Clinical trials: Critically Ill Patient
Shock, Systemic Inflammatory Response Syndrome (SIRS)
Optimization of Therapeutic Human Serum Albumin Infusion in Selected Critically Ill Patients
Primary purpose : mortality at Day 28 Secondary purposes : Daily SOFA (Sequential Organ Failure Assessment) score lessening within Intensive Care Unit (ICU) Duration of increasing doses of norepinephrine infusion to maintain…
- Conditions
- Shock, Systemic Inflammatory Response Syndrome (SIRS), Hypoalbuminaemia
- Trial name
- AlbAlsace (NCT02755155)
- Testing
- Human serum albumin infusion 4%, Human serum albumin infusion 20%
- Where
- France
- Volunteers
- 138 people
- Sponsor
- University Hospital, Strasbourg, France
Critical Illness, Post Intensive Care Syndrome (PICS)
Effectiveness of a Structured Multidimensional Tele-rehabilitation Intervention in Cardiac Patients With Post-Intensive Care Syndrome (CARDIO-PICS)
This two-arm, parallel-group randomized clinical trial investigates the effectiveness of an additional telerehabilitation program compared with standard care in patients with Post-Intensive Care Syndrome (PICS).
- Conditions
- Critical Illness, Post Intensive Care Syndrome (PICS), Cardiopathy
- Trial name
- CARDIO-PICS (NCT07599306)
- Testing
- Tele-rehabilitation, Standard of Care
- Where
- Italy
- Volunteers
- 326 people
- Sponsor
- Fondazione Don Carlo Gnocchi ETS
Bed-ridden Patient, Solid Organ Transplant
Use of an Off-the-Shelf Exergame as an In-Bed Gamified Rehabilitation Intervention for Severely Deconditioned Inpatients: A Feasibility Study
1. Study Title: Use of an Off-the-Shelf Exergame as an In-Bed Gamified Rehabilitation Intervention for Severely Deconditioned Inpatients: A Feasibility Study 2.
- Conditions
- Bed-ridden Patient, Solid Organ Transplant, Post Critical Care
- Trial name
- NCT06937463
- Testing
- Rehabilitation
- Where
- South Korea
- Volunteers
- 26 people
- Sponsor
- Asan Medical Center
Mechanical Ventilation, Critically Ill Patients
Saline Instillation Before Tracheal Suctioning and the Incidence of Ventilator Associated Pneumonia
Compare the incidence of ventilator associated pneumonia with or without tracheal isotonic saline instillation before tracheal suctioning
- Trial name
- NCT00432718
- Testing
- Saline Instillation before Tracheal Suctioning
- Where
- Brazil
- Volunteers
- 260 people
- Sponsor
- Hospital do Cancer, Sao Paulo
Dyspnea During Mechanical Ventilation, Inspiratory Effort
Association of Inspiratory Effort With Dyspnea During Assisted Mechanical Ventilation in Critically Ill Patients
During assisted mechanical ventilation, breathing results from the interaction between the patient and the ventilator. Optimal titration of pressure support is essential to maintain a balance between over-assistance and…
- Conditions
- Dyspnea During Mechanical Ventilation, Inspiratory Effort, Mechanical Ventilation
- Trial name
- NCT07877350
- Where
- Greece
- Volunteers
- 50 people
- Sponsor
- University of Crete
Critical Illness, Hyperglycemia
Comparing Two Ways of Controlling Blood Sugar With Insulin in Patients Admitted to the Intensive Care Unit
The purpose of this study is to determine if there is any difference between two ways of controlling blood sugar with insulin. In patients admitted to the intensive care unit, blood sugar levels often rise due to the stress of…
- Trial name
- NCT00166491
- Testing
- Insulin
- Where
- United States
- Volunteers
- 238 people
- Sponsor
- Mayo Clinic
Cardiogenic Shock, Euthyroid Sick Syndrome
Factors Influencing Outcomes in ECMO and Impella Patients: Metabolic and Thyroid Hormone Dynamics
This prospective, single-center, consecutive observational study evaluates clinical, metabolic, and endocrine factors influencing survival and clinical outcomes in adult patients undergoing temporary mechanical circulatory…
- Conditions
- Cardiogenic Shock, Euthyroid Sick Syndrome, Critical Illness
- Trial name
- NCT07885618
- Where
- Hungary
- Volunteers
- 160 people
- Sponsor
- Gottsegen National Cardiovascular Institute
Infection, Antimicrobial Stewardship
Quality Improvement Intervention for a Safe Antimicrobial Use Reduction in Critically Ill Patients
The goal of this clinical trial is to learn if an educational intervention with audit and feedback on physicians and health care professionals who participate in antimicrobial treatment decisions can reduce the use of…
- Conditions
- Infection, Antimicrobial Stewardship, Critically Ill Intensive Care Unit Patients
- Trial name
- SAFE-REDUCE (NCT07093450)
- Testing
- Educational Quality Improvement Intervention
- Where
- 9 sites in Brazil
- Volunteers
- 9,000 people
- Sponsor
- Hospital Sirio-Libanes
Early Mobilization, Critically Ill
Effect of Early Extracorporeal Diaphragm Pacing Combined With Tilt Table in Ventilated Patients.
