Clinical trials: Critical Ill Patients
Bronchoalveolar Lavage, COVID-19 Pneumonia
Comparison of the Results of Bronchoalveolar Lavage Culture and Endotracheal Aspirate Culture in Intubated Critically Ill COVID-19 Patients
Introduction: Secondary pneumonia is frequently seen in COVID-19 cases followed up intubated, and high mortality rates can be observed.
- Conditions
- Bronchoalveolar Lavage, COVID-19 Pneumonia, Critical Illness
- Trial name
- NCT05403489
- Testing
- Bronchoalveolar lavage, endotracheal aspirate culture
- Where
- Turkey (Türkiye)
- Volunteers
- 67 people
- Sponsor
- Basri Cakiroglu
Critical Illness
Safety and Efficacy of Vancomycin Plus Beta-lactams
The combination of vancomycin and piperacillin-tazobactam has been associated with an increased risk of acute kidney injury (AKI) in non-critically ill patient populations, but it is still unknown if this association exists in…
- Trial name
- SEVPB (NCT03776409)
- Testing
- vancomycin plus piperacillin/tazobactam, vancomycin plus other beta-lactams
- Where
- China
- Volunteers
- 700 people
- Sponsor
- First Affiliated Hospital Xi'an Jiaotong University
Septic Shock, Acute Respiratory Distress Syndrome
CytOSorb TreatMent Of Critically Ill PatientS Registry
Registry intended to provide a data repository and reporting infrastructure for the surveillance of CytoSorb device use in real-world critical care settings, and to serve as an objective, comprehensive, and scientifically-based…
- Conditions
- Septic Shock, Acute Respiratory Distress Syndrome, Trauma, Rhabdomyolysis
- Trial name
- COSMOS (NCT05146336)
- Testing
- CytoSorb
- Where
- 28 sites in Austria, Germany and 4 more
- Volunteers
- 3,000 people
- Sponsor
- CytoSorbents, Inc
Augmented Renal Clearance, Critical Illness
Incidence and Associated Risk Factors of ARC in the Trauma Critically Ill Older Than 50 Years Old
This single-center prospective cohort study conducted at the adult trauma ICU of the Montreal General Hospital (MGH) affiliated with the McGill University Health Centre (MUHC) aims to determine the incidence and associated risk…
- Conditions
- Augmented Renal Clearance, Critical Illness, Polytrauma, Traumatic Brain Injury
- Trial name
- NCT04766944
- Testing
- No intervention
- Where
- Canada
- Volunteers
- healthy volunteers welcome
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Shock, Right Ventricular Dysfunction
Right Ventriculo-Arterial Coupling During Fluid Loading in ICU Patients
Preload responsiveness and venous congestion have largely been investigated independently in recent literature. However, recent data report a similar incidence of venous congestion regardless of fluid responsiveness status…
- Conditions
- Shock, Right Ventricular Dysfunction, Venous Congestion
- Trial name
- RVPA-FLICU (NCT07537621)
- Testing
- Echography
- Where
- France
- Volunteers
- 100 people
- Sponsor
- CHU de Reims
Critical Illness, Respiration, Artificial
Non-sedation Versus Sedation With a Daily Wake-up Trial in Critically Ill Patients Receiving Mechanical Ventilation
Background: Every year 30,000 Danish patients are admitted to Intensive Care Units (ICU), accounting for 2-3% of all patients in hospital and 30% of the yearly hospital expenditure.
- Trial name
- NONSEDA (NCT01967680)
- Testing
- Non-sedation for intubated, mechanically ventilated patients, Controlgroup, sedation with daily wake-up trial
- Where
- 8 sites in Denmark, Norway and 1 more
- Volunteers
- 700 people
- Sponsor
- Palle Toft
Airway Clearance, Mechanical Insufflation-exsufflation
Mechanical Insufflation-Exsufflation in Critically Ill Patients
Mechanical insufflation-exsufflation (MI-E) is an established airway clearance technique for patients with chronic conditions like neuromuscular diseases.
- Conditions
- Airway Clearance, Mechanical Insufflation-exsufflation, Mechanical Insufflation-exsufflation Session ( With Cough Assist), Delphi Study
- Trial name
- DELMI-E (NCT07420946)
- Testing
- Delphi Questionnaire
- Where
- 4 sites in Italy, Spain and 1 more
- Volunteers
- 30 people
- Sponsor
- Medipol University
Critical Illness, Covid19
Body Composition Study in Critically Ill Patients-Extended to COVID-19
Muscle loss (ultrasound quadricep muscle) and muscle strength (handgrip and knee extension strength) will be compared between COVID-19 and non COVID-19 critically ill patients.
- Conditions
- Critical Illness, Covid19, Muscle Atrophy, Muscle Strength
- Trial name
- COVID-MUSCLE (NCT04849624)
- Testing
- No Intervention
- Where
- Malaysia
- Volunteers
- 59 people
- Sponsor
- University of Malaya
Critical Illness, Acute Disease
Simple Intensive Care Studies I (SICS-I)
Circulatory shock is a condition of generalized inadequate blood flow through the body, leading to insufficient tissue perfusion and inadequate delivery of oxygen and other nutrients, to the extent that tissues are damaged.
- Conditions
- Critical Illness, Acute Disease, Shock
- Trial name
- SICS-I (NCT02912624)
- Where
- Netherlands
- Volunteers
- 1,090 people
- Sponsor
- University Medical Center Groningen
Intensive Care Unit, Muscle Strength
Normative Values for Peripheral Muscle Strength in Critical Patients and Healthy Individuals
Muscle strength is an important indicator of overall health and is a factor that has been associated with increased mortality in critical patients.
