Clinical trials: Critical Illness, completed
Critical Illness, Intensive Care (ICU) Myopathy
Early Goal-Directed Nutrition in ICU Patients - EAT-ICU Trial
An increasing number of patients survive critical illness and intensive care, but describe having impaired physical function several years after discharge as a consequence of extensive loss of muscle mass.
- Conditions
- Critical Illness, Intensive Care (ICU) Myopathy, Muscle Wasting, Loss of Physical Function
- Trial name
- EAT-ICU (NCT01372176)
- Testing
- Early Goal-Directed Nutrition, ASPEN-guidelines
- Where
- Denmark
- Volunteers
- 203 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Infectious Disease
Beta-lactams Therapeutic Drug Monitoring in Critically Ill Patients
The population of these monocentric and retrospective study includes patients hospitalized in one of the critical care services of Nîmes' community hospital.
- Trial name
- SPT BETALACT (NCT05352997)
- Where
- France
- Volunteers
- 156 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Gram-negative Bacteremia
Rapid Identification and Phenotypic Susceptibility Testing for Gram-Negative Bacteremia
RAPIDS-GN is a multi-center, prospective, randomized, controlled trial to evaluate the following strategies for patients with confirmed gram-negative bacillus bacteremia (GNB): 1.
- Trial name
- RAPIDS-GN (NCT03218397)
- Testing
- Accelerate PhenoTest™ BC Kit, Standard Culture and AST
- Where
- 2 sites in United States
- Volunteers
- 500 people
- Sponsor
- Duke University
Critically Ill
The Effect of Standardized Enteral Nutrition on Critically Ill Patients
The goal of this study is to evaluate whether a standard enteral nutrition protocol can improve the efficiency in achieving nutritional goals and improve prognosis in critically ill patients.
- Trial name
- NCT02976155
- Testing
- A standard enteral nutrition protocol
- Where
- China
- Volunteers
- 439 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Critical Illness
Decision-making - the Benefit of Bedside CRP Within Ambulance Care
Patients with degreased (DGC) for ambiguous reasons receive low triage priority. Their death risk is triple. Tools are needed to identify the critically ill patients from this group. The triage used today is not effective.
- Trial name
- Q-CRP (NCT04097210)
- Testing
- POC
- Volunteers
- 110 people
- Sponsor
- Helsinki University Central Hospital
Liver Cirrhosis
Sustained Low Efficiency Dialysis Versus Continuous Renal Replacement Therapy for Acute Kidney Injury in Critically Ill Cirrhotics
The current prospective pliot randomized controlled trial has been designed to demonstrate non-inferiority of sustained low efficiency dialysis (SLED) when compared to continuous renal replacement therapy in managing AKI in…
- Trial name
- NCT04494542
- Testing
- Sustained Low Efficiency Dialysis (SLED), Continuous Renal Replacement Therapy
- Where
- India
- Volunteers
- 62 people
- Sponsor
- Institute of Liver and Biliary Sciences, India
Critically Ill, Body Weight
Comparison of Body Weights Via Visual Estimation, Anthropometric Calculation, and Actual Measured in Critically Ill Patients
Rapid and accurate determination of body weight in adult intensive care patients is very important for both calculating target tidal volume during invasive mechanical ventilation support and dose dependent drug administration.
- Trial name
- NCT06269861
- Testing
- patient transfer scale
- Where
- Turkey (Türkiye)
- Volunteers
- 200 people
- Sponsor
- Gazi University
Sepsis, Critical Illness
Provider Perspectives on Beta-lactam Therapeutic Drug Monitoring Programs in the Critically Ill
The purpose of the study is to characterize various healthcare practitioners' perspectives on implementation of beta-lactam therapeutic drug monitoring in critical care practice.
- Trial name
- NCT04755777
- Where
- 3 sites in United States, Australia
- Volunteers
- 138 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Covid19, Organ Failure, Multiple
DNA Damage in Critically Ill COVID-19 Patients
Critically ill patients with COVID-19 are exposed to high oxidative stress which is potential harm to the DNA. Peripheral lymphocytes' DNA will be investigated using the comet assay on changes in oxidative damage to the purine…
- Conditions
- Covid19, Organ Failure, Multiple, DNA Damage
- Trial name
- NCT04772703
- Testing
- COMET ASSAY
- Where
- Czechia
- Volunteers
- 10 people
- Sponsor
- University Hospital Hradec Kralove
Cardiac Surgery Associated - Acute Kidney Injury, Critical Illness
Prognostic Value of Novel Biomarkers on Adverse Renal Outcomes in High-Risk Cardiac Surgery Patients
This project aims to detect novel biomarkers from preoperative and early postoperative serum and urine samples of patients to screen and analyze the risk factors for predicting adverse postoperative renal outcomes in high-risk…
- Trial name
- NCT07418242
- Testing
- Standard care "bundle"
- Where
- 2 sites in China
- Volunteers
- 319 people
- Sponsor
- Guowei Tu
Mechanical Ventilation, Airway Patency
The Effects of Ketamine on Respiratory Stimulation and Transpulmonary Pressures
Impairment of airway patency is a common cause of extubation failure and opioids and hypnotics can adversely affect airway patency.
