Clinical trials: Critically Ill Child
Child, Intensive Care Unit Acquired Weakness
Clinical Effectiveness of the "PICU Up!" Multifaceted Early Mobility Intervention for Critically Ill Children
While mortality in U.S. pediatric intensive care units (PICUs) is improving, surviving children frequently develop persistent physical, cognitive, and psychological impairments.
- Conditions
- Child, Intensive Care Unit Acquired Weakness, Critical Illness, Hospital Acquired Pressure Ulcer
- Trial name
- PICU Up! (NCT04989790)
- Testing
- PICU Up!
- Where
- 11 sites in United States
- Volunteers
- 1,470 people
- Sponsor
- Johns Hopkins University
Extracorporeal Membrane Oxygenation
Oxygen Consumption In Critically Ill Children
The investigators propose to examine the relationship between DO2 and VO2 in critically ill patients requiring an Extracorporeal Membrane Oxygenation (ECMO) machine.
- Trial name
- NCT01521195
- Testing
- Extracorporeal blood flow via ECMO machine
- Where
- Canada
- Volunteers
- 11 people
- Sponsor
- The Hospital for Sick Children
Pain, Delirium in the Intensive Care Unit
Therapeutic Cuddling in Critically Ill Children
2.1 CONTEXT Pain and agitation are common comorbidities of pediatric critical illness due to both underlying disease processes and ICU related therapies.
- Trial name
- THE ChICKS (NCT07562048)
- Testing
- Therapeutic cuddling, Standard of care
- Where
- Canada
- Volunteers
- 112 people
- Sponsor
- University of Calgary
Children
Safety and Efficacy of Fentanyl Citrate in Children
Title: Safety and efficacy of fentanyl citrate in combination with midazolam in critically ill children with mechanical ventilation Objective: To evaluate the safety and efficacy of fentanyl citrate in combination with midazolam…
- Trial name
- NCT02172014
- Testing
- midazolam and fentanyl citrate infusion, midazolam and normal saline infusion
- Where
- South Korea
- Volunteers
- 44 people
- Sponsor
- Seoul National University Hospital
Critical Illness, Enteral Feeding Intolerance
Evaluation of Enteral Nutrition in Critically Ill Children
The aim of this study was to evaluate the effect of calorie and enteral feeding timing on survival in critically ill children receiving inotropic, vasopressor and inodilatory supplements.
- Trial name
- NCT04013893
- Where
- Turkey (Türkiye)
- Volunteers
- 20 people
- Sponsor
- Cukurova University
Critical Illness
Live Music for Critically Ill Children
Rationale: Admission into a pediatric intensive care unit (PICU) can be a highly stressful experience, with many children demonstrating posttraumatic stress symptoms.
- Trial name
- NCT06845787
- Testing
- Live-music therapy
- Volunteers
- 50 people
- Sponsor
- University Medical Center Groningen
Sepsis, Severe
Effect of Probiotics on Cytokines in Sepsis in Children
To assess the effect of probiotics on cytokine's level(interleukin 6 and Transforming growth factor-β1)in children admitted to PICU with sepsis.
- Trial name
- NCT05467605
- Testing
- probiotics( Lactobacillus acidophilus, lactobacillus delbruekii and lactobacillus fermentum 10 billions),, maltose dissolved in distilled water
- Where
- Egypt
- Volunteers
- 80 people
- Sponsor
- Cairo University
Critical Illness, Child
A Prospective Longitudinal Mixed Study on the Change Track of Sleep Quality in Critically Ill Children
This research adopts the uniform parallel hybrid research design; The quantitative data and qualitative data were collected at the same time, and then the quantitative and qualitative data were analyzed respectively.
- Conditions
- Critical Illness, Child, Sleep Disorder
- Trial name
- NCT05863299
- Where
- China
- Volunteers
- 247 people
- Sponsor
- Children's Hospital of Fudan University
Refeeding Syndrome
Prevention of Refeeding Syndrome
To determine effects of different caloric density intake in prevention of refeeding syndrome in critically ill children
- Trial name
- NCT06589479
- Volunteers
- 50 people
- Sponsor
- Assiut University
Catheter Complications, Critical Illness
"Syringe Free" Long-Axis In-Plane vs. Short-Axis Out-of-Plane Approach for Central Venous Catheter Placement
Internal jugular, subclavian, or femoral veins are often used for central venous catheter (CVC) placement. Regardless of which vein is preferred, the "Seldinger" technique is used most frequently.
- Trial name
- NCT04684069
- Testing
- Long-axis syringe free in-plane, Short-axis out-of-plane
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Ataturk University
Fluid Therapy, Hemodynamics
Predicting Fluid Responsiveness in Mechanically Ventilated Critically Ill Children Using Transthoracic Echocardiography
Initial fluid resuscitation remains the first treatment step for most children experiencing circulatory failure and/or systemic hypotension.
