Clinical trials: Critical Illness, completed
Temperature Monitoring
Accuracy of Infrared Thermography for Detecting Febrile Critically Ill Patients
Accurate determination of critically ill patient of being febrile or not is an essential part of management critically ill patients as it prompt investigating the underlying cause and initiating therapeutic action.
- Trial name
- NCT04571554
- Where
- Egypt
- Volunteers
- 135 people
- Sponsor
- Kasr El Aini Hospital
Insufficient Breast Milk Syndrome
Comparison of Breast Pump Suction Patterns
Compare effectiveness of breast pump patterns on lactation outcomes of pump dependent mothers of critically ill infants
- Trial name
- NCT06061913
- Testing
- Breast Pump suction pattern
- Where
- United States
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- University of Florida
Delirium
External Validation of Delirium Prediction Models for Intensive Care Patients
Delirium is frequently observed among critically ill patients and is associated with detrimental outcomes. Currently, no evidence-based prevention or treatment exists for delirium, and especially, the inability to identify…
- Trial name
- NCT05084482
- Testing
- Prediction models
- Where
- Denmark
- Volunteers
- 660 people
- Sponsor
- Zealand University Hospital
Ventilator Weaning, Weaning Failure
Voices of Patients' Relatives to Support Weaning From Mechanical Ventilation
Patients with severe brain injuries, such as ischemic stroke and intracranial hemorrhage, frequently require mechanical ventilation. Weaning of stroke patients is complicated by impaired consciousness and respiratory drive.
- Conditions
- Ventilator Weaning, Weaning Failure, Brain Injuries
- Trial name
- VOICE-WEANING (NCT03795623)
- Testing
- Voice-Weaning
- Where
- Germany
- Volunteers
- 45 people
- Sponsor
- University of Erlangen-Nürnberg Medical School
Critical Illness
Ultrasound Guided Vascular Access in Pediatric Intensive Care Patients
The purpose of this study is to see how fast and accurate two different techniques used by physicians to insert catheters in children are.
- Trial name
- NCT00207883
- Where
- United States
- Volunteers
- 212 people
- Sponsor
- Children's Healthcare of Atlanta
Mechanical Ventilation, Respiratory Distress Syndrome, Adult
Practice of Ventilation in Middle-Income Countries
The purpose of this international, multicenter service review is to describe and compare ventilation management in patients at risk of acute respiratory distress syndrome (ARDS) versus patients not at risk and patients with…
- Conditions
- Mechanical Ventilation, Respiratory Distress Syndrome, Adult, Acute Respiratory Failure
- Trial name
- PRoVENT-iMIC (NCT03188770)
- Where
- 51 sites in Bangladesh, India and 8 more
- Volunteers
- 1,315 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Anemia
Research Into the Treatment of Anemia for Critically Ill Patients Admitted to Intensive Care Units (ICU)
Erythropoietin (EPO) is a hormone produced in the kidney. Its function is to stimulate the production of red cells in the bone marrow.
- Trial name
- NCT00091910
- Testing
- Epoetin alfa
- Volunteers
- 1,460 people
- Sponsor
- Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
Intra-Abdominal Infection, Candida
Rezafungin Peritoneal Diffusion for Intra-abdominal Candidiasis
ntra-abdominal candidiasis is a serious infection common in critically ill patients, often leading to high mortality if not treated quickly.
- Conditions
- Intra-Abdominal Infection, Candida, Abdominal Surgery Patients, Critically Ill Intensive Care Unit Patients
- Trial name
- REAREZ (NCT07093203)
- Where
- France
- Volunteers
- 18 people
- Sponsor
- Central Hospital, Nancy, France
Critical Illness, Shock
Impact of Early Low-Calorie Low-Protein Versus Standard Feeding on Outcomes of Ventilated Adults With Shock
Among critically ill patients requiring mechanical ventilation and catecholamines for shock, nearly 40% to 50% die, and functional recovery is often delayed in survivors.
- Conditions
- Critical Illness, Shock, Mechanical Ventilation, Critical Illness Myopathy
- Trial name
- NUTRIREA3 (NCT03573739)
- Testing
- low-calorie low-protein, standard-calorie/standard-protein
- Where
- 59 sites in France, Guadeloupe
- Volunteers
- 3,044 people
- Sponsor
- Nantes University Hospital
Critical Ill Patients, Central Venous Catheter
Development and Validation of an Ultrasound-Based Difficult Cannulation Risk Score
Ultrasound-guided internal jugular vein (IJV) catheterization is widely used in critically ill patients. Despite ultrasound guidance, difficult catheterization and first-pass failure remain clinically important and may increase…
- Trial name
- ROTATE-ICU (NCT07764562)
- Testing
- IJV Catheterization
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people
- Sponsor
- Antalya Health Sciences University
Analgesia, Sedation
Surgical Stress Index as a Tool for Monitoring Analgesia and/or Sedation in Critically Ill Patients
The hypothesis of the study is: Does the Surgical Stress Index (SSI) correlate with the Behavioral Pain Scale (BPS), the Ramsay Sedation Scale (RSS)and/or the Behavioral Pain Scale(BPV) and can therefore be used to monitor the…
- Conditions
- Analgesia, Sedation, Mechanical Ventilation, Pain
- Trial name
- NCT00789412
- Where
- Germany
- Volunteers
- 60 people
- Sponsor
- University Hospital Schleswig-Holstein
Acute Kidney Injury
A Net Ultrafiltration Challenge to Predict Preload-dependence (UF CHALLENGE)
Hemodynamic instability episodes are a frequent complication of renal replacement therapies in critically ill patients, and their incidence is associated with worse survival.
