Clinical trials: Critically Ill Child
Hemodynamically Stable, Critical Illness
Comparing USCOM and Echocardiographic Hemodynamic Measurements in Children (CUE Study)
The primary objective of this study is to evaluate the agreement between hemodynamic measurements obtained using the Ultrasound Cardiac Output Monitor (USCOM®; USCOM Ltd., Sydney, Australia), and reference standards as determined…
- Trial name
- NCT02083172
- Testing
- Ultrasound Cardiac Output Monitor and 2 D-Echo
- Where
- Canada
- Volunteers
- 78 people
- Sponsor
- McMaster University
Critical Illness, Dysbiosis
Influences of High-fiber, Organic Whole-food Formula on the Gut Microbiome in Critically Ill Children
This study evaluates the effects of either Pediasure or Nourish formulas on the gastrointestinal microbiome in critically-ill children. Patients will be randomized to received either Pediasure or Nourish.
- Conditions
- Critical Illness, Dysbiosis, Pediatric ALL
- Trial name
- NCT03414775
- Testing
- Nourish, Pediasure
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- University of Pittsburgh
Bloodstream Infection Due to Central Venous Catheter, Central Line-associated Bloodstream Infections
Chlorhexidine Bathing in Critically Ill Children
Central line-associated bloodstream infections are associated with increased mortality, morbidity, and length of hospital stay. The incidence has decreased significantly with the strict implementation of preventive bundle cares…
- Trial name
- NCT05995080
- Testing
- clorhexidine gluconate bathing
- Where
- Turkey (Türkiye)
- Volunteers
- 247 people
- Sponsor
- Istanbul Medeniyet University
Malnutrition, Critical Illness
Assessment of Nutritional Status in Critically Ill Children in PICU
This prospective cohort study aims to assess the nutritional status of critically ill children aged 1 month to 5 years admitted to the pediatric intensive care unit using a comprehensive ABCD approach including anthropometric…
- Trial name
- NCT07830966
- Volunteers
- 103 people
- Sponsor
- Assiut University
Critical Illness, Sepsis, Severe
Effects of IL-1β and Its Receptor Antagonists in the Treatment of Severe Infection and Inflammatory Storm in Children
In severe infective patients who survive the initial inflammatory storm, the immune response often evolves toward a state of immunosuppression, which contributes to increased mortality and severe secondary hospital-acquired…
- Trial name
- NCT04821414
- Sponsor
- Children's Hospital of Fudan University
Deep Venous Thrombosis
Catheter-Related Early Thromboprophylaxis With Enoxaparin Studies
The goal of the CRETE Studies is to investigate the newly identified age-dependent heterogeneity in the efficacy of enoxaparin in reducing the risk of central venous catheter-associated deep venous thrombosis in critically ill…
- Trial name
- CRETE (NCT04924322)
- Testing
- Enoxaparin
- Where
- 22 sites in United States
- Volunteers
- 258 people
- Sponsor
- Yale University
Oropharyngeal Dysphagia
Nursing Care Bundle on Oral Intake Among Critically Ill Children With Post-Extubation Dysphagia
the aim of this study is to evaluate the effect of Nursing care Bundle on Oral Intake among Critically Ill Children with Post-Extubation Dysphagia
- Trial name
- NCT06814457
- Testing
- a nursing care bundle on oral intake
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Kafrelsheikh University
Critical Illness, Pediatrics
Effect of Giving Reduced Fluid in Children After Trauma
This study is designed to help decide how much intravenous (IV) fluid should be given to pediatric trauma patients. No standard currently exists for managing fluids in critically ill pediatric trauma patients, and many fluid…
- Conditions
- Critical Illness, Pediatrics, General Surgery, Fluid Therapy
- Trial name
- NCT04201704
- Testing
- Balanced crystalloid solution volume administration, Packed Erythrocytes Units, Blood Product Unit volume, Plasma volume
- Where
- 4 sites in United States
- Volunteers
- 250 people
- Sponsor
- Columbia University
Lung Collapse
Brochoscopic Intervention Versus Conventional Management in Acute Lung Collapse in the Pediatric Intensive Care Unit
This prospective RCT at Cairo University Children Hospitals enrolls critically ill pediatric patients (intubated, NIV, or post-extubation) with lung atelectasis unresponsive to 48 hours of conventional recruitment.
- Trial name
- picu (NCT07383129)
- Testing
- bronchoscope, chest physiotherapy and suction
- Where
- Egypt
- Volunteers
- 36 people
- Sponsor
- Cairo University
Enteral Nutrition, Feeding Intolerance
Evaluation of Status of Early Reached Target Enteral Nutrition and IFABP as Biomarker of Feeding Intolerance in Critically Ill Children
Stage 1 - Evaluation of Status of Early Reached Target Enteral Nutrition in critically ill children in the PICU (ERTEN in PICU).
