Clinical trials: Critically Ill Surgical Patients
Nicotine Dependence
Prevention of Nicotine Abstinence in Critically Ill Patients After Major Surgery
The primary objective of this study is to determine whether the application of transdermal nicotine patches in critically ill patients after major surgery with nicotine abstinence condition is associated with a lower incidence of…
- Trial name
- NCT03847155
- Testing
- Nicotine patch
- Where
- Czechia
- Volunteers
- 52 people
- Sponsor
- University Hospital Ostrava
Sedation
Impact of a Nurse Implemented Sedation and Analgesia Algorithm in Surgical Intensive Care Unit
To show that the nurse implementation of a sedation and analgesia algorithm is beneficial to the patient in terms of sedative drugs reduction and thus overall decrease in duration of mechanical ventilation and the morbidity and…
- Trial name
- ALGOSEDA (NCT03186521)
- Where
- France
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University Hospital, Caen
Acute Kidney Injury, Critical Illness
Renal Resistive Index as a Predictor of Acute Renal Impairment in High-risk Patients
To study the ability of RRI, measured by bedside Doppler ultrasound, in detecting acute kidney injury in high-risk patients admitted to surgical intensive care unit, Aswan university hospital, compared with renal biomarkers and…
- Trial name
- NCT06386796
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Aswan University
Sepsis, Trauma
BIA Assessment of Polymyoneuropathy in Critically Ill Patients
The aim of the study is to monitor and evaluate changes in body composition, with a special emphasis on muscle mass, in the context of polyneuromyopathy of critically-ill patients at ICU, on artificial ventilation (duration of…
- Conditions
- Sepsis, Trauma, Respiratory Insufficiency, Surgery
- Trial name
- NCT04758676
- Testing
- Nutritional and physiotherapy protocol, BIA, Standard of care
- Where
- 2 sites in Czechia
- Volunteers
- 60 people
- Sponsor
- University Hospital Ostrava
Critical Illness, Surgery
Diluted and Undiluted Enteral Nutrition
Adult patients after elective major abdominal surgeries who are planned to be admitted to the Intensive Care Unit (ICU) can be included in the trial. Each patient will be fed via the gastrointestinal tract.
- Conditions
- Critical Illness, Surgery, Enteral Feeding Intolerance, Gastro-Intestinal Disorder
- Trial name
- NCT06516835
- Testing
- Enteral fluid, Intravenous fluid
- Where
- 5 sites in Poland
- Volunteers
- 60 people
- Sponsor
- Medical University of Lublin
Critical Illness
Feasibility of Tight Blood Glucose Control With the Space TGC System in Surgical ICU Patients
Hyperglycemia is common in critically ill patients and associated with an adverse outcome. Thus, glycaemic control is an important issue in critical care.
- Trial name
- DELIOS 03 (NCT01146847)
- Testing
- Space TGC
- Where
- Germany
- Volunteers
- 20 people
- Sponsor
- B. Braun Melsungen AG
Critically Ill
PEP uP Protocol in Surgical Patients
The main objective of this project is to asses for safety, feasibility and effectiveness of an aggressive feeding protocol, PEP uP (Enhanced Protein-Energy Provision via the Enteral Route Feeding Protocol) in increasing protein…
- Trial name
- NCT02459275
- Testing
- PEP uP Protocol, Metoclopramide
- Where
- 4 sites in United States
- Volunteers
- 36 people
- Sponsor
- Clinical Evaluation Research Unit at Kingston General Hospital
Critically Ill, Cardiac Disease
Respired Gases in Patients Post Cardiac Surgery
Certain diseases relating to the heart can only be definitively treated with surgery. When untreated, these can lead to heart failure with a lack of supply of oxygen-rich blood to the tissues, leading to damage to other organs.
- Conditions
- Critically Ill, Cardiac Disease, Mitral Valve Disease
- Trial name
- REGAPS (NCT05531253)
- Testing
- Data collection using the Optical Gas Analyser
- Where
- United Kingdom
- Volunteers
- 25 people
- Sponsor
- University of Oxford
Neurosurgical Patients, Elderly Patients
Investigating Nutrition and Functional Outcome in Critically Ill Patients
This is a single-center, multi-ICU prospective observational trial evaluating current nutritional practice and its influence of the physical function of critically ill patients.
- Conditions
- Neurosurgical Patients, Elderly Patients, Obese Patients, Cardiac Surgery Patients
- Trial name
- INFO (NCT04180852)
- Testing
- Functional tests without clinical consequence for the patients therapy
- Where
- Germany
- Volunteers
- 100 people
- Sponsor
- RWTH Aachen University
Delirium, Intensive Care Unit Syndrome
Risk Factors for Delirium in Critically Ill Surgical Patients
Delirium is characterized by changes in mental status, inattension, disorganized thinking, and altered consciousness. Prevalence of delirium in critically ill patients has varied from 20~80% depending on the severity of illness.
- Trial name
- NCT03050021
- Where
- South Korea
- Volunteers
- 251 people
- Sponsor
- Suk-Kyung
Critical Illness, Malabsorption Syndromes
The Early Nasojejunal Tube to Meet Energy Requirements in Intensive Care (ENTERIC) Study
This is a multi-centre randomised controlled trial comparing early jejunal feeding (using a frictional nasojejunal [NJ] tube) and standard feeding in critical illness.
