Clinical trials: Critical Ill Patients
Sepsis, Septic Shock
Determination of the Dissociation Constant (Ka) of Plasma and Whole Blood in Septic Patients
Alterations of acid-base equilibrium are very common in critically ill patients and understanding their pathophysiology can be important to improve clinical treatment.
- Conditions
- Sepsis, Septic Shock, Critical Illness, Respiratory Acidosis
- Trial name
- ENTERPRISE (NCT03966664)
- Testing
- In vitro determination the dissociation constant (Ka) and total amount of non-volatile buffers (Atot) in isolated plasma., In vitro determination the dissociation constant (Ka) and total amount of non-volatile buffers (Atot) in whole blood, Biomolecular analysis of plasma proteins.
- Where
- 2 sites in Czechia, Italy
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
Respiratory Insufficiency
Conventional Intubation Versus VivaSight™-SL
It has been shown that videolaryngoscopy may be superior to direct laryngoscopy for endotracheal intubation in intensive care. Recently, an endotracheal tube with an integrated camera at its tip has been introduced (VivaSight-SL)…
- Trial name
- VivaITN (NCT02837055)
- Testing
- VivaSight intubation, conventional intubation
- Where
- Germany
- Volunteers
- 54 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Traumatic Brain Injury, Subarachnoid Hemorrhage
Near Infrared Spectroscopy (NIRS) as Transfusion Indicator in Neurocritical Patients
Neurocritical ill patients are frequently transfused. Red blood cell transfusion (RBCT) in these patients has been associated with deleterious effects, including higher rates of nosocomial infections, multi-organ failure, and…
- Conditions
- Traumatic Brain Injury, Subarachnoid Hemorrhage, Intracerebral Hemorrhage
- Trial name
- NCT00566709
- Testing
- Red blood cells transfusion
- Where
- Spain
- Volunteers
- 102 people
- Sponsor
- Hospitales Universitarios Virgen del Rocío
Acute Kidney Injury
Dexmedetomidine Pharmacokinetics During Continuous Renal Replacement Therapy (CRRT)
The purpose of this study is to determine dexmedetomidine pharmacokinetics during continuous renal replacement therapy on critically ill patients.
- Trial name
- NCT01314209
- Testing
- Dexmedetomidine
- Where
- Finland
- Volunteers
- 10 people
- Sponsor
- Helsinki University Central Hospital
Ventilation and Oxygenation, Obese; Positioning
Reverse Trendelenburg Position Versus Semi-recumbent Position in Obese Critically Ill Patients
The aim of this study is to assess the effect of reverse Trendelenburg position versus semi-recumbent position on ventilation and oxygenation parameters of obese critically ill patients
- Conditions
- Ventilation and Oxygenation, Obese; Positioning, Critically Ill
- Trial name
- NCT04376047
- Testing
- Reverse Trendelenburg position, Semi-recumbent position
- Where
- Egypt
- Volunteers
- 110 people
- Sponsor
- Alexandria University
Critical Illness
Database for Predicting Clinical Outcomes of Critically Ill Patients
Australian and New Zealand Intensive Care Society (ANZICS) has built a Center of Outcome and Resource Evaluation (CORE) adult patients database (APD) of adult critically ill patients.
- Trial name
- NCT04541849
- Testing
- Critical Care
- Where
- Taiwan
- Volunteers
- 20,000 people
- Sponsor
- National Taiwan University Hospital
Critically Ill
Testing of a New Therapeutic Vibration Device to Reduce Neuromuscular Weakness in Hospitalized Patients (Hospital Testing)
Objective: Test the ability of vibration to produce physiologic, biochemical, and anatomic changes consistent with exercise that would help prevent the development of muscle weakness that occurs when patients are immobile for…
- Trial name
- NCT05352100
- Testing
- Therapeutic Vibration Device
- Where
- United States
- Sponsor
- University of Michigan
Critical Illness, Mechanical Ventilation
Daily Sedative Interruption in Critically Ill Patients Being Managed With a Sedation Protocol
All critically ill, mechanically ventilated patients in the Intensive Care Unit receive medications to relieve pain and anxiety.
- Trial name
- NCT00298493
- Testing
- Sedation management strategy
- Where
- Canada
- Volunteers
- 65 people
- Sponsor
- Mount Sinai Hospital, Canada
Critical Illness and Mechanical Ventilation
Early Goal-Directed Sedation Compared With Standard Care in Mechanically Ventilated Critically Ill Patients
The Use of sedative drugs in intensive care is widespread. A cohort study conducted in Australia and New Zealand in 2010 revealed a high prevalence of deep sedation within the first 48 hours of mechanical ventilation which was…
- Trial name
- SPICE III RCT (NCT01728558)
- Testing
- Early goal Directed Sedation, Standard care sedation
- Where
- 74 sites in Australia, Ireland and 6 more
- Volunteers
- 4,000 people
- Sponsor
- Australian and New Zealand Intensive Care Research Centre
Critically Ill, Extubation
Does Tracheal Suction During Extubation in Intensive Care Unit Decrease Functional Residual Capacity
Little is known about the procedure of extubation of patients admitted in Intensive Care Units (ICU). In particular, effects of tracheal suction during extubation have never been evaluated.
