Clinical trials: Critical Illness, completed
Critical Illness, Septic Shock
Musculoskeletal Ultrasound Study in Critical Care: Longitudinal Evaluation
Each year, 110,000 English/Welsh patients are admitted to Intensive Care Units (ICU). Many face prolonged disability as a result.
- Conditions
- Critical Illness, Septic Shock, Trauma, Organ Failure
- Trial name
- MUSCLE (NCT01106300)
- Where
- 3 sites in United Kingdom
- Volunteers
- 63 people
- Sponsor
- University College, London
Critical Illness, Invasive Candidiasis
Pharmacokinetics of Micafungin in Critically Ill Patients
A study of micafungin in ICU versus non-ICU patients showed a significantly lower treatment success in ICU patients compared with non-ICU patients.
- Trial name
- NCT01716988
- Where
- Netherlands
- Volunteers
- 19 people
- Sponsor
- University Medical Center Groningen
Intubation, Intratracheal, Critical Illness
Post-extubation Assessment of Laryngeal Symptoms and Severity
The goal of this study is to learn more about voice and airway problems that patients experience during and after the time patients have an oral endotracheal tube in patients' airway to help patients breathe while receiving…
- Conditions
- Intubation, Intratracheal, Critical Illness, Mechanical Ventilation Complication, Complication of Ventilation Therapy
- Trial name
- PALSS (NCT03726086)
- Testing
- laryngoscopy
- Where
- United States
- Volunteers
- 365 people
- Sponsor
- Johns Hopkins University
Acute Respiratory Failure, Critical Illness
Muscle Ultrasound Signifies Condition Upgrade Leading Approach to Recovery
Examination of serial muscle ultrasounds and muscle sampling within the population of ICU patients who require mechanical ventilation for acute respiratory failure, will lead to the ability of investigators to link specific…
- Trial name
- MUSCULAR (NCT02014285)
- Testing
- Muscle Ultrasound and Muscle Sample
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Wake Forest University Health Sciences
Invasive Candidiasis, Critically Ill
Pharmacokinetics of Anidulafungin on Intensive Care Unit (ICU)
The objective of this study is to determine whether pharmacokinetic parameters of anidulafungin correlate with disease severity and plasma protein levels in critically ill patients.
- Trial name
- NCT01047267
- Where
- Netherlands
- Volunteers
- 20 people
- Sponsor
- University Medical Center Groningen
Pancreatitis
Assess the Effect of Erythromycin on the Rate of Success in Placement of a Self-propelled Feeding Tube
The purpose of this study is to assess the effect of erythromycin on the Rate of Success in Placement of a Self-propelled Feeding Tube.
- Trial name
- NCT00999232
- Testing
- Erythromycin
- Sponsor
- Canisius-Wilhelmina Hospital
Critical Illness, Child
A Prospective Longitudinal Mixed Study on the Change Track of Sleep Quality in Critically Ill Children
This research adopts the uniform parallel hybrid research design; The quantitative data and qualitative data were collected at the same time, and then the quantitative and qualitative data were analyzed respectively.
- Conditions
- Critical Illness, Child, Sleep Disorder
- Trial name
- NCT05863299
- Where
- China
- Volunteers
- 247 people
- Sponsor
- Children's Hospital of Fudan University
Gastrointestinal Dysfunction, Critical Illness
Predictive Value of Transabdominal Intestine Sonography in Critically Ill Patients
It is very important to evaluate the degree of gastrointestinal dysfunction in critical ill patients. Thus the investigators conducted transabdominal intestine ultrasonography(US) in critical ill patients to evaluated the degree…
- Conditions
- Gastrointestinal Dysfunction, Critical Illness, Intestine Ultrasonography
- Trial name
- NCT03589248
- Testing
- GIF score, US score
- Volunteers
- 136 people
- Sponsor
- Nanjing PLA General Hospital
Covid-19, Thromboembolic Events
Anticoagulant Therapy and 28-days Mortality in Critically Ill COVID-19 Patients
The aims of the study are to to associate anticoagulation (AC) regime with outcome in critically ill patients with Covid-19. This will be done by describe baseline characteristics and comorbidities before hospital admission…
- Conditions
- Covid-19, Thromboembolic Events, Bleeding
- Trial name
- NCT04412304
- Testing
- Dose of Tinzaparin or Dalteparin
- Where
- Sweden
- Volunteers
- 166 people
- Sponsor
- Karolinska Institutet
Critical Illness, Oncology
Giving Information Systematically and Transparently in Lung and GI Cancer Phase 1
When advanced disease progresses, there comes a time when an oncologists must explain to their patients that they only have months left to live.
