Clinical trials: Critical Ill Patients
Critical Illness, Multiple Organ Failure
Impact of Human Blood Serum From Critically Ill Patients on Human Colon Neuronal Networks.
Critical illness in the ICU setting has high medical and socioeconomic importance. Critically ill patients frequently develop severe neurologic impairment during their course of disease, typically presenting as…
- Conditions
- Critical Illness, Multiple Organ Failure, Polyneuropathy, Myopathy
- Trial name
- NCT02706314
- Where
- Germany
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- University of Rostock
Covid19, Critically Ill
Risk Factors for Mortality for COVID-19 Admitted to an Intensive Care Unit
Studying clinical characterization of critically ill COVID-19 patients in a single center Studying Risk factors for Day 28 Mortality in COVID-19 patients admitted to intensive care unit
- Trial name
- ICUCOVID-KK (NCT04805645)
- Testing
- No intervention (Retrospective Cohort Observational)
- Where
- Malaysia
- Volunteers
- 50 people
- Sponsor
- Clinical Research Centre, Malaysia
Covid19
Selenium as a Potential Treatment for Moderately-ill, Severely-ill, and Critically-ill COVID-19 Patients.
Given its anti-viral, anti-oxidative, immune-enhancing, cytokine-modulating, and anticoagulant properties, the investigators hypothesize that Selenium infusion at supranutritional doses for moderately-ill, severely-ill, and…
- Trial name
- SeCOVID (NCT04869579)
- Testing
- Selenium (as Selenious Acid)
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- CHRISTUS Health
Critical Illness
Physical Therapist Inter-Rater Reliability in Neuro-Muscle Ultrasound in Critically Ill Patients
The goal of this observational study is to evaluate the feasibility and inter-rater reliability of muscle and peripheral nerve ultrasound for the early detection of ICU-acquired weakness (ICU-AW) in critically ill patients.
- Trial name
- NMusICU-R (NCT07032870)
- Where
- Chile
- Volunteers
- 37 people
- Sponsor
- University of Chile
Acute Stress Disorder, Anxiety
GASA-CIR Trail (Guidance and the Symptoms of Acute Stress and Anxiety in Critically Ill Patients Relatives in Intensive Care Unit)
A randomized clinical trial 1:1 among relatives of patients admitted to an intensive care unit, the intervention group will be composed by family members who receive a printed brochure and will be encouraged to visit a website…
- Conditions
- Acute Stress Disorder, Anxiety, Depression
- Trial name
- GASA-CIR (NCT03812458)
- Testing
- website and brochure
- Where
- Brazil
- Volunteers
- 190 people, healthy volunteers welcome
- Sponsor
- Federal University of Rio Grande do Sul
Critically Ill
Hypocaloric Enteral Nutrition in the Critically Ill Patient
The aim of this study is to compare two nutritional regimes in critically ill patients. Patients will be randomized to standard care (25 kcal per kg) or to hypocaloric nutrition (15 kcal per kg).
- Trial name
- hipoentnut (NCT02577211)
- Testing
- Hipocaloric enteral nutrition, Normocaloric enteral nutrition
- Where
- Colombia
- Volunteers
- 120 people
- Sponsor
- Lafrancol S.A.
Shock, Sepsis
Single Dose Enteral Tranexamic Acid in Critically Ill Patients
The premise of this study is that enteral tranexamic acid will help to maintain small bowel integrity, which is often compromised by critical illness due to inadequate cardiovascular perfusion (i.e., shock), and that maintenance…
- Conditions
- Shock, Sepsis, Hypotension, Critical Illness
- Trial name
- NCT01683747
- Testing
- Tranexamic Acid, Control Intervention (Carrier fluid only)
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- San Diego Veterans Healthcare System
Critical Illness
Bedside Renal Ultrasound Assessment in Patients With Acute Kidney Injury
Exploring the predictive and evaluative value of various indicators of bedside critical renal ultrasound in critically ill patients with acute kidney injury (AKI)
- Trial name
- NCT06156098
- Testing
- No Intervention
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Qin Zhang
Delirium
Evaluation of Delirium Prevention in Critically Ill Patients
Haloperidol is prescribed in high risk ICU patients concerning delirium (50% or more chance to develop delirium detected with the delirium prediction model PRE-DELIRIC, or patients with history of dementia or alcohol abuse)since…
- Trial name
- NCT01187667
- Where
- Netherlands
- Volunteers
- 650 people
- Sponsor
- Radboud University Medical Center
Intra-Abdominal Hypertension, Critical Illness
Intra-Abdominal Pressure Changes During Continuous Renal Replacement Therapy in Critically Ill Patients
This prospective observational study will evaluate changes in intra-abdominal pressure in critically ill adult patients receiving continuous renal replacement therapy in the intensive care unit.
- Conditions
- Intra-Abdominal Hypertension, Critical Illness, Continuous Renal Replacement Therapy
- Trial name
- NCT07823387
- Testing
- Intravesical Intra-abdominal Pressure Measurement
- Where
- Turkey (Türkiye)
- Volunteers
- 95 people
- Sponsor
- Bursa Yuksek Ihtisas Training and Research Hospital
Critical Illness Myopathy
Effects of Neuromuscular Electrical Stimulation on Exercise Capacity in Respiratory Critically Ill Patients
Neuromuscular electrical stimulation (NMES) implemented during the intensive care unit(ICU) stay may improve exercise capacity and prevent muscular weakness in critically ill patients with respiratory disease.
