Clinical trials: Critical Ill Patients
Acute Kidney Failure With or Without:, MODS
Citrate Pharmacokinetics and Regional Citrate Anticoagulation in CRRT
1. To compare the differences of citrate pharmacokinetics in healthy individuals and critically ill patients as well as the influential factors. 2. To validate a pharmacokinetic model which has been established in a formal paper.
- Conditions
- Acute Kidney Failure With or Without:, MODS, Sepsis, Hepatic Insufficiency
- Trial name
- NCT00948558
- Where
- China
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Huashan Hospital
Pain, Brain Injuries
Validity and Reliability Study of the Pain Indicator Behavior Scale-Brain Damage (ESCID-DC)
A multicentre observational study to validate the adaptation of the Pain Indicator Behavior Scale (ESCID) for patients with acquired Brain Damage (ESCID-DC), as a measuring instrument.
- Conditions
- Pain, Brain Injuries, Behavior
- Trial name
- ESCID-DC (NCT04898491)
- Testing
- Pain assessment using a behavioral scale
- Where
- Spain
- Volunteers
- 300 people
- Sponsor
- Candelas Lopez Lopez
Extubation Failure, Mechanical Ventilation
Swallowing Assessment for Predicting Extubation Failure in Critically Ill Patients
Extubation failure, defined as the need for reintubation after planned removal of the endotracheal tube, occurs in up to 20% of critically ill patients and is associated with prolonged mechanical ventilation, longer intensive…
- Conditions
- Extubation Failure, Mechanical Ventilation, Critical Illness
- Trial name
- APEX (NCT07659275)
- Where
- Brazil
- Volunteers
- 800 people
- Sponsor
- Universidade Federal de Pernambuco
Critical Illness
Intrahospital Transport in Patients With High-flow Nasal Oxygenation: Prospective Observational Study
High-flow nasal oxygen therapy is commonly used in intensive care unit (ICU). Intra-hospital transfer of critical patients is frequent: 1) to perform diagnostic 2) between emergency room or medical wards and ICU.
- Trial name
- HospiFlow (NCT05311007)
- Testing
- Evaluation of the incidence and nature of adverse events
- Where
- 4 sites in France
- Volunteers
- 175 people
- Sponsor
- Centre Hospitalier Régional d'Orléans
Sepsis, Heart Failure
Mean Systemic Filling Pressure Continuous Diuretics Critical Care Patients
Within clinical settings observation of hemodynamic changes (e.g. mean systemic filling pressure, cardiac output) in critically ill patients with a clinical indication for deresuscitation with intravenous diuretic therapy.
- Conditions
- Sepsis, Heart Failure, Heart Diseases, Septic Shock
- Trial name
- NCT03395951
- Testing
- Diuretics
- Where
- Netherlands
- Volunteers
- 18 people
- Sponsor
- Catharina Ziekenhuis Eindhoven
Gram Negative Bacterial Infections
Efficacy and Mortality of a Loading Dose of Colistin in Critical Ill Patients
The study hypothesis is that the loading dose of intravenous colistin (6 million of international units) is associated with greater clinical and microbiological efficacy, and reduced mortality of critically ill patients infected…
- Trial name
- NCT02117986
- Testing
- colistin
- Where
- 2 sites in Chile
- Volunteers
- 200 people
- Sponsor
- Hospital Barros Luco Trudeau
Critical Illness, Muscle Loss
Body Composition Study in Critically Ill Patients
This is a single-center prospective observational study that aimed to describe the trajectory of change in body composition among critically ill patients who were able to function independently prior to admission.
- Trial name
- NCT04262531
- Where
- Malaysia
- Volunteers
- 90 people
- Sponsor
- University of Malaya
Vitamin D Deficiency, Sarcopenia
Effect of Vitamin D3 Supplementation on Muscle Mass in ICU Patient
A randomized double blind placebo control trial study will be conducted in critically ill patients with vitamin D deficiency. Investigator aimed to study the effect of oral vitamin D3 supplementation, compare to placebo, on…
- Conditions
- Vitamin D Deficiency, Sarcopenia, Critical Illness
- Trial name
- NCT02594579
- Testing
- Vitamin D3
- Where
- Thailand
- Volunteers
- 40 people
- Sponsor
- Mahidol University
Cancer
Application of Artificial Intelligence and Iron Metabolism Markers in Predicting ICU Outcomes for Critically Ill Cancer Patients
This study aimed to develop a more accurate way to predict the 30-day survival of cancer patients admitted to the intensive care unit (ICU).
- Trial name
- NCT07408661
- Volunteers
- 1,137 people
- Sponsor
- Tongji University
Critical Illness, Sepsis
Does GM-CSF Restore Neutrophil Phagocytosis in Critical Illness?
Despite the introduction of multiple preventative measures rates of hospital acquired infection in the intensive care unit remain high. New approaches to tackling this problem are required.