- Trial name
- ENTERIC (NCT00163813)
- Testing
- Early jejunal feeding (using frictional NJ tube), Standard feeding (using nasogastric [NG] tube)
- Where
- Australia
- Volunteers
- 180 people
- Sponsor
- Bayside Health
Hyperglycemia
Continuous Glucose Monitoring in Critically Ill Surgical Patients
The specific aim of this study is to identify the degree of correlation between real time subcutaneous glucose monitoring and intermittent glucose monitoring using capillary glucose samples, arterial blood samples and venous…
- Trial name
- NCT01108640
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Yale University
Critical Illness
Perioperative Fluid Management in Patients Receiving Major Abdominal Surgery - Effects of Normal Saline Versus an Acetate Buffered Balanced Infusion Solution on the Necessity of Catecholamines for Cardiocirculatory Support
Background Intraoperative hypotension is a common problem that significantly contributes to perioperative mortality and morbidity.
- Trial name
- KATECHOL (NCT02414555)
- Testing
- vasopressor, fluid bolus, oesophagus doppler (CardioQ)
- Where
- Austria
- Volunteers
- 60 people
- Sponsor
- Medical University of Vienna
Neuromuscular Electrical Stimulation, Intensive Care Unit Acquired Weakness
Effects of Neuromuscular Electrical Stimulation on Muscle Mass and Strength in Critically Ill Patients After Cardiothoracic Surgery
The purposes of this study are 1) to determine whether neuromuscular electrical stimulation (NMES) is effective in preventing loss of muscle mass and strength and 2) to observe the time variation of MLT and strength from…
- Conditions
- Neuromuscular Electrical Stimulation, Intensive Care Unit Acquired Weakness, Muscle Wasting, Muscle Loss
- Trial name
- Catastim 2 (NCT02391103)
- Testing
- Compex 3 Professional (CefarCompex Medical AB) stimulator
- Volunteers
- 54 people
- Sponsor
- Medical University of Vienna
Prevalence of Augmented Renal Clearance, Risk Factors for Augmented Renal Clearance
Augmented Renal Clearance in the Adult Non-critically Ill Surgery Patient: a Prospective Point Prevalance Study
This point prevalence study investigates the prevalence of augmented renal clearance (i.e. a measured 8-hour urinary creatinine clearance >= 120 ml/min/1.73m²) in an adult non-critically ill abdominal and trauma surgery…
- Trial name
- ARCPPS (NCT02228551)
- Testing
- Augmented renal clearance Point prevalence study
- Where
- Belgium
- Volunteers
- 279 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Critical Illness, Intensive Care
Registration Enabling Study of the Safety and Efficacy of the Use of the Navigator Circulatory Management System
A multicentre, open, RCT to assess the safety and efficacy of the Navigator Guided Circulatory Management System versus conventional care in post-operative cardiac surgery patients.
- Trial name
- NAV-1 (NCT00468247)
- Testing
- Navigator, Conventional care
- Where
- 7 sites in Australia
- Volunteers
- 112 people
- Sponsor
- Applied Physiology Pty Ltd
Critical Illness, Trauma
Fluid Resuscitation Optimization in Surgical Trauma Patients (FROST)
The aim of this study is to determine if the incidence of post-operative complications can be decreased by the implementation of intra-operative, minimally invasive hemodynamic monitoring (MIHM) via FloTrac™ and EV1000™ in trauma…
- Trial name
- FROST (NCT02742974)
- Testing
- Device: FloTrac™ and EV1000™, Volume Challenge, Vasopressor Therapy
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- CAMC Health System
Sepsis, Burn Injury
Surgical Critical Care Initiative (SC2i) Tissue and Data Acquisition Protocol (TDAP) in Burn Patients Improving the Robustness and Generalizability of Post-burn Sepsis Prediction With the Post-Burn Sepsis Digital Twin. Group 1
This study is following adult patients with serious burn injuries to better understand how their bodies respond to treatment and recovery.
- Conditions
- Sepsis, Burn Injury, Wound Healing, Critical Illness
- Trial name
- NCT07249762
- Testing
- Observational Cohort (No Intervention)
- Where
- 3 sites in United States
- Volunteers
- 40 people
- Sponsor
- Henry M. Jackson Foundation for the Advancement of Military Medicine
Delirium in Old Age
Combination of Haloperidol and Magnesium for Delirium Prevention in Critically Ill Elderly
Objective: The aim of this randomized double blinded study is to investigate the effectiveness and safety of the prophylactic use of haloperidol with or without magnesium (Mg) for delirium in high risk elderly patients…
- Trial name
- NCT06168773
- Testing
- Haloperidol Injection
- Where
- Egypt
- Volunteers
- 135 people
- Sponsor
- Ain Shams University
Malnutrition in Pregnancy, Malnutrition; Protein
Value of Early Postoperative Peptide-based Formula in Critically Ill Obstetrics on Recovery Enhancement
This is the first trial to assess the early semi-elemental postoperative formula load to meet the protein requirements in the first and second day postoperative to enhance the recovery of critically ill parturient (value on ERAS…
- Conditions
- Malnutrition in Pregnancy, Malnutrition; Protein, Postpartum Disorder, Patient Satisfaction
- Trial name
- NCT06164301
- Testing
- Elemental amino-acids
- Where
- Egypt
- Volunteers
- 83 people
- Sponsor
- Ain Shams University