Clinical trials: Critical Illness, completed
Critical Illness Myopathy, Respiratory Paralysis
ICU Acquired Neuromyopathy and Diaphragm Function
Critical illness neuromyopathy is a common disease acquired during ICU stay leading to a deep weakness involving the respiratory muscle work which result in a delayed weaning of mechanical ventilation.
- Trial name
- NCT01968889
- Testing
- Non invasive phrenic nerve stimulation
- Where
- France
- Volunteers
- 60 people
- Sponsor
- University Hospital, Montpellier
Critical Illness, Shock
Midodrine for the Early Liberation of Vasopressor Support in the ICU
Vasopressors are medications that are given intravenously to increase the blood pressure of patients with illnesses that cause dangerous blood pressure drops.
- Trial name
- LIBERATE (NCT04489589)
- Testing
- Midodrine
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- University of Alberta
Critical Illness, Hyperglycemia
Effects of a Complete Diet in Critically Ill Patients With Stress Hyperglycemia
The aim of the study is to evaluate the beneficial effects of the administration of a complete diet rich in monounsaturated fatty acids (MUFA) and slow absorption carbohydrate in patients with stress hyperglycemia(T-Diet Plus…
- Conditions
- Critical Illness, Hyperglycemia, Dietary Modification, Metabolic Stress Hyperglycemia
- Trial name
- NCT01233726
- Testing
- T-Diet plus Diabet IR, ISOSOURCE PROTEIN FIBRE, GLUCERNA SELECT
- Where
- 2 sites in Spain
- Volunteers
- 159 people
- Sponsor
- Vegenat, S.A.
Critically Ill, Septic Shock
Fludrocortisone Dose Response Relationship in Septic Shock - FluDReSS
The purpose of this study is to determine the most suitable dose of Fludrocortisone in reversal of sepsis and shock associated with sepsis in patients who are admitted to the ICU.
- Trial name
- FluDReSS (NCT04494789)
- Testing
- Fludrocortisone Acetate, Standard Therapy
- Where
- 9 sites in Australia
- Volunteers
- 155 people
- Sponsor
- The George Institute
Glycemic Control, Insulin
Insulin Degludec vs Insulin Glargine for Glycemic Control in Critical Illness Hyperglycemia
The role of ultralong insulin in the control of the blood glucose level in diabetic patients is well known, the current study will discuss the role of ultralong insulin in controlling of hyperglycaemia in critical illness defined…
- Conditions
- Glycemic Control, Insulin, Critical Illness
- Trial name
- NCT06178874
- Testing
- Insulin Glargine, Insulin Degludec, Insulin regular
- Where
- Egypt
- Volunteers
- 90 people
- Sponsor
- Ain Shams University
Critical Illness, Muscle Weakness
Progressive Mobility Program and Technology to Improve the Level of Physical Activity and Functionality of ICU Patients
The purpose of this study is to verify if a protocol of early and progressive mobility which includes the use of technology is able to increase the level of physical activity and improve functionality and respiratory and muscular…
- Trial name
- NCT02889146
- Testing
- Conventional Physical Therapy, Early and progressive mobilization program, Respiratory therapy
- Where
- Brazil
- Volunteers
- 98 people
- Sponsor
- University of Sao Paulo General Hospital
PICS
Feasibility Trial of the Early Psychological Support for the Critically Ill
This is a pilot study designed to test feasibility of a psychotherapeutic intervention for the critically ill patients in intensive care units. Intervention is named Early Psychological Support for the Critically Ill (EPSCI)
- Trial name
- NCT02739022
- Testing
- Early Psychological Support for the Critically Ill (EPSCI)
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Mayo Clinic
Blood Glucose, Humans
The Performance of Dexcom G6 Glucose Monitoring in Critically Ill Patients
This is an investigator-initiated, prospective, observational accuracy-study. The aim of the study is to test the feasibility, safety, and accuracy of a subcutaneous continuous glucose monitoring system (the Dexcom G6 glucose…
- Conditions
- Blood Glucose, Humans, Critical Care
- Trial name
- NCT05255783
- Testing
- subcutaneous continuous glucose sensor
- Where
- Sweden
- Volunteers
- 40 people
- Sponsor
- Region Stockholm
Methicillin-resistant Staphylococcus Aureus, Sepsis
Cystatin-C C-guided Vancomycin Dosing in Critically Ill Patients: A Quality Improvement Project
Determine if a cystatin C-inclusive vancomycin dosing algorithm improved target trough achievement compared to creatinine clearance-guided vancomycin therapy in critically ill patients.
- Conditions
- Methicillin-resistant Staphylococcus Aureus, Sepsis, Critical Illness
- Trial name
- NCT02945241
- Testing
- Vancomycin, Cystatin C dosing algorithm, Creatine clearance dosing algorithm
- Volunteers
- 399 people
- Sponsor
- Mayo Clinic
Critically Ill Patients
Therapeutic Drug Monitoring of Fluconazole in Critically Ill Patients
This prospective study will research the exposure and its variability to fluconazole after longitudinal administration in critically ill patients
- Trial name
- NCT04252027
- Testing
- Sample collection
- Where
- Belgium
- Volunteers
- 43 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
ARDS
NMR Based Metabolomics Kinetics in ARDS Patients
Acute respiratory distress syndrome (ARDS) is a life-threatening condition requiring respiratory support to maintain oxygenation.
