Clinical trials: Critical Illness, completed
Acute Kidney Injury
Standard vs. Accelerated Initiation of RRT in Acute Kidney Injury (STARRT-AKI: Principal Trial)
The objectives of this trial are to determine whether, in critically ill patients with severe acute kidney injury (AKI), randomization to accelerated initiation of renal replacement therapy (RRT), compared to standard initiation…
- Trial name
- NCT02568722
- Testing
- Standard RRT initiation, Accelerated RRT initiation
- Where
- 105 sites in United States, Australia and 13 more
- Volunteers
- 3,019 people
- Sponsor
- Unity Health Toronto
SARS-CoV 2
Efficacy of Tocilizumab on Patients With COVID-19
This is a randomized, double blind, multi-center study to evaluate the effects of tocilizumab compared to placebo on patient outcomes in participants with confirmed SARS-CoV-2 infection and evidence of systemic inflammation.
- Trial name
- NCT04356937
- Testing
- Tocilizumab
- Where
- 3 sites in United States
- Volunteers
- 243 people
- Sponsor
- Massachusetts General Hospital
Coronavirus
Cyclo-Ergometry in the Patient With Acute Respiratory Distress Syndrome
In March 2020 the World Health Organization declares the Coronavirus disease pandemic 2019. Intensive Care Units deal entirely with patients with pneumonia complicated by Acute Respiratory Distress Syndrome, requiring aggressive…
- Trial name
- NPIDRA2021 (NCT06226428)
- Testing
- Bed cyclo-ergonometry, Bed mobility activities (turning, pelvic elevation and sitting), standing, transfers and walking., Progressive upper and lower limb strength training
- Where
- Spain
- Volunteers
- 35 people
- Sponsor
- Biogipuzkoa Health Research Institute
Acute Respiratory Failure
Nutrition and Exercise in Critical Illness
This study proposes a novel early intervention combining Intravenous (IV) amino acids plus in-bed cycle ergometry exercise to improve physical outcomes in critically ill patients.
- Trial name
- NEXIS (NCT03021902)
- Testing
- IV amino acids, In-bed cycle ergometry exercise
- Where
- 7 sites in United States
- Volunteers
- 115 people
- Sponsor
- Clinical Evaluation Research Unit at Kingston General Hospital
Arterial Puncture
Simple Psychological Interventions and Cryoanalgesia
This study aims to explore the effect of using simple psychological interventions and cryoanalgesia for reducing arterial punctures pain and anxiety in critically ill patients
- Trial name
- NCT06661187
- Testing
- Cryoanalgesia, Psychological instructions, Routine care
- Where
- 2 sites in Egypt
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Damanhour University
Critical Illness, Multiple Organ Failure
Impact of Human Blood Serum From Critically Ill Patients on Human Colon Neuronal Networks.
Critical illness in the ICU setting has high medical and socioeconomic importance. Critically ill patients frequently develop severe neurologic impairment during their course of disease, typically presenting as…
- Conditions
- Critical Illness, Multiple Organ Failure, Polyneuropathy, Myopathy
- Trial name
- NCT02706314
- Where
- Germany
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- University of Rostock
Critical Illness, Sedation
Analgosedative adjuncT keTAmine Infusion iN Mechanically vENTilated ICU Patients
The purpose of this study is to investigate the efficacy and safety of a low dose ketamine infusion used in combination of standard of care in critically ill patients to test whether ketamine can help to shorten the time of being…
- Conditions
- Critical Illness, Sedation, Mechanical Ventilation
- Trial name
- ATTAINMENT (NCT04075006)
- Testing
- Ketamine
- Where
- Saudi Arabia
- Volunteers
- 84 people
- Sponsor
- King Faisal Specialist Hospital & Research Center
Neuromuscular Blockade, Human Characteristics
Sparing in Neuromuscular Blockade in COVID 19 ICU
This is a retrospective case-controlled study of the effect of the use of a neuromuscular blockade (NMB) monitor on the consumption of NMB agents in patients under mechanical ventilation in the context of COVID-19.
- Conditions
- Neuromuscular Blockade, Human Characteristics, Complication of Medical Care, Intensive Care Unit Acquired Weakness
- Trial name
- TOF-COVID (NCT04459533)
- Testing
- TOF protocol
- Where
- France
- Volunteers
- 250 people
- Sponsor
- Hospices Civils de Lyon
Gastrointestinal Dysfunction, Critical Illness
Predictive Value of Transabdominal Intestine Sonography in Critically Ill Patients
It is very important to evaluate the degree of gastrointestinal dysfunction in critical ill patients. Thus the investigators conducted transabdominal intestine ultrasonography(US) in critical ill patients to evaluated the degree…
- Conditions
- Gastrointestinal Dysfunction, Critical Illness, Intestine Ultrasonography
- Trial name
- NCT03589248
- Testing
- GIF score, US score
- Volunteers
- 136 people
- Sponsor
- Nanjing PLA General Hospital
Critical Illness
A Trial of Enteral Colostrum on Intestinal Permeability in Critically Ill Patients
The effects of colostrum on intestinal permeability in critical ill patients has not been investigated. In current trial, intensive care unit patients with enteral feeding will receive either enteral colostrum or maltodextrin as…
- Trial name
- NCT03186716
- Testing
- Colostrum, Maltodextrin
- Where
- Iran
- Volunteers
- 70 people
- Sponsor
- National Nutrition and Food Technology Institute
SARS-Associated Coronavirus, Covid19
Treatment of Critically Ill Patients With Covid-19 With Convalescent Plasma
This study aims to collect convalescent plasma and use it as experimental treatment in critically ill Covid-19 patients in order to reduce mortality and length of stay in intensive care unit.
