Clinical trials: Critically Ill Child
Pediatric ALL, Critical Illness
Singapore's Health Outcomes After Critical Illness in Kids
What is the problem? Every year about 2.5 million children are affected by critical illness and require admission to the pediatric intensive care unit (PICU).
- Conditions
- Pediatric ALL, Critical Illness, Post Intensive Care Unit Syndrome
- Trial name
- SHACK (NCT04637113)
- Testing
- This is a non-interventional study
- Where
- Singapore
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- KK Women's and Children's Hospital
Skeletal Muscle Ultrasonography
Skeletal Muscle Ultrasonography in Detection of Malnutrition
To detect the role of Skeletal Muscle Ultrasonography in Detection of Malnutrition and Prediction of The Outcome among critically ill children.
- Trial name
- NCT06382766
- Testing
- Skeletal Muscle Ultrasonography
- Volunteers
- 50 people
- Sponsor
- Assiut University
Critical Illness
Early Rehabilitation in Critically Ill Children Pilot Study
Critically ill patients are often confined to bedrest, because of the nature of their illness. However, it has now been shown that prolonged bedrest and immobility, particularly in critically ill adults and children, can lead to…
- Trial name
- WeeHab in PCCU (NCT01531816)
- Testing
- Early Rehabilitation intervention
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- McMaster University
Respiratory Insufficiency, Pneumonia, Aspiration
Feeding Children Nasogastrically Versus Nasojejunally While Receiving Noninvasive Positive Pressure Ventilation
The investigators are studying whether it is safe and effective to provide enteral nutrition to critically ill children via the nasogastric route, as opposed to the nasojejunal route, while they are receiving noninvasive positive…
- Conditions
- Respiratory Insufficiency, Pneumonia, Aspiration, Nutrition Disorders
- Trial name
- FeedNIV (NCT01301352)
- Testing
- Route of feeding (nasogastric vs. nasojejunal)
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Electrolytes Abnormalities, Children
Serum Electrolyte Abnormalities as Prognostic Factor for Outcome in Critically Ill Children
The aim of this study is to evaluate the clinical profile and outcome of children with serum electrolyte abnormalities admitted at Pediatric Intensive Care Unit in Assuit University Children Hospital.
- Conditions
- Electrolytes Abnormalities, Children, Prognostic Factors
- Trial name
- NCT07205562
- Volunteers
- 200 people
- Sponsor
- Assiut University
Sepsis Induced Cardiomyopathy, Sepsis Induced Myocardial Dysfunction
Sepsis Induced Myocardial Injury in Critically Ill Children
Sepsis is a dysregulated immune response due to infection, leading to life-threatening organ dysfunction affecting respiratory, renal, immunological, digestive, neurological, and cardiovascular organs.
- Trial name
- NCT07497139
- Testing
- observational study
- Where
- Egypt
- Volunteers
- 84 people
- Sponsor
- Assiut University
Critical Illness, Respiratory Failure (Pediatric Patients)
Ventilator Settings and Outcomes in Pediatric Patients on ECMO for Severe Respiratory Failure
This study aims to describe the effects of ECMO initiation on the intensity of ventilation in the first 24 hours after ECMO initiation and to explore associations between changes in ventilation intensity and hospital mortality in…
- Trial name
- NCT06899009
- Where
- Netherlands
- Volunteers
- 750 people
- Sponsor
- University Medical Center Groningen
Critical Illness
Functional Outcomes in Children Post Critical Illness
Improvements in medical care have led to decreasing mortality rates in critically ill children, which have been reported to be as low as 5%.
- Trial name
- NCT03730844
- Where
- Singapore
- Volunteers
- 129 people, healthy volunteers welcome
- Sponsor
- KK Women's and Children's Hospital
Critical Illness
U/S Guided vs. Traditional Palpation for Radial Artery Cannulation
The purpose of this study is to compare the efficacy of ultrasound- guided with the traditional palpation radial artery cannulation in critically ill children.
- Trial name
- NCT02668471
- Testing
- Ultrasound, traditional method
- Where
- Thailand
- Volunteers
- 84 people
- Sponsor
- Ramathibodi Hospital
Circadian Dysrhythmia, Sleep Disturbance
PICU-related Sleep and Circadian Dysregulation Pilot Study
A single center pilot trial investigating the feasibility of using actigraphy and salivary melatonin levels to measure the sleep and circadian rhythm of critically ill children aged 3 to 6 years old.
- Conditions
- Circadian Dysrhythmia, Sleep Disturbance, Critical Illness, Children, Only
- Trial name
- NCT06505447
- Testing
- Daytime light exposure, Daytime restricted feeding
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- State University of New York at Buffalo
Critically Ill
Protein Supplementation vs Standard Feeds in Underweight Critically Ill Children: A Dual-Centre Pilot RCT
This pilot trial is part of a long-term research program leading to a large trial to determine if a strategy of supplementing protein in a subset of critically ill children is superior to standard enteral nutrition care.