- Trial name
- UF CHALLENGE (NCT05214729)
- Testing
- Fast ultrafiltration challenge, Slow ultrafiltration challenge
- Where
- France
- Volunteers
- 20 people
- Sponsor
- Hospices Civils de Lyon
Bacteremia, Intensive Care
Bacteremia Antibiotic Length Actually Needed for Clinical Effectiveness
The World Health Organization, U.S. Centers for Disease Control and Prevention, Association of Medical Microbiology and Infectious Diseases (AMMI) Canada, and Health Canada have all declared antimicrobial resistance a global…
- Conditions
- Bacteremia, Intensive Care, Critically Ill, Sepsis
- Trial name
- BALANCE (NCT03005145)
- Testing
- 7 days of adequate antibiotic treatment, 14 days of adequate antibiotic treatment.
- Where
- 68 sites in United States, Australia and 5 more
- Volunteers
- 3,622 people
- Sponsor
- Sunnybrook Health Sciences Centre
Critical Illness, Acute Kidney Injury
Isotonic Solutions and Major Adverse Renal Events Trial in the Non-Medical Intensive Care Unit (SMART-SURG)
The administration of intravenous fluids is ubiquitous in the care of the critically ill. Commonly available isotonic crystalloid solutions contain a broad spectrum electrolyte compositions including a range chloride…
- Trial name
- SMART-SURG (NCT02547779)
- Testing
- 0.9% Saline, Physiologically-balanced isotonic crystalloid
- Where
- United States
- Volunteers
- 10,421 people
- Sponsor
- Vanderbilt University
Cancer, Bleeding
Bleeding in Critically Ill Children With Underlying Oncologic Diagnoses
"Bleeding in Critically Ill Children with Underlying Oncologic Diagnoses ," will be a prospective observational cohort study looking at the epidemiology of bleeding in the pediatric ICU population at MSK.
- Trial name
- NCT04170231
- Where
- United States
- Volunteers
- 93 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Sepsis, Cognitive Impairment
HMGB1 in ICU-survivors
Is HMGB1 (High Mobility Group Box 1) elevated in sepsis patients for weeks after recovery from severe sepsis/septic shock, similar to what has been observed in mice? Do patients recovering from severe sepsis/septic shock suffer…
- Trial name
- NCT02914756
- Where
- Sweden
- Volunteers
- 100 people
- Sponsor
- Karolinska University Hospital
Liver Cirrhoses
Indirect Calorimeter Based Study in Patients With Liver Cirrhosis
Part I- Observational study In the first part , investigator would investigate and compare the energy requirements and substrate utilization in healthy subjects and in patients with liver cirrhosis of various etiologies across…
- Trial name
- METALIC (NCT03871894)
- Testing
- Indirect calorimetry based nutritional intervention till patient in ICU(Intensive care unit), Standard and fixed nutritional intervention till patient in ICU
- Where
- India
- Volunteers
- 83 people, healthy volunteers welcome
- Sponsor
- Institute of Liver and Biliary Sciences, India
Tracheostomy
Percutaneous Tracheostomy
Description of a technical modification of percutaneous tracheostomy that involves a safety method for confirming the intratracheal location of the needle at the time of puncture, with preventing serious complications such as…
- Trial name
- NCT05343442
- Testing
- Percutaneous tracheostomy
- Where
- Egypt
- Volunteers
- 386 people
- Sponsor
- Alexandria University
Invasive Candidiasis
Invasive Candidiasis in Saudi ICUs
Epidemiology and clinical outcomes of invasive candidiasis in critically ill patients in Saudi Arabia is not well studied. This observational study objectives include to determine the epidemiology, risk factors and outcomes of…
- Trial name
- ICIP-SA (NCT01490684)
- Where
- 2 sites in Saudi Arabia
- Volunteers
- 162 people
- Sponsor
- Hasan Al-Dorzi
Critical Illness, Deep Venous Thrombosis
PROphylaxis for ThromboEmbolism in Critical Care Trial (PROTECT)
The purpose of this study is to evaluate the effect of Low Molecular Weight Heparin (LMWH) (Fragmin, dalteparin) versus Unfractionated Heparin (UFH) on the primary outcome of proximal leg Deep Vein Thrombosis (DVT) diagnosed by…
- Trial name
- NCT00182143
- Testing
- LMWH (Fragmin, dalteparin), Unfractionated Heparin
- Where
- 67 sites in United States, Australia and 4 more
- Volunteers
- 3,659 people
- Sponsor
- McMaster University
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