Clinical trials: Critical Ill Patients
Acute Kidney Failure Stage 3
Venous Excess and Lung Ultrasound During Continuous Kidney Replacement Therapy in Critically Ill Patients
Hemodynamic management of critically ill patients has long been focused on the arterial side of the vasculature by assessing adequate perfusion pressure. However, the venous pressure is also of critical importance.
- Trial name
- VExLUS-KRT (NCT06254703)
- Testing
- VExUS (venous excess ultrasound), modified VExUS (modified venous excess ultrasound)
- Where
- Thailand
- Volunteers
- 100 people
- Sponsor
- Chulalongkorn University
Critical Care, Mechanical Ventilation
Prevention of Ventilator Associated Pneumonia With Toothbrushing in Oral Care of Critically Ill Mechanically Ventilated Patients
Effect of toothbrushing in oral care of mechanically ventilated critically ill patients on prevention of ventilator associated pneumonia
- Conditions
- Critical Care, Mechanical Ventilation, Ventilator Associated Pneumonia Prevention, Toothbrushing
- Trial name
- NCT02400294
- Testing
- Toothbrushing
- Where
- France
- Volunteers
- 2,030 people
- Sponsor
- University Hospital, Clermont-Ferrand
Nutrition Disorder, Trauma
Supplemental Enteral Protein in Critical Illness
The aim of this study is too determine the effect of enteral protein supplementation on biochemical measures of inflammation and protein metabolism in critically ill surgical patients.
- Conditions
- Nutrition Disorder, Trauma, Critical Illness
- Trial name
- NCT03170401
- Testing
- Protein supplementation, Standard enteral nutrition
- Where
- United States
- Volunteers
- 500 people
- Sponsor
- University of Washington
Critical Care
Relationship Between Blood Glucose Levels and Variability and Infections Development in Critically Ill Patient
Our multicenter prospective observational study aims to show the relationship between blood glucose levels and glycemic variability and the development of infections during the ICU stay and with outcome.
- Trial name
- NCT02659995
- Testing
- No intervention
- Where
- Italy
- Volunteers
- 3,300 people
- Sponsor
- Università Politecnica delle Marche
Critical Illness
Diagnosis of Microaspiration in Intubated Critically Ill Patients: Pepsin vs 99m Technetium
Microaspiration of contaminated oropharyngeal secretions and gastric contents frequently occurs in intubated critically ill patients, and plays a major role in the pathogenesis of ventilator-associated pneumonia.
- Trial name
- NCT02169193
- Testing
- 99mTc-Rhenium Sulfide Nanocolloid
- Where
- France
- Sponsor
- University Hospital, Lille
Critical Illness, Dysphagia
MuScle WastIng and DysphaGia iN CriticAlly IlL Patients (SIGNAL)
The goal of this study is to find out how muscle wasting in the mouth and throat affects swallowing (dysphagia) in adults who are critically ill and being treated in intensive care units.
- Conditions
- Critical Illness, Dysphagia, Muscle Wasting in Critically Ill, Swallowing Disorders
- Trial name
- SIGNAL (NCT07076524)
- Where
- United Kingdom
- Volunteers
- 160 people
- Sponsor
- Barts & The London NHS Trust
Sepsis, Infection
Genomics in Infection and Sepsis to Predict Organ Dysfunction and Outcomes in Sepsis
This is a prospective cohort study using gene expression to study patients with infection and sepsis from pneumonia.
- Conditions
- Sepsis, Infection, Pneumonia
- Trial name
- NCT04199962
- Where
- Hong Kong
- Volunteers
- 120 people
- Sponsor
- Chinese University of Hong Kong
Acute Kidney Failure, Mechanical Ventilation Strategies
Driving Pressure Optimization, RV-PA Coupling, and AKI in Mechanically Ventilated Critically Ill Patients
This study evaluates the effect of driving pressure optimization on right ventricular-pulmonary artery (RV-PA) coupling, assessed by TAPSE/PASP ratio, and its association with acute kidney injury (AKI) progression in mechanically…
- Conditions
- Acute Kidney Failure, Mechanical Ventilation Strategies, Right Ventricular (RV) Dysfunction, Critical Illness
- Trial name
- NCT07836387
- Testing
- Driving Pressure-Guided Ventilator Optimization
- Where
- Egypt
- Volunteers
- 90 people
- Sponsor
- Nardin Aymn Boshra
Contrast Induced Nephropathy, Critically Ill
N-Acetylcysteine in Critically Ill Patients Undergoing Contrast Enhanced Computed Tomography
Critically ill patients frequently undergo contrast enhanced computed tomography (CT) to establish diagnoses and direct management. Contrast agents can disturb kidney function and result in kidney dysfunction.
- Trial name
- NCT00830193
- Testing
- N-acetylcysteine
- Where
- 2 sites in Canada
- Volunteers
- 45 people
- Sponsor
- Unity Health Toronto
Empirical Antimicrobial Therapy, Critically Ill
Empirical Meropenem Dosing in Critically Ill Patients: Early Assessment of Plasma Exposure and Minimum Inhibitory Concentration Targets
The goal of this prospective cohort study is to characterize meropenem exposure in critically ill adult patients receiving empiric antibiotic treatment in the intensive care unit (ICU).
