Clinical trials: Critical Ill Patients
Critical Illness, Sepsis
Trial of Glutamine and Antioxidant Supplementation in Critically Ill Patients
The purpose of this study is to determine whether providing high dose glutamine and antioxidants to critically ill patients will be associated with improved survival.
- Conditions
- Critical Illness, Sepsis, Multiple Organ Failure
- Trial name
- REDOXS (NCT00133978)
- Testing
- Glutamine, Antioxidants, Glutamine + Antioxidants
- Where
- 34 sites in United States, Belgium and 3 more
- Volunteers
- 1,223 people
- Sponsor
- Daren K. Heyland
Gastrointestinal Motility
Clinical Evaluation Gastrointestinal Motility With PillCam
The purpose of this study is to evaluate the clinical usefulness of a video camera pill (PillCam) in assessing intestinal function in the small intestines of patients.
- Trial name
- NCT01158989
- Testing
- PillCam
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- University of Louisville
Gastric Emptying, Delayed Gastric Emptying
Prevalence and Measurement of Delayed Gastric Emptying in Patients Receiving Extracorporeal Membrane Oxygenation
The goal of this observational study is to learn whether the stomach takes longer to empty in patients on the intensive care unit who are receiving ECMO (a machine that temporarily takes over the role of the lungs and heart)…
- Conditions
- Gastric Emptying, Delayed Gastric Emptying, Critical Illness, ExtraCorporeal Membrane Oxygenation (ECMO)
- Trial name
- PROPEL-ECMO (NCT07779174)
- Testing
- Gastric (stomach) ultrasound measurement, 'Residual volume' measurement, Scintigraphy (standard research method)
- Where
- United Kingdom
- Volunteers
- 72 people
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
Community-acquired Pneumonia, Critical Illness
Point-of-Care Multiplex for Adult Patients With Severe Community-acquired Pneumonia
Clinical Impact on Point-of-Care Multiplex PCR Testing for Critically Ill Adult Patients With Community-acquired Pneumonia - A cluster randomization study in ICU units within one medical center.
- Trial name
- NCT04835818
- Testing
- Provide the panel report to the primary care physician
- Where
- Taiwan
- Volunteers
- 60 people
- Sponsor
- National Taiwan University Hospital
Delirium, Critical Illness
The EARLY DELTA Trial
Rationale: Delirium is a type of acute encephalopathy that is triggered by an underlying somatic disorder. Patients experience disturbances in attention, alertness and other cognitive functions.
- Conditions
- Delirium, Critical Illness, Acute Encephalopathy
- Trial name
- EARLY DELTA (NCT05403268)
- Testing
- DeltaScan
- Where
- 2 sites in Netherlands
- Volunteers
- 131 people
- Sponsor
- Thomas Ottens
Transfusion-Related Acute Lung Injury, ARDS, Human
Comparison of the Proteome in ICU Patients in Search for TRALI Biomarkers: A Case-control Study Using Both Retrospective and Prospective Samples
Transfusion-related acute lung injury (TRALI) is a severe complication of blood transfusions. After a transfusion, TRALI develops in 0.08-15% of cases depending on the characteristics of the studied population.
- Trial name
- CURIE (NCT06444750)
- Testing
- Blood sample collection
- Volunteers
- 210 people, healthy volunteers welcome
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Hemodynamic Instability, Hypovolemia
Comparison of PPV and LVOT VTI During Passive Leg Raising to Predict Fluid Responsiveness
Hemodynamic instability remains one of the leading causes of morbidity and mortality among critically ill patients in intensive care units. One major contributor to this instability is intravascular fluid deficit.
- Conditions
- Hemodynamic Instability, Hypovolemia, Critical Illness, Pulse Pressure Variation
- Trial name
- NCT07304661
- Where
- Turkey (Türkiye)
- Volunteers
- 48 people
- Sponsor
- Izmir Katip Celebi University
Critical Illness, Wounds and Injury
Strategy to Avoid Excessive Oxygen for Critically Ill Trauma Patients
The objective is to determine the effectiveness of a multimodal educational intervention to reduce supplemental oxygen use in critically injured patients.