- Conditions
- Mechanical Ventilation, Airway Patency, Respiratory Depression
- Trial name
- NCT01969227
- Testing
- Subanesthetic ketamine
- Where
- 2 sites in United States
- Volunteers
- 15 people
- Sponsor
- Massachusetts General Hospital
Septic Shock
Temporal Changes of Lactate in CLASSIC Patients
This study aim to examine if randomization to different treatment strategies had any effect on the time to normalization of lactate in intensive care patients treated for septic shock.
- Trial name
- NCT05629780
- Testing
- Resuscitation fluid
- Where
- Sweden
- Volunteers
- 777 people
- Sponsor
- Karolinska University Hospital
Posterior Reversible Encephalopathy Syndrome
Copeptin Kinetics in Critically Ill Patients With Posterior Reversible Encephalopathy Syndrome
XPRESSE is a multicenter observational prospective biomarker study in which critically ill patients with MRI-based PRES diagnosis will have copeptin kinetics from a daily blood sample for 6 days and a 3-month follow-up.
- Trial name
- XPRESSE (NCT04950270)
- Testing
- Blood copeptin monitoring, phone interview
- Where
- 4 sites in France
- Volunteers
- 24 people
- Sponsor
- University Hospital, Tours
Nutrition, Enteral
A More Physiological Feeding Process in ICU:the Intermittent Infusion With Semi-solidification of Nutrients
Malnutrition and underfeeding are major challenges in caring for critically ill patients. Continuous feeding were thought to be better tolerated by patients with the limited absorptive gut surface area or gastrointestinal…
- Trial name
- NCT03017079
- Testing
- semi-solid agent with standard enteral feeding, standard enteral feeding
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Critical Illness Polyneuromyopathy, Critical Illness
Robotic Assisted Early Mobilization in Ventilated ICU Patients
Feasibility trial investigating robotic assisted early mobilization vs. early mobilization in critically ill patients.
- Conditions
- Critical Illness Polyneuromyopathy, Critical Illness, Early Ambulation, Rehabilitation
- Trial name
- ROBEM-I (NCT04423796)
- Testing
- Robotic-assisted early mobilization, Early mobilization
- Where
- Germany
- Volunteers
- 21 people
- Sponsor
- Charite University, Berlin, Germany
Critically Ill
Time to Protein Target Using a High Whey Protein Enteral Nutrition in Critically Ill Patients
This study evaluates the feasibility of a high whey-protein enteral nutrition formula in 20 ventilated ICU patients. The primary endpoint of study is the feasibility to attain the individualized protein target (≥1.2 g/kg ideal…
- Trial name
- NCT02815527
- Testing
- Fresubin intensive
- Where
- Netherlands
- Volunteers
- 20 people
- Sponsor
- Amsterdam UMC, location VUmc
Delirium
External Validation of Delirium Prediction Models for Intensive Care Patients
Delirium is frequently observed among critically ill patients and is associated with detrimental outcomes. Currently, no evidence-based prevention or treatment exists for delirium, and especially, the inability to identify…
- Trial name
- NCT05084482
- Testing
- Prediction models
- Where
- Denmark
- Volunteers
- 660 people
- Sponsor
- Zealand University Hospital
Infections, Critical Illness
Ventilator-Associated Pneumonia in Critically Ill COVID-19 vs. Non-COVID-19 Patients
The COVID-19 pandemic has led to an increased incidence of ventilator-associated pneumonia (VAP) among critically ill patients. However, in a context of high prevalence of multidrug-resistant organisms (MDROs) there is a lack of…
- Conditions
- Infections, Critical Illness, Superinfection, Organ Failure, Multiple
- Trial name
- NCT05972980
- Testing
- COVID-19
- Where
- Italy
- Volunteers
- 200 people
- Sponsor
- University of Turin, Italy
ICU Length of Stay
Primary Intensivists and Primary Nurses to Decrease Pediatric ICU Length of Stay
This is a randomized control trial of PICU patients admitted for 7 days and expected to remain for at least another 3 days and who have a complex chronic condition.
- Trial name
- PIPRNs (NCT03364933)
- Testing
- Primary intensivist and nurses
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Columbia University
Atrial Fibrillation New Onset
Use of Red Cell Distribution Width for Prediction of New-onset Atrial Fibrillation in Critically Ill Sepsis Patients
Red cell distribution width variations are increased in a variety of medical conditions such as congestive heart failure, acute myocardial infarction, pulmonary embolism, pneumonia, critical illness, and cardiac arrest , and is a…
- Trial name
- NCT03523676
- Testing
- Red Cell Distribution Width
- Volunteers
- 70 people
- Sponsor
- Ain Shams University
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