The aim of this study is to test the effect of 1week of extracorporeal diaphragm pacing (EDP) combined either with or without tilt table verticalization (TTV) on diaphragm function in patients with mechanical ventilation compared…
- Conditions
- Early Mobilization, Critically Ill, Mechanical Ventilation, Diaphragm Dysfunction
- Trial name
- NCT05953649
- Testing
- Extracorporeal Diaphragm Pacing, Tilt Table Verticalization, Conventional Physiotherapy
- Volunteers
- 90 people
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Vancomycin
The Influencing Factors of Vancomycin Trough Level and the Rate Achieving the Target Trough Level
The aim of this study was to assess factors that may influence vancomycin trough level and the rate achieving the target trough level in critically ill patients.
- Trial name
- NCT03806543
- Testing
- Vancomycin
- Volunteers
- 165 people
- Sponsor
- Southeast University, China
Delirium, Critical Illness
Pilot Study of Haloperidol to Treat Critical Illness Delirium
The goal of this study is to determine whether haloperidol reduces the time on the breathing machine in critically ill patients with delirium.
- Trial name
- NCT00429676
- Testing
- Haloperidol
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Colorado, Denver
Emergency Surgery
Preoperative Rapid Pou Ultrasound Assessment in Critically Ill Patients Undergoing Emergency Surgery
With the development of society, the number of emergency critical operations is increasing year by year. Traditionally, the patient's systemic and circulatory status is indirectly assessed by testing and blood pressure heart…
- Trial name
- NCT04111783
- Testing
- POU protocol ultrasound
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Shenzhen People's Hospital
Invasive Fungal Infection
Voriconazole Plasma Level in Intensive Care Unit (ICU) Patients
Voriconazole, a newer triazole-derivative, has become the drug of choice for many invasive fungal infections, including invasive Aspergillosis.
- Trial name
- NCT01185405
- Testing
- Use of different strategy for voriconazole dosage adjustment
- Where
- South Korea
- Sponsor
- Asan Medical Center
Renal Replacement Therapy
Impact of Dialysis Modality on Coagulation and Platelet Function
The investigators will evaluate the impact of dialysis modality (intermittent hemodialysis or continuous renal replacement therapy) in coagulation and platelet function in critically ill patients
- Trial name
- NCT04512131
- Testing
- dialysis mode
- Where
- South Korea
- Volunteers
- 60 people
- Sponsor
- Seoul National University Hospital
Trauma, Critical Illness
Personalized Nutrition Delivery to Improve Resilience in Older Adult Trauma Patients
This is a Pilot study designed to set up for an randomized clinical trial (RCT) comparing the SeND Home pathway to a standard of care nutrition delivery in critically ill older adult trauma patients.
- Trial name
- SeND Home (NCT05544162)
- Testing
- Nutrition supplement - Ensure shakes
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Duke University
Critical Illness, Acute Respiratory Failure
Trial of Supplemental Parenteral Nutrition in Under and Over Weight Critically Ill Patients (TOP-UP)
The specific aim of the proposed study is to conduct a pilot study involving 160 critically-ill lean and obese patients enrolled at 11 sites in Canada, the United States of America, Belgium and France in order to: Specific Aims…
- Trial name
- TOP-UP (NCT01206166)
- Testing
- Olimel (5.7%E / N9E)
- Where
- 12 sites in United States, Belgium and 2 more
- Volunteers
- 125 people
- Sponsor
- Clinical Evaluation Research Unit at Kingston General Hospital
Severe Acute Respiratory Syndrome Coronavirus 2, Aspergillosis Invasive
Isavuconazole for the Prevention of COVID-19-associated Pulmonary Aspergillosis
The objective of this study is to evaluate whether antifungal prophylaxis with isavuconazole can reduce the incidence of SARS-CoV-2-associated invasive aspergillosis in patients in the ICU (intensive care unit) with severe…
- Trial name
- Isavu-CAPA (NCT04707703)
- Testing
- Isavuconazonium Injection [Cresemba]
- Where
- 3 sites in United States
- Volunteers
- 8 people
- Sponsor
- Jeffrey Jenks, MD, MPH
Sepsis, Respiratory Failure
Use of Lactate-to-Albumin, CRP-to-Albumin, and Procalcitonin-to-Albumin Ratios to Predict Mortality in ICU Patients
This observational study aims to determine whether three blood test ratios - lactate-to-albumin, CRP-to-albumin, and procalcitonin-to-albumin - can predict in-hospital mortality among critically ill adults.
- Conditions
- Sepsis, Respiratory Failure, Cardiac Arrest, Circulatory Failure
- Trial name
- LAR-CAR-PAR (NCT07242027)
- Where
- Poland
- Volunteers
- 212 people
- Sponsor
- Medical University of Silesia
Critical Illness, Pupillometry
Dynamic Trajectories of Pupillary Light Reflex Parameters and Prognosis in Critically Ill Patients: A Multicenter Prospective Cohort Study
This multicenter prospective observational cohort study aims to investigate the association between early dynamic trajectories of pupillary light reflex parameters and clinical outcomes in critically ill patients admitted to…
- Conditions
- Critical Illness, Pupillometry, Prognosis
- Trial name
- PUPIL (NCT07616518)
- Volunteers
- 700 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Sepsis, Critical Illness
Evaluation of the Effect of Immune Modulating Enteral Nutrition Formula
The aim is to compare the efficacy and tolerability of an immune modulating enteral nutrition formula versus the regular formula on the outcomes of critically ill septic patients by assessment of clinical outcomes, immune…
- Trial name
- NCT05186480
- Testing
- Neo Mune
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- NewGiza University