Clinical trials: Critically Ill Child
Critical Illness, Pediatric Critical Illness
Brain Blood Flow and Cerebral Autoregulation Monitoring in Critically Ill Children
This study uses a non-invasive (external) ultrasound test called Transcranial Doppler (TCD) to measure how blood flows through the major arteries of the brain of children receiving care in the Pediatric Intensive Care Unit…
- Conditions
- Critical Illness, Pediatric Critical Illness, Respiratory Failure, Traumatic Brain Injury
- Trial name
- NCT07613918
- Testing
- Transcranial Doppler
- Where
- United States
- Volunteers
- 125 people
- Sponsor
- University of Wisconsin, Madison
Cardiac Output
Validation of Minimally Invasive Ultrasound Indicator Dilution Technique in Critically Ill Children
A novel method to measure cardiac index based on ultrasound indicator dilution technology (UIDT) has been developed by Transonic Systems Inc. (Ithaca, NY, USA).
- Trial name
- NCT00852254
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Transonic Systems Inc.
Sepsis, Critical Illness
Optimizing Vancomycin Therapy in Children
The purpose of Opt Vanc is to evaluate the feasibility of Bayesian dose adaptation, based on a previously-developed population pharmacokinetic (PK) model and a single optimally timed PK sample, to predict vancomycin area under…
- Conditions
- Sepsis, Critical Illness, Infections, Drug Toxicity
- Trial name
- Opt Vanc (NCT05691309)
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- Children's Hospital of Philadelphia
Critical Illness
Lorazepam Sedation for Critically Ill Children
This clinical trial is being performed under the Best Pharmaceuticals for Children Act, signed into law in 2002 in order to improve pediatric labeling for off-patent drugs.
- Trial name
- NCT00109395
- Testing
- Lorazepam, Midazolam, Lorazepam CI
- Where
- United States
- Volunteers
- 179 people
- Sponsor
- The Emmes Company, LLC
Cancer, Bleeding
Bleeding in Critically Ill Children With Underlying Oncologic Diagnoses
"Bleeding in Critically Ill Children with Underlying Oncologic Diagnoses ," will be a prospective observational cohort study looking at the epidemiology of bleeding in the pediatric ICU population at MSK.
- Trial name
- NCT04170231
- Where
- United States
- Volunteers
- 93 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Child, Critical Illness
Measuring the Metabolic Cost of Fever
Fever is part of the body's immune response, often triggered by infection. Fever is commonly treated with medicines such as paracetamol, mainly because people feel unwell with fever.
- Conditions
- Child, Critical Illness, Fever
- Trial name
- IGUANA (NCT02939781)
- Testing
- Indirect calorimetry
- Volunteers
- 12 people
- Sponsor
- Great Ormond Street Hospital for Children NHS Foundation Trust
Acute Kidney Injury
Role of Renal Artery Doppler in Critically Ill Children With Acute Kidney Injury
To detect frequency of acute kidney injury in critically ill children in Assuit university hospital. To detect associated AKI risk factors, severity and outcomes . To assess the value of use of renal Doppler ultrasound in AKI.
- Trial name
- NCT06202326
- Testing
- renal artery doppler
- Volunteers
- 45 people
- Sponsor
- Assiut University
Fluid Responsiveness, Cardiac Output
Echocardiography in Kids Intensive Care Decision Support
A study to determine if echocardiographically derived parameters, plethysmographic variability index and pulse pressure variation predict fluid responsiveness in children on PICU.
- Trial name
- ECHOKIDS (NCT01821742)
- Testing
- Ultrasound cardiac output measurement
- Where
- United Kingdom
- Volunteers
- 25 people
- Sponsor
- Imperial College London
Amoxicillin-clavulanate, Piperacillin-tazobactam
Precision Dosing of Beta-lactam Antibiotics in Critically Ill Children
The overall objective of this study is to investigate the impact of early model-informed precision dosing (MIPD) on target attainment of three beta-lactam antibiotics (amoxicillin-clavulanic acid, piperacillin-tazobactam and…
- Conditions
- Amoxicillin-clavulanate, Piperacillin-tazobactam, Meropenem
- Trial name
- MOMENTUM (NCT06929702)
- Testing
- Beta-lactam antibiotic, Beta-lactam model-informed precision dosing
- Where
- Belgium
- Volunteers
- 58 people
- Sponsor
- University Hospital, Ghent
Covid19, Pediatric ALL
Pediatric Intensive Care and COVID-19
In this prospective longitudinal cohort the investigators reported the clinical, and biological characteristics of all critically ill patients admitted in the pediatric intensive care unit (PICU) of Bicêtre Hospital during the…
- Conditions
- Covid19, Pediatric ALL, Infection, Critical Illness
- Trial name
- CLOVIS (NCT04544878)
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Bicetre Hospital
Intensive Care
Measurement of Cardiac Output and Intravascular Volume Status in Children Using COstatus (SH)
Assessment and monitoring of cardiac function in the pediatric intensive care unit (PICU) is an integral part of hemodynamic monitoring of critically ill patients whether it is done directly or indirectly.
