Clinical trials: Critically Ill Patients
Critical Illness
Predictive Value of Heart Rate Variability on Outcome in Patients Admitted to the Intensive Care Department
This study is designed to evaluate the predictive value of heart rate variability on medial outcome in patients admitted to the intensive care department
- Trial name
- NCT02892669
- Testing
- non interventional study
- Volunteers
- 300 people
- Sponsor
- Rambam Health Care Campus
Polyneuropathies
The Impact of IVIG Treatment on Critical Illness Polyneuropathy and/or Myopathy in Patients With MOF and SIRS/Sepsis
Critical illness polyneuropathy and/or myopathy (CIPNM) is a severe complication of critical illness. Retrospective data suggest that early application of IgM-enriched intravenous immunoglobulin (IVIG) may prevent or mitigate…
- Trial name
- CIPNM (NCT01867645)
- Testing
- IgM-enriched Intravenous Immunoglobulins, Human Albumin
- Where
- Austria
- Volunteers
- 38 people
- Sponsor
- Medical University of Vienna
Critical Illness, Muscle Weakness
Can Beta-Hydroxy-beta-Methylbutyrate Supplementation Counteract Muscle Catabolism in Critically Ill Patients?
The rapid decline of muscle mass and function in mechanically ventilated critically ill patients is associated with prolonged length of mechanical ventilation, prolonged intensive care (ICU) and hospital stay, increased ICU and…
- Trial name
- HMB-ICU-CH (NCT03628365)
- Testing
- HMB (beta-hydroxy beta-methylbutyrate)
- Where
- Switzerland
- Volunteers
- 37 people
- Sponsor
- Mette M Berger
Cardiogenic Shock, Septic Shock
Levosimendan Versus Dobutamine in Shock Patients
The purpose of the study is to compare the efficacy of levosimendan with that of dobutamine in patients with unstable hemodynamics (shock).
- Trial name
- NCT00093301
- Testing
- Levosimendan, Dobutamine
- Where
- Australia
- Volunteers
- 40 people
- Sponsor
- Wentworth Area Health Services
Critically Ill, Enteral Feeding
The Effects of Pancreatic Enzyme Supplementation in Critically Ill Patients on Enteral Feeding
Determine the effect of high-dose pancreatic enzyme supplementation on nutritional indicators and clinical course in critically ill patients undergoing enteral nutrition.
- Conditions
- Critically Ill, Enteral Feeding, Exocrine Pancreatic Insufficiency
- Trial name
- PREZENT (NCT05112328)
- Testing
- Exocrine Pancreatic Enzyme
- Where
- South Korea
- Volunteers
- 170 people
- Sponsor
- Seoul National University Hospital
Frailty Syndrome
Adaptation and Validation of Frailty Scales in Intensive Care Units in Spain
Increased life expectancy leads to population aging, increased morbidities and aging of hospitalized patients. The acquisition of frailty leads to worse outcomes derived from hospitalization, but although frailty has been related…
- Trial name
- NCT04830865
- Where
- Spain
- Volunteers
- 512 people
- Sponsor
- Hospital Universitario Getafe
Post Intensive Care Syndrome, Intensive Care Unit Acquired Weakness
Validity and Reliability of Korean Version of AM-PAC Inpatient Short Form (Low Function) in Critically Ill Patients
The Activity Measure for Post Acute Care (AM-PAC) inpatient short form (low function) evaluates the level of assistance a patient requires another person to provide for distinct functional mobility and daily activities.
- Trial name
- AM-PAC (NCT06440265)
- Testing
- AM-PAC inpatient short form (low function)
- Where
- South Korea
- Volunteers
- 38 people
- Sponsor
- Seoul National University Hospital
Critical Illness, Elevated Left Atrial Pressure
The Use of Single-Beat TE-e' in Evaluation of Left Atrial Pressure in Critically Ill Patients: The TELAP-ICU Trial
This study evaluates a new single-beat echocardiographic technique (TE-e', the time difference between the onset of the mitral inflow E wave and the septal e' wave on tissue Doppler imaging) for estimating left atrial pressure…
- Conditions
- Critical Illness, Elevated Left Atrial Pressure, Left Ventricular Diastolic Dysfunction, Echocardiography
- Trial name
- TELAP-ICU (NCT07820319)
- Testing
- Echocardiography
- Where
- Hong Kong
- Volunteers
- 50 people
- Sponsor
- Queen Mary Hospital, Hong Kong
Critically Ill
Progressive Mobilization With Dose Control and Training Load in in Critically Ill Patients
Immobilization and bed rest of patients in intensive care units (ICU) increases their risk for muscle dysfunction and prolonged mechanical ventilation, leading to physical deconditioning and loss of functionality.
- Trial name
- NCT03596853
- Testing
- Progressive mobilization, Usual Care
- Where
- Brazil
- Volunteers
- 104 people
- Sponsor
- Federal University of Bahia
Anemic, Critically Ill Patients
Efficacy of Enteral Iron Supplementation in Critical Illness
The purpose of this study is to investigate the efficacy of enteral iron supplementation for improving anemia, decreasing the risk of blood transfusion, and decreasing mortality in patients who are hospitalized in the intensive…
- Trial name
- NCT00450177
- Testing
- Ferrous Sulfate
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Weill Medical College of Cornell University
Ventilator Weaning, Weaning Failure
Voices of Patients' Relatives to Support Weaning From Mechanical Ventilation
Patients with severe brain injuries, such as ischemic stroke and intracranial hemorrhage, frequently require mechanical ventilation. Weaning of stroke patients is complicated by impaired consciousness and respiratory drive.
