Clinical trials: Critical Illness, completed
Critical Illness, Acute Kidney Failure
Implementation of CRRT KPI Reports to Standardize and Improve the Quality of CRRT Delivery in Alberta "QUALITY CRRT"
Acute kidney replacement therapy (i.e., dialysis) is used in 6-10% of patients admitted to intensive care units (ICUs). The amount of acute kidney replacement therapy use has increased in Canadian ICUs over the last several…
- Trial name
- QUALITY-CRRT (NCT04221932)
- Testing
- CRRT KPI Reports
- Where
- 14 sites in Canada
- Volunteers
- 945 people
- Sponsor
- University of Alberta
Sepsis, Cognitive Impairment
HMGB1 in ICU-survivors
Is HMGB1 (High Mobility Group Box 1) elevated in sepsis patients for weeks after recovery from severe sepsis/septic shock, similar to what has been observed in mice? Do patients recovering from severe sepsis/septic shock suffer…
- Trial name
- NCT02914756
- Where
- Sweden
- Volunteers
- 100 people
- Sponsor
- Karolinska University Hospital
Acute Respiratory Failure, Critical Illness
"VARIABLE-PSV" Study
Variable PSV is a new ventilatory mode which delivered a pressure support "variable" from 0 to 100% variation of the set PSV level.This study aimed to compare the ventilatory behavior, sleep quality and gas exchange between…
- Conditions
- Acute Respiratory Failure, Critical Illness, Ventilation Weaning
- Trial name
- NCT01580956
- Testing
- VARIABLE-PSV ventilatory mode, STANDARD-PSV ventilatory mode
- Where
- France
- Volunteers
- 20 people
- Sponsor
- University Hospital, Montpellier
Critically Ill
Directed Immuno Nutrition by L-arginine for Critically Ill Patients
The main objective of this proof-of-concept study is to demonstrate that the only administration of L-arginine, based on a suspected deficit monitored by nasal nitric oxide measurement, can improve immune functions in critically…
- Trial name
- Immunolarg (NCT01038622)
- Testing
- L-arginine
- Where
- France
- Volunteers
- 30 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Gastric Emptying, Mechanically Ventilation
Metoclopramide on Gastric Emptying in Mechanically Ventilated Patients
The aim of this study is to evaluate the prokinetic effect of metoclopramide on gastric emptying in critically ill mechanically ventilated patients .
- Conditions
- Gastric Emptying, Mechanically Ventilation, Randomized Controlled Trial, Metoclopramide
- Trial name
- NCT05641051
- Testing
- Metoclopramide
- Where
- Egypt
- Volunteers
- 80 people
- Sponsor
- Tanta University
Respiration, Artificial, Sedated
Influence of Chronic Vascular Diseases on Transcranial Doppler Profiles in Critically Ill Patients
The primary objective of this study is to show that cardiovascular risk factors associated with the chronic elevation of arterial resistance may be associated with "false" profiles of intracranial hypertension during transcranial…
- Trial name
- CritiDop (NCT02898389)
- Where
- France
- Volunteers
- 91 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Critically Ill Patients
Impact of Interventions on Admission SOFA Score on Clinical Outcomes of Critically Ill Patients
Introduction: The SOFA score (Sequential Organ Function Assessment) and its derived measures, such as the Delta SOFA, are used worldwide to determine the severity and prognosis of critically ill patients.
- Trial name
- NCT05790915
- Testing
- Standardized interventions
- Where
- Brazil
- Volunteers
- 849 people
- Sponsor
- Hospital Sao Domingos
Critical Illness
Continuous Glucose Monitoring in Critically Ill Patients
The purpose of this study is to determine whether subcutaneous continuous glucose monitoring in critically ill patients is clinically feasible accurate and reliable.
- Trial name
- NCT00494455
- Testing
- continuous subcutaneous glucose monitoring
- Where
- Austria
- Volunteers
- 50 people
- Sponsor
- Medical University of Vienna
Sleep Disturbance, Critical Illness
Sleep Quantity and Quality in the ICU: a Prospective Observational Stud
Several evidences in the literature suggest sleep interruption in critical care patients. Nowadays, the amount and the quality of sleep phases during the length of stay in the intensive care unit are largely unknown.
- Trial name
- NCT03796338
- Testing
- Sleep Profiler
- Where
- Italy
- Volunteers
- 72 people
- Sponsor
- Careggi Hospital
Acute Kidney Injury, Critical Illness
Preventing Acute Kidney Injury and Improving Outcome in Critically Ill Patients Utilising Risk Prediction Score
An interventional controlled trial to test the feasibility of applying risk score based prevention for critically ill patient at high risk to develop acute kidney injury (AKI)
- Trial name
- PRAIOC-RISKS (NCT03178435)
- Testing
- Measures to prevent AKI among critically ill patients
- Where
- Egypt
- Volunteers
- 198 people
- Sponsor
- Kasr El Aini Hospital
Pharmacokinetics, Critical Illness
Optimization of PK/PD Target Attainment for Ceftriaxone in Critically Ill Patients With Community-acquired Pneumonia.