- Trial name
- NCT03083652
- Testing
- Neuromuscular electrical stimulation
- Where
- Spain
- Volunteers
- 40 people
- Sponsor
- Hospital Clinic of Barcelona
Sepsis
Curcumin in Critically Ill Patients With Sepsis
Sepsis is a life-threatening condition that occurs when the body's response to an infection becomes overwhelming and damages its own organs.
- Trial name
- NCT07436130
- Testing
- Curcumin
- Where
- Mexico
- Volunteers
- 56 people
- Sponsor
- Hospital Civil de Guadalajara
Critical Illness, Intolerance; Nutritional
Clinical Evaluation of the VIPUN Balloon Catheter 0.2 in Critically Ill Patients
An open label, non-randomized, monocentric, interventional investigation in a cohort of adult critically ill patients
- Conditions
- Critical Illness, Intolerance; Nutritional, Delayed Gastric Emptying, Gastric Motor Dysfunction
- Trial name
- ANTERO-2 (NCT03512145)
- Testing
- VIPUN Balloon Catheter
- Where
- Belgium
- Volunteers
- 30 people
- Sponsor
- Prof Dr Jan Tack
Critical Illness
Optimal Protein Supplementation for Critically Ill Patients
It is well accepted that during critical illness there is an increase in protein breakdown and loss of lean body mass. Previous studies have shown that during critical illness muscle breakdown increases dramatically.
- Trial name
- NCT01934595
- Testing
- Beneprotein
- Where
- United States
- Sponsor
- University of Oklahoma
Intubation Complication, Critically Ill
Effect of Endotracheal Tube Plus STYLET Versus Endotracheal Tube Alone
Patients admitted to Intensive Care Units (ICU) often require respiratory support. Orotracheal intubation is one of the most frequent procedures performed in ICU.When performed in emergency settings, intubation is a challenging…
- Trial name
- STYLETO (NCT04079387)
- Testing
- ENDOTRACHEAL TUBE + STYLET, ENDOTRACHEAL TUBE ALONE
- Where
- France
- Volunteers
- 1,040 people
- Sponsor
- University Hospital, Montpellier
Laparotomy, Critical Illness
Are Standard Dosing Regimens of Piperacillin-Tazobactam Suitable in Critically Ill Patients With Open Abdomen and Negative Pressure Wound Therapy? A Population Pharmacokinetic Study.
For several years, open abdomen with temporary abdominal closure using Negative Pressure Therapy (OA/NPT) has become one of the leading strategies to treat or prevent intra-abdominal hypertension in critically ill surgical…
- Conditions
- Laparotomy, Critical Illness, Piperacillin, Tazobactam Drug Combination
- Trial name
- PK-LAP (NCT04915872)
- Testing
- Blood sampling (T0, inclusion), other samplings (T1)
- Where
- France
- Volunteers
- 46 people
- Sponsor
- University Hospital, Bordeaux
Critically Ill
Hemodynamic Monitoring With Mixed Venous Saturation
In this study the investigators aim to evaluate the utility of a continuous mixed venous saturation monitoring compared to a clinical examination in a group of critically ill patients.
- Trial name
- NCT00303043
- Testing
- Mixed venous saturation monitoring
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- Policlinico Hospital
Grief, Trauma
A Clinical Trial of Interventions to Support Family Surrogates of Critically Ill Patients
Hypotheses 1a and 1b: Compared to Supportive Conversation arm, the EMPOWER intervention will significantly decrease surrogate decision makers' symptoms of grief and Post Traumatic Stress Disorder (PTSD) (primary outcomes); and…
- Conditions
- Grief, Trauma, Psychotherapy, Critical Care
- Trial name
- NCT05587517
- Testing
- EMPOWER, Supportive Conversation
- Where
- 3 sites in United States
- Volunteers
- 172 people, healthy volunteers welcome
- Sponsor
- Weill Medical College of Cornell University
Critically Ill, Intra-Abdominal Hypertension
The Influence of Fluid Removal Using Continuous Venovenous Hemofiltration (CVVH) on Intra-abdominal Pressure and Kidney Function
Intra- abdominal hypertension (IAH) and abdominal compartment syndrome (ACS) are a cause of organ dysfunction in critically ill patients.
- Conditions
- Critically Ill, Intra-Abdominal Hypertension, Abdominal Compartment Syndrome, Acute Kidney Injury
- Trial name
- NCT01077895
- Testing
- CVVH, ultrafiltration, ultrafiltration control group
- Where
- 2 sites in Belgium
- Sponsor
- University Hospital, Ghent
Critical Illness, Mechanical Ventilation
Metabolic Response to Supine Physiotherapy in Mechanically Ventilated ICU Patients
Critically ill patients who require mechanical ventilation frequently experience rapid loss of muscle mass and physical function during their stay in the intensive care unit (ICU).
- Conditions
- Critical Illness, Mechanical Ventilation, Intensive Care Unit-Acquired Weakness, Physical Rehabilitation in the Intensive Care Unit
- Trial name
- NCT07361419
- Testing
- Supine Physiotherapy Session
- Where
- Spain
- Volunteers
- 40 people
- Sponsor
- Universidad de Extremadura