- Trial name
- NCT04565613
- Testing
- Enteral protein supplementation
- Where
- Singapore
- Volunteers
- 34 people
- Sponsor
- KK Women's and Children's Hospital
Extracorporeal Membrane Oxygenation, Children
Biomarkers of Brain Injury in Critically-Ill Children on Extracorporeal Membrane Oxygenation
The BEAM study is a multicenter, prospective, observational study in children supported on extracorporeal membrane oxygenation (ECMO).
- Conditions
- Extracorporeal Membrane Oxygenation, Children, Neurologic Injury
- Trial name
- BEAM (NCT05041712)
- Where
- 11 sites in United States
- Volunteers
- 455 people
- Sponsor
- Johns Hopkins University
Shock
Effectiveness and Safety of Penehyclidine Hydrochloride for Improving Microcirculatory Dysfunction in Critically Ill Children
This prospective randomized controlled trial was designed to evaluate whether the M1/M3-selective antagonist penehyclidine hydrochloride could more effectively reverse pediatric microcirculatory dysfunction than traditional…
- Trial name
- NCT07519226
- Testing
- atropine control group, penehyclidine hydrochloride group
- Where
- China
- Volunteers
- 98 people
- Sponsor
- Lihua Wen
Acute Kidney Injury, Acute Kidney Injury Due to Sepsis
Use of NGAL for Fluid Dosing and CRRT Initiation in Pediatric and Neonatal AKI
This study will follow patients admitted to the PICU with sepsis, NICU with sepsis or after abdominal surgery, or CICU who are identified as being at risk for developing acute kidney injury.
- Conditions
- Acute Kidney Injury, Acute Kidney Injury Due to Sepsis, Neonatal Sepsis
- Trial name
- Taking Focus 2 (NCT05114057)
- Testing
- Renal Angina Index (RAI)
- Where
- United States
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Critical Illness
Timing of Initiation of Parenteral Nutrition for Critically Ill Children
Parenteral Nutrition (PN) is prescribed to children with a non functioning gut. Timing of initiation of PN for critically ill children is a hotly issue.
- Trial name
- TPN (NCT04693143)
- Testing
- A randomized controlled open-label clinical trial.
- Volunteers
- 140 people
- Sponsor
- Menoufia University
Ventilator Associated Pneumonia, Tracheobronchitis
A Multi-Center Diagnostic Stewardship Program to Improve Respiratory Culture Utilization in Critically Ill Children
The objective of this study is to evaluate implementation of diagnostic stewardship programs as a strategy to safely reduce antibiotic use, and to generate evidence and tools to support dissemination of diagnostic stewardship…
- Trial name
- BrighT STAR (NCT04987840)
- Where
- 8 sites in United States
- Volunteers
- 15 people
- Sponsor
- Johns Hopkins University
Mechanical Ventilator Weaning, Critically Ill
Neurally Adjusted Ventilatory Assist for Weaning From Invasive Mechanical Ventilation in Critically Ill Children
The goal of this clinical trial is to compare weaning from mechanical ventilation in critically ill children. The main questions it aims to answer are: Will weaning with neurally adjusted ventilatory assist (NAVA) mode…
- Conditions
- Mechanical Ventilator Weaning, Critically Ill, Mechanical Ventilation, Neurally Adjusted Ventilatory Assist
- Trial name
- NCT06157593
- Testing
- NAVA
- Where
- Thailand
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Chulalongkorn University
Vitamin A Deficiency in Children
Prevalence Of Vitamin A Deficiency In Critically Ill Children With Sepsis And Its Association With Clinical Outcomes
Aim of the work is to assess the prevalence of vitamin A deficiency in critically ill children with sepsis and the association between vitamin A deficiency and clinical outcomes
- Trial name
- NCT06391437
- Testing
- Extraction of blood sample
- Where
- Egypt
- Volunteers
- 220 people, healthy volunteers welcome
- Sponsor
- Benha University
Airway Disease
Bronchoscopy Versus Imaging in Diagnosis of Airway Diseases in Critically Ill Children
Patients with suspected airway illness often go through a diagnostic assessment that includes chest radiographs, Computed tomography scans, and fiber optic bronchoscopy.
- Trial name
- NCT06526780
- Testing
- Bronchscopy
- Volunteers
- 100 people
- Sponsor
- Assiut University
Heart Arrest, Out-Of-Hospital, Wounds and Injuries
Pediatric Prehospital Airway Resuscitation Trial
This study is a Phase 3, multi-center, Bayesian Adaptive Sequential Platform Trial testing the effectiveness of different prehospital airway management strategies in the care of critically ill children.
- Conditions
- Heart Arrest, Out-Of-Hospital, Wounds and Injuries, Respiratory Insufficiency in Children, Child, Only
- Trial name
- Pedi-PART (NCT06364280)
- Testing
- BVM, SGA, ETI
- Where
- 10 sites in United States
- Volunteers
- 3,000 people
- Sponsor
- Ohio State University