Clinical trials: Critical Ill Patients
Microbiome,Immune Function, Critically Ill
Microecology and Host Immunity in Patients With Severe COVID-19 Infection
The purpose of this study was to analyze the relationship between the microbial community, host immunity and the prognosis of patients with severe COVID-19.
- Trial name
- NCT05670275
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Chinese PLA General Hospital
Respiration, Artificial, Mechanical Ventilation
Continuous Evaluation of Diaphragm Function
Aim of mechanical ventilation is to improve gas exchange and to unload the respiratory muscles delivering a form of mechanical support to the ventilation.
- Conditions
- Respiration, Artificial, Mechanical Ventilation, Critical Illness
- Trial name
- NCT03941002
- Testing
- Assesment of diaphragm function
- Where
- Italy
- Volunteers
- 25 people
- Sponsor
- University of Milan
Muscle Weakness or Atrophy, Mechanical Ventilation Complication
NMES Role to Prevent Respiratory Muscle Weakness in Critically Ill Patients and Its Association to Changes in Myokines.
Particularly, muscle respiratory wasting will occur early (18 to 69 hours) in up to 60% of patients with mechanical ventilation (MV), leading rapidly to diaphragmatic weakness, which is associated with prolonged MV use, longer…
- Conditions
- Muscle Weakness or Atrophy, Mechanical Ventilation Complication, Electrical Stimulations
- Trial name
- NCT05536531
- Testing
- Neuromuscular electrical stimulation (NMES)
- Where
- Chile
- Volunteers
- 32 people
- Sponsor
- Pontificia Universidad Catolica de Chile
Critical Illness, Antibiotic Toxicity
Target Attainment of TDM-guided Infusion of Piperacillin/Tazobactam and Cefepim in Critically Ill Patients
Although alternative dosing strategies can improve antimicrobial exposure in critically ill patients, the high PK variability in this population means that some may still receive sub-optimal antibiotic exposure leading to…
- Conditions
- Critical Illness, Antibiotic Toxicity, Sepsis, Septic Shock
- Trial name
- DOSATB (NCT04530045)
- Testing
- dosage of concentration of piperacillin and cefepim
- Where
- 2 sites in France
- Volunteers
- 99 people
- Sponsor
- Central Hospital, Nancy, France
Critically Ill, Enteral Feeding
The Effects of Pancreatic Enzyme Supplementation in Critically Ill Patients on Enteral Feeding
Determine the effect of high-dose pancreatic enzyme supplementation on nutritional indicators and clinical course in critically ill patients undergoing enteral nutrition.
- Conditions
- Critically Ill, Enteral Feeding, Exocrine Pancreatic Insufficiency
- Trial name
- PREZENT (NCT05112328)
- Testing
- Exocrine Pancreatic Enzyme
- Where
- South Korea
- Volunteers
- 170 people
- Sponsor
- Seoul National University Hospital
Critical Illness, Hyperglycemia
Early Glucose States and 72-Hour Care-Metabolic Clusters in Critically Ill Patients
Blood glucose patterns during critical illness may change together with treatment, nutritional support, organ support, and the frequency of glucose monitoring.
- Trial name
- NCT07851545
- Testing
- Early glucose state, 72-hour integrated care-metabolic cluster
- Where
- China
- Volunteers
- 5,109 people
- Sponsor
- Shanghai Zhongshan Hospital
Eye Injuries, Critically Ill
Does the Use of a Moisture Chamber Decrease the Incidence of Corneal Abrasions in Critically Ill Pediatric Patients?
The purpose of this study is to identify the incidence of scratches on the surface of the eye in children who cannot blink due to medication use and to identify how best to reduce the risk of a scratch on the surface of the eye…
- Trial name
- NCT00129077
- Testing
- plastic wrap over eye & lubrication applied q6 hrs
- Where
- 2 sites in United States
- Volunteers
- 207 people
- Sponsor
- Ann & Robert H Lurie Children's Hospital of Chicago
Renal Failure, Critically Ill
Forced Diuresis Versus Observation in Resolving Renal Failure After Haemofiltration in Critically Ill Patients
Intensive care patients with multiple organ dysfunction syndrome often show renal failure with the need for hemofiltration. Resolving renal failure after cessation of hemofiltration may or may not be accompanied by oliguria.
- Trial name
- NCT00298454
- Testing
- Furosemide
- Where
- Netherlands
- Volunteers
- 72 people
- Sponsor
- Frisius Medisch Centrum
Critical Illness, ICU-acquired Weakness
Beyond Voluntary Effort: Reliability and Validity of Magnetic Femoral Nerve Stimulation for Assessing Quadriceps Strength in Critically Ill Patient
Intensive care unit-acquired weakness (ICU-AW) is a common complication of critical illness and can negatively affect recovery and long-term physical functioning.
