Clinical trials: Critical Illness, completed
Critically Ill Mechanically Ventilated Subjects
The DIVINE Study: DIetary Management of Glucose VarIability iN thE ICU
To compare the nutritional effect on blood glucose of two commercially available enteral diets in overweight or obese patients in the Intensive Care Unit.
- Trial name
- NCT02337556
- Testing
- Peptamen Bariatric, Replete
- Where
- 7 sites in United States, Canada
- Volunteers
- 106 people
- Sponsor
- Société des Produits Nestlé (SPN)
Hyperglycemia
Feasibility Study to Evaluate Safety and Device Performance of the Hospital Glucose Management System (HGMS)
The purpose of this study is to assess safety and device performance of the Medtronic Hospital Glucose Management System (HGMS) for up to 72-hours.
- Trial name
- MAHI (NCT01763567)
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- Medtronic MiniMed, Inc.
Critical Illness, Dietary Modification
Meeting Protein Targets in Critically Ill Patients
This is a retrospective study of protein and energy intake in enterally fed critically ill adult patients before and after the introduction of a very high protein enteral nutrition formula in a single center medical/surgical ICU.
- Trial name
- PROTARGET (NCT03319836)
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- Société des Produits Nestlé (SPN)
Cardiac Output
Validation of Minimally Invasive Ultrasound Indicator Dilution Technique in Critically Ill Children
A novel method to measure cardiac index based on ultrasound indicator dilution technology (UIDT) has been developed by Transonic Systems Inc. (Ithaca, NY, USA).
- Trial name
- NCT00852254
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Transonic Systems Inc.
Critical Illness, Hyperglycemia
Effects of a Complete Diet in Critically Ill Patients With Stress Hyperglycemia
The aim of the study is to evaluate the beneficial effects of the administration of a complete diet rich in monounsaturated fatty acids (MUFA) and slow absorption carbohydrate in patients with stress hyperglycemia(T-Diet Plus…
- Conditions
- Critical Illness, Hyperglycemia, Dietary Modification, Metabolic Stress Hyperglycemia
- Trial name
- NCT01233726
- Testing
- T-Diet plus Diabet IR, ISOSOURCE PROTEIN FIBRE, GLUCERNA SELECT
- Where
- 2 sites in Spain
- Volunteers
- 159 people
- Sponsor
- Vegenat, S.A.
Critical Illness
Study of Arginine Free IED in Critically Ill Patients.
This study intends to investigate the clinical outcomes of a new immunoenhancing formula which composed arginine free compare to isonitrogenous, isocaloric standard formula in ICU patients.The study design is multicenter…
- Trial name
- ROSIED (NCT01713257)
- Testing
- Immunoenhancing diet, Isocaloric, isonitrogenous diet
- Where
- 3 sites in Thailand
- Volunteers
- 172 people
- Sponsor
- Thai Otsuka Pharmaceutical Co., Ltd.
Sepsis, Systemic Inflammatory Response Syndrome (SIRS)
Effect of Lactiplantibacillus Plantarum DAD-13 on Inflammatory Markers in ICU Sepsis Patients
This study investigated whether giving the probiotic Lactiplantibacillus plantarum DAD-13 to sepsis patients in the intensive care unit (ICU) could help reduce inflammation and improve bowel function.
- Conditions
- Sepsis, Systemic Inflammatory Response Syndrome (SIRS), Critical Illness
- Trial name
- LactoSepsis (NCT07072871)
- Testing
- Lactiplantibacillus plantarum DAD-13
- Where
- Indonesia
- Volunteers
- 32 people
- Sponsor
- PT Royal Medikalink Pharmalab
Acute Kidney Injury
A Sample Collection Study to Validate the Astute Medical NephroCheck Test in Critically Ill Subjects at Risk for Acute Kidney Injury
The objective of this sample collection study is to collect blood and urine samples. This study is observational and will have no impact on the medical management of the subject.
- Trial name
- NCT01573962
- Where
- 23 sites in United States
- Volunteers
- 420 people
- Sponsor
- Astute Medical, Inc.
Anemia
Research Into the Treatment of Anemia for Critically Ill Patients Admitted to Intensive Care Units (ICU)
Erythropoietin (EPO) is a hormone produced in the kidney. Its function is to stimulate the production of red cells in the bone marrow.
- Trial name
- NCT00091910
- Testing
- Epoetin alfa
- Volunteers
- 1,460 people
- Sponsor
- Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
Acute Kidney Injury
Specimen Stability Study
To collect and process urine samples from critically ill subjects for use in assessing the effects of various urine sample freezing and storage conditions on biomarker test results.
