Clinical trials: Critical Ill Patients
Critical Illness
Integrated Supportive and Palliative Care for Older Adults in the ICU
The National Academy of Medicine and the National Institutes of Health have called for urgent action to improve the care delivered to the nearly 1,000,000 older Americans who die in intensive care units (ICUs) annually, or…
- Trial name
- ProPACC (NCT04921631)
- Testing
- Early Integration of Specialty Palliative Care with Critical Care
- Where
- United States
- Volunteers
- 1,091 people
- Sponsor
- University of Pittsburgh
Symptoms and Signs, Symptom Cluster
Patient Reported Symptoms the First Week After Intensive Care Unit Discharge and up to Hospital Discharge
The overall objective of this study is a) to increase knowledge about ICU patient's symptoms and symptom clusters during the first week after ICU discharge, and b) to identify cognitive, psychological, and physical symptoms and…
- Conditions
- Symptoms and Signs, Symptom Cluster, Follow-up Care, Critical Illness
- Trial name
- NCT05266118
- Where
- 2 sites in Norway
- Volunteers
- 177 people
- Sponsor
- Ostfold Hospital Trust
Healthcare Associated Infection, Critically Ill
Dynamic Full-field Optical Coherence Tomography for Structural and Microbiological Characterization of Endotracheal Tube Biofilm in Critically Ill Patients
Biofilm is a microstructure organised into aggregates of microbiological species within a polymeric matrix. As early as the 2000s, the Centers for Disease Control and Prevention (CDC) recognised the possible role of the biofilm…
- Conditions
- Healthcare Associated Infection, Critically Ill, Endotracheal Tube
- Trial name
- BIOPAVIR2 (NCT06379139)
- Testing
- •Dynamic Full-Field Optical Coherence Tomography analysis of endotracheal tube
- Where
- 2 sites in France
- Volunteers
- 80 people
- Sponsor
- Centre Hospitalier Universitaire Dijon
Intra Abdominal Infections, Candidiasis, Invasive
Peritoneal 1.3-ß-D-glucan for the Diagnosis of Intra-abdominal Candidiasis in Critically Ill Patients (pBDG2)
New rapid diagnostic strategies are warranted in intra-abdominal candidiasis (IAC). A previous retrospective study showed that one measure, the day of the surgery, of peritoneal 1.3-Beta-D-Glucan ≤ 310pg/ml could rule out an IAC.
- Conditions
- Intra Abdominal Infections, Candidiasis, Invasive, Peritoneal Candidiasis, Critically Ill
- Trial name
- pBDG2 (NCT03997929)
- Testing
- 1.3 BETA D GLUCAN
- Where
- 4 sites in France
- Volunteers
- 200 people
- Sponsor
- Central Hospital, Nancy, France
Pneumonia, Critically Ill
Impact of Rapid Pathogen Detection in ICU Patients With Suspected Pneumonia on Antimicrobial Therapy
The goal of this intervention trial is to determine the feasibility, safety, and potential impact of rapid respiratory pathogen detection by FA Pneumonia Panel on antibiotic therapy in mechanically ventilated critically ill…
- Trial name
- IRISPAT-1 (NCT06478953)
- Testing
- FA Pneumonia Panel
- Where
- Hong Kong
- Volunteers
- 40 people
- Sponsor
- Chinese University of Hong Kong
Critical Illness, Respiratory Failure
PRactice of VENTilation in Critically Ill PEDiatric Patients
The goal of this worldwide observational study is to investigate ventilation practice in critically ill pediatric patients. The main questions it aims to answer are: 1.
- Trial name
- PRoVent-PED (NCT06220825)
- Where
- Netherlands
- Volunteers
- 2,500 people
- Sponsor
- University Medical Center Groningen
Critically Ill, H1N1/Influenza Infection
Collaborative H1N1 Adjuvant Treatment Pilot Trial
Study Design: A, multinational, double blind, placebo-controlled pilot RCT involving 80 patients in the general ICUs of 30 centres.
- Trial name
- CHAT (NCT01033955)
- Testing
- Rosuvastatin
- Where
- 9 sites in Canada
- Volunteers
- 8 people
- Sponsor
- Canadian Critical Care Trials Group
Metabolomic
Metabolomic in Critical Ill Patients
Analysis of blood, urinary, and intrathecal metabolites of critical ill patients will be checked for possible correlations between metabolomics patterns and patients' outcomes.
- Trial name
- NCT01506674
- Where
- Italy
- Volunteers
- 94 people
- Sponsor
- Università Vita-Salute San Raffaele
Critical Illness, Feeding Intolerance
JLU_Nutr_FI Registry: A Prospective Registry of Feeding Intolerance in Critically Ill Patients
This prospective observational cohort study aims to characterize feeding intolerance in critically ill adult patients and to identify clinical, physiological, laboratory, electrophysiological, and imaging factors associated with…
- Trial name
- NCT07844538
- Volunteers
- 2,000 people
- Sponsor
- The First Hospital of Jilin University
Critically Ill
Continuous Temperature Measurement by Thermal Imaging Camera
This study explores the significance of body temperature monitoring in hospitalized patients, particularly in critical care environments.