- Conditions
- Critical Illness, Sepsis, Immuno-suppression
- Trial name
- GMCSF (NCT01653665)
- Testing
- Leukine, Normal Saline
- Where
- 4 sites in United Kingdom
- Volunteers
- 64 people
- Sponsor
- Newcastle-upon-Tyne Hospitals NHS Trust
Hyperglycaemia, Hypoglycaemia
Continuous Glucose Monitoring by Subcutaneous Measurement Compared to Frequent Point of Care Measurement by Accu Chek in Critically Ill Patients
The purpose of this study is to evaluate the accuracy and reliability of the continuous glucose monitoring system the FreeStyle Navigator® (Abbott, Diabetes Care) in critically ill patients by comparing subcutaneous measuring…
- Trial name
- RESCUEII (NCT01526044)
- Testing
- Freestyle Navigator
- Where
- Netherlands
- Volunteers
- 178 people
- Sponsor
- Onze Lieve Vrouwe Gasthuis
Antibiotic Resistant Infection, Critical Illness
Bolus Versus Continuous Infusion of Meropenem
This study arises from the need to optimize antibacterial drug usage to face increasing drug resistance among gram-negative pathogens in intensive care units.
- Trial name
- MERCY (NCT03452839)
- Testing
- Meropenem
- Where
- 26 sites in Croatia, Italy and 2 more
- Volunteers
- 607 people
- Sponsor
- Università Vita-Salute San Raffaele
Critically Ill, Acute Renal Failure
2012_PharmacoCRRT-study:Pharmacokinetics of Anti-infectives in Critically Ill Patients in Need of Continuous Renal Replacement Therapy (CRRT)
The main purpose of the study is to examine if changes in pharmacokinetics of important antiinfectives in Critically Ill patients in need of continuous renal replacement therapy (CRRT), causes inadequate concentrations in plasma.
- Conditions
- Critically Ill, Acute Renal Failure, Acute Kidney Injury
- Trial name
- PharmacoCRRT (NCT01582360)
- Where
- Norway
- Volunteers
- 640 people
- Sponsor
- Oslo University Hospital
Critically Ill
24 Hour Intensivist Coverage in the Medical Intensive Care Unit
The Hospital of the University of Pennsylvania's Medical ICU (MICU) is implementing a model of 24-hour intensivist staffing in September 2011.
- Trial name
- NCT01434823
- Testing
- Nocturnal coverage
- Where
- United States
- Volunteers
- 1,609 people
- Sponsor
- University of Pennsylvania
Respiratory Insufficiency, Metabolic Disease
Is Venous to Arterial Conversion (v-TAC) of Blood Gas Reliable in Critical Ill Patients in the ICU?
Objective: Arterial blood gas (ABG) is essential in the clinical assessment of potential acutely ill patients venous to arterial conversion (v-TAC), a mathematical method, has recently been developed to convert peripheral venous…
- Conditions
- Respiratory Insufficiency, Metabolic Disease, Acidosis, Alkalosis
- Trial name
- NCT03309423
- Testing
- venous to arterial conversion (v-TAC)
- Where
- Denmark
- Volunteers
- 50 people
- Sponsor
- Aalborg University
Disorders of Consciousness Due to Severe Brain Injury, Minimally Conscious State
Assessment of Consciousness With CRS-R and SECONDs
Accurately determining the level of consciousness in patients with severe brain injury is essential for treatment planning, prognosis, and ethical decision-making.
- Conditions
- Disorders of Consciousness Due to Severe Brain Injury, Minimally Conscious State, Unresponsive Wakefulness Syndrome
- Trial name
- AssessConsc (NCT07456020)
- Testing
- Simplified Evaluation of CONsciousness Disorders (SECONDs), Coma Recovery Scale-Revised (CRS-R)
- Where
- Germany
- Volunteers
- 110 people
- Sponsor
- BDH-Klinik Hessisch Oldendorf
Critical Illness, Malabsorption Syndromes
The Early Nasojejunal Tube to Meet Energy Requirements in Intensive Care (ENTERIC) Study
This is a multi-centre randomised controlled trial comparing early jejunal feeding (using a frictional nasojejunal [NJ] tube) and standard feeding in critical illness.
- Trial name
- ENTERIC (NCT00163813)
- Testing
- Early jejunal feeding (using frictional NJ tube), Standard feeding (using nasogastric [NG] tube)
- Where
- Australia
- Volunteers
- 180 people
- Sponsor
- Bayside Health
Sedation, Critical Illness
Musical Intervention and Physiological Stress and Inflammatory Biomarkers in Mechanically Ventilated ICU Patients
This randomized clinical trial evaluates the effects of a musical intervention on hormonal and inflammatory biomarkers in sedated adult patients undergoing invasive mechanical ventilation in an intensive care unit.
- Conditions
- Sedation, Critical Illness, Respiration, Artificial, Inflammation
- Trial name
- NCT06120660
- Testing
- Music Therapy
- Where
- Spain
- Volunteers
- 110 people
- Sponsor
- University of Oviedo
ARDS
NMR Based Metabolomics Kinetics in ARDS Patients
Acute respiratory distress syndrome (ARDS) is a life-threatening condition requiring respiratory support to maintain oxygenation.
- Trial name
- NCT06036056
- Where
- India
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Sanjay Gandhi Postgraduate Institute of Medical Sciences
Critical Illness, Surgery
Gastric US in ICU Patient
This is a case series study using gastric ultrasound in critically ill patients to quantify gastric residual volumes to compare the efficacy of different NPO protocols.
- Conditions
- Critical Illness, Surgery, Aspiration Pneumonia
- Trial name
- NCT05526105
- Testing
- Gastric Ultrasound
- Where
- United States
- Sponsor
- Dartmouth-Hitchcock Medical Center