Clinical trials: Critical Illness
Anemic, Critically Ill Patients
Efficacy of Enteral Iron Supplementation in Critical Illness
The purpose of this study is to investigate the efficacy of enteral iron supplementation for improving anemia, decreasing the risk of blood transfusion, and decreasing mortality in patients who are hospitalized in the intensive…
- Trial name
- NCT00450177
- Testing
- Ferrous Sulfate
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Weill Medical College of Cornell University
Critical Illness
Body Positioning and Pulmonary Aeration During Mechanical Ventilation
The present randomized crossover clinical trial aims to evaluate the influence of different body postures on pulmonary aeration among mechanically ventilated critically ill patients.
- Trial name
- NCT04176445
- Testing
- Orthostatic board posture, Bedside sitting posture
- Where
- 2 sites in Brazil
- Volunteers
- 19 people
- Sponsor
- Hospital Moinhos de Vento
Hyperglycemia
Feasibility Study to Evaluate Safety and Device Performance of the Hospital Glucose Management System (HGMS)
The purpose of this study is to assess safety and device performance of the Medtronic Hospital Glucose Management System (HGMS) for up to 72-hours.
- Trial name
- MAHI (NCT01763567)
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- Medtronic MiniMed, Inc.
Diabetes
Continuous Glucose Monitoring in Critically Ill
The goal of this clinical research study is to learn if The Guardian® blood-sugar monitoring device can be used reliably in patients with high blood sugar who are receiving care in the ICU.
- Trial name
- NCT00707434
- Testing
- Guardian® blood-sugar monitoring device
- Where
- 6 sites in United States
- Volunteers
- 6 people
- Sponsor
- M.D. Anderson Cancer Center
Gastroparesis
Nutritional Adequacy Therapeutic Enhancement in the Critically Ill. The NUTRIATE Study
This is a multi-center, parallel group, placebo-controlled and active-compared, randomized study to assess the ability of GSK962040 to enhance the delivery of enteral feed to critically ill subjects that are predisposed to…
- Trial name
- NCT01934192
- Testing
- GSK962040 50 mg, Metoclopramide 10 mg
- Where
- 19 sites in United States, Australia and 1 more
- Volunteers
- 91 people
- Sponsor
- GlaxoSmithKline
Acute Renal Failure
Acute Renal Failure Trial Network (ATN) Study
This is a multi-center, prospective, randomized, parallel-group trial of an intensive strategy vs conventional strategy of renal replacement therapy for the treatment of acute renal failure secondary to acute tubular necrosis in…
- Trial name
- ATN (NCT00076219)
- Testing
- renal replacement therapy
- Where
- 22 sites in United States
- Volunteers
- 1,124 people
- Sponsor
- US Department of Veterans Affairs
Bacterial Infections
Pharmacokinetics of Ceftazidime-avibactam Among Critically-ill Patients Receiving CVVHDF
Ceftazidime-avibactam is used for treatment of invasive Gram-negative bacterial infections among critically ill patients, including those on continuous venovenous hemodiafiltration .
- Trial name
- NCT04358991
- Testing
- Ceftazidime-avibactam
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Pittsburgh
Critically Ill, Respiratory Failure
The Effect of Thiamine vs. Placebo on VO2 in Critical Illness
The objective of this study is to determine the effect of thiamine therapy on oxygen consumption (VO2) in critically-ill patients.
- Trial name
- TVO2_RCT (NCT01985685)
- Testing
- Thiamine
- Where
- United States
- Volunteers
- 66 people
- Sponsor
- Beth Israel Deaconess Medical Center
Complications of Surgical and Medical Care: General Terms, Adverse Reaction to Drug
The Thai Surgical Intensive Care Study (Thai-SICU Study)
The study observed the 28 days mortality of 9 participated University base surgical intensive care unit (SICU) as well as the occurrence of adverse events in SICU.
- Conditions
- Complications of Surgical and Medical Care: General Terms, Adverse Reaction to Drug, Sequelae of External Causes of Morbidity and Mortality, Critical Illness
- Trial name
- THAI-SICU (NCT01354197)
- Where
- 9 sites in Thailand
- Volunteers
- 4,652 people
- Sponsor
- Royal College of Anesthesiologists of Thailand
Acute Renal Failure
High Dose CVVHDF Compared to Standard Dose CVVHDF
In the last three decades, the mortality associated with acute renal failure (ARF) in the ICU has remained unchanged at greater than 50%, despite improvements in dialysis technology.
- Trial name
- CVVHDF (NCT00561431)
- Testing
- Standard dose of dialysis, High dose of dialysis
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- University of Alabama at Birmingham
Critically Ill
24 Hour Intensivist Coverage in the Medical Intensive Care Unit
The Hospital of the University of Pennsylvania's Medical ICU (MICU) is implementing a model of 24-hour intensivist staffing in September 2011.
