Clinical trials: Critically Ill Intensive Care Unit Patients
COVID-19
Therapeutic Plasmapheresis in Critically Ill Adult Patients With COVID-19 Confirmed Diagnosis
Introduction: The SARS-CoV-2 outbreak has left more than two million infected worldwide in the first four months of COVID-19 epidemic.
- Trial name
- PLASMA (NCT04480632)
- Testing
- Convalescent plasma
- Where
- Colombia
- Volunteers
- 44 people
- Sponsor
- Fundación Cardiovascular de Colombia
Gastric Residual Volume, Abdominal Distension
Abdominal Massage for Gastric Residual Volume in Surgical Patients
This randomized controlled trial aimed to evaluate the effect of abdominal massage on gastric residual volume (GRV) and abdominal distension in surgical intensive care patients receiving enteral nutrition.
- Conditions
- Gastric Residual Volume, Abdominal Distension, Enteral Nutrition, Massage Therapy
- Trial name
- NCT07018414
- Testing
- Abdominal Massage
- Where
- Turkey (Türkiye)
- Volunteers
- 84 people
- Sponsor
- Marmara University
Physician-Family Communication in Intensive Care Units, Surrogate Decision-making for Critically Ill Patients
Family Support Intervention in Intensive Care Units (The Four Supports Study)
The purpose of this study is to test the effectiveness of a multi-faceted communication intervention for family members of critically ill patients to reduce the family members' long-term symptoms of depression and anxiety.
- Trial name
- NCT01107704
- Testing
- Family Support Intervention
- Where
- United States
- Volunteers
- 159 people
- Sponsor
- University of Pittsburgh
Critically Ill, Extubation
Does Tracheal Suction During Extubation in Intensive Care Unit Decrease Functional Residual Capacity
Little is known about the procedure of extubation of patients admitted in Intensive Care Units (ICU). In particular, effects of tracheal suction during extubation have never been evaluated.
- Conditions
- Critically Ill, Extubation, Intensive Care Unit
- Trial name
- NCT03681626
- Testing
- no tracheal suction, tracheal suction
- Where
- France
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University Hospital, Rouen
Device Dislocation
A Comparative Study of Support Devices for Ventilator-Assisted ICU Patients
Assisting critically ill patients with early mobilization or early ambulation during their stay in the intensive care unit (ICU) can reduce the duration of mechanical ventilation use, length of ICU or hospital stay, probability…
- Trial name
- NCT05996055
- Testing
- improved version_support device, the NTUH version_support device
- Where
- Taiwan
- Volunteers
- 30 people
- Sponsor
- National Taiwan University Hospital
Delirium
Environmental Intervention on Delirious Patients
The implementation of environmental intervention program reduced the duration of delirium and length of stay at the ICU in critically-ill surgical patients.
- Trial name
- NCT04042649
- Testing
- environmental intervention
- Where
- South Korea
- Volunteers
- 192 people
- Sponsor
- Asan Medical Center
Nutritional Therapy in an ICU, Critically Ill Patients Requiring Mechanical Ventilation
Will the Use of Respiratory Quotient ''RQ'' Improve Treatment Outcomes for Intensive Care Unit (ICU) Patients?
Introduction and assumptions of the research project: Patients treated in intensive care units (ICUs) require comprehensive treatment. Nutrition is an important and integral part of this therapy.
- Trial name
- RQCal (NCT07457554)
- Testing
- RQ guided nutrition, Standard Treatment (Guideline-Based)
- Where
- Poland
- Volunteers
- 236 people
- Sponsor
- Poznan University of Medical Sciences
Critical Illness, Intensive Care Unit
Intensive Care Unit Activity in France From the National Database Between 2013 and 2019
Using data from the French National Uniform Hospital Discharge Database (systematically collecting administrative and medical information related to all hospitalized patients in France for care reimbursement purposes), the…
- Trial name
- ICU_ACTIVITY (NCT05353023)
- Where
- France
- Volunteers
- 1,594,801 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Critical Illness, Fever
Safety and Efficacy of Acetaminophen in the Intensive Care Unit.
The intensive care unit (ICU) team needs to know what effects acetaminophen has in critically ill patients. Acetaminophen is better known as Tylenol. It is the drug given to reduce fever.
- Trial name
- SEA-ICU (NCT02280239)
- Testing
- Acetaminophen
- Where
- Canada
- Volunteers
- 10 people
- Sponsor
- University of British Columbia
Sleep Disorders, Delirium
Evaluation of Risk Factors of Sleep Quality in Intensive Care Unit
The aim of this study was to investigate the relationship between sleep disturbances and delirium in surgical ICU patients. The study set up to test the hypothesis that the occurrence of delirium is associated to the alteration…
- Trial name
- NCT00507481
- Where
- 2 sites in Italy
- Sponsor
- University of Turin, Italy
Analgesia, Sedation
Surgical Stress Index as a Tool for Monitoring Analgesia and/or Sedation in Critically Ill Patients
The hypothesis of the study is: Does the Surgical Stress Index (SSI) correlate with the Behavioral Pain Scale (BPS), the Ramsay Sedation Scale (RSS)and/or the Behavioral Pain Scale(BPV) and can therefore be used to monitor the…
- Conditions
- Analgesia, Sedation, Mechanical Ventilation, Pain
- Trial name
- NCT00789412
- Where
- Germany
- Volunteers
- 60 people
- Sponsor
- University Hospital Schleswig-Holstein
Critical Illness
Administrative Workload in the Intensive Care Unit
A prospective observational study in the Intensive Care Unit and the Medium Care Unit in a university hospital in Amsterdam. Recent studies show that administrative tasks occupy more than 30% of the workload.
