Clinical trials: Critically Ill Child, active
Clinical Implementation, Standardized Tube Feeding Care
Clinical Implementation of the Group Standard for Enteral Feeding Care in Critically Ill Children
This study aims to evaluate the feasibility and effectiveness of the " Standard for Enteral Feeding Care in Critically Ill Pediatric Patients " (T/CNAS 45-2024) in a multicenter setting.
- Conditions
- Clinical Implementation, Standardized Tube Feeding Care, Enteral Nutrition
- Trial name
- NCT07441746
- Testing
- Evidence-based tube feeding care, Routine Enteral Feeding Care
- Where
- China
- Volunteers
- 500 people
- Sponsor
- Children's Hospital of Fudan University
Ventilator Associated Pneumonia ( VAP)
Pre-clinical Diagnosis Using Integrated Microbial and Host Response Signatures to Improve Outcomes From Ventilator-associated Pneumonia in Critically Ill Children
Ventilator-associated pneumonia (VAP), defined as pneumonia occurring 48 hours after initiation of invasive mechanical ventilation, is insidious in onset and severe in consequence.
- Trial name
- VAP-Dx (NCT07026656)
- Where
- United Kingdom
- Volunteers
- 300 people
- Sponsor
- University of Cambridge
Renal Disease, Liver Diseases
Outcomes of Children After Hospitalization in Intensive Care Unit
More than 10,000 children are hospitalized in an PICU every year in Canada. While most of them will survive their PICU hospitalization and their critical illness, some children will not recover to their pre-illness level.
- Conditions
- Renal Disease, Liver Diseases, Heart Diseases, Trauma Injury
- Trial name
- APCI (NCT06124092)
- Testing
- neurocognitive tests
- Where
- 8 sites in Canada
- Volunteers
- 690 people
- Sponsor
- St. Justine's Hospital
Pediatric Intensive Care Units
A Korean Point Prevalence Study of Acute Rehabilitation for Kids in the PICU (PARK-PICU)
This study investigates the prevalence of acute rehabilitation practices among children in pediatric intensive care units (PICUs).
- Trial name
- NCT07629297
- Testing
- Acute Rehabilitation (Observed Practice)
- Where
- 13 sites in South Korea
- Volunteers
- 396 people
- Sponsor
- Samsung Medical Center
Electrolytes Abnormalities, Children
Serum Electrolyte Abnormalities as Prognostic Factor for Outcome in Critically Ill Children
The aim of this study is to evaluate the clinical profile and outcome of children with serum electrolyte abnormalities admitted at Pediatric Intensive Care Unit in Assuit University Children Hospital.
- Conditions
- Electrolytes Abnormalities, Children, Prognostic Factors
- Trial name
- NCT07205562
- Volunteers
- 200 people
- Sponsor
- Assiut University
Probiotic, Ventilator Associated Pneumonia
Probiotic Role in Prevention of Ventilator Associated Pneumonia in Critically- Ill Children Admitted at Pediatric Intensive Care Unit
The aim of the work is to evaluate the impact of Probiotics supplementation on prevention of ventilator associated pneumonia in critically ill children admitted at Pediatric Intensive Care Unit at Tanta University Hospitals.
- Conditions
- Probiotic, Ventilator Associated Pneumonia, Critically- Ill Children
- Trial name
- NCT07848165
- Testing
- Probiotics, Standard management
- Where
- Egypt
- Volunteers
- 68 people
- Sponsor
- Tanta University
Critical Illness, Severe Sepsis
A Multi-Center Data System and Collaborative Network in China for Severe Infection and Sepsis Children
1. To research the current situation of severe infection in children in China, and to investigate the incidence, prognosis and disease burden of severe infection in children in different regions of China. 2.
- Trial name
- NCT04955210
- Testing
- Not applicable（Cohort study）
- Where
- China
- Volunteers
- 5,000 people
- Sponsor
- Children's Hospital of Fudan University
Decision Making, Neonatal Critical Illness
Building Relationship, Improving Dialogue, and Growing Empathy (BRIDGE): An Intervention to Support Decision Making for Critically Ill Children
Parents of young children in the intensive care unit may be faced with decisions about their child's care. The Building Relationship, Improving Dialogue, and Growing Empathy (BRIDGE) intervention was designed to help support…
- Conditions
- Decision Making, Neonatal Critical Illness, Pediatric Critical Illness
- Trial name
- BRIDGE (NCT07390773)
- Testing
- BRIDGE intervention
- Where
- 3 sites in United States
- Volunteers
- 495 people
- Sponsor
- Duke University
Critical Illness
PICU Up!: A Pilot Stepped-wedge Trial of a Multicomponent Early Mobility Intervention for Critically Ill Children
Recent decreases in Pediatric Intensive Care Unit (PICU) mortality rates have been offset by increased morbidity and length of stay for vulnerable young patients.
- Trial name
- PICU Up! (NCT03860168)
- Testing
- PICU Up!
- Where
- United States
- Volunteers
- 2,500 people
- Sponsor
- Johns Hopkins University
Critical Illness, Respiratory Failure
PRactice of VENTilation in Critically Ill PEDiatric Patients
The goal of this worldwide observational study is to investigate ventilation practice in critically ill pediatric patients. The main questions it aims to answer are: 1.
