Clinical trials: Critical Ill Patients
Critically Ill, Nutrition Disorders
Early Goal Nutrition Therapy Guided by Indirect Calorimetry and Nitrogen Balance Among Critically Ill Patients With Acute Kidney Injury (ENGINE Study)
The goal of this clinical trial is to investigate the effects of nutrition therapy guided by indirect calorimetry and nitrogen balance among critically ill patients with acute kidney injury.
- Conditions
- Critically Ill, Nutrition Disorders, Acute Kidney Injury
- Trial name
- ENGINE (NCT06238674)
- Testing
- indirect calorimetry and nitrogen balance, Indirect calorimetry (Standard care nutrition arm)
- Where
- Thailand
- Volunteers
- 80 people
- Sponsor
- Wankawee Jeerangsapasuk
Critically Ill, Body Weight
Comparison of Body Weights Via Visual Estimation, Anthropometric Calculation, and Actual Measured in Critically Ill Patients
Rapid and accurate determination of body weight in adult intensive care patients is very important for both calculating target tidal volume during invasive mechanical ventilation support and dose dependent drug administration.
- Trial name
- NCT06269861
- Testing
- patient transfer scale
- Where
- Turkey (Türkiye)
- Volunteers
- 200 people
- Sponsor
- Gazi University
Critically Ill
Time to Protein Target Using a High Whey Protein Enteral Nutrition in Critically Ill Patients
This study evaluates the feasibility of a high whey-protein enteral nutrition formula in 20 ventilated ICU patients. The primary endpoint of study is the feasibility to attain the individualized protein target (≥1.2 g/kg ideal…
- Trial name
- NCT02815527
- Testing
- Fresubin intensive
- Where
- Netherlands
- Volunteers
- 20 people
- Sponsor
- Amsterdam UMC, location VUmc
Infections, Critical Illness
Ventilator-Associated Pneumonia in Critically Ill COVID-19 vs. Non-COVID-19 Patients
The COVID-19 pandemic has led to an increased incidence of ventilator-associated pneumonia (VAP) among critically ill patients. However, in a context of high prevalence of multidrug-resistant organisms (MDROs) there is a lack of…
- Conditions
- Infections, Critical Illness, Superinfection, Organ Failure, Multiple
- Trial name
- NCT05972980
- Testing
- COVID-19
- Where
- Italy
- Volunteers
- 200 people
- Sponsor
- University of Turin, Italy
Persistent Critical Illness
Comparing Metabolic Characteristics of Persistent Critically Ill Non-COVID and COVID-19 Patients
The Corona Virus Disease-19 (COVID-19) pandemic has resulted in an overwhelming number of intensive care (ICU) patient admissions, generally for acute respiratory distress, often resulting in persistent critical illness (PCI).
- Trial name
- MetaCO-nonCO (NCT05026151)
- Testing
- Nutrition therapy according to ICU protocol
- Where
- Switzerland
- Volunteers
- 110 people
- Sponsor
- Centre Hospitalier Universitaire Vaudois
Critical Ill Patients, Ventilated Patients
Closed-loop Versus Conventional Ventilation Mode During Mobilization Period in Critical Care Patients
Nursing is essential in critically ill patients care but with high risk of hypoxia, especially during mobilization. Full closed-loop control ventilation is well established for her safety in unselected ventilated critical care…
- Trial name
- I-Nursing (NCT03176329)
- Testing
- Nursing 1 : INTELLIVENT-ASV, Nursing 2 : INTELLIVENT-ASV, Nursing 1 : Conventional mode
- Where
- France
- Volunteers
- 267 people
- Sponsor
- Hopital of Melun
Critical Illness
Prognosticating Outcomes and Nudging Decisions With Electronic Records in the ICU Trial
This is a pragmatic, stepped-wedge, cluster randomized trial testing the real-world effectiveness of two different electronic health record (EHR) behavioral interventions in improving a number of patient- and family-centered…
- Trial name
- PONDER-ICU (NCT03139838)
- Testing
- EHR-Based Intervention A, EHR-Based Intervention B
- Where
- 10 sites in United States
- Volunteers
- 3,500 people
- Sponsor
- University of Pennsylvania
Critical Illness, Respiratory Failure (Pediatric Patients)
Ventilator Settings and Outcomes in Pediatric Patients on ECMO for Severe Respiratory Failure
This study aims to describe the effects of ECMO initiation on the intensity of ventilation in the first 24 hours after ECMO initiation and to explore associations between changes in ventilation intensity and hospital mortality in…
- Trial name
- NCT06899009
- Where
- Netherlands
- Volunteers
- 750 people
- Sponsor
- University Medical Center Groningen
Critical Illness
Comparison of Neuromuscular Blockade's Monitoring and Clinical Assessment During Cisatracurium Paralysis in Critically Ill Patients
The main objectives of the prolonged resuscitation paralysis are usually adaptation to mechanical ventilation, lower insufflation pressures and cough suppression.
