Clinical trials: Critical Illness, completed
Critical Illness, Epidural Analgesia
Epidural Analgesia in Intensive Care Unit (APD-REA: Analgesie PeriDurale en REAnimation)
Epidural analgesia (EA) has been mainly investigated during the perioperative period. In the intensive care unit settings, EA should be proposed in critically ill patients, such as postoperative or trauma patients, typically.
- Trial name
- NCT01437358
- Testing
- Epidural analgesia
- Where
- France
- Volunteers
- 80 people
- Sponsor
- University Hospital, Clermont-Ferrand
Acute Kidney Injury, Critical Illness
Assessment of Hydration Status Using Bioelectrical Impedance Vector Analysis
The state of hyperhydration in critically ill patients with acute kidney injury (AKI) is associated with increased mortality. Bioelectrical impedance vector analysis (BIVA) appears to be a viable method to access the fluid status…
- Trial name
- NCT02936440
- Volunteers
- 224 people
- Sponsor
- Catholic University of Pelotas
Pediatric Disorder, Critical Illness
Attitudes to Decisions to Withdraw or Withhold Life-sustaining Treatments in Critically Ill Children
The aim of this study is to investigate attitudes on decisions to withdraw or withhold life-sustaining treatments in critically ill children in Swedish intensive care units.
- Conditions
- Pediatric Disorder, Critical Illness, Ethics, Narrative
- Trial name
- LSTPedSurvey (NCT06281743)
- Testing
- Survey
- Where
- Sweden
- Volunteers
- 100 people
- Sponsor
- Göteborg University
Large Volume Resuscitation, Acute Kidney Injury
Resuscitation Fluid Choice and Clinical Outcomes
This observational study evaluates the potential benefits, costs and clinical outcomes of albumin over saline and other non-saline fluids in patients receiving large volume resuscitation.
- Conditions
- Large Volume Resuscitation, Acute Kidney Injury, Hyperchloremic Metabolic Acidosis
- Trial name
- NCT02641119
- Volunteers
- 65,800 people
- Sponsor
- University of Pittsburgh
Acute Respiratory Distress Syndrome (ARDS)
Clinical and Functional Outcomes of Critically Ill Patients With COVID-19
People affected by Severe Acute Respiratory Syndrome (SARS) by COVID-19 virus my require a long lasting invasive mechanical ventilation life support.
- Trial name
- COVIDPTcare (NCT05024500)
- Testing
- ARDSNet table, Driving Pressure, Electrical Impedance Tomography
- Where
- 4 sites in Brazil
- Volunteers
- 75 people
- Sponsor
- University of Pernambuco
Persistent Critical Illness
Comparing Metabolic Characteristics of Persistent Critically Ill Non-COVID and COVID-19 Patients
The Corona Virus Disease-19 (COVID-19) pandemic has resulted in an overwhelming number of intensive care (ICU) patient admissions, generally for acute respiratory distress, often resulting in persistent critical illness (PCI).
- Trial name
- MetaCO-nonCO (NCT05026151)
- Testing
- Nutrition therapy according to ICU protocol
- Where
- Switzerland
- Volunteers
- 110 people
- Sponsor
- Centre Hospitalier Universitaire Vaudois
Critical Illness
Prognosticating Outcomes and Nudging Decisions With Electronic Records in the ICU Trial
This is a pragmatic, stepped-wedge, cluster randomized trial testing the real-world effectiveness of two different electronic health record (EHR) behavioral interventions in improving a number of patient- and family-centered…
- Trial name
- PONDER-ICU (NCT03139838)
- Testing
- EHR-Based Intervention A, EHR-Based Intervention B
- Where
- 10 sites in United States
- Volunteers
- 3,500 people
- Sponsor
- University of Pennsylvania
Diabetes Mellitus
Investigation of Critically Ill Patients With Newly Diagnosed Diabetes
The purpose of this study is to investigate the clinical outcomes and glucose control metrics of critically ill patients with previously undiagnosed diabetes compared to those with known diabetes at the time of admission to the…
- Trial name
- NCT05256043
- Testing
- Diabetes Diagnosis
- Where
- United States
- Volunteers
- 1,777 people
- Sponsor
- Stamford Hospital
Critical Illness
Comparison of Neuromuscular Blockade's Monitoring and Clinical Assessment During Cisatracurium Paralysis in Critically Ill Patients
The main objectives of the prolonged resuscitation paralysis are usually adaptation to mechanical ventilation, lower insufflation pressures and cough suppression.
