Clinical trials: Critical Ill Patients
Weaning Failure, Muscle Weakness
TESTO-TRIAL: Use of Testosterone in Critically Ill Patients
The objective of this study is to evaluate whether the use of the anabolic agent testosterone cypionate in critically ill patients, compared to placebo, increases the number of ventilator-free days
- Conditions
- Weaning Failure, Muscle Weakness, Mechanical Ventilation Complication, ICU Acquired Weakness
- Trial name
- TT (NCT06592144)
- Testing
- Testosterone cypionate (200mg/3ml), Sesame oil (3ml)
- Where
- Brazil
- Volunteers
- 94 people
- Sponsor
- Leticia Maria Defendi Barboza Marson
Acid-Base Imbalance, Respiratory Acidosis
Non Carbonic Buffer Power of Critical Ill Patients With Sepsis
Alterations of acid-base equilibrium are very common in critically ill patients and understanding their pathophysiology can be important to improve clinical treatment.
- Conditions
- Acid-Base Imbalance, Respiratory Acidosis, Respiratory Alkalosis
- Trial name
- NCT03503214
- Testing
- In vitro determination of non-carbonic buffer power, Classic description of acid-base status
- Where
- Italy
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
Critical Care Nursing
Speech-to-speech Voice-cloning Care (SVCC) to Improve ICU-acquired Anxiety for Critically Ill Patients
The goal of this clinical trial is to learn the effect of Speech-to-speech Voice-Cloning Care (SVCC) on improving ICU-acquired anxiety for critically ill patients.
- Trial name
- NCT06743321
- Testing
- Speech-to-speech Voice-Cloning Care (SVCC)
- Where
- China
- Volunteers
- 234 people
- Sponsor
- Peking Union Medical College Hospital
Critical Illness
Protein Dosing Strategies in Critically Ill Patients: Comparing Actual Body Weight and Fat-Free Mass Approaches in an Observational Cohort Study
This study investigates how different methods of calculating protein intake affect recovery and muscle preservation in critically ill patients in the Intensive Care Unit (ICU).
- Trial name
- NCT07312708
- Where
- Netherlands
- Volunteers
- 620 people
- Sponsor
- Gelderse Vallei Hospital
Critical Illness
Ultrasound-guided Axillary Artery vs Femoral Artery Cannulation.
The main purpose of the study is to compare two ultrasound-guided arterial cannulation procedures: in-plane infraclavicular axillary artery cannulation and out-of-plane femoral artery cannulation.
- Trial name
- AxFemArt (NCT02801825)
- Testing
- Real-time ultrasound-guided in-plane infraclavicular axillary artery cannulation., Real-time ultrasound-guided out-of-plane femoral artery cannulation.
- Where
- Poland
- Volunteers
- 110 people
- Sponsor
- Uniwersytecki Szpital Kliniczny w Opolu
Critically Ill, Intensive Care Unit Delirium
Physical Restraints in Intensive Care Unit Patients
The use of physical restraints is common practice in Intensive Care Units (ICU). This medically prescribed procedure requires full attention of medical and paramedical teams for its implementation, monitoring and ending, as a…
- Conditions
- Critically Ill, Intensive Care Unit Delirium, Delirium Confusional State, Agitation,Psychomotor
- Trial name
- ARBORéa (NCT04957238)
- Testing
- ARBORea decision-making tool
- Where
- 19 sites in France
- Volunteers
- 4,000 people
- Sponsor
- University Hospital, Clermont-Ferrand
Ventilator-associated Pneumonia
A Pharmacokinetic-pharmacodynamic Dose Comparison Study of 8 mg/kg of Inhaled or Parenteral Gentamicin in 12 Mechanically Ventilated Critically Ill Patients Treated for Ventilator-associated Pneumonia
Ventilator associated pneumonia (VAP) remains in the intensive care unit the infection associated with the highest morbidity and mortality. Respiratory infection with resistant organism are increasing in prevalence.
- Trial name
- GENTAERO (NCT02515448)
- Testing
- gentamicin
- Where
- 2 sites in France
- Volunteers
- 12 people
- Sponsor
- Poitiers University Hospital
Acute Renal Failure, SIRS
BK Virus and Renal Dysfunction in Postoperative/Posttraumatic Critically Ill Patients
The purpose of this study is to find out whether acute renal failure is associated with BK virus reactivation in postoperative/posttraumatic critically ill patients with severe SIRS/sepsis and shock.
- Conditions
- Acute Renal Failure, SIRS, Sepsis, Critically Ill
- Trial name
- BICUK (NCT00736827)
- Where
- Germany
- Volunteers
- 51 people
- Sponsor
- University of Ulm
Acute Kidney Injury
Effect of a Furosemide Stress Test-Guided Strategy on Liberation From Continuous Renal Replacement Therapy in Critically Ill Patients With Acute Kidney Injury
Currently, continuous renal replacement therapy (CRRT) is the main modality for renal support in critically ill patients with hemodynamic instability. Most studies have investigated the timing of RRT initiation.
- Trial name
- FST-LIBERATE (NCT06229990)
- Testing
- Furosemide Injection
- Where
- Thailand
- Volunteers
- 88 people
- Sponsor
- Chiang Mai University
Vitamin D Deficiency, Critical Illness
Cholecalciferol Supplementation in Critically Ill Patients With Severe Vitamin D Deficiency.
The purpose of the research study is to determine whether a single high dose of vitamin D is helpful in reducing critical illness related complications in intensive care patients who are having sever vitamin D deficiency.
