Clinical trials: Critical Ill Patients
Critically Ill Adult Patients With Difficult Weaning
Pressure Support and Positive End Expiratory Pressure During Spontaneous Breathing Trial
The aim of this study is to assess if a bundle associating pressure support and positive end-expiratory pressure during spontaneous breathing trial and detection by T-piece of patients with high-risk of extubation failure can…
- Trial name
- SBT-ICU (NCT03861117)
- Testing
- Assisted strategy, Non assisted strategy
- Where
- France
- Volunteers
- 98 people
- Sponsor
- Hospices Civils de Lyon
Sepsis
Immunity in Critical Sepsis
Sepsis is a life-threatening organ dysfunction caused by a dysregulated host immune response to infection, and remains the leading cause of death in critical care medicine worldwide.
- Trial name
- NCT07770347
- Testing
- Individualized anti-infective therapy, Individualized immunomodulatory therapy, Individualized organ function support therapy
- Where
- China
- Volunteers
- 2,400 people
- Sponsor
- Beijing Chao Yang Hospital
Critical Illness, Asthma
Ketamine Efficacy for Acute Severe Bronchospasm in ICU: MACANUDO Trial
Despite few scientific evidence that could support the use of ketamine in adult patients undergoing acute bronchospasm requiring mechanical ventilation (MV), ketamine is largely employed in this setting.
- Conditions
- Critical Illness, Asthma, Bronchospasm
- Trial name
- MACANUDO (NCT03000413)
- Testing
- Ketamine, Fentanyl
- Where
- Brazil
- Volunteers
- 45 people
- Sponsor
- Hospital Nossa Senhora da Conceicao
Critical Illness Polyneuropathy, Critical Illness Myopathy
Evaluation of the NeuroMuscular Junction Using the Single Fiber Electromyography and Reliability of Train-Of-Four in Critically Ill Patients.
Patients suffering from critical illnesses who are admitted to the Intensive Care Unit (ICU) are often affected by multiple organ failure.
- Conditions
- Critical Illness Polyneuropathy, Critical Illness Myopathy, Weakness Due to Disease, Neuromuscular Blockade
- Trial name
- NCT03893058
- Where
- Italy
- Volunteers
- 85 people, healthy volunteers welcome
- Sponsor
- Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia
Adult-Onset Still Disease, Critically Ill
Admission of Adult-onset Still Disease Patients in the ICU
Since its first description in 1971, diagnosing adult-onset Still's disease (AOSD), a rare multisystemic disorder considered as a multigenic autoinflammatory syndrome, remains challenging.
- Trial name
- Still-ICU (NCT03276650)
- Testing
- data collection
- Where
- France
- Volunteers
- 45 people
- Sponsor
- Central Hospital, Nancy, France
Critical Illness, Gastro Intestinal Surgery
Undiluted and Diluted Nutrition
Adult patients after elective major abdominal surgeries who are planned to be admitted to the Intensive Care Unit (ICU) can be included in the trial. Each patient will be fed via the gastrointestinal tract.
- Conditions
- Critical Illness, Gastro Intestinal Surgery, Enteral Feeding Intolerance, Gastro-Intestinal Disorder
- Trial name
- NCT07352150
- Testing
- Enteral fluid, Intravenous fluid
- Where
- 2 sites in Poland
- Volunteers
- 80 people
- Sponsor
- John Paul II Catholic University of Lublin
Critically Ill, Sepsis
Early Diagnostic Biomarkers of Sepsis
A Comparison between CRP, ferritin, and serum zinc as early diagnostic biomarkers of sepsis in critically ill patients
- Trial name
- NCT05112406
- Volunteers
- 70 people
- Sponsor
- Assiut University
Intensive Care Unit (ICU) Acquired Weakness (ICU - AW), Critical Illness
Effectiveness of Virtual Reality in Improving Upper Limb Function in Critically Ill Patients
Millions of people are hospitalized every year in Intensive Care Units (ICUs) with severe health conditions due to various causes and categories of diseases, such as stroke, Traumatic Brain Injuries (TBI), polytrauma, sepsis, and…
- Trial name
- EVOLUTION (NCT07901855)
- Testing
- Conventional Physiotherapy and Occupational Therapy, Fully Immersive Virtual Reality Training
- Where
- Greece
- Volunteers
- 48 people
- Sponsor
- National and Kapodistrian University of Athens
Vitamin D Deficiency, Critical Illness
Early Vitamin D3 Supplementation for Critically Ill Patients
There are no clear international guidelines for dosing vitamin D based on deficiency severity. Therefore, a new clinical trial is needed to evaluate the benefits of early vitamin D supplementation in maintaining sufficient levels…
- Trial name
- NCT05937789
- Testing
- Vitamin D3, Medium Chain Triglycerides (MCT)
- Where
- Taiwan
- Volunteers
- 240 people
- Sponsor
- National Taiwan University Hospital
Critical Illness
Influence of Patient/Ventilador Decoupling in Neurocognitive and Psychopathological Sequelae in ICU Patients
Mechanical ventilation (MV) is a vital support tool for critically ill patients. However, it may present several adverse effects, such as the development of cognitive and psychopathological alterations.