- Conditions
- SARS-Associated Coronavirus, Covid19, SARS-CoV Infection
- Trial name
- NCT04468009
- Testing
- Convalescent plasma
- Where
- Argentina
- Volunteers
- 134 people, healthy volunteers welcome
- Sponsor
- Hospital de Infecciosas Francisco Javier Muniz
Muscle Weakness, Critical Illness
Critical Illness Neuromuscular Abnormalities in Neurocritical Care Patients
The aim of this research is to investigate critical illness neuromuscular abnormalities in neurocritical care patients.
- Trial name
- NCT00893633
- Where
- Russia
- Volunteers
- 135 people
- Sponsor
- Clinical Institute of the Brain, Russia
Critical Illness
Multidimensional Dysfunction in Patients With Chronic Critical Illness in China
Over the past two decades, rapid advances in critical care medicine have markedly reduced short-term mortality among critically ill patients.
- Trial name
- NCT07585578
- Testing
- Data Collection and Assessment
- Where
- 4 sites in China
- Volunteers
- 888 people
- Sponsor
- Hongying Jiang, MD
Sepsis
Evaluation of Serum Procalcitonin in Critically Ill Patients With Suspected Sepsis
Procalcitonin is a promising marker of sepsis in critically ill patients. Procalcitonin have better diagnostic accuracy compared to White blood cell count and C - reactive protein.
- Trial name
- NCT03506152
- Testing
- Serum Procalcitonin
- Where
- Pakistan
- Volunteers
- 103 people
- Sponsor
- Aga Khan University
Acute Respiratory Failure Requiring Mechanical Ventilation
Eye-Control Trial: Wearable Eye-Tracking Device as Means of Communication
The purpose of this study is to evaluate the feasibility of use of a wearable communication device for critically ill patients who are admitted to the intensive care unit (ICU) and mechanically ventilated.
- Trial name
- NCT04582149
- Testing
- EyeControl Eye-tracking Device
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Emory University
Platelet Indices, Mortality
Platelet Indices in Prediction of Mortality in Critically Ill Septic Patients
Platelets (PLT), a major and essential constituent of blood, plays an important role in physiological and pathological processes such as coagulation, thrombosis, inflammation and maintenance of vascular endothelial cells the…
- Conditions
- Platelet Indices, Mortality, Sepsis
- Trial name
- NCT04335955
- Where
- Egypt
- Volunteers
- 54 people
- Sponsor
- Amany Faheem
Catheter-related Bloodstream Infection
Recent Techniques for Diagnosing Central Venous Catheter-related Bloodstream Infections in Children
Removal of a central venous catheter (CVC) is often useful to prove its responsibility in a bloodstream infection. To avoid unnecessary removal of CVC, some catheter-spearing diagnostic methods have been recently developed.
- Trial name
- Incat (NCT01249976)
- Testing
- blood culture
- Where
- France
- Volunteers
- 148 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Anxiety, Depression
Improving Patient and Family Centered Care in Advanced Critical Illness
One in five deaths in the U.S. occurs in or shortly after discharge from an intensive care unit (ICU), typically following decisions made by surrogate decision makers to forego life prolonging treatment.
- Trial name
- PARTNER (NCT01844492)
- Testing
- The PARTNER Intervention, ICU Usual Care Control
- Where
- United States
- Volunteers
- 1,420 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Critical Illness, Muscle Loss
Investigating the Anabolic Response to Resistance Exercise After Critical Illness (ARTIST-2)
ICU survivors often suffer from long-term functional disability. An attenuated response to physical exercise in skeletal muscle after critical illness may contribute to persisting weakness.
- Trial name
- ARTIST-2 (NCT05261984)
- Testing
- Resistance exercise, Oral protein supplementation
- Where
- Sweden
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Karolinska University Hospital
Critically Ill
Screening Elderly Patients for Weaning
During weaning the work of breathing is transferred from the ventilator back to the patient. Approximately 40% of the time on ventilators is spent weaning.
- Trial name
- NCT02243449
- Testing
- Once daily screening, At least twice daily screening
- Where
- 8 sites in Canada
- Volunteers
- 102 people
- Sponsor
- Unity Health Toronto
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