Clinical trials: Critically Ill Child
Hypoxia, Respiratory Acidosis
FIRST-line Support for Assistance in Breathing in Children (FIRST-ABC) Feasibility Study
A feasibility study to inform the design and conduct of a randomised controlled trial of high flow nasal cannula (HFNC) versus continuous positive airway pressure (CPAP) for non-invasive respiratory support in critically ill…
- Conditions
- Hypoxia, Respiratory Acidosis, Moderate/Severe Respiratory Distress
- Trial name
- FIRST-ABC (NCT02612415)
- Testing
- Treatment strategy: Non-invasive respiratory support delivered via high flow nasal cannula, Treatment strategy: Non-invasive respiratory support delivered via continuous positive airway pressure
- Where
- 3 sites in United Kingdom
- Volunteers
- 121 people
- Sponsor
- Great Ormond Street Hospital for Children NHS Foundation Trust
Bed Sore, Pressure Ulcer
Use of Honey for Pressure Ulcers in Critically Ill Children
The enrolled children would be randomized to one of the groups 'study group' or 'Honey dressing group' or 'Group I' (honey dressing containing Active Leptospermum Honey also known as Manuka honey would be used), changed every…
- Conditions
- Bed Sore, Pressure Ulcer, Pressure Sore, Critically Ill Children
- Trial name
- NCT03391310
- Testing
- Honey (medicated)
- Where
- 2 sites in India
- Volunteers
- 100 people
- Sponsor
- All India Institute of Medical Sciences
Critical Illness, Depressive Symptoms
Subanesthetic Ketamine Infusions for Depressive Symptoms in Intensive Care Unit Patients
Depressive symptoms are common among patients admitted to the intensive care unit (ICU) and may adversely affect recovery, participation in care, treatment adherence, quality of life, and outcomes after critical illness.
- Trial name
- KID-ICU (NCT07639359)
- Testing
- Ketamine (0.5 mg/kg), Normal Saline (0.9% NaCl)
- Where
- 2 sites in United States, Argentina
- Volunteers
- 50 people
- Sponsor
- Hospital Italiano de Buenos Aires
Quadriceps Femoris Measurement as a Surrogate of Muscle Mass Assessment in Critically Ill Children
Ultrasound and MRI Measurement of Quadriceps Femoris Muscle in Critically Ill Children
A vast majority of children admitted to paediatric intensive care (PICU) present with faltering growth during their admission. Muscle mass loss is an early, intense and frequent phenomenon in this setting, which is associated…
- Trial name
- Echo-QF-IRM (NCT05108441)
- Testing
- Ultrasound and magnetic resonance imaging measurements of quadriceps femoris
- Where
- France
- Volunteers
- 35 people
- Sponsor
- Hospices Civils de Lyon
Pneumonia, Resistant Pneumonia
Flexible Bronchoscopy in Resistant Pneumonia in PICU
Pneumonia remains a leading cause of morbidity and mortality among critically ill children admitted to Pediatric Intensive Care Units (PICUs).
- Conditions
- Pneumonia, Resistant Pneumonia, Resistant Pneumonia in Critically Ill Pedaitric Patients
- Trial name
- FFP-RP PICU (NCT07421440)
- Testing
- Flexible fiberoptic bronchoscopy with bronchoalveolar lavage (BAL)
- Where
- Egypt
- Volunteers
- 70 people
- Sponsor
- Mansour Gomaa Mohammed Saleh