- Conditions
- Critical Illness, Oncology, Communication
- Trial name
- Oncolo-GIST (NCT04158908)
- Testing
- Oncolo-GIST
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Weill Medical College of Cornell University
Closed-Loop Communication
Computer Assisted Vasopressor Titration in Critically Ill Patients
The purpose of this pilot study is to evaluate the performance of a novel closed-loop (automated) vasopressor administration system that delivers norepinephrine using feedback from standard operating room hemodynamic monitor…
- Trial name
- NCT04106791
- Testing
- closed-loop system for vasopressor administration
- Where
- Belgium
- Volunteers
- 10 people
- Sponsor
- Erasme University Hospital
Respiratory Failure
Safety and Efficacy of Endotracheal Intubation Using Glidescope Video-Laryngoscope
The safety and efficacy of a video-laryngoscope as a primary intubation tool in urgent endotracheal intubation of critically-ill patients has not been well-described in the literature.
- Trial name
- NCT01683526
- Testing
- Direct laryngoscopy, Video laryngoscopy (Glidescope)
- Where
- United States
- Volunteers
- 117 people
- Sponsor
- Beth Israel Medical Center
Critical Illness
An Infraclavicular Landmark-based Approach to the Axillary Vein
The central line placement is the widespread procedure performed in the intensive care and emergency medicine. Indications for this procedure are chiefly lack of peripheral catheters, administration some medications, renal…
- Trial name
- NCT02083458
- Testing
- Catheterization of the axillary vein.
- Where
- Poland
- Volunteers
- 153 people
- Sponsor
- Uniwersytecki Szpital Kliniczny w Opolu
Critical Illness
Clinical and Economic Outcome of Simvastatin in Critically Ill Septic Patient
determination of the effectiveness and the cost-effectiveness of simvastatin(Zocor 40 mg) plus standard therapy (SSCG)versus standard therapy alone in critically ill septic patient from the societal perspective over one year.
- Trial name
- NCT02067949
- Testing
- Simvastatin
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- sara mostafa amin eladawy
Hyperglycemia in Critically Ill Patients
The Accuracy of Continuous Glucose Monitoring Systems in Critically Ill Patients
Abstract: Hyperglycemia, hypoglycemia, and glucose variability in ICU patients are associated with adverse outcomes. Continuous Glucose Monitoring Systems (CGMS) offer dynamic glucose monitoring and early warnings to improve…
- Trial name
- NCT07201155
- Testing
- Continuous Glucose Monitoring Systems, Continuous Glucose Monitoring, CGMS
- Where
- China
- Volunteers
- 55 people
- Sponsor
- Nanfang Hospital, Southern Medical University
Brain Injuries
Controlled MAP in the Brain Injury Patient (COMAT Study)
The goal of this randomized controlled trial will be to show that the use of a novel automated system to guide vasopressor administration in brain injury patients will results in more time spent with a mean arterial pressure…
- Trial name
- COMAT (NCT03991052)
- Testing
- EV1000 and closed-loop system, Control group
- Where
- France
- Volunteers
- 23 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Bronchoalveolar Lavage, COVID-19 Pneumonia
Comparison of the Results of Bronchoalveolar Lavage Culture and Endotracheal Aspirate Culture in Intubated Critically Ill COVID-19 Patients
Introduction: Secondary pneumonia is frequently seen in COVID-19 cases followed up intubated, and high mortality rates can be observed.
- Conditions
- Bronchoalveolar Lavage, COVID-19 Pneumonia, Critical Illness
- Trial name
- NCT05403489
- Testing
- Bronchoalveolar lavage, endotracheal aspirate culture
- Where
- Turkey (Türkiye)
- Volunteers
- 67 people
- Sponsor
- Basri Cakiroglu
Respiration, Artificial, Ventilators, Mechanical
Pivotal Evaluation of Abdominal Neuromuscular Electrical Stimulation (VentFree) for Weaning From Mechanical Ventilation
The objective of this study is to evaluate the efficacy of the VentFree Respiratory Muscle Stimulator (VentFree) in critically ill adult patients who require invasive mechanical ventilation, when compared to sham.
- Trial name
- PREVENT (NCT05759013)
- Testing
- Breath synchronized abdominal FES
- Where
- 27 sites in United States, Australia and 2 more
- Volunteers
- 250 people
- Sponsor
- Liberate Medical
Acute Respiratory Distress Syndrome, Vitamin D Deficiency
Vitamin D to Improve Outcomes by Leveraging Early Treatment
Vitamin D deficiency is a common, potentially reversible contributor to morbidity and mortality among critically ill patients. We conducted a randomized, double-blind, placebo-controlled, phase 3 trial of early vitamin D3…
- Conditions
- Acute Respiratory Distress Syndrome, Vitamin D Deficiency, Critical Illness
- Trial name
- VIOLET (NCT03096314)
- Testing
- Vitamin D3
- Where
- 47 sites in United States
- Volunteers
- 1,358 people
- Sponsor
- Massachusetts General Hospital
Healthy
Comparison of Ertapenem Distribution in the Muscle of Six Healthy Volunteers and Six Critically Ill Patients by Microdialysis
Ertapenem is an antibiotic that is highly bound to plasma protein (> 95%). The effects of this high protein binding on tissue distribution of antibiotics have been few evaluated yet.
- Trial name
- NCT01061047
- Testing
- Ertapeneme
- Where
- France
- Volunteers
- healthy volunteers welcome
- Sponsor
- Poitiers University Hospital
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