- Trial name
- NCT03198637
- Testing
- Cisatracurium's monitoring by TOF (train-of-four) WATCH device., clinical assessment
- Where
- France
- Volunteers
- 50 people
- Sponsor
- Poitiers University Hospital
Surgery-Complications, Acute Kidney Injury
The Effectiveness of Urine mtDNA and Beta 2-MG to Predict Acute Kidney Injury for Critically Ill Surgical Patients
1. Research background 1. Research hypothesis The development of acute kidney injury (AKI) can be predicted using urine mitochondrial deoxyribonucleic acid (UmtDNA), serum and urine beta-2 microglobulin (β2-MG) in critically ill…
- Conditions
- Surgery-Complications, Acute Kidney Injury, Critical Illness
- Trial name
- NCT05458063
- Where
- South Korea
- Volunteers
- 113 people
- Sponsor
- Wonju Severance Christian Hospital
Intubated Requiring Sedation for Greater Than 48 Hours
AnaConDa Long Term Sedation Study
Heavy sedation or sleep is a common problem within the intensive care unit (ICU) using our standard intravenous medications. This commonly leads to confusion, low blood pressure, slow wake up and removal of the artificial…
- Trial name
- VALTS (NCT01983800)
- Testing
- Isoflurane, Propofol/midazolam
- Where
- 2 sites in Canada
- Volunteers
- 60 people
- Sponsor
- University Health Network, Toronto
COVID19, Thromboembolism
Impact of an Intensified Thromboprofylaxis Protocol in COVID-19
The aim of this study is to investigate and compare the mortality, the incidence of DVT and the incidence of kidney and liver failure in patients admitted to the ICU before and after the implementation of an intensified…
- Trial name
- NCT04394000
- Testing
- thromboprofylaxis protocol, standard protocol
- Where
- Belgium
- Volunteers
- 72 people
- Sponsor
- Jessa Hospital
COVID-19 Acute Respiratory Distress Syndrome, Viral Disease
Registry for Hemoperfusion of Covid-19 ICU Patients
The ongoing COVID-19 pandemic caused high hospitalization and mortality rates especially in critically ill patients. Unfortunately, there is no present study with a large number of patients that would offer us clear answers on…
- Conditions
- COVID-19 Acute Respiratory Distress Syndrome, Viral Disease, Critical Illness, Multi Organ Failure
- Trial name
- HERICC (NCT05470907)
- Testing
- Hemoperfusion
- Where
- Croatia
- Volunteers
- 1,050 people
- Sponsor
- Croatian Society for Organ Support
ARDS, COVID-19 Acute Respiratory Distress Syndrome
Comparison of ARDS COVID-19 (WHO) vs ARDS Influenza in the ICU
Since the beginning of the SARS CoV 2 pandemia, the SARS CoV 2 was frequently compared with the seasonal influenza virus. However, few studies compared patients presenting acute respiratory distress syndrome (ARDS) induced by…
- Conditions
- ARDS, COVID-19 Acute Respiratory Distress Syndrome, Influenza
- Trial name
- NCT04941092
- Testing
- no intervention
- Where
- France
- Volunteers
- 157 people
- Sponsor
- Central Hospital, Nancy, France
Multiple Organ Failure, Critical Illness
Supplemental Parenteral Nutrition in Critically Ill Adults: A Pilot Randomised Controlled Trial
One of the essential treatments for assisting patients in their recovery from illness is the provision of nutrition in a liquid form which is delivered into the stomach or as a fluid into the vein.
- Trial name
- NCT01847534
- Testing
- Supplemental PN, Standard Care
- Where
- 6 sites in Australia, New Zealand
- Volunteers
- 100 people
- Sponsor
- Australian and New Zealand Intensive Care Research Centre
Acute Kidney Injury
Continuous Venovenous Hemodiafiltration Versus Sustained Low-efficiency Hemodialysis for Critically Ill Patients With Acute Kidney Injury in Intensive Care Unit
The investigators conducted a comparison trial between SLED and CRRT in critically ill patients to evaluate the outcome for all cause mortality at 30 day .
- Trial name
- NCT02879201
- Testing
- Slow efficiency dialysis
- Where
- Thailand
- Volunteers
- 27 people
- Sponsor
- Bangkok Metropolitan Administration Medical College and Vajira Hospital
Edema, Hypoproteinemia
Furosemide and Albumin for Diuresis of Edema: A Pilot Randomized Controlled Trial
Critically ill patients usually require intravenous fluids to correct low blood pressure and improve blood flow to vital organs.
- Trial name
- FADE (NCT02055872)
- Testing
- Intravenous albumin, Normal saline
- Where
- Canada
- Volunteers
- 46 people
- Sponsor
- Hamilton Health Sciences Corporation
Circulatory Failure
Fluid Responsiveness Predicted by PtcO2 in Critically Ill Patients
Our goal was to study the feasibility of predicting fluid responsiveness by transcutaneous partial pressure of oxygen (PtcO2) in the critically ill patients.
- Trial name
- PtcO2-FR (NCT02083757)
- Where
- China
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Southeast University, China
SARS-Associated Coronavirus, Covid19
Treatment of Critically Ill Patients With Covid-19 With Convalescent Plasma
This study aims to collect convalescent plasma and use it as experimental treatment in critically ill Covid-19 patients in order to reduce mortality and length of stay in intensive care unit.
- Conditions
- SARS-Associated Coronavirus, Covid19, SARS-CoV Infection
- Trial name
- NCT04468009
- Testing
- Convalescent plasma
- Where
- Argentina
- Volunteers
- 134 people, healthy volunteers welcome
- Sponsor
- Hospital de Infecciosas Francisco Javier Muniz
Effect of RBC Transfusions on Cerebral Oxygen Saturation
Monitoring the Effect of Red Blood Cell Transfusion on Cerebral Oxygen Saturation With Near Infrared Spectroscopy (NIRS) in Critically Ill Patients
Critically ill patients are frequently transfused with red blood cell (RBC) units with the predominant intention to increase arterial oxygen content and thus oxygen delivery to the tissues.
- Trial name
- NCT02232412
- Where
- Germany
- Volunteers
- 25 people
- Sponsor
- Johann Wolfgang Goethe University Hospital
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