Clinical trials: Critical Illness, completed
Patient Activation, Mobilization
Evaluation of the Effect of Robot-assisted Early Mobilization - Project MobiStaR
Within the MobiStaR project the adaptation of procedures in an intensive care unit combined with the use of this robotic system will create the conditions to increase the mobilization rate of critically ill intensive care…
- Conditions
- Patient Activation, Mobilization, Robotics
- Trial name
- MobiStaR (NCT05071248)
- Testing
- VEMO (Reactive Robotics GmbH)
- Where
- Germany
- Volunteers
- 23 people
- Sponsor
- Ludwig-Maximilians - University of Munich
Critical Illness, Therapeutic Drug Monitoring
Anti-Xa Level With Thromboprophylactic Dosage Nadroparin in Critically Ill COVID-19 and Non-COVID-19 Patients
Primary objective The objective of this study is to compare anti-Xa levels obtained with a standard high dose thrombosis prophylaxis in COVID-19 intensive care-patients compared with anti-Xa levels obtained with a normal dose…
- Conditions
- Critical Illness, Therapeutic Drug Monitoring, Venous Thromboembolism
- Trial name
- NADRO (NCT05926518)
- Testing
- blood sampling
- Where
- Netherlands
- Volunteers
- 62 people
- Sponsor
- Rijnstate Hospital
Covid-19, Critical Illness
Understanding Community Considerations, Opinions, Values, Impacts, and Decisions for COVID-19
The novel coronavirus (COVID-19) is affecting the way many people live their lives, including seeking medical care and maintaining good self-care to keep healthy.
- Conditions
- Covid-19, Critical Illness, Attitude of Health Personnel, Attitude to Health
- Trial name
- UC-COVID (NCT04373135)
- Testing
- Brief educational video
- Where
- United States
- Volunteers
- 1,971 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Critical Illness
The Diagnosis and Incidence of Critical Illness Polyneuromyopathy in Medical and Neurosurgical ICU Patients
This study plans to learn more about whether simpler diagnostic tests can be used to identify the development of acute neuromuscular loss of function in patients with critical illness and respiratory failure receiving mechanical…
- Trial name
- NCT02634658
- Testing
- Muscle Ultrasound, Nerve Conduction Study, Electromyography
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- University of Colorado, Denver
Ventilator Associated Pneumonia
Reducing the Incidence of VAP in Critically Ill Children and Assessment of Oral Care With CHX
This was a single-centered, randomized, placebo-controlled double-blind clinical trial conducted in the pediatric intensive care unit (PICU), in patients who were aged 1 month to 18 years, needing MV for at least 48 hours, to…
- Trial name
- NCT04527276
- Testing
- Oral care with 0,12% Chlorhexidine
- Where
- Turkey (Türkiye)
- Volunteers
- 138 people
- Sponsor
- Istanbul Medeniyet University
Ventilator-associated Pneumonia
Medico-economic Study of the Subglottic Secretions Drainage in Prevention of Ventilator-associated Pneumonia (DEMETER)
In France, despite the implementation of bundles to prevent Ventilator-Associated Pneumonia (VAP) in the last decades, the VAP incidence remains high above 10 per cent.
- Trial name
- DEMETER (NCT02515617)
- Testing
- Endotracheal tubes not allowing SSD, Endotracheal tubes allowing SSD
- Where
- 25 sites in Belgium, France and 2 more
- Volunteers
- 2,577 people
- Sponsor
- Centre Hospitalier Departemental Vendee
Cardiac Output, Low
Corticosteroids in Postoperative Critically Ill Neonates With Low Cardiac Output Syndrome With Congenital Heart Disease
Babies having heart surgery often have problems after surgery with their blood pressure and getting enough blood to their bodies.
- Trial name
- Corti (NCT00590018)
- Testing
- Hydrocortisone
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Baylor College of Medicine
Critical Illness, Sepsis
Cerebral Oxygenation and Neurological Outcomes FOllowing CriticAL Illness
Purpose of the Study Critical illness requiring life support affects over 150 000 people in Ontario every year. With aggressive support, the number of people who die from critical illness is decreasing.
- Conditions
- Critical Illness, Sepsis, Delirium, Respiratory Failure
- Trial name
- CONFOCAL (NCT02344043)
- Testing
- Near infrared spectroscopy
- Where
- Canada
- Volunteers
- 116 people
- Sponsor
- Queen's University
Adult-Onset Still Disease, Critically Ill
Admission of Adult-onset Still Disease Patients in the ICU
Since its first description in 1971, diagnosing adult-onset Still's disease (AOSD), a rare multisystemic disorder considered as a multigenic autoinflammatory syndrome, remains challenging.
- Trial name
- Still-ICU (NCT03276650)
- Testing
- data collection
- Where
- France
- Volunteers
- 45 people
- Sponsor
- Central Hospital, Nancy, France
Critical Illness
Prediction Model of Vitamin D Deficiency
Many studies have pointed out that patients with vitamin D deficiency have a longer stay in the intensive care unit and a poor prognosis.