- Conditions
- Enteral Nutrition, Feeding Intolerance, Intestinal Fatty Acid Binding Protein
- Trial name
- ERTENIFABPICU (NCT02598375)
- Testing
- Feeding intolerance
- Where
- Germany
- Volunteers
- 150 people
- Sponsor
- Gazi University
ICU Length of Stay
Primary Intensivists and Primary Nurses to Decrease Pediatric ICU Length of Stay
This is a randomized control trial of PICU patients admitted for 7 days and expected to remain for at least another 3 days and who have a complex chronic condition.
- Trial name
- PIPRNs (NCT03364933)
- Testing
- Primary intensivist and nurses
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Columbia University
Pediatric Intensive Care Units
A Korean Point Prevalence Study of Acute Rehabilitation for Kids in the PICU (PARK-PICU)
This study investigates the prevalence of acute rehabilitation practices among children in pediatric intensive care units (PICUs).
- Trial name
- NCT07629297
- Testing
- Acute Rehabilitation (Observed Practice)
- Where
- 13 sites in South Korea
- Volunteers
- 396 people
- Sponsor
- Samsung Medical Center
Prophylactic, Anticoagulation
Prophylactic Anticoagulation for Central Venous Line Insertion in Critically Ill Children
This will be a Prospective, randomized, open- label, parallel-group, center trial, which will include 80 of Children which will be admitted at Pediatric Intensive Care Unit (PICU) of Menoufia university Hospital from August 2026…
- Trial name
- NCT07710482
- Testing
- Enoxaparin
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Menoufia University
Pediatric Disorder, Critical Illness
Attitudes to Decisions to Withdraw or Withhold Life-sustaining Treatments in Critically Ill Children
The aim of this study is to investigate attitudes on decisions to withdraw or withhold life-sustaining treatments in critically ill children in Swedish intensive care units.
- Conditions
- Pediatric Disorder, Critical Illness, Ethics, Narrative
- Trial name
- LSTPedSurvey (NCT06281743)
- Testing
- Survey
- Where
- Sweden
- Volunteers
- 100 people
- Sponsor
- Göteborg University
Fever
Fever Observational Study
To inform the feasibility of conducting a study to test different temperature thresholds at which clinicians deliver interventions to reduce fever (i.e.
- Trial name
- NCT03028818
- Where
- United Kingdom
- Volunteers
- 3,960 people
- Sponsor
- Intensive Care National Audit & Research Centre
Decision Making, Neonatal Critical Illness
Building Relationship, Improving Dialogue, and Growing Empathy (BRIDGE): An Intervention to Support Decision Making for Critically Ill Children
Parents of young children in the intensive care unit may be faced with decisions about their child's care. The Building Relationship, Improving Dialogue, and Growing Empathy (BRIDGE) intervention was designed to help support…
- Conditions
- Decision Making, Neonatal Critical Illness, Pediatric Critical Illness
- Trial name
- BRIDGE (NCT07390773)
- Testing
- BRIDGE intervention
- Where
- 3 sites in United States
- Volunteers
- 495 people
- Sponsor
- Duke University
Nutrition Disorder, Child
Role of Nutritional Intervention in Critically Ill Child
Assess the nutritional status of critically ill children using different nutritional assessment tools in management. Assess accuracy and validity of screening tools in diagnosis of malnutrition by the following: Strong kids Stamp…
- Trial name
- NCT04862728
- Testing
- - Strong kids screening tool - Stamp screening tool - PYMS screening tool
- Volunteers
- 100 people
- Sponsor
- Assiut University
Probiotic, Ventilator Associated Pneumonia
Probiotic Role in Prevention of Ventilator Associated Pneumonia in Critically- Ill Children Admitted at Pediatric Intensive Care Unit
The aim of the work is to evaluate the impact of Probiotics supplementation on prevention of ventilator associated pneumonia in critically ill children admitted at Pediatric Intensive Care Unit at Tanta University Hospitals.
- Conditions
- Probiotic, Ventilator Associated Pneumonia, Critically- Ill Children
- Trial name
- NCT07848165
- Testing
- Probiotics, Standard management
- Where
- Egypt
- Volunteers
- 68 people
- Sponsor
- Tanta University
Hemodynamic Instability
Uninvasive Cardiac Output Monitoring (USCOM) in Critically Ill Children: Validation and Prediction of Hemodynamic Instability
Hemodynamically unstable ventilated PICU \& PCICU patients, which a decision for commencement in inotropic therapy or fluid bolus has been made, will be recruited.
- Trial name
- NCT02945748
- Where
- Israel
- Volunteers
- 52 people
- Sponsor
- Rabin Medical Center
Critical Illness
Improving Outcomes After PICU Admission: A Pilot Study
1. Evaluate the feasibility and acceptability of an information based intervention delivered to parents following their child's admission to paediatric intensive care; 2.
- Trial name
- NCT01737021
- Testing
- Psycho-education
- Volunteers
- 31 people
- Sponsor
- Imperial College London