WP2.1. PK/PD target attainment Plasma exposure ELF exposure WP2.2. Predictive dosing algorithm WP2.3. ECMO subset
- Trial name
- NCT03438981
- Where
- Belgium
- Volunteers
- 30 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Critical Illness
Validation of an Early Warning Score Based Triage System in the Emergency Department
At Bispebjerg Hospital we have introduced an Early Warning Score based triage system , called Bispebjerg Early Warning Score (BEWS), in order to identify critically ill patient on arrival at the emergency department.
- Trial name
- NCT01243021
- Where
- Denmark
- Volunteers
- 300 people
- Sponsor
- Bispebjerg Hospital
Critically Ill Patients Under Mechanical Ventilation, Sedated Patients
Haemodynamic and Metabolism Response During Early Rehabilitation in Sedated Patients
Despite several positive studies, benefits of early rehabilitation on recovery and motor performance improvement need to be demonstrate.
- Trial name
- NCT02920684
- Testing
- Passive legs mobilisation, Passive cycloergometer, Muscular electrical stimulation
- Where
- France
- Volunteers
- 20 people
- Sponsor
- University Hospital, Rouen
Critical Illness
Study of Arginine Free IED in Critically Ill Patients.
This study intends to investigate the clinical outcomes of a new immunoenhancing formula which composed arginine free compare to isonitrogenous, isocaloric standard formula in ICU patients.The study design is multicenter…
- Trial name
- ROSIED (NCT01713257)
- Testing
- Immunoenhancing diet, Isocaloric, isonitrogenous diet
- Where
- 3 sites in Thailand
- Volunteers
- 172 people
- Sponsor
- Thai Otsuka Pharmaceutical Co., Ltd.
Sepsis, Systemic Inflammatory Response Syndrome (SIRS)
Effect of Lactiplantibacillus Plantarum DAD-13 on Inflammatory Markers in ICU Sepsis Patients
This study investigated whether giving the probiotic Lactiplantibacillus plantarum DAD-13 to sepsis patients in the intensive care unit (ICU) could help reduce inflammation and improve bowel function.
- Conditions
- Sepsis, Systemic Inflammatory Response Syndrome (SIRS), Critical Illness
- Trial name
- LactoSepsis (NCT07072871)
- Testing
- Lactiplantibacillus plantarum DAD-13
- Where
- Indonesia
- Volunteers
- 32 people
- Sponsor
- PT Royal Medikalink Pharmalab
Acute Kidney Injury KDIGO 3, Continuous Renal Replacement Therapy Initiated by the Clinician in Charge Without Emergency
Is Myocardial Stunning Induced by Continuous Renal Replacement Therapy a Reality in Critically Ill Patients?
Myocardial stunning during chronic intermittent hemodialysis is a well-described phenomenon. Little case series of patients presenting myocardial stunning during renal replacement therapy for acute kidney injury in critically ill…
- Conditions
- Acute Kidney Injury KDIGO 3, Continuous Renal Replacement Therapy Initiated by the Clinician in Charge Without Emergency, Myocardial Stunning
- Trial name
- MS-CRRT (NCT05209230)
- Testing
- Continuous renal replacement therapy, Control group
- Where
- 3 sites in France
- Volunteers
- 42 people
- Sponsor
- Hospices Civils de Lyon
Pressure Ulcer, Critical Care
Prevalence of Pressure Ulcers Among Critically Ill Patients and Factors Associated With Their Occurrence in the ICU
The prevalence of and risk factors for pressure ulcers (PUs) in critically ill patients have been poorly studied. The main objective of this study was to describe the prevalence of PUs in critically ill patients.
- Conditions
- Pressure Ulcer, Critical Care, Intensive Care Unit Syndrome
- Trial name
- PRESSURE (NCT03912467)
- Testing
- Pressure Ulcer Evaluation
- Where
- 60 sites in France
- Volunteers
- 1,228 people
- Sponsor
- French Society for Intensive Care
Critically Ill Patients
Ultrasound Assessment of Residual Gastric Content in Critically Ill Patients
This prospective observational study aims to assess whether ultrasound assessment of gastric content may be useful for the monitoring of the gastric residual content in critically ill patients
- Trial name
- GastrICU (NCT03205592)
- Testing
- Ultrasound examination of the antrum
- Where
- 3 sites in France
- Volunteers
- 61 people
- Sponsor
- Hôpital Edouard Herriot
Sleep Disturbances in Survivors of Critical Illness
Johrei Therapy and CBT-I in Facilitating Sleep in ICU Survivors
The purpose of this project is to compare the effectiveness of Johrei therapy (JT) and Cognitive-behavioral Therapy for Insomnia (CBT-I) in the treatment of sleep disturbances in survivors of critical illness.
- Trial name
- NCT02059421
- Testing
- Cognitive Behavioral Therapy for Insomnia (CBT-I), Johrei therapy
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Arizona
Type 2 Diabetes
Efficacy, Usability Study of the GlucoTab System for Glycaemic Management in Type 2 Diabetic Patients at General Wards
Objective: To investigate the performance (safety) of the GlucoTab system for glycaemic management in non-critically ill patients with type 2 diabetes at general wards.
- Trial name
- NCT01932775
- Testing
- GlucoTab System
- Where
- Austria
- Volunteers
- 99 people
- Sponsor
- Medical University of Graz
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