- Trial name
- NCT01613859
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Transonic Systems Inc.
Emergencies, Cardiopulmonary Arrest
Simulation Trial of Telemedical Support for Paramedics
In the United States, the current standard of prehospital (i.e. outside of hospitals) emergency care for children with life-threatening illnesses in the community includes remote physician support for paramedics providing…
- Conditions
- Emergencies, Cardiopulmonary Arrest, Acute Respiratory Failure, Status Epilepticus
- Trial name
- R01 (NCT06441760)
- Testing
- Video teleconsultation, Audio support
- Where
- 9 sites in United States
- Volunteers
- 420 people
- Sponsor
- Boston Medical Center
Critically Ill
The Association of Vitamin D Supplementation With the Outcome in Critically Ill Children
Vitamin D deficiency is highly prevalent in critically ill adult and pediatric population that causes multiple adverse health outcomes including higher illness severity score, increased morbidity and mortality, multiple organ…
- Trial name
- NCT04536831
- Testing
- Vitamin D, Normal saline
- Where
- Pakistan
- Volunteers
- 96 people
- Sponsor
- Dr Mustahsin Khalil
Anemia
A Study to Observe the Causes and Treatment of Anemia in Critically Ill Children
The purpose of this study is to determine the incidence of anemia and blood transfusions and management of these in critically ill children
- Trial name
- NCT00211055
- Volunteers
- 1,201 people
- Sponsor
- Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
Heart Defects, Congenital, Critical Illness
Leuven Growing Into Deficit Follow-up Study
The key objective of the Leuven growing-into-deficit (GID) follow-up-study is to test the hypothesis that children with a congenital heart disease (CHD) show more neurocognitive impairment at the second follow-up at 7 years old…
- Conditions
- Heart Defects, Congenital, Critical Illness, Mental Processes, Child
- Trial name
- Leuven-GID (NCT01632813)
- Where
- Belgium
- Volunteers
- 172 people, healthy volunteers welcome
- Sponsor
- KU Leuven
Acute Lung Injury
Transfusion-related Acute Lung Injury: a Prospective Cohort Study in Critically Ill Children
Transfusions cause more adverse events in children than in adults. Patients in pediatric intensive care units (PICU) are particularly exposed to transfusions of plasma-rich blood products (red blood cell (RBC), plasma and…
- Trial name
- TRALI (NCT02613377)
- Testing
- Blood transfusion
- Where
- 4 sites in Canada
- Volunteers
- 717 people
- Sponsor
- St. Justine's Hospital
Pediatric Acute Respiratory Distress Syndrome (PARDS), Pediatric Respiratory Diseases
IPV and Lung Compliance in Invasively Ventilated Children
The goal of this observational study is to determine if Intrapulmonary Percussive Ventilation (IPV) improves lung compliance in children receiving conventional invasive mechanical ventilation.
- Conditions
- Pediatric Acute Respiratory Distress Syndrome (PARDS), Pediatric Respiratory Diseases, Lung Compliance
- Trial name
- NCT06836050
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Northwell Health
Delirium
Quetiapine Treatment for Pediatric Delirium
This is a prospective, double-blind, randomized controlled trial to begin determining the efficacy of quetiapine as a treatment for pediatric delirium in patients admitted to the pediatric intensive care unit (PICU)
- Trial name
- NCT03572257
- Testing
- Quetiapine
- Where
- United States
- Sponsor
- Medical College of Wisconsin
Acute Respiratory Infections, Critical Illness in Children
Serum Vitamin D Status in Critically Ill Children With Acute Respiratory Infections
Acute respiratory infections (ARIs) are among the leading causes of hospitalization, morbidity, and mortality in children worldwide, particularly among critically ill patients admitted to pediatric intensive care units (PICUs).
- Conditions
- Acute Respiratory Infections, Critical Illness in Children, Vitamin D Deficiency, Pediatric Respiratory Infections
- Trial name
- VITD-ARI (NCT06547749)
- Testing
- Serum 25-Hydroxyvitamin D Assessment
- Where
- Egypt
- Volunteers
- 63 people
- Sponsor
- Assiut University
Deep Venous Thrombosis
Catheter-Related Early Thromboprophylaxis With Enoxaparin (CRETE) Trial
The purpose of this phase 2a, multi-center, randomized controlled study, is to explore the efficacy of early prophylaxis against catheter-associated deep venous thrombosis (CADVT) in critically ill children.
- Trial name
- CRETE (NCT03003390)
- Testing
- Enoxaparin
- Where
- 6 sites in United States
- Volunteers
- 51 people
- Sponsor
- Yale University