- Conditions
- Fluid Therapy, Hemodynamics, Hypovolemia, Shock
- Trial name
- PREDIPEN (NCT05054452)
- Testing
- Echocardiographic assessment
- Where
- France
- Volunteers
- 4 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Critical Illness, Hyperglycemia
Study of High Blood Sugars and Insulin in Hospitalized, Critically Ill Children
BACKGROUND AND PURPOSE Critical illness hyperglycemia (CIH) - elevated blood glucose in the critically ill patient population - has gained much interest among health care providers over the past several years.
- Trial name
- CIH (NCT00487006)
- Testing
- Serum Lab testing
- Where
- United States
- Volunteers
- 209 people
- Sponsor
- Children's Healthcare of Atlanta
Septic Shock
Neuroimaging and Neuromonitoring in Critically Ill Children With Sepsis
In critically ill children with severe sepsis, neurophysiologic derangements often proceed undetected and can lead to irreversible brain injury causing neurocognitive and behavioral deficits.
- Trial name
- NCT03055455
- Testing
- MR imaging
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Children's Hospital of Philadelphia
Critical Illness
Use of In-Line Filtration in Critically Ill Children
The purpose of this study is to determine whether the use of in-line filtration shows any effect on the outcome of sepsis, systemic inflammatory response syndrome (SIRS), thrombosis, or organ failure in critically ill children…
- Trial name
- NCT00209768
- Testing
- Filter: NOE96E, ELD96E, NLF1E, TNA1E
- Where
- Germany
- Volunteers
- 821 people
- Sponsor
- Hannover Medical School
Mechanical Ventilation
Assessment of Esophageal Pressure Reliability to Estimate Pleural Pressure in Critically Ill Children
Background During ventilatory assistance, optimization of settings is critical to allow a personalized support and avoid over- or under-assistance.
- Trial name
- APPLE (NCT02762279)
- Testing
- esophageal and pleural pressure measurement
- Where
- Canada
- Volunteers
- 12 people
- Sponsor
- St. Justine's Hospital
Acute Kidney Injury, Acute Kidney Injury Due to Sepsis
QUELIMMUNE (SCD-PED) PediAtric SurVeillance REgistry
QUELIMMUNE is FDA-approved under an HDE for the treatment of pediatric patients (weight ≥10kg and age ≤22 years) with AKI due to sepsis or a septic condition on antibiotic therapy and requiring RRT.
- Trial name
- SAVE (NCT06517810)
- Testing
- QUELIMMUNE (SCD-PED)
- Where
- 15 sites in United States
- Volunteers
- 50 people
- Sponsor
- SeaStar Medical
Children in the Pediatric Intensive Care Unit or General Pediatric Care Unit Requiring a Central Venous Catheter
Study of the Use of Coated Venous Catheters in the Critically Ill Child
This study should help determine to determine whether or not the use of an antibiotic coated catheter will significantly reduce the number of central line related bloodstream infections in children requiring a CVC.
- Trial name
- NCT00202813
- Testing
- Cook Spectrum Pediatric Central Venous Catheter Anti-microbial Impregnated Polyurethane and Arrow Pediatric Central Venous Catheter
- Where
- United States
- Volunteers
- 500 people
- Sponsor
- Corewell Health West
Dexmedetomidine, Mechanical Ventilation Complication
DOSE Trial of Opioid Sparing Effect
Multicenter, double blind randomized controlled trial of fentanyl vs. fentanyl + dexmedetomidine as the initial regimen for maintenance of sedation in mechanically-ventilated, critically ill children.
- Conditions
- Dexmedetomidine, Mechanical Ventilation Complication, Critically Ill
- Trial name
- DOSE (NCT03938857)
- Testing
- Fentanyl, Dexmedetomidine
- Where
- 19 sites in United States
- Volunteers
- 30 people
- Sponsor
- Duke University
Critical Illness
Tight Glycemic Control With Intensive Insulin Therapy in PICU
In a previous study, the investigators showed that tight blood glucose control with insulin during intensive care reduced morbidity and mortality in adult intensive care patients.
- Trial name
- NCT00214916
- Testing
- intensive insulin therapy (Actrapid IV to normoglycemia), conventional insulin therapy (Actrapid IV only for excessive hyperglycemia)
- Where
- Belgium
- Volunteers
- 700 people
- Sponsor
- Greet Van den Berghe
Critical Illness, Children
Functional Recovery in Critically Ill Children
Intensive Care Unit-acquired weakness (ICU-AW) is a well-recognized, important and preventable sequelae of critical illness, affecting up to 60% of adult ICU patient.
- Trial name
- NCT01724593
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- Karen Choong