- Trial name
- PVI-NCOG (NCT02390024)
- Testing
- Invasive Mechanical Ventilation
- Where
- Spain
- Volunteers
- 156 people
- Sponsor
- Corporacion Parc Tauli
Hypernatremia, Critically Ill
Continuous Venovenous Hemofiltration Versus Conventional Treatment for Acute Severe Hypernatremia
The patients with severe hypernatremia who received conventional treatment are often undertreated. Continuous venovenous hemofiltration (CVVH) can effectively remove solute or water from circulation system.
- Trial name
- NCT02449382
- Testing
- continuous venovenous hemofiltration, Control group
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Air Force Military Medical University, China
Traumatic and/or Non-traumatic Brain Injury, Critically Ill
Efficiency of a Small-peptide Enteral Feeding Formula Compared to a Whole-protein Formula
An early and efficient enteral nutritional support could improve the clinical outcomes of brain injured critically ill patients.
- Trial name
- NUTRI_REA (NCT01833624)
- Testing
- Peptamen® AF, Sondalis® HP
- Where
- France
- Volunteers
- 206 people
- Sponsor
- Centre Hospitalier Universitaire de Besancon
Fluid Overload
Controlled Fluid Removal in Critical Ill Patients With Fluid Overload in the Intensive Care Unit.
This study evaluates the benefits and harms of goal directed fluid removal with furosemide versus placebo in critical ill adult patients with fluid overload in the intensive care unit.
- Trial name
- GODIF (NCT04180397)
- Testing
- Furosemide, Isotonic saline
- Where
- 29 sites in Australia, Czechia and 7 more
- Volunteers
- 1,000 people
- Sponsor
- Morten H. Bestle
Critically Ill, Renal Replacement Therapy
Analgesia Nociception Index to Explore Autonomic Nervous System in Patients With Continuous Renal Replacement Therapy
The Analgesia Nociception Index (ANI) reflects the balance between sympathetic and parasympathetic tone. It is based on a specific interpretation of the R-R interval variation.
- Trial name
- UFANI (NCT06285162)
- Where
- France
- Volunteers
- 30 people
- Sponsor
- Hospices Civils de Lyon
Critical Illness
Application of Prophylactic Low Calorie Feeding in Critically Ill Patients With High-risk Refeeding Syndrome
Critically ill patients with high-risk nutrition are often at risk of refeeding syndrome(RFS), that the incidence of RFS is as high as 30-50%.
- Trial name
- NCT04005300
- Testing
- standard enteral nutrition, restricted enteral nutrition
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Acute Kidney Injury
Hemodynamic and Respiratory Tolerance of Intermittent Hemodialysis in Critically Ill Patients
Acute kidney injury (AKI) affects up to 30% of critically ill patients and is associated with increased rates of mortality. Up to 60% of patients with AKI will ultimately require renal replacement therapy (RRT).
- Trial name
- COOBrA (NCT04444765)
- Testing
- Collection of clinical and biological data during renal replacement therapy sessions
- Where
- France
- Volunteers
- 200 people
- Sponsor
- University Hospital, Toulouse
Critical Illness
Enteral and Parenteral Feeding in Critically Ill Patients
Supplementation of insufficient enteral nutrition with parenteral nutrition may optimize nutritional support and avert negative energy balance in critically ill patients, thereby improving outcome.
- Trial name
- NCT03277300
- Testing
- dietary supplement
- Volunteers
- 100 people
- Sponsor
- Assiut University
Delirium
Validating a Delirium Prediction Model for Critically Ill Patients
The objective of this study is to determine the incidence of delirium in adults patients who are admitted at the critical care unit of a Dutch University Hospital with the mapping of relevant delirium risk factors The primary aim…
- Trial name
- NCT00961389
- Where
- Netherlands
- Volunteers
- 650 people
- Sponsor
- Radboud University Medical Center
Critical Illness
Prediction Model of Vitamin D Deficiency
Many studies have pointed out that patients with vitamin D deficiency have a longer stay in the intensive care unit and a poor prognosis.
- Trial name
- NCT05376774
- Testing
- Admitted to intensive care units
- Where
- Taiwan
- Volunteers
- 662 people
- Sponsor
- National Taiwan University Hospital
Hyperglycemia, Critical Illness
Stress Hyperglycemia. Potential Role of Incretin Analogs
This is a prospective observational study to examine the levels of glucoregulatory hormones, with special focus on incretins levels, in critically ill patients with stress hyperglycemia.
- Trial name
- NCT01087372
- Where
- Spain
- Volunteers
- 60 people
- Sponsor
- Hospital Universitari Son Dureta