Clinical trials: Critically Ill Patients
Respiratory Failure
Safety and Efficacy of Endotracheal Intubation Using Glidescope Video-Laryngoscope
The safety and efficacy of a video-laryngoscope as a primary intubation tool in urgent endotracheal intubation of critically-ill patients has not been well-described in the literature.
- Trial name
- NCT01683526
- Testing
- Direct laryngoscopy, Video laryngoscopy (Glidescope)
- Where
- United States
- Volunteers
- 117 people
- Sponsor
- Beth Israel Medical Center
Anemic, Critically Ill Patients
Efficacy of Enteral Iron Supplementation in Critical Illness
The purpose of this study is to investigate the efficacy of enteral iron supplementation for improving anemia, decreasing the risk of blood transfusion, and decreasing mortality in patients who are hospitalized in the intensive…
- Trial name
- NCT00450177
- Testing
- Ferrous Sulfate
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Weill Medical College of Cornell University
COVID-19
Anticoagulation in Critically Ill Patients With COVID-19 (The IMPACT Trial)
The purpose of this study is to determine if therapeutic dose anticoagulation (experimental group) improves 30-day mortality in participants with COVID-19 compared to those patients receiving the intermediate dose prophylaxis…
- Trial name
- IMPACT (NCT04406389)
- Testing
- Enoxaparin sodium, Unfractionated heparin, Fondapariniux
- Where
- 2 sites in United States
- Volunteers
- 14 people
- Sponsor
- Weill Medical College of Cornell University
Critically Ill
Impact of SPN on Infection Rate, Duration of Mechanical Ventilation & Rehabilitation in ICU Patients
Rationale: Enteral nutrition (EN) in the intensive care (ICU) patients is recommended as a standard of care. However, EN alone is often associated with insufficient energy intakes and increased complication rates.
- Trial name
- NCT00802503
- Testing
- SPN
- Where
- 2 sites in Switzerland
- Volunteers
- 305 people
- Sponsor
- University Hospital, Geneva
Post-Resuscitation Syndrome, Critical Illness
Predicting Mortality in Patients With Return of Spontaneous Circulation After Cardiac Arrest
This retrospective observational cohort study aims to identify early predictors of short- and mid-term mortality in adult patients who achieved return of spontaneous circulation (ROSC) after cardiac arrest.
- Conditions
- Post-Resuscitation Syndrome, Critical Illness, Cardiac Arrest, Hypoxic-Ischemic Encephalopathy
- Trial name
- PROM-ROSC (NCT07020091)
- Where
- Turkey (Türkiye)
- Volunteers
- 168 people
- Sponsor
- Ahmet Düzgün
Anemia
Assess Functional Outcomes in Anemic, Critically Ill, Trauma Patients When Taking Epoetin Alfa
The purpose of this trial is to evaluate the physical function outcomes in anemic, critically ill, trauma subjects treated with epoetin alfa (PROCRIT®) compared to placebo.
- Trial name
- NCT00210626
- Testing
- PROCRIT
- Where
- 21 sites in United States
- Volunteers
- 192 people
- Sponsor
- Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
Hyperglycemia
Feasibility Study to Evaluate Safety and Device Performance of the Hospital Glucose Management System (HGMS)
The purpose of this study is to assess safety and device performance of the Medtronic Hospital Glucose Management System (HGMS) for up to 72-hours.
- Trial name
- MAHI (NCT01763567)
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- Medtronic MiniMed, Inc.
Sedation, Critical Illness
Musical Intervention and Physiological Stress and Inflammatory Biomarkers in Mechanically Ventilated ICU Patients
This randomized clinical trial evaluates the effects of a musical intervention on hormonal and inflammatory biomarkers in sedated adult patients undergoing invasive mechanical ventilation in an intensive care unit.
- Conditions
- Sedation, Critical Illness, Respiration, Artificial, Inflammation
- Trial name
- NCT06120660
- Testing
- Music Therapy
- Where
- Spain
- Volunteers
- 110 people
- Sponsor
- University of Oviedo
Critically Ill Patients
Esketamine Induction Intubation in ICU Patients.
Intubation in the intensive care unit (ICU) is usually an emergency. Pathophysiological changes such as shock, respiratory failure, and metabolic acidosis in critically ill patients can significantly increase the incidence of…
- Trial name
- NCT05464979
- Testing
- Esketamine Hydrochloride 28 Mg in 0.2 mL NASAL SOLUTION [Spravato], midazolam, fentanyl
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Delirium
The Effect of Guanfacine on Delirium in Critically Ill Patients
Delirium in patients in the intensive care unit (ICU) is a common problem associated with increased mortality and morbidity, including increased hospital and ICU length of stay, greater hospital cost, increased ventilator days…
- Trial name
- NCT04578886
- Testing
- Guanfacine
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of Alabama at Birmingham
Weaning Failure, Mechanical Ventilation Complication
Comparison of Two Extubation Techniques in Critically Ill Adult Patients
Orotracheal extubation consists in the removal of the endotracheal tube (ETT) when it is no longer required. This procedure may carry a considerable risk of complications and extubation failure.
