Clinical trials: Critically Ill Patient
ICU Stay & Mortality
Observational, Prospective, Single-center Study: Should Body Mass Index (BMI) be Added to the Scoring Criteria of Hepatic Critically Ill Patients in Intensive Care Unit??
The purpose of the study is to evaluate the hypothesis of poor clinical outcomes in critically ill patients that are having abnormal BMI.
- Trial name
- NCT03461523
- Where
- Egypt
- Volunteers
- 517 people, healthy volunteers welcome
- Sponsor
- National Hepatology & Tropical Medicine Research Institute
COVID, Shock
Endothelial Function, Inflammation and Organ Dysfunction in COVID-19
COVID-19 is a rapidly evolving pandemic with approximately 5% of all patients which require intensive care unit admission. In critically ill patients infected with COVID-19, approximately 15% had severe shock requiring…
- Trial name
- NCT04408365
- Where
- United Kingdom
- Volunteers
- 82 people
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
Enteral Feeding Intolerance
Ultrasound Meal Accommodation Test for Enteral Feeding in the Critically Ill
Within the context of intensive care units (ICU), enteral nutrition (NE) is an essential tool in the management of critical patients.
- Trial name
- UMATI (NCT03851354)
- Testing
- Ultrasound meal acommodation test
- Where
- Mexico
- Volunteers
- 61 people
- Sponsor
- Grupo Mexicano para el Estudio de la Medicina Intensiva
Acute Kidney Injury (Nontraumatic)
Exploring the Relationship Among BNP, Fluid Status and Acute Kidney Injury in Critically Ill Patients
B-type natriuretic peptide (BNP) is rapidly released by the ventricles of the heart in response to myocardial stretch. This cardiac neurohormone is mostly elevated in patients with fluid overload or myocardium dysfunction.
- Trial name
- NCT02095275
- Where
- Taiwan
- Volunteers
- 300 people
- Sponsor
- National Taiwan University Hospital
Renal Failure, Critically Ill
Forced Diuresis Versus Observation in Resolving Renal Failure After Haemofiltration in Critically Ill Patients
Intensive care patients with multiple organ dysfunction syndrome often show renal failure with the need for hemofiltration. Resolving renal failure after cessation of hemofiltration may or may not be accompanied by oliguria.
- Trial name
- NCT00298454
- Testing
- Furosemide
- Where
- Netherlands
- Volunteers
- 72 people
- Sponsor
- Frisius Medisch Centrum
Anxiety, Depression
PARTNER II: Improving Patient and Family Centered Care in Advanced Critical Illness
This is a stepped wedged randomized controlled trial comparing the PARTNER intervention with usual care in 5 Intensive Care Units.
- Trial name
- NCT02445937
- Testing
- PARTNER II
- Where
- 2 sites in United States
- Volunteers
- 848 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Sepsis, Septic Shock
Impact of Aminoglycosides-based Antibiotics Combination and Protective Isolation on Outcomes in Critically-ill Neutropenic Patients With Sepsis: (Combination-Lock01)
Sepsis remains the leading cause of ICU admission in neutropenic patients. This condition remains associated with a high morbidity and mortality, with hospital mortality of 60% when vasopressors are required.
- Conditions
- Sepsis, Septic Shock, Hematologic Malignancy, Tumor
- Trial name
- NCT05443854
- Testing
- Aminoglycosides intervention, Lack of protective isolation intervention, No systematic aminoglycosides intervention - standard arm
- Volunteers
- 340 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Critical Illness, Dietary Modification
Probiotics in Enteral Feeding in Critically Ill Patients
The purpose of this study is to investigate the effect of probiotics in enteral nutrition on improving gut function, inflammatory markers and clinical outcomes in critically ill patients admitted to the intensive care unit.
- Conditions
- Critical Illness, Dietary Modification, Probiotics, Gut Failure
- Trial name
- NCT01792401
- Testing
- Probiotics
- Where
- Malaysia
- Volunteers
- 49 people
- Sponsor
- University of Malaya
Shock, Peripheral Venous Catheterization
Pulse Study: Peripheral Use of Low-dose Vasopressors for Safety and Efficacy in the Intensive Care Unit
Using medications to increase blood pressure, called vasopressors, is invaluable in treating patients who have difficulty maintaining stable blood pressure.
- Conditions
- Shock, Peripheral Venous Catheterization, Central Venous Catheterization, Critically Ill Patients Admitted in ICU
- Trial name
- PULSE (NCT06920173)
- Testing
- Experiemental: Peripheral Venous Catheter
- Where
- Canada
- Volunteers
- 50 people
- Sponsor
- Kingston Health Sciences Centre
Critical Care, Mechanical Ventilation
Prevention of Ventilator Associated Pneumonia With Toothbrushing in Oral Care of Critically Ill Mechanically Ventilated Patients
Effect of toothbrushing in oral care of mechanically ventilated critically ill patients on prevention of ventilator associated pneumonia
- Conditions
- Critical Care, Mechanical Ventilation, Ventilator Associated Pneumonia Prevention, Toothbrushing
- Trial name
- NCT02400294
- Testing
- Toothbrushing
- Where
- France
- Volunteers
- 2,030 people
- Sponsor
- University Hospital, Clermont-Ferrand
Weaning Failure, Fluid Overload
Fluid unLoading On Weaning (FLOW)
The purpose of this study is to determine if testing preload responsiveness, the normal physiologic state that means that changes in preload determine changes in cardiac output, allows an earlier and physiologically safer weaning…
- Conditions
- Weaning Failure, Fluid Overload, Cardiac Failure Acute
- Trial name
- FLOW (NCT04496583)
- Testing
- Fluid depletion strategy
- Where
- Chile
- Volunteers
- 46 people
- Sponsor
- Pontificia Universidad Catolica de Chile
Trauma, Acute Pain
Magnesium Infusion for Pain Management in Critically Ill Trauma Patients
Magnesium is a naturally occurring mineral that is important for your body and brain. Magnesium sulfate (study drug) is a medication containing magnesium that is commonly used to improve low blood levels of magnesium.