- Trial name
- NCT03198637
- Testing
- Cisatracurium's monitoring by TOF (train-of-four) WATCH device., clinical assessment
- Where
- France
- Volunteers
- 50 people
- Sponsor
- Poitiers University Hospital
Critical Care
Bed Bath With Auditory Hypnosis on ICU Patients
Intensive care units (ICUs) are specialized units where complex life-saving treatment and care activities are performed. Due to the treatment procedures performed in these specialized units, a large number of…
- Trial name
- RCS (NCT07019467)
- Testing
- Bed Bath With Auditory Hypnosis
- Where
- Turkey (Türkiye)
- Volunteers
- 66 people
- Sponsor
- Banu Terzi
Surgery-Complications, Acute Kidney Injury
The Effectiveness of Urine mtDNA and Beta 2-MG to Predict Acute Kidney Injury for Critically Ill Surgical Patients
1. Research background 1. Research hypothesis The development of acute kidney injury (AKI) can be predicted using urine mitochondrial deoxyribonucleic acid (UmtDNA), serum and urine beta-2 microglobulin (β2-MG) in critically ill…
- Conditions
- Surgery-Complications, Acute Kidney Injury, Critical Illness
- Trial name
- NCT05458063
- Where
- South Korea
- Volunteers
- 113 people
- Sponsor
- Wonju Severance Christian Hospital
Intensive Care Units (ICUs)
Body Lateralization and Its Effects on Respiratory Drive, Ventilation, and Pulmonary Aeration in Critically Ill Patients
The goal of this quasi-experimental study is to investigate how different body positions, performed through Automatic Lateralization Therapy, affect respiratory drive, ventilation, and pulmonary aeration in critically ill adult…
- Trial name
- LATLUNG (NCT07323472)
- Testing
- Automatic Lateralization Therapy, Supine Positioning
- Where
- Brazil
- Volunteers
- 30 people
- Sponsor
- University of Pernambuco
Effect of RBC Transfusions on Cerebral Oxygen Saturation
Monitoring the Effect of Red Blood Cell Transfusion on Cerebral Oxygen Saturation With Near Infrared Spectroscopy (NIRS) in Critically Ill Patients
Critically ill patients are frequently transfused with red blood cell (RBC) units with the predominant intention to increase arterial oxygen content and thus oxygen delivery to the tissues.
- Trial name
- NCT02232412
- Where
- Germany
- Volunteers
- 25 people
- Sponsor
- Johann Wolfgang Goethe University Hospital
Critical Illness, Invasive Candidiasis
Pharmacokinetics of Micafungin in Critically Ill Patients
A study of micafungin in ICU versus non-ICU patients showed a significantly lower treatment success in ICU patients compared with non-ICU patients.
- Trial name
- NCT01716988
- Where
- Netherlands
- Volunteers
- 19 people
- Sponsor
- University Medical Center Groningen
Severe Malnutrition
Management and Treatment of Patients With Severe Malnutrition in Intensive Care Unit: a Registry
Severe malnutrition can be seen as a low BMI, great weight loss, and even low levels of micronutrients. Current studies on severe malnutrition are mainly in patient with anorexia nervosa.
- Trial name
- NCT03055104
- Testing
- management of severe malnutrition
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Peking University Third Hospital
Shock, Critical Illness
Enteral Versus Parenteral Nutrition During Recovery After Shock
This study compares enteral nutrition and parenteral nutrition in critically ill adult patients recovering from shock while receiving decreasing doses of vasopressors in the intensive care unit.
- Conditions
- Shock, Critical Illness, Nutritional Support, Vasopressor Therapy
- Trial name
- NCT07411014
- Testing
- enteral nutrition, Parenteral Nutrition
- Where
- South Korea
- Volunteers
- 1,150 people
- Sponsor
- Samsung Medical Center
Invasive Candidiasis, Critically Ill
Pharmacokinetics of Anidulafungin on Intensive Care Unit (ICU)
The objective of this study is to determine whether pharmacokinetic parameters of anidulafungin correlate with disease severity and plasma protein levels in critically ill patients.
- Trial name
- NCT01047267
- Where
- Netherlands
- Volunteers
- 20 people
- Sponsor
- University Medical Center Groningen
Gastrointestinal Dysfunction, Critical Illness
Predictive Value of Transabdominal Intestine Sonography in Critically Ill Patients
It is very important to evaluate the degree of gastrointestinal dysfunction in critical ill patients. Thus the investigators conducted transabdominal intestine ultrasonography(US) in critical ill patients to evaluated the degree…
- Conditions
- Gastrointestinal Dysfunction, Critical Illness, Intestine Ultrasonography
- Trial name
- NCT03589248
- Testing
- GIF score, US score
- Volunteers
- 136 people
- Sponsor
- Nanjing PLA General Hospital
Respiratory Failure
Safety and Efficacy of Endotracheal Intubation Using Glidescope Video-Laryngoscope
The safety and efficacy of a video-laryngoscope as a primary intubation tool in urgent endotracheal intubation of critically-ill patients has not been well-described in the literature.
- Trial name
- NCT01683526
- Testing
- Direct laryngoscopy, Video laryngoscopy (Glidescope)
- Where
- United States
- Volunteers
- 117 people
- Sponsor
- Beth Israel Medical Center
Critical Illness
Clinical and Economic Outcome of Simvastatin in Critically Ill Septic Patient
determination of the effectiveness and the cost-effectiveness of simvastatin(Zocor 40 mg) plus standard therapy (SSCG)versus standard therapy alone in critically ill septic patient from the societal perspective over one year.
- Trial name
- NCT02067949
- Testing
- Simvastatin
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- sara mostafa amin eladawy