- Trial name
- NCT06036056
- Where
- India
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Sanjay Gandhi Postgraduate Institute of Medical Sciences
Weaning Failure
Volume Responsiveness Before SBT Predicts the Outcome of Mechanical Ventilation Weaning in Critically Ill Patients
To evaluate the performance of volume responsiveness in predicting the outcome of mechanical ventilation weaning in critically ill patients.
- Trial name
- weaning (NCT01867853)
- Testing
- PLR
- Where
- China
- Volunteers
- 82 people, healthy volunteers welcome
- Sponsor
- Southeast University, China
COVID-19, ARDS
Assessment of Analgesics and Sedatives in Mechanically Ventilated Patients With COVID-19
The analgesic and sedation requirements in critically ill patients with COVID-19 have yet to be described. There are various factors that are likely affecting the agents being utilized for analgesia and sedation in these patients…
- Conditions
- COVID-19, ARDS, Withdrawal Syndrome, Iatrogenic Disease
- Trial name
- NCT05336656
- Where
- United States
- Volunteers
- 353 people
- Sponsor
- Wilkes University
ARDS, Critical Illness
Implementation of Nudges to Promote Utilization of Low Tidal Volume Ventilation (INPUT) Study
This study is a large pragmatic stepped-wedge trial of electronic health record (EHR)-based implementation strategies informed by behavioral economic principles to increase lung-protective ventilation (LPV) utilization among all…
- Conditions
- ARDS, Critical Illness, Acute Respiratory Distress Syndrome, Acute Respiratory Failure
- Trial name
- INPUT (NCT04663802)
- Testing
- Default order set, Physician-targeted accountable justification, Respiratory therapist (RT)-targeted accountable justification
- Where
- 5 sites in United States
- Volunteers
- 7,342 people
- Sponsor
- University of Pennsylvania
Septic Shock
PK Analysis of Piperacillin in Septic Shock Patients
Antibiotic dosing in septic shock patients poses a challenge for clinicians due to the pharmacokinetic changes seen in this population.
- Trial name
- NCT02306928
- Testing
- Blood draw
- Where
- Denmark
- Volunteers
- 15 people
- Sponsor
- University of Aarhus
Critically Ill Child, Nutritional Status
Height Measurement in Critically Ill Children
Height/length has to be assessed accurately in critically ill children, as its value is required to assess nutritional status, to calculate nutritional requirements, to calculate body surface area (involved in drug…
- Conditions
- Critically Ill Child, Nutritional Status, Height, Length
- Trial name
- EvTaRéaP (NCT03572504)
- Testing
- critically ill children
- Where
- France
- Volunteers
- 140 people
- Sponsor
- University Hospital, Strasbourg, France
Critical Illness, Self-Assessment
Comparison of Self-assessment vs. Assessment by Others of Critically Ill Patients
We will test the results of standardized questionnaires for patients admitted to intensive care assessed by relatives/caregivers compared to the patient itself.
- Conditions
- Critical Illness, Self-Assessment, Assessment, Self
- Trial name
- ASTON (NCT03785444)
- Testing
- WHODAS 2.0, EQ5D, IADL
- Where
- 2 sites in Germany
- Volunteers
- 200 people
- Sponsor
- Technical University of Munich
Water-Electrolyte Imbalance, Intensive Care Units
Fluid Overload and Pulmonary Function
Esophageal atresia is a rare but severe malformation, and it requires early surgery. Coloesophagoplasty is surgical repair of the esophageal with an isoperistaltic transverse colon graft.
- Conditions
- Water-Electrolyte Imbalance, Intensive Care Units, Pediatric, Critical Illness
- Trial name
- NCT05129930
- Where
- Russia
- Volunteers
- 40 people
- Sponsor
- Pirogov Russian National Research Medical University
Nursing Caries, Satisfaction
In-Situ Simulation Different Debriefing Methods
The goal of this pre-test-post-test randomized controlled experimental study is to examined the effects of the learning conversation (LC)-based, 3D model-based, and standard debriefing methods on critical thinking, debriefing…
- Conditions
- Nursing Caries, Satisfaction, Simulation of Physical Illness
- Trial name
- NCT06052007
- Testing
- LC-Based Debriefing, 3D Model-Based Debriefing
- Where
- Turkey (Türkiye)
- Volunteers
- 119 people, healthy volunteers welcome
- Sponsor
- Sakarya University
Weaning Failure, Mechanical Ventilation Complication
Lung Impedetiometric Modification in SBT and Extubation Failure
Weaning is the entire process aimed at liberating patients from mechanical ventilation and endotracheal intubation. Weaning should be considered as early as possible in order to reduce the time spent in invasive mechanical…
- Trial name
- CPAP2-EIT (NCT03894332)
- Testing
- Electrical Impedance Tomography (EIT)
- Volunteers
- 80 people
- Sponsor
- University Magna Graecia
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