- Trial name
- HHD-ICU (NCT06296381)
- Where
- 4 sites in Brazil
- Volunteers
- 180 people
- Sponsor
- University of Pernambuco
Critically Ill
Optimization of Nutritional Therapy in Mechanically Ventilated, Critically Ill Patients.
The aim of this study is to investigate whether an individualized determination of energy requirements using indirect calorimetry instead of a formula-based approach leads to an optimized nutritional support and as a consequence…
- Trial name
- ONCA (NCT03249051)
- Testing
- Indirect Calorimetry
- Where
- Germany
- Volunteers
- 40 people
- Sponsor
- University of Hohenheim
Critically Ill Patients, Cardiac Surgery
Impact Of Antioxidant Micronutrients On Intensive Care Unit (ICU) Outcome
Critically ill patients are generally exposed to an increased oxidative stress, which is proportional to the severity of their condition.
- Conditions
- Critically Ill Patients, Cardiac Surgery, Trauma, Subarachnoid Hemorrhage
- Trial name
- Etude-AOX (NCT00515736)
- Testing
- Selenium (Se), Zinc (Zn), Vitamin C, Vitamin B1, Vitamin E
- Where
- Switzerland
- Volunteers
- 200 people
- Sponsor
- Centre Hospitalier Universitaire Vaudois
Critically Ill, Acute Respiratory Failure
The EXCEL Registry of Patients Requiring ECMO
ECMO is associated with significant costs, risks and requires specialist training and expertise. EXCEL is a novel, high-quality, detailed prospective registry of patients requiring ECMO in Australia and New Zealand.
- Conditions
- Critically Ill, Acute Respiratory Failure, Acute Heart Failure, Cardiac Arrest
- Trial name
- NCT03793257
- Where
- 29 sites in Australia, New Zealand
- Volunteers
- 3,000 people
- Sponsor
- Australian and New Zealand Intensive Care Research Centre
Critically Ill
Randomized Trial of Continuous Versus Intermittent Cefotaxime Infusion on ICU.
This study evaluates target attainment after either intermittent intravenous bolus or intravenous continuous infusion of cefotaxime in critically ill patients.
- Trial name
- NCT02560207
- Testing
- Cefotaxime
- Where
- Netherlands
- Volunteers
- 60 people
- Sponsor
- University Medical Center Groningen
Critical Illness, Mechanical Ventilation Complication
The PREDICT Study- a Registry in Critically Ill Patients to Determine Predictors of Disability Free Survival
As mortality from critical illness has reduced, the importance of measuring disabilities (cognitive, functional and psychological) in surviving critically ill patients has become more important.
- Conditions
- Critical Illness, Mechanical Ventilation Complication, Disabilities Multiple, Quality of Life
- Trial name
- PREDICT (NCT03226912)
- Where
- Australia
- Volunteers
- 500 people
- Sponsor
- Australian and New Zealand Intensive Care Research Centre
Intensive Care Medicine, Respiratory Distress Syndrome (RDS)
Improving Sedation Practice in Critically Ill Adult Patients Using a Co-designed Sedation Protocol
Sedation (painkillers and sedative drugs) treats pain, reduces suffering, and helps patients in the intensive care unit (ICU) receiving extracorporeal membrane oxygenation (ECMO) remain comfortable.
- Conditions
- Intensive Care Medicine, Respiratory Distress Syndrome (RDS), Sedation and Analgesia, ExtraCorporeal Membrane Oxygenation (ECMO)
- Trial name
- ECMO-SED (NCT07032987)
- Testing
- Not an intervention study
- Where
- United Kingdom
- Volunteers
- 120 people
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
Critical Illness
The Effect of Applying Modified NUTRIC Scoring System to Evaluate the Nutrition Risk and Giving Different Types of Nutritional Support on Clinical Outcomes in Critically Ill Patients
Malnutrition is very common in critically ill patients. It is quite important to evaluate nutritional status precisely. Heyland et al firstly reported NUTRIC score including age, APACHE II score, SOFA score, number of…
- Trial name
- NCT03365258
- Testing
- Trophic feeding, volume-based feeding
- Where
- Taiwan
- Volunteers
- 150 people
- Sponsor
- Taichung Veterans General Hospital
Critically Ill, Deep Sedation
Efficacy and Safety of Remimazolam Besylate Versus Propofol for Sedation in Critically Ill Patients With Deep Sedation
The purpose of this study is to evaluate the efficacy and safety of remimazolam besylate compared to propofol for sedation in critically ill patients with deep sedation.
- Trial name
- NCT05539521
- Testing
- Remimazolam Besylate, Propofol
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Critical Ill Patient Undergone Parenteral Nutrition
Tight Glycemic Control and Insulin Administration During Parenteral Nutrition
In this study the investigators want to comare safety and efficacy of two different metods to administrate insulin during parenteral nutrition.
- Trial name
- NCT02035943
- Testing
- Insulin separated, Insulin added to parenteral nutrition
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- Policlinico Hospital
Vitamin D Deficiency, Critical Illness
Prevalence of Deficiency of Vitamin D in Critically Ill Patients
Vitamin D has been shown to related to clinical outcomes in critically ill patients. The object of this study is to investigate the prevalence of Vitamin D deficiency in critically ill patients with various length of ICU stay .
- Trial name
- NCT03639584
- Where
- Taiwan
- Volunteers
- 662 people
- Sponsor
- National Taiwan University Hospital