- Trial name
- AWIC (NCT02730221)
- Where
- Netherlands
- Volunteers
- 200 people
- Sponsor
- Amsterdam UMC, location VUmc
Critical Illness, Acute Kidney Injury
Development of a Web-based Multicenter Registry on the Use of oXiris Membrane for EBPTs in Critically Ill Patients
The use of extracorporeal blood purification therapies (EBPT) is becoming increasingly widespread worldwide in everyday clinical practice, particularly in the critical care setting.
- Conditions
- Critical Illness, Acute Kidney Injury, Sepsis, Systemic Inflammatory Response Syndrome
- Trial name
- NCT03807414
- Testing
- oXiris
- Where
- 12 sites in Italy
- Volunteers
- 270 people
- Sponsor
- Careggi Hospital
ICU Patients
Scandinavian Intensive Care Unit (ICU) Glutamine Study
This is a prospective double-blinded placebo-controlled block randomized study in intensive care patients comparing intravenous glutamine supplementation to placebo. The hypothesis is an improvement of clinical outcome.
- Trial name
- NCT00922714
- Testing
- Glutamine
- Where
- Sweden
- Volunteers
- 1,000 people
- Sponsor
- Scandinavian Critical Care Trials Group
Sepsis - to Reduce Mortality in the Intensive Care Unit, Sepsis
Beta-Lactam Antibiotics InitiaL ExpoSure OptimisEd in CriticallY Ill Patients with SEpsis
The aim of this study is to investigate if an initial short double dose of beta-lactam antibiotics will reduce mortality in critically ill patients with sepsis.
- Conditions
- Sepsis - to Reduce Mortality in the Intensive Care Unit, Sepsis, Septic Shock
- Trial name
- BULLSEYE (NCT06766461)
- Testing
- Double dosing of beta-lactam antibiotic
- Where
- Netherlands
- Volunteers
- 980 people
- Sponsor
- Erasmus Medical Center
Post-Intensive Care Syndrome (PICS), Critical Illness Recovery
Virtual Reality for Recovery After Intensive Care (PICS)
The goal of this clinical trial is to learn if virtual reality (VR) helps improve thinking and memory skills in adults who have stayed in the intensive care unit (ICU).
- Conditions
- Post-Intensive Care Syndrome (PICS), Critical Illness Recovery, Rehabilitation After Critical Illness, Rehabilitation Exercise of ICU Patients
- Trial name
- VR4ICU (NCT07585500)
- Testing
- Immersive VR Multi-Domain Rehabilitation, Tablet-Based Multi-Domain Training
- Where
- Portugal
- Volunteers
- 51 people
- Sponsor
- University of Minho
Critical Illness, Infection
Pharmacokinetics/Pharmacodynamics (PK/PD) of Caspofungin in Intensive Care Unit (ICU) Patients. An Open Observational Study for Antifungal Treatment's Optimization
PK of Caspofungin in ICU septic patients might be changed as compared to healthy volunteers due to sepsis-related pathophysiology.
- Trial name
- NCT03798600
- Testing
- Caspofungin
- Volunteers
- 20 people
- Sponsor
- Careggi Hospital
Critical Illness, Intensive Care Units
Characterising Changes in Muscle Quantity and Quality in Patients Requiring ECMO Oxygen During Critical Illness
This study will identify the changes in different muscles of patients receiving Extracorporeal Membrane Oxygenation (ECMO) during critical illness and admission to Intensive Care Unit (ICU).
- Conditions
- Critical Illness, Intensive Care Units, Extracorporeal Membrane Oxygenation
- Trial name
- ECMO USS (NCT02995811)
- Testing
- Observational Cohort
- Where
- United Kingdom
- Volunteers
- 21 people
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
Cardiovascular Physiological Phenomena, Intensive Care Unit Syndrome
Echocardiographic Measurement of Myocardial Work
Echocardiography is recommended for the hemodynamic management of patients with shock. Recently, a new echocardiographic method has been proposed that provides a non-invasive measurement of myocardial work incorporating different…
- Trial name
- MYOLOAD (NCT06422481)
- Testing
- Fluid administration, Norepinephrine administration or increase in norepinephrine dosage
- Where
- 3 sites in France
- Volunteers
- 110 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Critical Illness, Anemia
Hemoglobin Trends as a Predictor of Outcomes in Critically Ill Patients (The TRENT-ICU Study)
The goal of this observational study is to evaluate if early absolute hemoglobin decline (during the first 24 hours of admission) can predict prolonged intensive care unit stay (8 days or more) and in-hospital mortality in…
- Trial name
- NCT07761832
- Testing
- Early Absolute Hemoglobin Decline
- Where
- Mexico
- Volunteers
- 128 people
- Sponsor
- Hospital H+ Queretaro