- Trial name
- NCT05376774
- Testing
- Admitted to intensive care units
- Where
- Taiwan
- Volunteers
- 662 people
- Sponsor
- National Taiwan University Hospital
Critical Illness
Multidimensional Dysfunction in Patients With Chronic Critical Illness in China
Over the past two decades, rapid advances in critical care medicine have markedly reduced short-term mortality among critically ill patients.
- Trial name
- NCT07585578
- Testing
- Data Collection and Assessment
- Where
- 4 sites in China
- Volunteers
- 888 people
- Sponsor
- Hongying Jiang, MD
Endotracheal Tube, Tracheostomy
Safety of Mechanical Insufflation-exsufflation and Hypertonic Saline
Conventional catheter suctioning of respiratory tract secretions is a mandatory procedure in intubated patients. Poor tolerance, pain and other, sometimes severe, lung and cardiovascular complications may occur during suctioning.
- Trial name
- SMASH (NCT03940118)
- Testing
- Catheter secretion suctioning, Secretion suctioning + hypertonic saline, Ins-exsufflation
- Where
- Spain
- Volunteers
- 120 people
- Sponsor
- Hospital San Carlos, Madrid
Brain Injuries, Stroke
Effects of Prolonged and Chronic Critical Illness Induced by Brain Injury on Metabolic State
Brain injuries, including acute stroke (AS) and traumatic brain injury (TBI), are prevalent pathologies with severe consequences.
- Conditions
- Brain Injuries, Stroke, Malnutrition, Critical Illness
- Trial name
- NCT06545825
- Testing
- Standard enteral nutrition
- Where
- Russia
- Volunteers
- 30 people
- Sponsor
- Federal Research and Clinical Centre of Intensive Care Medicine and Rehabilitology
Severe Sepsis, Carbapenem Resistant Bacterial Infection
Clinical Study on Monitoring the Plasma Concentration of Ceftazidime-Avibactam in Critically Ill Patients
This prospective observational study is conducted at the First Affiliated Hospital of Zhejiang University School of Medicine from June 1, 2021 to January 1, 2024.
- Trial name
- NCT05413343
- Testing
- Ceftazidime-avibactam
- Where
- China
- Volunteers
- 33 people
- Sponsor
- First Affiliated Hospital of Zhejiang University
Systemic Inflammatory Response Syndrome (SIRS)
Myostatin and Irisin Levels in Predicting the Outcome of Patients With Systemic Inflammation: A Prospective Observational Study
Systemic inflammatory response syndrome (SIRS) is associated with severe metabolic stress that can lead to rapid breakdown of skeletal muscle and the development of stress-related malnutrition.
- Trial name
- NCT07476391
- Where
- Czechia
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Charles University, Czech Republic
Delirium
Dexmedetomidine Versus Propofol for Prolonged Sedation in Critically Ill Trauma and Surgical Patients
The purpose of this study is to assess the efficacy of dexmedetomidine versus propofol for prolonged sedation in trauma and surgical patients.
- Trial name
- NCT02548923
- Testing
- Dexmedetomidine
- Where
- United States
- Volunteers
- 57 people, healthy volunteers welcome
- Sponsor
- University of Tennessee Graduate School of Medicine
Psychomotor Agitation
Quetiapine for Delirium Prophylaxis in High-risk Critically Ill Patients
Scheduled, low-dose quetiapine is effective in preventing delirium in high-risk critically ill, trauma/surgical patients. Prophylaxis also reduced ventilator duration and ICU length of stay.
- Trial name
- NCT02612948
- Testing
- Quetiapine
- Where
- United States
- Volunteers
- 82 people, healthy volunteers welcome
- Sponsor
- University of Tennessee Graduate School of Medicine
Sleep Deprivation, Critically Ill
Impact of Gabapentin on Slow Wave Sleep in Adult Critically Ill Patient
The investigators proposed that gabapentin will increase slow-wave sleep in adult critically ill patients. Increasing slow-wave sleep will improve the patients' outcomes (shortening ICU length of stay, improving ventilator free…
- Trial name
- GASWAC (NCT04818450)
- Testing
- Gabapentin
- Where
- Thailand
- Volunteers
- 60 people
- Sponsor
- Mahidol University
Hyperglycemia, Critical Illness
Computerized Glucose Control in Critically Ill Patients
The aim of the study is to determine whether the use of the CGAOtm software is associated with a decrease in 90-day mortality when compared with the use of standard care methods for glucose control with target blood glucose…
- Trial name
- CGAO-REA (NCT01002482)
- Testing
- CGAO-based Glucose Control, Standard-Care Glucose Control
- Where
- 35 sites in France
- Volunteers
- 2,684 people
- Sponsor
- Centre Hospitalier of Chartres
Critical Illness
Body Impedance Analysis to Detect ICUAW
The aim of the study is to detect a value of muscle and organ mass measured by body impedance analysis and its correlation with the Medical Research Council (MRC) score.
- Trial name
- BIAMI (NCT05572138)
- Testing
- Body Impedance Analysis
- Where
- Germany
- Volunteers
- 62 people
- Sponsor
- Charite University, Berlin, Germany
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