- Conditions
- Empirical Antimicrobial Therapy, Critically Ill, Meropenem, Pharmacokinetics and Pharmacodynamics
- Trial name
- NCT07681544
- Testing
- Blood extraction
- Where
- Argentina
- Volunteers
- 26 people
- Sponsor
- Hospital Italiano de Buenos Aires
Invasive Fungal Disease, Critical Illness
De-escalation - Antifungal Treatment Immunocompromised Patients
A small proportion of intensive care unit patients receiving antifungals have a proven invasive fungal infection. However, antifungal treatment has side effects such as toxicity, emergence of resistance, and high cost.
- Trial name
- D-ATFIM (NCT03774316)
- Where
- France
- Volunteers
- 275 people
- Sponsor
- University Hospital, Lille
ICU Ill Patients, Critical Illness
Evolution of Physical and Emotional Distress in ICU
Emotional distress is prevalent in ICU patients and may be influenced by physical symptoms such as dyspnea and pain, yet its evolution and interactions during ICU stay remain insufficiently explored.
- Trial name
- CARE-ICU (NCT07153380)
- Where
- Spain
- Volunteers
- 62 people
- Sponsor
- Corporacion Parc Tauli
Critically Ill
Feasibility of End-tidal Oxygen Concentration Monitoring During Preoxygenation for Intubation in the Intensive Care Unit.
Intubation is a common procedure in the intensive care unit. Hypoxemia is the most frequent complication of this procedure. Monitoring the end-tidal of oxygen is recommended in operating room (OR).
- Trial name
- IMPROVE-Pre (NCT05409573)
- Testing
- double monitoring of EtO2
- Where
- France
- Volunteers
- 30 people
- Sponsor
- Centre Hospitalier Régional d'Orléans
Trauma, Resistant Infection
Polymyxin B Monotherapy vs Combination Therapy in Critically Ill Patients With Multi-drug Resistant Pathogens
The purpose of this study is to assess the safety and efficacy of polymyxin B as monotherapy versus a combined polymyxin B-carbapenem therapy against multidrug-resistant (MDR) gram negative infections.
- Conditions
- Trauma, Resistant Infection, Critical Illness
- Trial name
- MUSEUM (NCT03159078)
- Testing
- Polymyxin B
- Where
- Puerto Rico
- Volunteers
- 40 people
- Sponsor
- University of Puerto Rico
Underweight, Critical Illness
Nutritional Therapy on Underweight Critically Ill Patients: an Observational Study
Critically ill patients with body mass index (BMI) inferior to 20 kg/m2 have worse outcomes compared to normal and overweight patients. The impact nutrition therapy in this population is not yet stablished.
- Trial name
- NCT03398343
- Where
- Brazil
- Volunteers
- 450 people
- Sponsor
- Hospital de Clinicas de Porto Alegre
Pain
Evaluation of the Analgesic Effect of Music Therapy in Critically Ill Patients During Potentially Painful Nursing Procedures: a Pilot Study
Pain is a common problem encountered in about 60 % of critically ill patients who can communicate. Its occurrence can be related to several causes, mainly dominated by invasive procedures.
- Trial name
- Painkiller (NCT02883959)
- Testing
- music therapy
- Where
- France
- Volunteers
- 60 people
- Sponsor
- Versailles Hospital
Covid19, Thromboembolism
Dosing of Thromboprophylaxis and Mortality in Critically Ill COVID-19 Patients
The aim of the study is to associate dose of thromboprophylaxis with outcome in critically ill COVID-19 patients. This will be done by associating dose of thromboprophylaxis with 28-day mortality, survival outside ICU…
- Trial name
- NCT04593654
- Testing
- Dose of tinzaparin or dalteparin
- Where
- Sweden
- Volunteers
- 257 people
- Sponsor
- Karolinska Institutet
Sepsis, Relative Adrenal Insufficiency
Impact of Hydrocortisone Administration on White Blood Cell Gene Expression in Patients With Severe Sepsis
The purpose of this pilot study is to (1) examine the changes in gene expression in patients who suffer from severe sepsis and whose shock (inadequate oxygen delivery to vital organs) state does not respond to fluid and…
- Trial name
- NCT00185783
- Testing
- Hydrocortisone Administration (Standard of Care Therapy)
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Stanford University
Liver Failure, Critical Illness
Safety and Tolerance on Lipids of Parenteral and Enteral Nutrition in Critically Ill Patients With Liver Failure
The purpose of the study is to determine the tolerance on lipid metabolism and the safety of short-term parenteral nutrition as compared to enteral nutrition in critically ill patients with liver failure.
- Trial name
- SELLIFA (NCT00522730)
- Testing
- Parenteral nutrition, Enteral nutrition
- Where
- Belgium
- Volunteers
- 45 people
- Sponsor
- Cliniques universitaires Saint-Luc- Université Catholique de Louvain
Hypernatremia, Critical Illness
Safety and Efficacy of Hydrochlorothiazide in the Treatment of Hypernatremia in Critically Ill Patients
HYDRA is a randomized clinical trial designed to evaluate safety and efficiency of hydrochlorothiazide in critical patients with hypernatremia
- Trial name
- HYDRA (NCT03658850)
- Testing
- Hydrochlorothiazide 50Mg
- Where
- Brazil
- Volunteers
- 184 people
- Sponsor
- University of Sao Paulo