Clinical trials: Critically Ill Children
Acute Respiratory Infections, Critical Illness in Children
Serum Vitamin D Status in Critically Ill Children With Acute Respiratory Infections
Acute respiratory infections (ARIs) are among the leading causes of hospitalization, morbidity, and mortality in children worldwide, particularly among critically ill patients admitted to pediatric intensive care units (PICUs).
- Conditions
- Acute Respiratory Infections, Critical Illness in Children, Vitamin D Deficiency, Pediatric Respiratory Infections
- Trial name
- VITD-ARI (NCT06547749)
- Testing
- Serum 25-Hydroxyvitamin D Assessment
- Where
- Egypt
- Volunteers
- 63 people
- Sponsor
- Assiut University
Sedation Complication
Validation of a Processed EEG Device for Monitoring Sedation in PICU
The goal of this prospective observational study is to validate pEEG as a monitoring tool for the analgosedation level in mechanically-ventilated critically ill children, receiving or not-receiving NMBAs.
- Trial name
- NCT05969483
- Testing
- pEEG monitoring
- Where
- Italy
- Volunteers
- 150 people
- Sponsor
- Azienda Ospedaliera di Padova
Hearing Status
The Effect of Continuous, Various Doses of Furosemide Drip on Hearing as Measured by Acoustic Emission
Pediatric patients, during their illness often treated with furosemide (Lasix) continuous drip, often, with dosages above 4-6mg/kg/day (the recommended dose).
- Trial name
- NCT00945386
- Where
- Israel
- Volunteers
- 60 people
- Sponsor
- Rabin Medical Center
Catheter Complications, Critical Illness
"Syringe Free" Long-Axis In-Plane vs. Short-Axis Out-of-Plane Approach for Central Venous Catheter Placement
Internal jugular, subclavian, or femoral veins are often used for central venous catheter (CVC) placement. Regardless of which vein is preferred, the "Seldinger" technique is used most frequently.
- Trial name
- NCT04684069
- Testing
- Long-axis syringe free in-plane, Short-axis out-of-plane
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Ataturk University
Hyperoxia, Hypoxia
Computer-assisted Oxygen Therapy Weaning in Critically Ill Children
The study is designed to evaluate the feasibility, safety and clinical utility of using an adaptive model to wean oxygen by computer assistance.
- Trial name
- NCT03550469
- Testing
- Computer-assisted Oxygen Weaning
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- Stanford University
Refeeding Syndrome, Syndrome, Refeeding
Refeeding Syndrome in Critically Ill Children
Refeeding syndrome (RFS) is the a metabolic disturbance which occurs as a result of reinstitution of nutrition in people who are starved, severely malnourished, or metabolically stressed because of severe illness.
- Trial name
- NCT06583928
- Volunteers
- 54 people
- Sponsor
- Assiut University
Oropharyngeal Dysphagia
Nursing Care Bundle on Oral Intake Among Critically Ill Children With Post-Extubation Dysphagia
the aim of this study is to evaluate the effect of Nursing care Bundle on Oral Intake among Critically Ill Children with Post-Extubation Dysphagia
- Trial name
- NCT06814457
- Testing
- a nursing care bundle on oral intake
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Kafrelsheikh University
Metabolic Acidosis, Acid-Base Imbalance
Frequency of Metabolic Acidosis in the Pediatric Intensive Care Unit
Metabolic acidosis is one of the most common acid-base disturbances encountered in critically ill children and often reflects underlying disease severity.
- Conditions
- Metabolic Acidosis, Acid-Base Imbalance, Critical Illness in Children
- Trial name
- NCT07803263
- Volunteers
- 140 people
- Sponsor
- Assiut University
Critical Illness
Safety and Dose Escalation Study of Zinc Supplementation in Critically Ill Children
The purpose of the study is 1) to determine whether administration of intravenous zinc to critically ill children is safe, and 2) to determine an appropriate dose of zinc supplementation.
- Trial name
- NCT01062009
- Testing
- Zinc sulfate
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- UCSF Benioff Children's Hospital Oakland
Fluid Therapy, Hemodynamics
Predicting Fluid Responsiveness in Mechanically Ventilated Critically Ill Children Using Transthoracic Echocardiography
Initial fluid resuscitation remains the first treatment step for most children experiencing circulatory failure and/or systemic hypotension.
- Conditions
- Fluid Therapy, Hemodynamics, Hypovolemia, Shock
- Trial name
- PREDIPEN (NCT05054452)
- Testing
- Echocardiographic assessment
- Where
- France
- Volunteers
- 4 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Critical Illness, Mechanical Ventilation Complication
Enteral Feeding in Mechanically Ventilated Children
This prospective cohort study aims to assess enteral feeding practices and the adequacy of energy and protein delivery among mechanically ventilated children admitted to the pediatric intensive care unit.