- Trial name
- TWITCH FORCE (NCT07891273)
- Testing
- Magnetic Femoral Nerve Stimulation
- Volunteers
- 33 people
- Sponsor
- Daniel Langer
Critical Illness, Starvation
Impact of Early Parenteral Nutrition Completing Enteral Nutrition in Adult Critically Ill Patients
In critically ill patients, a strategy aimed at an early delivery of full caloric support, with a combination of Enteral Nutrition (EN) and Parenteral Nutrition (PN) (in conditions preventing hyperglycemia and overfeeding)…
- Trial name
- EPaNIC (NCT00512122)
- Testing
- Withholding PN during the first week of ICU stay, Oliclinomel N71000 OR N71000E // Clinimix N17G35 OR N17G35E
- Where
- 3 sites in Belgium
- Volunteers
- 4,640 people
- Sponsor
- KU Leuven
Critically Ill, Acute Circulatory Failure
FLOTRAC/VIGILEO in Acute Circulatory Failure
Acute circulatory failure may be related to hypovolemia. Fluid loading increases stroke volume in approximatively half of challenges. Determining fluid responsiveness prevents unnecessary fluid loading.
- Conditions
- Critically Ill, Acute Circulatory Failure, Fluid Loading
- Trial name
- FLOVAC (NCT01090791)
- Testing
- Flotrac/Vigileo third generation software, Transthoracic echocardiography
- Where
- 2 sites in France
- Volunteers
- 1 people
- Sponsor
- Hôpital Européen Marseille
Critically Ill
The PREServation of MUScle Function in Critically Ill Patients (PRESMUS)
This study evaluates the effect of whey protein enriched enteral nutrition in addition to exercise training on the preservation of muscle function in critically ill patients.
- Trial name
- PRESMUS (NCT03231540)
- Testing
- Whey protein supplement
- Where
- Netherlands
- Volunteers
- 50 people
- Sponsor
- Amsterdam UMC, location VUmc
Substance Withdrawal Syndrome
Opioids Withdrawal Syndrome in Critically Ill Patients: a Multicenter Prospective Cohort Study
Critically ill patients who are mechanically ventilated may require prolonged administration of sedatives and analgesics. Their prolonged use has been associated with withdrawal symptoms upon rapid weaning in critically ill…
- Trial name
- WAAICUP (NCT02318290)
- Testing
- Opiates
- Where
- Canada
- Volunteers
- 54 people
- Sponsor
- Centre Integre Universitaire de Sante et Services Sociaux du Nord de l'ile de Montreal
Intubation, Extubation
Predictors Of Successful Extubation in Critically Ill Patients: Multicentre Observational Study
Extubation failure can directly worsen patient outcomes. Therefore, the decision to extubate is a critical moment during an intensive care unit (ICU) stay.
- Conditions
- Intubation, Extubation, Weaning, Mechanical Ventilation
- Trial name
- POSE (NCT03185962)
- Where
- Japan
- Volunteers
- 499 people
- Sponsor
- Osaka University
Multiple Trauma, Critically Ill
The Clinical Role of Intravenous Glutamine in Trauma Patients Receiving Enteral Nutrition
The purpose of this trial is to investigate if pharmacologically safe dose intravenous glutamine dipeptide supplementation to multiple trauma patients receiving enteral nutrition is associated with improved clinical outcomes in…
- Trial name
- GLINT (NCT01240291)
- Testing
- Dipeptiven, normal saline
- Where
- Australia
- Volunteers
- 88 people
- Sponsor
- Royal Brisbane and Women's Hospital
Critical Illness, Acute Gastrointestinal Injury
The Effect of Early Enteral Nutrition Feeding Process Assisted by Gastrointestinal Ultrasonography
In critical ill patients, feeding protocol is one of the important factor which determines the successful implementation of enteral nutrition（EN）.
- Trial name
- NCT05379582
- Testing
- Implement nutrition therapy according a procedure assisted by gastrointestinal ultrasound
- Where
- China
- Volunteers
- 294 people
- Sponsor
- Chinese Medical Association
Mechanical Ventilation, Critically Ill Patients
Machine Learning Ventilator Decision System VS. Standard Controlled Ventilation
Ventilator-induced lung injury is associated with increased morbidity and mortality. Despite intense efforts in basic and clinical research, an individualized ventilation strategy for critically ill patients remains a major…
- Trial name
- NCT05132751
- Testing
- Machine Learning Ventilator Decision System
- Volunteers
- 300 people
- Sponsor
- Hu Anmin
Sepsis, Hyperglycemia
The Effects of SGC on Glucose Control in Critically Ill Patients With Sepsis
Poorly glycemic control in critically ill patients can increase their mortality, while safe and efficient glucose control is laborious and time-consuming.
- Conditions
- Sepsis, Hyperglycemia, Critical Illness
- Trial name
- NCT02980588
- Testing
- SGC directed glycemic control
- Volunteers
- 60 people
- Sponsor
- Southeast University, China
Critically Ill
A Trial to Assess the Effect of High Nitrogen Intake in Critically Ill Patients
The patients with sepsis are in high risk of malnutrition, which could contribute to infection, difficulty in weaning from ventilators.
- Trial name
- NCT02106624
- Testing
- nitrogen supply
- Where
- China
- Volunteers
- 89 people
- Sponsor
- Shanghai Zhongshan Hospital
Bacterial Infections
Pharmacokinetics of Teicoplanin in Intensive Care and Haematology Patients
Characterize teicoplanin PK in critically ill patients with a specific focus on alterations of exposure due to variability in renal function.
- Trial name
- PLATO (NCT04096092)
- Testing
- No intervention
- Where
- Netherlands
- Volunteers
- 30 people
- Sponsor
- Radboud University Medical Center