fixed citrate doses protocol, adjusted citrate doses protocol
- Where
- China
- Volunteers
- 70 people
- Sponsor
- Peking Union Medical College Hospital
Outcome, Fatal, Infection
A Pharmacokinetics Study of Daptomycin in Critically Ill Patients and Effects of Daptomycin on Kidney
Daptomycin ，is the first approved member of a new class of antimicrobials, the cyclic lipopeptides, and presents selective action against gram-positive bacteria, including methicillin- and vancomycin-resistant strains，disrupting…
- Trial name
- NCT04277143
- Testing
- Daptomycin
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Zhongnan Hospital
Acute Kidney Injury
Urinary Parameters to Predict Weaning of Renal Replacement Therapy in the Critically Ill
Data on the optimal period for RRT weaning in critically ill patient are scarce. The current practice for RRT weaning is based on urine output, the threshold of which is debatable.
- Trial name
- WeCAN (NCT06214390)
- Testing
- Single strategy, Combined strategy
- Where
- 2 sites in France
- Volunteers
- 600 people
- Sponsor
- University Hospital, Montpellier
Acute Kidney Failure, Artificial Intelligence (AI)
Assessment of AI Prediction Models in Prediction of Acute Kidney Injury in Critical Patients
The assessment of AI -based prediction models in detecting AKI early in critically ill patients. Specifically, the aim is to evaluate the model's ability to predict the onset of AKI before it clinically manifests allowing for…
- Trial name
- NCT06857188
- Volunteers
- 1,000 people
- Sponsor
- Assiut University
Critically Ill, Malnutrition
Promotion of Oesophageal Motility to Prevent Regurgitation and Enhance Nutrition Intake in ICU Patients.
Early enteral feeding is a key component of the management of critically ill patients receiving mechanical ventilation. However, enteral feeding has been associated with serious complications such as gastro-esophageal reflux…
- Trial name
- PROPEL (NCT02515123)
- Testing
- E-Motion System
- Where
- 11 sites in Canada
- Volunteers
- 158 people
- Sponsor
- E-Motion Medical Ltd.
Delirium, Critical Illness
Haloperidol for Delirium in Adult Critically Ill Patients
The EuRIDICE trial will study whether haloperidol as a first line treatment for ICU delirium reduces delirium duration (and severity).
- Conditions
- Delirium, Critical Illness, Intensive Care Psychosis, Cognitive Impairment
- Trial name
- EuRIDICE (NCT03628391)
- Testing
- Haloperidol
- Where
- 8 sites in Netherlands
- Volunteers
- 142 people
- Sponsor
- Erasmus Medical Center
Critically Ill
The Effect of Standardized Enteral Nutrition on Critically Ill Patients
The goal of this study is to evaluate whether a standard enteral nutrition protocol can improve the efficiency in achieving nutritional goals and improve prognosis in critically ill patients.
- Trial name
- NCT02976155
- Testing
- A standard enteral nutrition protocol
- Where
- China
- Volunteers
- 439 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Venous Thromboembolism
Thromboprophylaxis in Critically Ill Patients
Intensive care patients are at high risk to develop deep venous thrombosis and pulmonary embolism. Despite anticoagulation with heparin 7% of ICU patients suffer from this serious complication.
- Trial name
- NCT00437697
- Testing
- dalteparin
- Where
- Austria
- Volunteers
- 90 people
- Sponsor
- Medical University of Vienna