- Trial name
- ExtubAR (NCT03918811)
- Testing
- Positive Pressure Extubation Technique, Traditional Extubation Technique
- Where
- Argentina
- Volunteers
- 725 people
- Sponsor
- Hospital Donación Francisco Santojanni
Tracheostomy, Communication
A Speech Recognition Application as a Communication Aid for Acute and Critical Care Patients With Tracheostomies
Patients in acute and critical care often undergo a tracheostomy. A tracheostomy is an incision at the front of the neck to insert a breathing tube directly into the airway.
- Conditions
- Tracheostomy, Communication, Acute/Critical Illness
- Trial name
- SRAVI (NCT06027866)
- Testing
- SRAVI (Speech Recognition Application for the Voice Impaired)
- Where
- United Kingdom
- Volunteers
- 31 people
- Sponsor
- Queen's University, Belfast
Critical Illness
Efficacy and Mechanisms of GLN Dipeptide in the SICU
Relative glutamine (GLN) deficiency may contribute to morbidity and mortality in surgical intensive care unit (SICU) patients. During critical illness, GLN utilization by the immune system, gut mucosa and other tissues exceeds…
- Trial name
- GLND (NCT00248638)
- Testing
- Glutamine dipeptide with 15% Clinisol, 15% Clinisol
- Where
- 5 sites in United States
- Volunteers
- 150 people
- Sponsor
- Emory University
SIRS, Sepsis
NT-proBNP in ICU Postoperative/Posttraumatic Patients With Shock
The purpose of this study is to determine the course of NT-proBNP plasma concentrations in the context of confounding parameters in postoperative/posttraumatic critically ill patients with severe SIRS/sepsis and shock.
- Conditions
- SIRS, Sepsis, Shock, Critically Ill
- Trial name
- NICUPS (NCT00736723)
- Where
- Germany
- Volunteers
- 51 people
- Sponsor
- University of Ulm
Brain Injury, Intracranial Pressure
Precedex Versus Propofol-Awakening for Reducing Brain Injury Expansion
The purpose of this study is to evaluate brain injury when two different drugs (propofol and precedex) are used to sedate patients who need a neurologic exam.
- Trial name
- PrePARE (NCT00538616)
- Testing
- Dexmedetomidine, Propofol
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Carmelo Graffagnino
Critical Illness, Fever
Safety and Efficacy of Acetaminophen in the Intensive Care Unit.
The intensive care unit (ICU) team needs to know what effects acetaminophen has in critically ill patients. Acetaminophen is better known as Tylenol. It is the drug given to reduce fever.
- Trial name
- SEA-ICU (NCT02280239)
- Testing
- Acetaminophen
- Where
- Canada
- Volunteers
- 10 people
- Sponsor
- University of British Columbia
Brain Injuries
Intravenous Exenatide in Patients With Acute Brain Injury
The purpose of this study is to assess the feasibility of exenatide infusion for the treatment of high blood sugars following acute brain injury.
- Trial name
- NCT02058940
- Testing
- Exenatide
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- University of North Carolina, Chapel Hill
Critical Illness
Dexmedetomidine Versus Midazolam for Facilitating Extubation
The purpose of this randomized, double-blind study is to evaluate the utility, safety, and cost of transitioning benzodiazepine sedation to dexmedetomidine in medical or surgical intensive care unit (ICU) patients requiring…
- Trial name
- NCT00744380
- Testing
- Midazolam, Dexmedetomidine
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- University of Colorado, Denver
Mechanical Ventilation, Airway Patency
The Effects of Ketamine on Respiratory Stimulation and Transpulmonary Pressures
Impairment of airway patency is a common cause of extubation failure and opioids and hypnotics can adversely affect airway patency.
- Conditions
- Mechanical Ventilation, Airway Patency, Respiratory Depression
- Trial name
- NCT01969227
- Testing
- Subanesthetic ketamine
- Where
- 2 sites in United States
- Volunteers
- 15 people
- Sponsor
- Massachusetts General Hospital
Critically Ill Renal Failure Requiring CVVHD and Oseltamivir, Critically Ill Requiring ECMO and Oseltamivir
Pharmacokinetics of Tamiflu® (Oseltamivir) in Patients Receiving Extracorporeal Membrane Oxygenation (ECMO)and or Continuous Venovenous Hemodialysis (CVVHD)
Critically ill patients with flu may receive a drug called oseltamivir. They may also receive medical therapies to support their lung function (extracorporeal membrane oxygenation; ECMO) and kidney function (continuous venovenous…
- Trial name
- NCT01048879
- Testing
- pharmacokinetic blood sampling, pharmacokinetic blood and dialysate sampling
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- University of Michigan