Clinical trials: Critical Ill Patients
Sepsis, Respiratory Failure
The Effect of Intensive Insulin Therapy in the Surgical Critical Care Unit
We sought to determine if there is a benefit to using an insulin drip to control hyperglycemia in the surgical critical care unit for patients who undergo general and vascular surgery.
- Conditions
- Sepsis, Respiratory Failure, Renal Failure, Surgical Site Infection
- Trial name
- NCT00282594
- Testing
- Novolin R (human recombinant Insulin)
- Where
- United States
- Volunteers
- 317 people
- Sponsor
- Genesys
Critical Illness
The Impact of IC-Guided Feeding Protocol on Clinical Outcomes in Critically Ill Patients (The IC-Study)
Adequate nutritional support is an essential element for achieving favourable outcomes in critically ill patients. Therefore, an accurate determination of patients' energy needs is required to optimize nutritional support and…
- Trial name
- NCT04479254
- Testing
- Enteral Nutrients ( Nutren Optimum, Nutren Diabetes, Novasource Renal ), Parenteral Nutrient ( Smofkabiven)
- Where
- Malaysia
- Volunteers
- 60 people
- Sponsor
- International Islamic University Malaysia
Critically Ill
Continuous Control of Tracheal Cuff Pressure and Microaspiration in Critically Ill Patients
We hypothesized that continuous control of tracheal cuff pressure would reduce microaspiration of gastric content as determined by pepsin level in tracheal aspirate.
- Trial name
- NCT01082666
- Testing
- Continuous control of cuff pressure, Manual control of cuff pressure
- Where
- France
- Volunteers
- 122 people
- Sponsor
- University Hospital, Lille
Infectious Diseases
Safety and Efficacy Study of High Dose Colistin
Colistin is a rapidly acting bactericidal antimicrobial agent that possesses a post antibiotic effect against MDRO Gram-negative bacteria, such as as Pseudomonas aeruginosa, Acinetobacterbaumannii, and Klebsiella pneumonia.
- Trial name
- NCT02162966
- Testing
- High Dose Colistin, Standard Dose Colistin
- Where
- Saudi Arabia
- Volunteers
- 330 people
- Sponsor
- King Saud Medical City
Critical Illness, Pain
Population Pharmacokinetics of Remifentanil in Low-Weight Critically Ill Patients
The goal of this prospective clinical study is to learn about the population pharmacokinetics (PopPK), safety, and efficacy of remifentanil in low-body-weight patients in the Intensive Care Unit (ICU) who require mechanical…
- Trial name
- NCT07301970
- Testing
- Remifentanil
- Where
- China
- Volunteers
- 45 people
- Sponsor
- Fudan University
Critical Illness, Oliguria
Performance of Diuretic Stress Test in Predicting Short Term Renal Recovery in Oliguric Critically-ill Patients Recovery in the Short Term
Acute kidney injury (AKI) is a common disorder and associated with high morbidity and mortality. However, distinguishing transient AKI from persistent AKI may help in individualizing treatment and limit short and long term…
- Trial name
- NCT02800135
- Testing
- Furosemide
- Where
- 4 sites in France
- Volunteers
- 93 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Pre-Eclampsia, Critical Illness
Homocysteine in Critically Ill Preeclampsia
Preeclampsia is a disorder characterized by the new onset of hypertension and proteinuria typically presenting after 20 weeks of gestation.
- Trial name
- NCT06413576
- Testing
- homocysteine measurement
- Where
- 2 sites in Egypt
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Fluid Overload, Critical Care, Intensive Care
Timing and Dose of Fluid Deresuscitation in Critically Ill Patients
Fluid deresuscitation is an important intervention in the Intensive Care Unit (ICU). This study aims to find (1) determinants of successful deresuscitation, (2) the optimal rate (dose) of deresuscitation based on these…
- Conditions
- Fluid Overload, Critical Care, Intensive Care, Deresuscitation
- Trial name
- TIDE (NCT07275658)
- Where
- 2 sites in Netherlands
- Volunteers
- 150 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Critical Illness, Low Peripheral Perfusion
Local Warming to Improve Pulse Oximetry Accuracy in Critically Ill Patients
Pulse oximeters are widely used in intensive care to continuously estimate the oxygen level in the blood. However, pulse oximeter measurements may be less accurate when blood flow to the fingers is poor, which is common in…
- Conditions
- Critical Illness, Low Peripheral Perfusion, Pulse Oximetry Accuracy
- Trial name
- PULSEWARM (NCT07792304)
- Testing
- Protocolized Local Warming
- Where
- 4 sites in Sweden
- Volunteers
- 240 people
- Sponsor
- Vastra Gotaland Region
Critically Ill
Diaphragmatic Function in Ventilated Patients
Animal studies showed that controlled mechanical ventilation (CMV) can induce dysfunction of the diaphragm, resulting in an early-onset and progressive decrease in diaphragmatic force-generating capacity, called…
- Trial name
- NCT00786526
- Where
- 2 sites in France
- Volunteers
- 55 people
- Sponsor
- University Hospital, Montpellier
Critical Illness, Dietary Modification
Protein Consumption in Critically Ill Patients
A retrospective study of protein intake and needs as well as outcomes in critically ill adult patients. Data will be collected for up to 7 days of ICU stay.