- Trial name
- NCT07884838
- Volunteers
- 60 people
- Sponsor
- Assiut University
Pediatric Disorder, Critical Illness
Attitudes to Decisions to Withdraw or Withhold Life-sustaining Treatments in Critically Ill Children
The aim of this study is to investigate attitudes on decisions to withdraw or withhold life-sustaining treatments in critically ill children in Swedish intensive care units.
- Conditions
- Pediatric Disorder, Critical Illness, Ethics, Narrative
- Trial name
- LSTPedSurvey (NCT06281743)
- Testing
- Survey
- Where
- Sweden
- Volunteers
- 100 people
- Sponsor
- Göteborg University
PTSD, Critical Illness
The Experiences of Children and Caregivers Given PICU Storybooks
1. To assess the acceptability and feasibility of a study design aimed at evaluating the efficacy of a newly developed intervention for children and their caregivers following discharge from PICU 2.
- Conditions
- PTSD, Critical Illness, Depression, Anxiety
- Trial name
- NCT04041401
- Testing
- PICU storybook
- Where
- United Kingdom
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Surrey
Heart Arrest, Out-Of-Hospital, Wounds and Injuries
Pediatric Prehospital Airway Resuscitation Trial
This study is a Phase 3, multi-center, Bayesian Adaptive Sequential Platform Trial testing the effectiveness of different prehospital airway management strategies in the care of critically ill children.
- Conditions
- Heart Arrest, Out-Of-Hospital, Wounds and Injuries, Respiratory Insufficiency in Children, Child, Only
- Trial name
- Pedi-PART (NCT06364280)
- Testing
- BVM, SGA, ETI
- Where
- 10 sites in United States
- Volunteers
- 3,000 people
- Sponsor
- Ohio State University
Intensive Care
Measurement of Cardiac Output and Intravascular Volume Status in Children Using COstatus (SH)
Assessment and monitoring of cardiac function in the pediatric intensive care unit (PICU) is an integral part of hemodynamic monitoring of critically ill patients whether it is done directly or indirectly.
- Trial name
- NCT01613859
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Transonic Systems Inc.
Critical Illness
PICU Patient Diary
The PICU-Diary study is a prospective single centre pilot study in the Pediatric Critical Care Unit at McMaster Children's Hospital.
- Trial name
- NCT03777527
- Where
- Canada
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- McMaster University
Clinical Implementation, Standardized Tube Feeding Care
Clinical Implementation of the Group Standard for Enteral Feeding Care in Critically Ill Children
This study aims to evaluate the feasibility and effectiveness of the " Standard for Enteral Feeding Care in Critically Ill Pediatric Patients " (T/CNAS 45-2024) in a multicenter setting.
- Conditions
- Clinical Implementation, Standardized Tube Feeding Care, Enteral Nutrition
- Trial name
- NCT07441746
- Testing
- Evidence-based tube feeding care, Routine Enteral Feeding Care
- Where
- China
- Volunteers
- 500 people
- Sponsor
- Children's Hospital of Fudan University
Emergencies, Cardiopulmonary Arrest
Simulation Trial of Telemedical Support for Paramedics
In the United States, the current standard of prehospital (i.e. outside of hospitals) emergency care for children with life-threatening illnesses in the community includes remote physician support for paramedics providing…
- Conditions
- Emergencies, Cardiopulmonary Arrest, Acute Respiratory Failure, Status Epilepticus
- Trial name
- R01 (NCT06441760)
- Testing
- Video teleconsultation, Audio support
- Where
- 9 sites in United States
- Volunteers
- 420 people
- Sponsor
- Boston Medical Center
Acetaminophen,Mechanical Ventilation,Critically Ill Children
Clinical Efficacy of Acetaminophen in Mechanical Ventilation in Children With New Coronary Pneumonia
Patients were randomized to receive either paracetamol during mechanical ventilation. When patients were randomized to receive paracetamol (40 mg/kg per day in 4 doses), a placebo infusion of normal saline was administered…
- Trial name
- NCT05691088
- Testing
- Paracetamol injection
- Where
- China
- Volunteers
- 128 people, healthy volunteers welcome
- Sponsor
- The Second Clinical Medical College of Jinan University
Vitamin A Deficiency in Children
Prevalence Of Vitamin A Deficiency In Critically Ill Children With Sepsis And Its Association With Clinical Outcomes
Aim of the work is to assess the prevalence of vitamin A deficiency in critically ill children with sepsis and the association between vitamin A deficiency and clinical outcomes
- Trial name
- NCT06391437
- Testing
- Extraction of blood sample
- Where
- Egypt
- Volunteers
- 220 people, healthy volunteers welcome
- Sponsor
- Benha University