- Trial name
- PRoVent-PED (NCT06220825)
- Where
- Netherlands
- Volunteers
- 2,500 people
- Sponsor
- University Medical Center Groningen
Acute Respiratory Infections, Critical Illness in Children
Serum Vitamin D Status in Critically Ill Children With Acute Respiratory Infections
Acute respiratory infections (ARIs) are among the leading causes of hospitalization, morbidity, and mortality in children worldwide, particularly among critically ill patients admitted to pediatric intensive care units (PICUs).
- Conditions
- Acute Respiratory Infections, Critical Illness in Children, Vitamin D Deficiency, Pediatric Respiratory Infections
- Trial name
- VITD-ARI (NCT06547749)
- Testing
- Serum 25-Hydroxyvitamin D Assessment
- Where
- Egypt
- Volunteers
- 63 people
- Sponsor
- Assiut University
Acute Kidney Injury, Renal Replacement Therapy
Use of NGAL for Fluid Dosing and CRRT Initiation in Pediatric AKI
This study follows a group of patients admitted to the PICU who are identified as being at risk for developing acute kidney injury.
- Conditions
- Acute Kidney Injury, Renal Replacement Therapy, Pediatric Intensive Care Units
- Trial name
- Taking Focus 2 (NCT03541785)
- Where
- United States
- Volunteers
- 420 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Emergencies, Cardiopulmonary Arrest
Simulation Trial of Telemedical Support for Paramedics
In the United States, the current standard of prehospital (i.e. outside of hospitals) emergency care for children with life-threatening illnesses in the community includes remote physician support for paramedics providing…
- Conditions
- Emergencies, Cardiopulmonary Arrest, Acute Respiratory Failure, Status Epilepticus
- Trial name
- R01 (NCT06441760)
- Testing
- Video teleconsultation, Audio support
- Where
- 9 sites in United States
- Volunteers
- 420 people
- Sponsor
- Boston Medical Center
Critical Illness
Live Music for Critically Ill Children
Rationale: Admission into a pediatric intensive care unit (PICU) can be a highly stressful experience, with many children demonstrating posttraumatic stress symptoms.
- Trial name
- NCT06845787
- Testing
- Live-music therapy
- Volunteers
- 50 people
- Sponsor
- University Medical Center Groningen
Critical Illness, Pediatric Critical Illness
Brain Blood Flow and Cerebral Autoregulation Monitoring in Critically Ill Children
This study uses a non-invasive (external) ultrasound test called Transcranial Doppler (TCD) to measure how blood flows through the major arteries of the brain of children receiving care in the Pediatric Intensive Care Unit…
- Conditions
- Critical Illness, Pediatric Critical Illness, Respiratory Failure, Traumatic Brain Injury
- Trial name
- NCT07613918
- Testing
- Transcranial Doppler
- Where
- United States
- Volunteers
- 125 people
- Sponsor
- University of Wisconsin, Madison
Pediatric Intensive Care Units
Nutritional Status of Critically Ill Children in Pediatric Intensive Care Units at Sohag University Hospitals
The goal of this observational study is to evaluate nutritional status of critically ill patients admitted to Pediatric Intensive Care Units (PICU) at Sohag University Hospital and its correlation with their outcome as regarding…
- Trial name
- NCT07041658
- Volunteers
- 100 people
- Sponsor
- Sohag University
Seizures
Electrographic Seizure Management and Neurobehavioral Outcomes in Critically Ill Children
Electrographic seizures are common in critically ill patients leading to increased use of resource-intense continuous EEG monitoring for seizure identification and management.
- Trial name
- NCT03419260
- Testing
- Clinically indicated EEG monitoring.
- Where
- United States
- Volunteers
- 2,500 people
- Sponsor
- Children's Hospital of Philadelphia
Gastrointestinal Manifestations in Critically Ill Children
Gastrointestinal Manifestations in Critically Ill Children Admitted in PICU of Children's Hospital Assuit University
Gastrointestinal complications are common in critically ill children. GIC are commonly observed, as either a primary reason for admission or as a part of multiple organ dysfunction syndromes MODS in children admitted in the…
- Trial name
- NCT06235528
- Volunteers
- 83 people
- Sponsor
- Assiut University
Deep Venous Thrombosis
Catheter-Related Early Thromboprophylaxis With Enoxaparin Studies
The goal of the CRETE Studies is to investigate the newly identified age-dependent heterogeneity in the efficacy of enoxaparin in reducing the risk of central venous catheter-associated deep venous thrombosis in critically ill…
- Trial name
- CRETE (NCT04924322)
- Testing
- Enoxaparin
- Where
- 22 sites in United States
- Volunteers
- 258 people
- Sponsor
- Yale University
Delirium, Critical Illness
Goal-Directed Sedation in Mechanically Ventilated Infants and Children
Ventilated pediatric patients are frequently over-sedated and the majority suffer from delirium, a form of acute brain dysfunction that is an independent predictor of increased risk of dying, length of stay, and costs.
- Conditions
- Delirium, Critical Illness, Sedation Complication, Executive Dysfunction
- Trial name
- mini-MENDS (NCT04801589)
- Testing
- Dexmedetomidine, Midazolam
- Where
- United States
- Volunteers
- 372 people
- Sponsor
- Vanderbilt University Medical Center