- Trial name
- NCT01846884
- Where
- 6 sites in United States
- Volunteers
- 124 people
- Sponsor
- Astute Medical, Inc.
Anemia, Critical Illness
Pharmacokinetic/ Pharmacodynamic Study of Epoetin Alfa (PROCRIT) in Critically Ill Patients.
The purpose of this study is to describe the pharmacokinetics (PK) of six different dosing regimens of epoetin alfa (PROCRIT®) in anemic critically ill subjects
- Trial name
- NCT00210756
- Testing
- epoetin alfa
- Volunteers
- 60 people
- Sponsor
- Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
Critical Illness
Feasibility of Blood Glucose Control With the Space TGC System in Medical ICU Patients
Hyperglycemia is common in critically ill patients and associated with an adverse outcome. Thus, glycaemic control is an important issue in critical care.
- Trial name
- DELIOS 01 (NCT01164423)
- Testing
- Space TGC
- Where
- Austria
- Volunteers
- 20 people
- Sponsor
- B. Braun Melsungen AG
Critical Illness
Observational Cohort Study on the Use of Parenteral Nutrition and Clinical Outcomes in Adult Critically Ill Patients
The aim of this study is to characterise the use of clinical nutrition support, especially of parenteral nutrition that is administered directly into a vein, in adult patients with critical illness.
- Trial name
- NCT04143503
- Where
- 76 sites in Austria, Belgium and 9 more
- Volunteers
- 1,208 people
- Sponsor
- Fresenius Kabi
Critical Illness
Feasibility of Tight Blood Glucose Control With the Space TGC System in Surgical ICU Patients
Hyperglycemia is common in critically ill patients and associated with an adverse outcome. Thus, glycaemic control is an important issue in critical care.
- Trial name
- DELIOS 03 (NCT01146847)
- Testing
- Space TGC
- Where
- Germany
- Volunteers
- 20 people
- Sponsor
- B. Braun Melsungen AG
Respiration, Artificial, Ventilators, Mechanical
Pivotal Evaluation of Abdominal Neuromuscular Electrical Stimulation (VentFree) for Weaning From Mechanical Ventilation
The objective of this study is to evaluate the efficacy of the VentFree Respiratory Muscle Stimulator (VentFree) in critically ill adult patients who require invasive mechanical ventilation, when compared to sham.
- Trial name
- PREVENT (NCT05759013)
- Testing
- Breath synchronized abdominal FES
- Where
- 27 sites in United States, Australia and 2 more
- Volunteers
- 250 people
- Sponsor
- Liberate Medical
Cardiovascular Disease
Retrospective Safety Study to Compare Mortality in Intensive Care Unite (ICU) Patients Undergoing Echocardiography With or Without DEFINITY®
Retrospective analysis to observe changes in short term mortality
- Trial name
- DEF-418 (NCT01299649)
- Where
- United States
- Volunteers
- 4,300,000 people
- Sponsor
- Lantheus Medical Imaging
Critical Illness, Obesity
Feeding Trial in the Obese Critical Care Population
This study will assess enteral feeding in an obese critically ill population with a higher protein whey based peptide formula.
- Trial name
- NCT01357200
- Testing
- enteral formula
- Where
- 2 sites in United States
- Volunteers
- 26 people
- Sponsor
- Société des Produits Nestlé (SPN)
Critical Illness
Parenteral Nutrition With Intravenous and Oral Fish Oil for Intensive Care Patients
The primary objective is to assess the effect of fish oil-enriched enteral and parenteral nutrition on blood oxygenation in critically ill patients.
- Trial name
- NCT01162928
- Testing
- Nutriflex Omega special + Oxepa, Nutriflex Lipid special + Pulmocare
- Where
- Israel
- Volunteers
- 100 people
- Sponsor
- B. Braun Melsungen AG
Intensive Care
Measurement of Cardiac Output and Intravascular Volume Status in Children Using COstatus (SH)
Assessment and monitoring of cardiac function in the pediatric intensive care unit (PICU) is an integral part of hemodynamic monitoring of critically ill patients whether it is done directly or indirectly.
- Trial name
- NCT01613859
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Transonic Systems Inc.
Surgery
Validation of Noninvasive Hemoglobin, Comparison of PVI to Standard Methods, and Validation of Clinical Efficacy of ORI
The study goal is to establish the correlation of hemoglobin values determined by the noninvasive pulse oximetry-determined hemoglobin (SpHb) system with hemoglobin as measured by other validated devices.
- Trial name
- NCT02841397
- Testing
- Masimo Pulse CO-Oximeter
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Masimo Corporation