Clinical trials: Critical Illness, completed
Hyperglycemia
Comparative Trial Between 3 Types of Insulin Infusion Protocols
Increasing evidence from observational studies in hospitalized patients with and without diabetes indicates that hyperglycemia is a predictor of poor outcome.
- Trial name
- NCT00582309
- Testing
- Glucommander-Guided Intravenous Insulin Infusion, Standard Intravenous Insulin Infusion, Simple Calculated Intravenous Insulin Infusion
- Where
- 3 sites in United States
- Volunteers
- 151 people
- Sponsor
- University of New Mexico
Fluid Responsiveness
Evaluation of Perfusion Index Change Post Passive Leg Raising for Fluid Responsiveness in Critically Ill
Peripheral Perfusion Index (PI) has been investigated for its use in hemodynamic monitoring. The PI is derived from the photoelectric plethysmographic signal of the pulse oximeter.
- Trial name
- NCT06063993
- Where
- Egypt
- Volunteers
- 91 people
- Sponsor
- National Hepatology & Tropical Medicine Research Institute
Sepsis .
Serum STREM and MNDA Mointoring in ICU
A total of 120 patients will be included in the study. Sixty patients are critically ill with evidence of sepsis during ICU stay (sepsis group) and sixty patients are critically ill without evidence of infectious organism (SIRS…
- Trial name
- NCT02120521
- Where
- Egypt
- Volunteers
- 120 people
- Sponsor
- Tanta University
Critical Illness
Dose of Early Therapeutic Mobility: Does Type or Frequency Matter?
This study will examine the effects of once and twice daily activity performed with patients who are breathing with the aid of a machine in an intensive care unit. Activity can occur in bed.
- Trial name
- ETM (NCT00999011)
- Testing
- once daily mobility activity, twice daily mobility activity
- Where
- United States
- Volunteers
- 54 people
- Sponsor
- Case Western Reserve University
Mechanically Ventilated Patients
Effect Of Clustered Nursing Interventions On Physiological Response In Critically Ill Patients
To determine physiological responses related to clustered nursing interventions among critically ill patients.
- Trial name
- NCT04134481
- Volunteers
- 80 people
- Sponsor
- Alexandria University
Critically Ill, Pain, Postoperative
Ketamine-fentanyl VS Fentanyl for Analgosedation in SICU
This is a randomized, double-blinded study to evaluate the analgosedative effect of ketamine in a surgical intensive care unit. The patients who will receive continuous fentanyl infusion for either pain control or sedation will…
- Trial name
- NCT03879564
- Testing
- Ketamine, Normal saline
- Where
- Thailand
- Volunteers
- 118 people
- Sponsor
- Mahidol University
Withdrawal Syndrome
Protocolized Sedative Weaning VS. Usual Care in Pediatric Critically Ill, RCT
Sedative and analgesic agents are widely used in the ICU. These agents can provide hypnotic effect, pain alleviation, cooperation, and synchronizing ventilatory support.
- Trial name
- NCT03018977
- Testing
- The sedative weaning protocol group, The usual group
- Where
- Thailand
- Volunteers
- 60 people
- Sponsor
- Ramathibodi Hospital
Low Cardiac Output Syndrome, Cardiogenic Shock
Milrinone Versus Dobutamine in Critically Ill Patients
The investigators are interested in determining if there is a meaningful difference between two of the most commonly used medications used to improve the pumping function of the heart among critically ill patients admitted to the…
- Conditions
- Low Cardiac Output Syndrome, Cardiogenic Shock, Acute Coronary Syndrome, Pulmonary Edema
- Trial name
- NCT03207165
- Testing
- Milrinone, Dobutamine
- Where
- Canada
- Volunteers
- 192 people
- Sponsor
- Ottawa Heart Institute Research Corporation
Colistin
Evaluation of Pharmacokinetic and Pharmacodynamic Properties of Intravenous Colistimethate Sodium
Colistin is a polymixin antibiotic used in the treatment of multidrug-resistant gram-negative infections. Given the limited use of colistin and previous challenges with laboratory assays to determine plasma concentrations, there…
- Trial name
- NCT02288429
- Testing
- colistimethate sodium
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- University of Colorado, Denver
Critical Illness, Social Isolation
Reducing Isolation and Feeling of Loneliness During Critical Illness
The trial is a pilot-randomized trial testing feasibility and limited-efficacy of delivering social engagement using technologic strategies to reduce periods of social isolation.