- Conditions
- Ventilator Weaning, Weaning Failure, Brain Injuries
- Trial name
- VOICE-WEANING (NCT03795623)
- Testing
- Voice-Weaning
- Where
- Germany
- Volunteers
- 45 people
- Sponsor
- University of Erlangen-Nürnberg Medical School
Dyspnea During Mechanical Ventilation, Inspiratory Effort
Association of Inspiratory Effort With Dyspnea During Assisted Mechanical Ventilation in Critically Ill Patients
During assisted mechanical ventilation, breathing results from the interaction between the patient and the ventilator. Optimal titration of pressure support is essential to maintain a balance between over-assistance and…
- Conditions
- Dyspnea During Mechanical Ventilation, Inspiratory Effort, Mechanical Ventilation
- Trial name
- NCT07877350
- Where
- Greece
- Volunteers
- 50 people
- Sponsor
- University of Crete
Anxiety
Evaluation of Touch Massage on Anxiety in Critically Ill Patients
Anxiety is a common problem encountered in a about 43 % of critically ill patients. Its occurrence can be related to several causes, mainly dominated by invasive procedures.
- Trial name
- REaLAX (NCT03030482)
- Testing
- touch massage
- Where
- France
- Volunteers
- 70 people
- Sponsor
- Versailles Hospital
Critical Illness, Mechanical Ventilation
Cost-Effectiveness of Inhaled Sedation Versus Intravenous Propofol in Mechanically Ventilated Critically Ill Adults
The goal of this observational study is to learn whether inhaled sedation is a cost-effective alternative to intravenous propofol in mechanically ventilated critically ill adults admitted to the intensive care unit.
- Conditions
- Critical Illness, Mechanical Ventilation, Respiratory Insufficiency
- Trial name
- NCT07734350
- Testing
- Isoflurane, Propofol (Astra-Zeneca)
- Volunteers
- 400 people
- Sponsor
- Hospital H+ Queretaro
Atrial Fibrillation New Onset
Use of Red Cell Distribution Width for Prediction of New-onset Atrial Fibrillation in Critically Ill Sepsis Patients
Red cell distribution width variations are increased in a variety of medical conditions such as congestive heart failure, acute myocardial infarction, pulmonary embolism, pneumonia, critical illness, and cardiac arrest , and is a…
- Trial name
- NCT03523676
- Testing
- Red Cell Distribution Width
- Volunteers
- 70 people
- Sponsor
- Ain Shams University
COVID-19 Disease
Systematic Assessment of SARS-CoV-2 Neurotropic Capacity in Modestly and Critically Ill Patients, and Patients Who Died From COVID-19
This study is to analyze the microglia reaction or direct neurotropic effects of CNS COVID-19 in pathogenesis and brain stem dysfunction in critically ill patients.
- Trial name
- NCT04472013
- Testing
- Data collection from lumbar puncture, Data collection from blood draw, CNS magnetic resonance imaging (MRI) imaging
- Where
- Switzerland
- Volunteers
- 40 people
- Sponsor
- University Hospital, Basel, Switzerland
Sepsis
Project 4B: Lower Extremity Strength Training in ICU Patients
The purpose of this research study is to see if electrical stimulation of the leg muscles will improve strength in patients receiving mechanical ventilation in the intensive care unit (ICU).
- Trial name
- NCT02467023
- Testing
- Muscle stimulation with Niveus medical stimulator, measurement of maximal isometric twitch strength, Muscle Biopsy
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- University of Florida
Mechanical Ventilation Complication, Hyperoxia
Oxidative Lipidomic Biomarkers During Mechanical Ventilation in Critically Ill Patients (OXY-BAL).
The aim of this study is to identify and determine the levels of oxidized lipids and lipid mediators following exposure to oxygen supplementation during mechanical ventilation by oxidative lipidomics.
- Trial name
- OXY-BAL (NCT05412810)
- Testing
- oxygen
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Ohio State University
Weakness, Muscle
Bed Rest and Muscle Strength in ICU: Interest in the Early Association of NEMS With Cyclo-ergometer Mobilization
Muscles atrophy and weakness are common in intensive care units, their origin is multifactorial. Passive then active mobilization with cyclo-ergometer have shown to improve functional abilities and limit muscle weakness among…
- Trial name
- AFMPR (NCT03987997)
- Testing
- Early association of electrical muscle stimulation with cyclo-ergometer
- Where
- France
- Volunteers
- 55 people
- Sponsor
- Direction Centrale du Service de Santé des Armées
Enteral Nutrition, COVID-19 Acute Respiratory Distress Syndrome
Early Versus Delayed Enteral Nutrition in Critically Ill Adults With COVID-19
The goal of this observational study is to determine the relationship between the nutritional profile of critically ill patients diagnosed with COVID-19 and disease severity, prognosis, and survival, to assess the ability to meet…
- Trial name
- NCT06134674
- Where
- Turkey (Türkiye)
- Volunteers
- 135 people
- Sponsor
- Ankara City Hospital Bilkent