- Trial name
- NCT03048487
- Where
- 3 sites in United States
- Volunteers
- 2,000 people
- Sponsor
- Société des Produits Nestlé (SPN)
Post-craniotomy, Critical Illness
Scores in Critically Ill Patients After Craniotomy
This study planned to review patients admitted to three ICU wards at Beijing Tiantan Hospital between 2017 and 2020. It focused on adult patients who had undergone craniotomy and stayed in the ICU for more than 24 hours.
- Conditions
- Post-craniotomy, Critical Illness, Mortality, Severity of Illness Scores
- Trial name
- SCORES (NCT06762184)
- Where
- Chile
- Volunteers
- 1,600 people
- Sponsor
- Beijing Tiantan Hospital
COVID-19
Therapeutic Plasmapheresis in Critically Ill Adult Patients With COVID-19 Confirmed Diagnosis
Introduction: The SARS-CoV-2 outbreak has left more than two million infected worldwide in the first four months of COVID-19 epidemic.
- Trial name
- PLASMA (NCT04480632)
- Testing
- Convalescent plasma
- Where
- Colombia
- Volunteers
- 44 people
- Sponsor
- Fundación Cardiovascular de Colombia
Critical Illness, Mechanical Ventilation Complication
Enteral Versus Intravenous Sedation in Critically Ill High-risk ICU Patients
Recent studies suggest the employment of 'conscious' sedation (1) for critically high - risk patients (2), showing more efficacy then deep sedation (3).
- Trial name
- NCT01360346
- Testing
- Enteral Sedation (EN), Control group: Intravenous Sedation (IV)
- Where
- Italy
- Volunteers
- 300 people
- Sponsor
- University of Milan
Critically Ill
Managing Acute Pain in Critically Ill Non-communicative Palliative Care Patients
The purpose of this project is to test an innovative method for managing pain in acutely ill hospitalized patients who are not able to report their pain verbally to health care professionals.
- Trial name
- NCT02127086
- Testing
- Intervention Group
- Where
- United States
- Volunteers
- 377 people
- Sponsor
- University of Maryland, Baltimore
Hyperglycemia, Critical Illness
Normoglycaemia in Intensive Care Evaluation and Survival Using Glucose Algorithm Regulation (NICE - SUGAR STUDY)
The primary aim of the study is to compare the effects of the two blood glucose targets on 90 day all-cause mortality in Intensive Care patients who are predicted on admission to stay in the ICU for at least one full calendar…
- Trial name
- NCT00220987
- Testing
- Intensive Insulin Therapy, Conventional Insulin therapy
- Where
- Australia
- Volunteers
- 6,104 people
- Sponsor
- The George Institute
Septic Shock, Fungal Infection
Pharmacokinetics of Caspofungin
The objective of this study is to describe the pharmacokinetics of standard doses of caspofungin in critically ill patients.
- Conditions
- Septic Shock, Fungal Infection, Critical Illness
- Trial name
- NCT03399032
- Testing
- Caspofungin
- Where
- Poland
- Volunteers
- 33 people
- Sponsor
- Medical University of Lublin
Intubation, Critically Ill
Airway IgA: Respiratory Tract IgA Levels in Critically Ill Intubated Patients
This study will examine the impact of acute illness on sequential airway IgA levels in intensive care patients who will require prolonged intubation.
- Trial name
- NCT00205309
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- University of Wisconsin, Madison
Critical Illness, Energy Supply; Deficiency, Severe
GLUCOSAFE 2 - A New Tool for Nutritional Management and Insulin-therapy in the Intensive Care Unit (ICU)
The survival and the outcomes of critically ill patients are strongly influenced by insulin-therapy and nutritional support. The GLUCOSAFE 2 pilot study, aims to test the performance and the security of the new GLUCOSAFE 2…
- Conditions
- Critical Illness, Energy Supply; Deficiency, Severe, Protein Deficiency, Hypoglycemia
- Trial name
- NCT03890432
- Testing
- GLUCOSAFE 2, Local protocol control group with routine care, Historical control group with routine care
- Where
- 2 sites in Switzerland
- Volunteers
- 213 people
- Sponsor
- HEIDEGGER CP
Thromboprophylaxis, Critical Illness
Pharmacokinetic Profiles of Subcutaneous Enoxaparin for Thromboprophylaxis in Critically Ill Patients With Renal Failure Treated or Not With Continuous Veno-veinous Hemofiltration.
Thromboprophylaxis is recommended for critically ill patients without contraindications and is usually achieved by the subcutaneous daily administration of a low dose of low molecular weight heparin (LMWH).
- Conditions
- Thromboprophylaxis, Critical Illness, Intensive Care (ICU)
- Trial name
- AKI-ENOXA (NCT07384598)
- Testing
- Anti-Xa profiles after the subcutaneous administration of a prophylactic dose of enoxaparin
- Volunteers
- 60 people
- Sponsor
- Clinique Saint Pierre Ottignies