- Trial name
- TermoCamUCI (NCT06256978)
- Volunteers
- 224 people
- Sponsor
- Universidad Europea de Madrid
Gastrointestinal Hemorrhage, Critical Illness
Gastrointestinal Bleeding in Critically Ill Patients
This prospective cohort study aims to determine the prevalence of gastrointestinal bleeding among critically ill patients admitted to intensive care units, identify independent risk factors, and describe clinical outcomes…
- Trial name
- NCT07822958
- Volunteers
- 310 people
- Sponsor
- Assiut University
Critical Illness, Organ Dysfunction
The Effect of the Timing of Supplemental Parenteral Nutrition on the Prognosis of Critically Ill Patients (T-SPN)
This multicenter, randomized controlled trial aims to evaluate whether early initiation of supplemental parenteral nutrition (SPN) (on day 4 of ICU admission) compared to late initiation (on day 8) can reduce 28-day all-cause…
- Conditions
- Critical Illness, Organ Dysfunction, Enteral Nutrition Intolerance, Inadequate Nutritional Intake
- Trial name
- NCT07085455
- Testing
- Early Supplemental Parenteral Nutrition (SPN), Late Supplemental Parenteral Nutrition (SPN)
- Where
- 2 sites in China
- Volunteers
- 946 people
- Sponsor
- Dong Zhang
Clinical Decision-Making
Mixed Methods Study Web-based Life Support Decision Aid
Patients and families want to be involved in healthcare decisions. When the decision-making process does not engage older patients and their families, the care provided does not match patient preferences or meet their needs.
- Trial name
- eLSDA (NCT03271658)
- Testing
- Web based life support patient decision aid, Decision coaching
- Where
- Canada
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of Saskatchewan
Venous Thromboembolism, Hemorrhage
A Clinical Cohort Study of Safety and Effectiveness of Venous Thromboembolism Prophylaxis in Critical Ill Patients
The purpose of this study is to analyze the effect of the prophylaxis of venous thromboembolism in the critical ill patients, and at the same time, to find out the risk of venous thromboembolism and hemorrhage events occurred…
- Trial name
- VTEH (NCT02213978)
- Where
- China
- Volunteers
- 1,114 people
- Sponsor
- Beijing Chao Yang Hospital
Critically Ill, Organ Failure, Multiple
Heterogeneity of Critical Illness: a Cohort Study
Rationale: There is large heterogeneity in disease states of critically ill patients at ICU admittance and there is also large heterogeneity in their disease severity during ICU stay.
- Trial name
- HEALICS (NCT04502511)
- Testing
- Standard diagnosis test
- Where
- Netherlands
- Volunteers
- 5,000 people
- Sponsor
- University Medical Center Groningen
Septic Shock
PK Analysis of Piperacillin in Septic Shock Patients
Antibiotic dosing in septic shock patients poses a challenge for clinicians due to the pharmacokinetic changes seen in this population.
- Trial name
- NCT02306928
- Testing
- Blood draw
- Where
- Denmark
- Volunteers
- 15 people
- Sponsor
- University of Aarhus
Respiratory Failure, Critical Illness
The Efficacy of P0.1-guided Sedation Protocol in Critically Ill Patients Receiving Invasive Mechanical Ventilation: A Randomized Controlled Trial
This clinical trial aims to assess the efficacy of sedation protocol targeting optimal respiratory drive using P0.1 and arousal level compared with conventional sedation strategy (targeting arousal level alone) in patients…
- Conditions
- Respiratory Failure, Critical Illness, Respiratory Distress Syndrome, Adult, Lung Injury
- Trial name
- NCT06203405
- Testing
- Titrating sedation targeting both optimal P0.1 and appropriate arousal level, Fentanyl, Midazolam
- Where
- Thailand
- Volunteers
- 214 people
- Sponsor
- Siriraj Hospital
Colistin
Evaluation of Pharmacokinetic and Pharmacodynamic Properties of Intravenous Colistimethate Sodium
Colistin is a polymixin antibiotic used in the treatment of multidrug-resistant gram-negative infections. Given the limited use of colistin and previous challenges with laboratory assays to determine plasma concentrations, there…
- Trial name
- NCT02288429
- Testing
- colistimethate sodium
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- University of Colorado, Denver
Delirium, Sedative Overdose
BIS-Guided Sedation in Critically Ill Patients Under Deep Sedation
The goal of this clinical trial is to investigate the effectiveness of sedation guided by the bispectral index (BIS) in reducing the incidence of delirium and the doses of sedative drugs used in critical patients who require deep…
- Trial name
- NCT03840577
- Testing
- Monitorization of sedation by Bispectral Index
- Where
- Argentina
- Volunteers
- 99 people
- Sponsor
- Hospital Italiano de Buenos Aires
Critical Illness, Sleep Deprivation
Reestablishing Sleep and Circadian Alignment in Medical Intensive Care Unit (MICU) Patients Via a Mechanistic RCT of an Sleep Chronobundle
More than 5 million patients are admitted to the intensive care unit every year in the United States; most of these patients experience profound sleep and circadian disruption.
- Conditions
- Critical Illness, Sleep Deprivation, Circadian Rhythm Sleep Disorder, Unspecified
- Trial name
- ReAlign-ICU (NCT05551325)
- Testing
- Chronobundle - light, chronobundle - feeding, chronobundle - mobility
- Where
- 2 sites in United States
- Volunteers
- 160 people
- Sponsor
- Yale University