Clinical trials: Critical Ill Patients
Paralytic Ileus, Critically Ill
Efficacy of PRUcalopride in Critically Ill Patients With Paralytic ILeus
Paralytic ileus is a common intestinal dysfunction in critically ill patients. There are still no established the effective medications except correcting the primary causes and prokinetics trial which limited in efficacy and…
- Trial name
- EPRUCIL (NCT04190173)
- Testing
- Prucalopride
- Where
- Thailand
- Volunteers
- 62 people
- Sponsor
- Prince of Songkla University
Acute Kidney Injury
Goal Directed Therapy for Acute Kidney Injury in Critical Ill Patients
Acute kidney injury (AKI) is a frequent complication in critically ill patients admitted to intensive care unit (ICU) and it is associated with increased morbimortality.
- Trial name
- GDT-AKIN (NCT02414906)
- Testing
- Goal-directed therapy
- Volunteers
- 99 people
- Sponsor
- Barretos Cancer Hospital
Sepsis, ARDS
Microcirculation and Oxidative Stress in Critical Ill Patients in Surgical Intensive Care Unit
As medicine advances, many lives can be saved in the intensive care unit. However, when multiple organ failure occurs, the mortality rate of patients increases dramatically.
- Conditions
- Sepsis, ARDS, Liver Failure, Renal Failure
- Trial name
- NCT00808691
- Testing
- Critical care
- Where
- Taiwan
- Volunteers
- 124 people
- Sponsor
- National Taiwan University Hospital
Respiratory Insufficiency
"TRAcheostomy With Single Use Bronchoscopes vs. Conventional Bronchoscopes"
Optical guidance for percutaneous tracheostomy in intensive care is usually performed by conventional multi use bronchoscopy. Recently a single use bronchoscope has been introduced that allows for endotracheal visualization.
- Trial name
- TraSUB (NCT03952247)
- Testing
- Single Use Bronchoscopy for PDT, Conventional Multi Use Bronchoscopy for PDT
- Where
- Germany
- Volunteers
- 46 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Critically Ill, Anti-Xa
Anti-Xa Levels in Critically Ill Patients Receiving Low-molecular-weight Heparin for Thromboprophylaxis in China
Critically ill Patients are at high risk to develop deep venous thrombosis. However, despite receiving of a standard dose of Low-molecular-weight Heparin（LMWH）, many patients still develop life-threatening embolism.
- Trial name
- NCT03311984
- Testing
- anti Xa level
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Southeast University, China
Critical Illness, D-Lactate
Diagnostic And Prognostic Value Of D-Lactate And Scube-1 Levels In Critically Ill Patients
The investigators aimed to investigate the diagnostic and prognostic levels of D-Lactate and SCUBE-1 in critically ill patients being admitted to the emergency department.
- Conditions
- Critical Illness, D-Lactate, SCUBE-1
- Trial name
- NCT06704438
- Testing
- D-Lactate
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Kanuni Sultan Suleyman Training and Research Hospital
Hemophagocytic Lymphohistiocytosis
Diagnostic Biomarkers for Adult Hemophagocytic Lymphohistiocytosis in Critically Ill Patients (HEMICU)
Hemophagocytic lymphohistiocytosis in adults (HLH) is at 68% mortality whereas 78% of all cases remain undiagnosed though therapies are available which clearly reduce mortality.
- Trial name
- NCT03510650
- Where
- Germany
- Volunteers
- 100 people
- Sponsor
- Charite University, Berlin, Germany
Critical Illness, Muscle Weakness
Diaphragm Protective Ventilation in the Intensive Care Unit
Due to an accident, pneumonia or surgery, patients can have severe shortness of breath or lung damage to such an extent that it compromises vital functions. At such times, mechanical ventilation can be lifesaving.
- Conditions
- Critical Illness, Muscle Weakness, Muscle Damage, Respiration, Artificial
- Trial name
- DiaPro (NCT03527797)
- Testing
- Titration of support level
- Where
- Netherlands
- Volunteers
- 41 people
- Sponsor
- Amsterdam UMC, location VUmc
Enteral Nutrition, Critical Illness
The Impact of Intervention With High-protein Enteral Formula in SICU.
The advantage of higher protein intake has been pointed for critically ill patients. However, it is not easy to achieve no overfeeding but adequate protein intakes for critically ill patients.
- Trial name
- NCT04868318
- Testing
- Very-high protein enteral formula, Standard-high protein enteral formula
- Where
- Taiwan
- Volunteers
- 280 people
- Sponsor
- Tungs' Taichung Metroharbour Hospital
Critical Illness
The Effect of Continuous Versus Intermittent Enteral Nutrition on Metabolic Outcomes in Critically Ill Patients
The goal of this clinical trial is to investigate the effect of continuous versus intermittent enteral nutrition on metabolic outcomes in critically ill adult patients.