- Trial name
- NCT04166877
- Testing
- Magnesium Sulfate in Parenteral Dosage Form
- Where
- United States
- Volunteers
- 156 people
- Sponsor
- University of California, Davis
Ascites Hepatic, Cirrhosis, Liver
Continuous Passive Paracentesis for Intra-abdominal Hypertension
Liver cirrhosis patients in Intensive Care present intra-abdominal hypertension and this is an independent risk factor for increased organ disfunction and mortality.
- Conditions
- Ascites Hepatic, Cirrhosis, Liver, Hypertension, Intraabdominal, Critical Illness
- Trial name
- COPPTRIAHL (NCT04322201)
- Testing
- continuous drainage of ascitic fluid using an intra-abdominal double lumen central venous catheter, Ultrasound-guided intermittent large-volume paracentesis
- Where
- Portugal
- Volunteers
- 60 people
- Sponsor
- Centro Hospitalar de Lisboa Central
Critical Illness
Specialized Treatment, Rehabilitation and Outcome in Patients With Prolonged Critical Illness
This prospective observational study aims to describe the outcome for patients with persistent or chronic critical illness treated at Remeo, a clinic specialized for patients in need of prolonged intensive care and intensive care…
- Trial name
- CritillPro (NCT04247607)
- Where
- Sweden
- Volunteers
- 250 people
- Sponsor
- Remeo AB
Mechanical Ventilation
Practice of Ventilation in Critically Ill Patients Without ARDS
The purpose of this international, multicenter study is to determine ventilation practice and outcomes of intubated and ventilated intensive care unit (ICU) patients.
- Trial name
- PRoVENT (NCT01868321)
- Where
- 13 sites in Austria, Belgium and 7 more
- Volunteers
- 1,030 people
- Sponsor
- Prof. Dr. Marcus J. Schultz
Post-Intensive Care Syndrome (PICS), Critical Illness Recovery
Virtual Reality for Recovery After Intensive Care (PICS)
The goal of this clinical trial is to learn if virtual reality (VR) helps improve thinking and memory skills in adults who have stayed in the intensive care unit (ICU).
- Conditions
- Post-Intensive Care Syndrome (PICS), Critical Illness Recovery, Rehabilitation After Critical Illness, Rehabilitation Exercise of ICU Patients
- Trial name
- VR4ICU (NCT07585500)
- Testing
- Immersive VR Multi-Domain Rehabilitation, Tablet-Based Multi-Domain Training
- Where
- Portugal
- Volunteers
- 51 people
- Sponsor
- University of Minho
PICS
The Impact of a Bundle of Preventive Measures for Post-intensive Care Syndrome on the Outcome of Critically Ill Patients
This prospective observational cohort study will investigate the impact of a bundle of nine preventive measures (Assessment, prevention and management of pain; spontaneous awaking trial; spontaneous breathing trial; choice of…
- Trial name
- NCT03398707
- Where
- Brazil
- Volunteers
- 300 people
- Sponsor
- Hospital Sao Domingos
Critical Illness
A Trial of Enteral Colostrum on Intestinal Permeability in Critically Ill Patients
The effects of colostrum on intestinal permeability in critical ill patients has not been investigated. In current trial, intensive care unit patients with enteral feeding will receive either enteral colostrum or maltodextrin as…
- Trial name
- NCT03186716
- Testing
- Colostrum, Maltodextrin
- Where
- Iran
- Volunteers
- 70 people
- Sponsor
- National Nutrition and Food Technology Institute
Critical Illness, Pain
Treatment of Procedural Pain Associated With Turning in Patients With Mechanical Ventilation
Background: Few studies have addressed the situation of procedural pain and the use of preemptive analgesia for turning in patients under mechanical ventilation.
- Trial name
- NCT01950000
- Testing
- Fentanyl
- Where
- Spain
- Volunteers
- 75 people
- Sponsor
- Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
Critically Ill Patients With a Predicted Prolonged ICU Stay
NMES in Critically Ill Patients
Critically ill patients with a predicted prolonged ICU stay will receive neuromuscular electrical stimulation (NMES) of one quadriceps muscle.
- Trial name
- NESCI (NCT02133300)
- Testing
- electrical stimulation
- Where
- Belgium
- Volunteers
- 50 people
- Sponsor
- KU Leuven