- Conditions
- Critically Ill, Extubation, Intensive Care Unit
- Trial name
- NCT03681626
- Testing
- no tracheal suction, tracheal suction
- Where
- France
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University Hospital, Rouen
Critical Illness, Nurse-patient Communication
Nursing Interventions in Communication for the Critically Ill Patient: CONECTEM Programme
The aim of this quasi-experimental study is to find out whether the effectiveness of a communication intervention based on basic and assisted communication techniques improves the psycho-emotional effects of critical patients…
- Trial name
- NCT06901882
- Testing
- CONECTEM, Communication based in BCS (basic communication skills) and AAC ( aumentative alternative communicatiton)
- Where
- Spain
- Volunteers
- 180 people
- Sponsor
- University of Barcelona
Critical Illness
Ultrasound Guided Axillary Versus Jugular Central Venous Catheterization
The main intention of this study is to compare two ultrasound-guided central venous catheterization procedures namely: real-time, ultrasound-guided, in plane axillary vein catheterization and real-time, ultrasound-guided, out of…
- Trial name
- NCT02624323
- Testing
- Real-time ultrasound-guided central vein catheterization.
- Where
- 2 sites in Poland
- Volunteers
- 614 people
- Sponsor
- Uniwersytecki Szpital Kliniczny w Opolu
Gastroparesis, Shock
Gastric Emptying and Enteral Nutrition Tolerance According to Vasopressor Dose in ICU Patients
This study investigates whether the dose of vasopressor medications (drugs that maintain blood pressure in shock) affects gastric emptying during tube feeding in the intensive care unit (ICU).
- Conditions
- Gastroparesis, Shock, Critical Illness, Gastric Emptying
- Trial name
- NCT07802379
- Where
- Turkey (Türkiye)
- Volunteers
- 63 people
- Sponsor
- Başakşehir Çam & Sakura City Hospital
Critical Illness, Muscle Wasting
Leucine-enriched Branched-chain Amino Acid on Muscle Thickness, Interleukin-6, SOFA Score in Critical Illness
The goal of this clinical trial study is to test effects of leucine-enriched branched-chain amino acid (BCAA) in critically ill patients.
- Trial name
- SOFA (NCT06167772)
- Testing
- BCAA, Standard nutrition, Standard physiotherapy
- Where
- 2 sites in Indonesia
- Volunteers
- 40 people
- Sponsor
- Universitas Indonesia
Systemic Inflammatory Response Syndrome
Optimal Oxygenation in the Intensive Care Unit
Objectives: 1. To study the short- and long-term effect of two different PaO2 targets on circulatory status, organ dysfunction and outcome in patient admitted to the ICU with Systemic Inflammatory Response Syndrome (SIRS)…
- Trial name
- O2-ICU (NCT02321072)
- Testing
- Oxygen
- Where
- Netherlands
- Volunteers
- 400 people
- Sponsor
- Amsterdam UMC, location VUmc
Critical Illness, Adult
A Study in Critically Ill Patients Investigating Tolerability and Efficacy of Low-volume Pharmaconutrition (Intestamin)
The aim of the study is to assess the efficacy and tolerability of the low-volume supplement. The investigators randomized critically ill patients to receive Intestamin plus Fresubin or Fresubin alone.
- Conditions
- Critical Illness, Adult, Sepsis, Systemic Inflammatory Response Syndrome
- Trial name
- Intestamin (NCT01167075)
- Testing
- Fresubin Original, Intestamin plus Fresubin Original
- Where
- Germany
- Volunteers
- 58 people
- Sponsor
- Hannover Medical School
Critical Illness, Dietary Modification
Probiotics in Enteral Feeding in Critically Ill Patients
The purpose of this study is to investigate the effect of probiotics in enteral nutrition on improving gut function, inflammatory markers and clinical outcomes in critically ill patients admitted to the intensive care unit.
- Conditions
- Critical Illness, Dietary Modification, Probiotics, Gut Failure
- Trial name
- NCT01792401
- Testing
- Probiotics
- Where
- Malaysia
- Volunteers
- 49 people
- Sponsor
- University of Malaya
Critical Illness
Early Passive Verticalization in Critically Ill Patients
In the critically patient bed rest and inmovilization are some of the responsable of the development of respiratory complications.
- Trial name
- TILT (NCT02270762)
- Testing
- Rest in bed, Passive verticalization
- Where
- Belgium
- Volunteers
- 10 people
- Sponsor
- Cliniques universitaires Saint-Luc- Université Catholique de Louvain
Anemia, Critical Illness
Oxygen Extraction-guided Transfusion in Critically Ill Patients
Anemia is common in intensive care unit (ICU) patients and often appears early in the ICU course. The optimal management red blood cells RBC transfusion in critically ill patients remains controversial and clinical studies in…
- Trial name
- NCT03767127
- Where
- Italy
- Volunteers
- 177 people
- Sponsor
- Università degli Studi di Ferrara
Vitamin C, COVID-19 Pneumonia
Efficacy of Megadose Vitamin C in Severe and Critical Ill COVID-19 Patients.
The main aim is to determine whether vitamin C can reduce 28-day all-cause mortality or persistent organ dysfunction compared with placebo in patients with severe and critical ill COVID-19 patients.
- Trial name
- NCT05694975
- Testing
- Vitamin C
- Where
- 4 sites in China
- Volunteers
- 608 people
- Sponsor
- Zhujiang Hospital