- Trial name
- NCT01434823
- Testing
- Nocturnal coverage
- Where
- United States
- Volunteers
- 1,609 people
- Sponsor
- University of Pennsylvania
Critical Illness
Use of Nudges To Enhance Enrollment in Critical Care Research
Difficulties enrolling patients in randomized clinical trials (RCTs) have long been recognized as a major barrier to successful evaluation of medical interventions.
- Trial name
- NCT03284359
- Testing
- Pre-Consent Nudge Bundle
- Where
- United States
- Volunteers
- 182 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Critical Illness, Hyperglycemia
Effects of a Complete Diet in Critically Ill Patients With Stress Hyperglycemia
The aim of the study is to evaluate the beneficial effects of the administration of a complete diet rich in monounsaturated fatty acids (MUFA) and slow absorption carbohydrate in patients with stress hyperglycemia(T-Diet Plus…
- Conditions
- Critical Illness, Hyperglycemia, Dietary Modification, Metabolic Stress Hyperglycemia
- Trial name
- NCT01233726
- Testing
- T-Diet plus Diabet IR, ISOSOURCE PROTEIN FIBRE, GLUCERNA SELECT
- Where
- 2 sites in Spain
- Volunteers
- 159 people
- Sponsor
- Vegenat, S.A.
Sepsis, Systemic Inflammatory Response Syndrome
PPV to Guide Fluid Management in the PICU
Children who are critically ill often require large amounts of fluid during their acute illness. It has been shown in multiple studies that appropriate administration of fluid decreases morbidity and mortality, but giving too…
- Trial name
- PPV (NCT02308371)
- Testing
- Automated Pulse Pressure Variation
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of North Carolina, Chapel Hill
Hypotension, Pressure Ulcer
Comparison of Nasal and Forehead Oximetry in Critically Ill Patients at Risk for Decreased Peripheral Perfusion
Continuous pulse oximetry monitoring is the standard of care in critically ill patients in emergency departments, operating rooms and intensive care units.
- Trial name
- NCT02382133
- Testing
- Nasal alar oxygen sensor
- Where
- United States
- Volunteers
- 43 people
- Sponsor
- Washington University School of Medicine
Weaning Failure, Mechanical Ventilation Complication
Comparison of Two Extubation Techniques in Critically Ill Adult Patients
Orotracheal extubation consists in the removal of the endotracheal tube (ETT) when it is no longer required. This procedure may carry a considerable risk of complications and extubation failure.
- Trial name
- ExtubAR (NCT03918811)
- Testing
- Positive Pressure Extubation Technique, Traditional Extubation Technique
- Where
- Argentina
- Volunteers
- 725 people
- Sponsor
- Hospital Donación Francisco Santojanni
Critical Illness
Family Satisfaction (FS) in the Intensive Care Unit
There is increasing awareness that high-quality care in the intensive care unit also includes care of visiting family members according to their needs.
- Trial name
- NCT01449734
- Where
- Germany
- Volunteers
- 217 people
- Sponsor
- Center for Sepsis Control and Care, Germany
Acute Respiratory Failure Requiring Mechanical Ventilation
Eye-Control Trial: Wearable Eye-Tracking Device as Means of Communication
The purpose of this study is to evaluate the feasibility of use of a wearable communication device for critically ill patients who are admitted to the intensive care unit (ICU) and mechanically ventilated.
- Trial name
- NCT04582149
- Testing
- EyeControl Eye-tracking Device
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Emory University
Pharmacokinetics
Pharmacokinetics of Ceftolozane/Tazobactam in Plasma and Cerebrospinal Fluid
Ceftolozane/tazobactam is an emerging newly available antibiotic that has a broad spectrum of activity, and could be potentially useful in the management of central nervous system infections.
- Trial name
- NCT03309657
- Testing
- Ceftolozane/tazobactam
- Where
- Australia
- Volunteers
- 10 people
- Sponsor
- Royal Brisbane and Women's Hospital
Diabetes Mellitus
Safety and Efficacy of Saxagliptin for Glycemic Control in Non-Critically Ill Hospitalized Patient
The purpose of this research study is to test the safety and efficacy of a drug called saxagliptin (Onglyza) for treatment of type 2 diabetes in non-critically ill hospitalized patients who have an HbA1c of 7.5 or lower, on 1 or…
- Trial name
- NCT02182895
- Testing
- Saxagliptin
- Where
- United States
- Volunteers
- 72 people
- Sponsor
- Brigham and Women's Hospital