- Trial name
- CONVEnIENT (NCT07173504)
- Testing
- Intermittent enteral nutrition
- Where
- 5 sites in Netherlands
- Volunteers
- 124 people
- Sponsor
- Gelderse Vallei Hospital
Nutrition, Muscle Loss
KetoNiFast: Cyclic Enteral Daytime Feeding With Ketogenic Nighttime Fasting
A physiological human nutrition includes circadian feeding and nighttime fasting during sleep. There is increasing evidence, that this natural fasting episode over nighttime majorly contributes to repair processes of the human…
- Conditions
- Nutrition, Muscle Loss, Inflammatory Response
- Trial name
- KetoNiFast (NCT06535815)
- Testing
- Cyclic enteral feeding with nighttime fasting and exogenous ketone salt supplementation (ß-hydroxybutyrate)
- Where
- Germany
- Volunteers
- 130 people
- Sponsor
- University Hospital of Cologne
Mechanically Ventilated ICU Patients
The Effect of Sodium Oxybate on Sleep Architecture
The purpose of this study is to determine what effect sodium oxybate has on the functions of sleep in mechanically ventilated, critically ill patients hospitalized in an intensive care unit.
- Trial name
- NCT00744393
- Testing
- sodium oxybate
- Where
- United States
- Sponsor
- Tufts Medical Center
Mechanical Ventilation, Critically Ill Intensive Care Unit Patients
Ketamine Sedation in the ICU (KANINE) RCT
Sedation is given to intensive care unit (ICU) patients to treat discomfort, anxiety, agitation, and to help facilitate care, particularly when they require a breathing tube.
- Trial name
- KANINE (NCT06767358)
- Testing
- ketamine hydrochloride
- Where
- 3 sites in Canada
- Volunteers
- 54 people
- Sponsor
- McMaster University
Liver Diseases, Liver Cirrhosis
Sepsis, Endothelial Function, and Lipids in Critically Ill Patients With Liver Failure (the SELLIFA Study)
The purpose of the study is to determine the role of new biomarkers in the diagnosis of sepsis in critically-ill patients with liver failure and to correlate the prognosis of these patients with parameters of endothelial function…
- Conditions
- Liver Diseases, Liver Cirrhosis, Sepsis, Critical Illness
- Trial name
- SELLIFA (NCT00488917)
- Where
- Belgium
- Volunteers
- 167 people
- Sponsor
- Cliniques universitaires Saint-Luc- Université Catholique de Louvain
Critical Illness
The Effect of High Protein and Early Resistance Exercise Versus Usual Care in Critically Ill Patients
This is a 2-arm, parallel-group, randomized controlled trial that investigates the effect of combined high protein and early resistance exercise versus usual care on muscle mass, quality and strength, clinical outcomes…
- Trial name
- EFFORT-X (NCT04261543)
- Testing
- High protein and early exercise, Usual Care
- Where
- Malaysia
- Volunteers
- 51 people
- Sponsor
- University of Malaya
Covid-19, Critical Illness
Prospective Observational Cohort Study of Critically Ill Patients With Covid-19 in Sweden
The study will prospectively collect data from patients with Covid-19 admitted to the Västerås Intensive Care Unit, Västerås Hospital. Demographic, clinical, radiographic and laboratory characteristics will be recorded.
- Trial name
- NCT04382417
- Testing
- Observational study
- Where
- Sweden
- Volunteers
- 57 people
- Sponsor
- Region Västmanland
Frailty, Critical Illness
Frailty, Outcomes, Recovery and Care Steps of Critically Ill Patients (FORECAST) Study Multi-Center Study
A prospective observational study of critically ill patients over the age of 50, studying the occurrence of frailty as measured by a variety of frailty measures, processes of care and long term outcomes.
- Trial name
- FORECAST (NCT05509036)
- Testing
- No interventions
- Where
- 11 sites in Canada
- Volunteers
- 700 people
- Sponsor
- Dr. John Muscedere
Acute Kidney Injury, Kidney Replacement
Proactive Prescription-based Fluid Management vs Usual Care in Critically Ill Patients on Kidney Replacement Therapy
A pilot randomized clinical trial comparing a protocol-based fluid management strategy to usual care in critically ill patients receiving kidney replacement therapy.
- Conditions
- Acute Kidney Injury, Kidney Replacement, Critical Illness
- Trial name
- Probe-Fluid (NCT05473143)
- Testing
- Protocol-based fluid management, Usual care
- Where
- Canada
- Volunteers
- 150 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Critically Ill
Optimized Caloric-proteic Nutrition in Critically Ill Patients
In this prospective randomized controlled trial the investigators intend to compare the use of a nutritional therapy based on caloric intake determined by indirect calorimetry and a high protein intake (2.0 to 2.2 g/kg/day) with…
- Trial name
- NCT03060668
- Testing
- Peptamen intense, Novasource senior
- Where
- Brazil
- Volunteers
- 138 people
- Sponsor
- Hospital Sao Domingos
Early Phase of Severe Sepsis and Septic Shock
Piperacillin/Tazobactam in Critically Ill Patients With Severe Sepsis and Septic Shock
This is prospective study to assess the pharmacodynamics (t>MIC) of 4.5 g every 6 h of piperacillin/tazobactam in patients with early phase of severe sepsis/septic shock following administration by a 30 min infusion.
- Trial name
- NCT02730624
- Testing
- Piperacillin-tazobactam
- Where
- Thailand
- Volunteers
- 50 people
- Sponsor
- Sutep Jaruratanasirikul