- Conditions
- Critical Illness, Social Isolation, Anxiety, Depression
- Trial name
- SOCIAL (NCT05537311)
- Testing
- Social Engagement
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Kirby Mayer
SARS-CoV-2, Covid19
Pathological Findings of Fatal COVID-19
The Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is a new coronavirus discovered in December 2019 in Wuhan, China and currently responsible of a worldwide outbreak and the death of more than 55,000 patients in…
- Conditions
- SARS-CoV-2, Covid19, Pathology, Intensive Care Units
- Trial name
- HISTOCOVID (NCT04675281)
- Testing
- 2 post-mortem transcutaneous lung biopsies (1 anterior ; 1 posterior) using anatomical landmarks
- Where
- 44 sites in France
- Volunteers
- 170 people
- Sponsor
- Nantes University Hospital
Noninvasive Ventilation, Nutrition Therapy
Nutrition Under Noninvasive Ventilation
Even though nutrition is a fundamental component of Intensive care unit (ICU) therapy, critically ill patients are frequently malnourished, a factor well known for its strong association with a higher risk of complications…
- Conditions
- Noninvasive Ventilation, Nutrition Therapy, Respiratory Insufficiency
- Trial name
- NUTRINIV (NCT06260202)
- Where
- Italy
- Volunteers
- 112 people
- Sponsor
- Università degli Studi del Piemonte Orientale Amedeo Avogadro
COVID-19, Outcome, Fatal
Critically Ill ICU Patients Under Casirivimab- and/or Tocilizumab Application
In a retrospective observational study, critically ill COVID-19 patients admitted to the ICU with the CoV-2 delta-variant between august 2021 and february 2022 were evaluated (ethics application nr.
- Conditions
- COVID-19, Outcome, Fatal, Tocilizumab, Interleukin 6
- Trial name
- CasiTocCOVID (NCT06233357)
- Testing
- treated without (N), with casirivimab / imdevimab (C) or tocilizumab (T), solely, or in combination of both (C + T)
- Where
- Germany
- Volunteers
- 95 people
- Sponsor
- University of Ulm
Acute Necrotizing Pancreatitis
CMV Reactivation in Acute Necrotizing Pancreatitis
Patients with the diagnosis of acute necrotizing pancreatitis (ANP) present with a wide spectrum of severity. These patients frequently require intensive care management.
- Trial name
- NCT05898048
- Where
- India
- Volunteers
- 41 people
- Sponsor
- Sanjay Gandhi Postgraduate Institute of Medical Sciences
Covid19, Muscle Atrophy
Electrical Stimulation for Critically Ill Covid-19 Patients
Unfortunately, hospital-acquired weakness is highly prevalent among COVID-19 hospitalized patients, who often require prolonged bed-rest or paralytics for an extended period of time in order to maintain oxygenation.
- Conditions
- Covid19, Muscle Atrophy, Muscle Weakness
- Trial name
- Phase I (NCT04685213)
- Testing
- Electrical Stimulation
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- Baylor College of Medicine
Critical Illness, Parenteral Nutrition
Protein Restriction In Parenteral Nutrition For Critically Ill Neonates During The Acute Phase: A Preliminary Study
This study aims to determine the differences in outcomes in groups with protein restriction in parenteral nutrition of critically ill infants, compared with protein regimens according to local guidelines.
- Trial name
- NCT07801040
- Testing
- Amino acid infusion
- Where
- Indonesia
- Volunteers
- 52 people
- Sponsor
- Universitas Indonesia
Critical Illness
The Optimization of Procedural Pain Control in Intensive Care Unit (ICU) Patients
The purpose of this study is to determine the influence of morphine 2,5 mg or morphine 7,5 mg iv during a painful and unavoidable intervention in critically ill patients.
- Trial name
- OPCIC (NCT00558090)
- Testing
- morphine
- Where
- Netherlands
- Volunteers
- 150 people
- Sponsor
- St. Antonius Hospital
Critical Illness, Hypoxemia
Exploring Pulse OXimeter Accuracy Across SKin Tones
This study within a trial (SWAT) will be a sub-study of the UK-ROX trial (ISRCTN13384956), which is currently running in intensive care units across the UK.
- Trial name
- EXAKT (NCT05481515)
- Testing
- Pulse oximetry, Spectrophotometry
- Where
- United Kingdom
- Volunteers
- 903 people
- Sponsor
- Intensive Care National Audit & Research Centre
Critical Illness
Evaluation of Bedside Methods to Measure Muscularity in Critically Ill Patients
Muscle wasting is a significant problem in critically ill patients, with reported losses of a half to three percent per day over the first ten days (for an average 70kg person this equates to 3 to 20kg of muscle loss).
- Trial name
- NCT03019913
- Testing
- Observational cohort
- Where
- Australia
- Volunteers
- 50 people
- Sponsor
- La Trobe University
Respiratory Failure
Early Mobilization in the ICU
To study all ICU patients with an independent baseline functional status , who experience a critical illness requiring intubation and mechanical ventilation evaluating long-term cognitive and executive function and long term cost…
- Trial name
- NCT01777035
- Testing
- early PT OT
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- University of Chicago
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