- Conditions
- Critical Illness, Wounds and Injury, Disease Attributes, Pathologic Processes
- Trial name
- SAVE-O2 (NCT04534959)
- Testing
- Targeting Normoxemia (SpO2 90-96%; PaO2 60-100 mmHg)
- Where
- 8 sites in United States
- Volunteers
- 6,000 people
- Sponsor
- University of Colorado, Denver
Respiration Failure, Cardio Vascular Disease
COMPARE-VENT Feasibility Pilot Study
Cardiac disease complicated by respiratory insufficiency comprises the most frequent indication for cardiac intensive care unit (CICU) admission, with nearly one-third patients requiring advanced respiratory support and over 20%…
- Conditions
- Respiration Failure, Cardio Vascular Disease, Cardiogenic Pulmonary Oedema, Critical Illness
- Trial name
- NCT07656259
- Testing
- Volume Controlled Mode, Pressure Controlled Mode
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- Mayo Clinic
Critically Ill
TEAM: A Trial of Early Activity and Mobility in ICU
Patients in the intensive care unit (ICU) traditionally receive bed rest as part of their care. They develop muscle weaknesses even after only a few days of mechanical ventilation that may prolong their time in ICU and in…
- Trial name
- TEAM-RCT (NCT01927510)
- Testing
- Early mobilisation
- Where
- 5 sites in Australia, New Zealand
- Volunteers
- 50 people
- Sponsor
- Australian and New Zealand Intensive Care Research Centre
Acute Kidney Injury
Role of Biomarkers in Predicting Contrast-induced Acute Kidney Injury in Critically Ill Patients
Title: "Role of biomarkers in predicting contrast-induced acute kidney injury in critically ill patients: a prospective observational study" Objective: To analyse the role of plasma and urinary biomarkers (Neutrophil…
- Trial name
- NCT02430844
- Where
- India
- Volunteers
- 85 people
- Sponsor
- Sanjay Gandhi Postgraduate Institute of Medical Sciences
Partial Pressure of Carbon Dioxide
Correlation Between Peripheral and Central Venous Blood Partial Pressure of Carbon Dioxide in Critical Ill Patients
Observational study to analyze correlation between partial pressure of carbon dioxide from blood obtained from peripheral and central veins
- Trial name
- NCT03269448
- Testing
- Peripheral venous blood sampling
- Where
- Thailand
- Volunteers
- 30 people
- Sponsor
- Ramathibodi Hospital
Critical Illness
LOGIC-Insulin Algorithm-guided Versus Nurse-directed Blood Glucose Control During Critical Illness
The LOGIC-Insulin computerized software algorithm will be compared with a nurse-directed protocol, both targeting a blood glucose level of 80-110 mg/dL, in critically ill patients
- Trial name
- LOGIC-1 (NCT01420302)
- Testing
- Nurse directed, LOGIC-Insulin
- Where
- Belgium
- Volunteers
- 300 people
- Sponsor
- Greet Van den Berghe
Sleep Deprivation
Sleep Promotion in Critically Ill and Injured Patients Cared for in the Intensive Care Unit
Sleep deprivation in healthy volunteers is associated with immune dysfunction. This adverse effect of sleep deprivation likely occurs in patients suffering from acute injury and critical illness requiring intensive care unit…
- Trial name
- NCT01082016
- Testing
- Sleep Enhancement Program (SEP)
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- University of Arizona
Critically Ill
Screening Elderly Patients for Weaning
During weaning the work of breathing is transferred from the ventilator back to the patient. Approximately 40% of the time on ventilators is spent weaning.
- Trial name
- NCT02243449
- Testing
- Once daily screening, At least twice daily screening
- Where
- 8 sites in Canada
- Volunteers
- 102 people
- Sponsor
- Unity Health Toronto
Critical Illness
Lorazepam Sedation for Critically Ill Children
This clinical trial is being performed under the Best Pharmaceuticals for Children Act, signed into law in 2002 in order to improve pediatric labeling for off-patent drugs.
- Trial name
- NCT00109395
- Testing
- Lorazepam, Midazolam, Lorazepam CI
- Where
- United States
- Volunteers
- 179 people
- Sponsor
- The Emmes Company, LLC
Sepsis, Septic Shock
Intravenously Administered M6229 in Critically Ill Sepsis Patients
Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to infection. Mortality is high and survivors frequently suffer from long-term sequelae.
- Conditions
- Sepsis, Septic Shock, Critical Illness
- Trial name
- HistoSeps (NCT05208112)
- Testing
- M6229
- Where
- 2 sites in Netherlands
- Volunteers
- 10 people
- Sponsor
- A.P.J. Vlaar
Bacterial Colonization, Multidrug Resistant Organisms
Enteral Nutrition and Colonization Resistance Through Microbiota Modulation in Critically Ill Patients
The goal of this clinical trial is to learn whether enteral nutrition enriched with fiber can influence gut microbiota and improve resistance to colonization with multidrug-resistant bacteria in critically ill patients.
- Conditions
- Bacterial Colonization, Multidrug Resistant Organisms, Critical Illness, Gut Microbiota Dysbiosis
- Trial name
- MICRON (NCT07719673)
- Testing
- Fibre-Enriched Enteral Nutrition, Standard Enteral Nutrition
- Where
- Romania
- Volunteers
- 60 people
- Sponsor
- Iuliu Hatieganu University of Medicine and Pharmacy
Procedural Pain
Stress-Ball Distraction for Pain and Anxiety During Painful Procedures in Critically Ill Patients
This study will examine whether using a small hand-held stress ball during painful procedures can help critically ill adult patients feel less pain and anxiety.
- Trial name
- NCT07836842
- Testing
- Stress-Ball Distraction, Standard care
- Volunteers
- 104 people
- Sponsor
- Alexandria University
Muscle Wasting in Critically Ill
The Effect of Muscle Stimulation and Amino Acid Intake on Protein Metabolism During Critical Illness
The goal of this clinical trial is to study how whole-body electrical stimulation combined with amino acid intake affects muscle health in ventilated ICU patients.
- Trial name
- SPICE I (NCT07430969)
- Testing
- NMES, Amino acid bolus (20g), Standard enteral nutrition
- Where
- Netherlands
- Volunteers
- 30 people
- Sponsor
- Wageningen University