- Trial name
- NCT02868827
- Testing
- Cholecalciferol, Milk (Nestle)
- Where
- Saudi Arabia
- Volunteers
- 127 people
- Sponsor
- King Abdullah Medical City
Critical Illness, Shock
Individualised Blood Pressure Targets Versus Standard Care Among Critically Ill Patients With Shock
Aim The aim of the proposed RCT is to determine effectiveness of a strategy, where MAP (mean arterial blood pressure) targets during vasopressor therapy for shock in ICU are individualized based on patients' own pre-illness MAP…
- Trial name
- REACT-SHOCK (NCT05850962)
- Testing
- Individualised MAP target
- Where
- Australia
- Volunteers
- 1,260 people
- Sponsor
- Rakshit Panwar
Critically Ill, Acute Kidney Injury
Remote Ischemic Preconditioning in Septic Patients
Acute kidney injury is a well-recognized complication in critically ill patients. Up to date there is no clinically established method to reduce the incidence or the severity of acute kidney injury.
- Conditions
- Critically Ill, Acute Kidney Injury, Sepsis
- Trial name
- RIPC-ICU (NCT05830669)
- Testing
- Remote ischemic preconditioning (RIPC)
- Where
- Germany
- Volunteers
- 64 people
- Sponsor
- Universität Münster
Autonomic Nervous System Dysfunction in Critically Ill
Transplanted-like Heart in Critical Ill Patients
The purpose of this study is to measure the dysfunction of the autonomic nervous system in modulating the heart rate variability and baroreflex control in critically ill.
- Trial name
- NCT01930669
- Testing
- Gravitational sympathetic stimulus
- Where
- 2 sites in Italy
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- ASST Fatebenefratelli Sacco
Tracheostomy, Prolonged Mechanical Ventilation
Incremental Dead Space Versus Capping Trial Before Tracheostomy Decannulation
Some critically ill patients need a breathing tube placed directly into the windpipe (tracheostomy) because they require long-term help from a breathing machine.
- Conditions
- Tracheostomy, Prolonged Mechanical Ventilation, Tracheostomy Decannulation
- Trial name
- NCT07810166
- Testing
- Incremental Instrumental Dead Space, Capping Trial
- Where
- Chile
- Volunteers
- 22 people
- Sponsor
- Pontificia Universidad Catolica de Chile
Terminal Illness, Intensive Care Unit Syndrome
End Of Life in the Critically Ill patiEnt
The purpose of this multicentric study is to evaluate the perception of the quality of the end of life in intensive care units seen from the side of the caregivers, trough the CAESAR scale.
- Trial name
- EOLE (NCT03392857)
- Testing
- Assessment by caregivers of the quality of the end of life in intensive care units
- Where
- 112 sites in France
- Volunteers
- 514 people
- Sponsor
- French Society for Intensive Care
Pneumonia
PNEUmonia DOSing in Critically Ill Patients (PNEUDOS)
Pneumonia is the most common infection in intensive care unit (ICU) patients and occurs in 10% of all ICU admissions. Unfortunately, ICU patient outcomes remain poor with a high mortality rate associated with pneumonia despite…
- Trial name
- PNEUDOS (NCT04986254)
- Testing
- Blood sampling, Epithelial lining fluid sampling, Urine sampling
- Where
- 6 sites in Australia, Belgium and 3 more
- Volunteers
- 179 people
- Sponsor
- The University of Queensland
Sepsis - to Reduce Mortality in the Intensive Care Unit, Sepsis
Beta-Lactam Antibiotics InitiaL ExpoSure OptimisEd in CriticallY Ill Patients with SEpsis
The aim of this study is to investigate if an initial short double dose of beta-lactam antibiotics will reduce mortality in critically ill patients with sepsis.
- Conditions
- Sepsis - to Reduce Mortality in the Intensive Care Unit, Sepsis, Septic Shock
- Trial name
- BULLSEYE (NCT06766461)
- Testing
- Double dosing of beta-lactam antibiotic
- Where
- Netherlands
- Volunteers
- 980 people
- Sponsor
- Erasmus Medical Center
Muscular Atrophy
Study in ICU Patients Regarding Protein Intake and CT-derived Body Composition
The purpose of this study is to determine whether protein intake during the first days of intensive care admission, in relation to body composition at intensive care admission as assessed on computed tomography scans made during…
- Trial name
- NCT02817646
- Testing
- Computed tomography scan made for clinical reasons, Nutrition as per hospital protocol
- Volunteers
- 800 people
- Sponsor
- Amsterdam UMC, location VUmc
Critical Illness, Pressure Injuries
Abdominal Massage and Range-of-motion Exercise in Enterally Fed ICU Patients With Pressure Injuries
The purpose of this study is to evaluate whether two nursing interventions, lower abdominal massage and range-of-motion (ROM) exercises (gentle movements of the arm and leg joints), affect the healing of pressure injuries (bed…
- Conditions
- Critical Illness, Pressure Injuries, Enteral Nutrition Intolerance in Critically Ill Patients
- Trial name
- pressure injur (NCT07904520)
- Testing
- LAM group, Intervention and control-group data were collected daily at 10:00 AM. In the intervention groups, each 15-minute session was followed by outcome measurements the next day before the following session,, ROM
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people
- Sponsor
- Bartın Unıversity
Intraabdominal Hypertension, Critically Ill
PEEP Levels on Intraabdominal Pressure and Hemodynamics in Critically Ill Patients
In this study, it was aimed to compare the effects of three different PEEP levels (0-4, 5-8, 9-12 cmH2O) on intraabdominal pressure and hemodynamic parameters of patients in intensive care unit.
- Conditions
- Intraabdominal Hypertension, Critically Ill, Hemodynamic Instability
- Trial name
- NCT03714724
- Testing
- Intraabdominal Pressure Measurement
- Where
- Turkey (Türkiye)
- Volunteers
- 66 people
- Sponsor
- Yuzuncu Yil University