Clinical trials: Critically- Ill Children
Enteral Nutrition, Feeding Intolerance
Evaluation of Status of Early Reached Target Enteral Nutrition and IFABP as Biomarker of Feeding Intolerance in Critically Ill Children
Stage 1 - Evaluation of Status of Early Reached Target Enteral Nutrition in critically ill children in the PICU (ERTEN in PICU).
- Conditions
- Enteral Nutrition, Feeding Intolerance, Intestinal Fatty Acid Binding Protein
- Trial name
- ERTENIFABPICU (NCT02598375)
- Testing
- Feeding intolerance
- Where
- Germany
- Volunteers
- 150 people
- Sponsor
- Gazi University
Critical Illness
Safety and Dose Escalation Study of Zinc Supplementation in Critically Ill Children
The purpose of the study is 1) to determine whether administration of intravenous zinc to critically ill children is safe, and 2) to determine an appropriate dose of zinc supplementation.
- Trial name
- NCT01062009
- Testing
- Zinc sulfate
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- UCSF Benioff Children's Hospital Oakland
Children
AI Based Multi-modal Parameter of Peripheral Blood Cells (MMPBC) Predicts Survival Risk in Critically Ill Children
This study aims to investigate whether an AI prediction model based on blood cell multi-modal data can achieve early warning of survival risk in critically ill children through a large-scale multi-center cohort of critically ill…
- Trial name
- NCT06034639
- Where
- China
- Volunteers
- 3 people
- Sponsor
- Zhujiang Hospital
Mechanical Ventilator Weaning, Critically Ill
Neurally Adjusted Ventilatory Assist for Weaning From Invasive Mechanical Ventilation in Critically Ill Children
The goal of this clinical trial is to compare weaning from mechanical ventilation in critically ill children. The main questions it aims to answer are: Will weaning with neurally adjusted ventilatory assist (NAVA) mode…
- Conditions
- Mechanical Ventilator Weaning, Critically Ill, Mechanical Ventilation, Neurally Adjusted Ventilatory Assist
- Trial name
- NCT06157593
- Testing
- NAVA
- Where
- Thailand
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Chulalongkorn University
Systemic Inflammatory Response Syndrome (SIRS), Sepsis
Electronic Application of a Severe Sepsis Screening Tool and Management Bundle
Thousands of children die from Sepsis following routine infections. Many of these deaths can be prevented with earlier recognition and focused management.
- Conditions
- Systemic Inflammatory Response Syndrome (SIRS), Sepsis, Severe Sepsis, Septic Shock
- Trial name
- eASSIST-M (NCT01724463)
- Testing
- Severe Sepsis Management Bundle
- Where
- United States
- Volunteers
- 30,000 people
- Sponsor
- University of Tennessee
Critical Illness, Mechanical Ventilation Complication
Enteral Feeding in Mechanically Ventilated Children
This prospective cohort study aims to assess enteral feeding practices and the adequacy of energy and protein delivery among mechanically ventilated children admitted to the pediatric intensive care unit.
- Trial name
- NCT07884838
- Volunteers
- 60 people
- Sponsor
- Assiut University
Sepsis, Critical Illness
Methionine Metabolism in Enterally Fed Pediatric Sepsis
Critically ill children have abnormal utilization of nutrients such as glucose, lipids and protein. Protein synthesis is increased mainly in the form of immune and signaling proteins, while muscle and structural protein synthesis…
- Trial name
- NCT01889264
- Testing
- Observational
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- The Cleveland Clinic
Critical Illness
U/S Guided vs. Traditional Palpation for Radial Artery Cannulation
The purpose of this study is to compare the efficacy of ultrasound- guided with the traditional palpation radial artery cannulation in critically ill children.
- Trial name
- NCT02668471
- Testing
- Ultrasound, traditional method
- Where
- Thailand
- Volunteers
- 84 people
- Sponsor
- Ramathibodi Hospital
Acute Respiratory Distress Syndrome
Restore Resilience in Critically Ill Children
The study design will allow investigators to describe usual care in each PICU and identify the facilitating and restraining factors impacting the implementation of R2 at each PICU.
- Trial name
- R2 (NCT04695392)
- Testing
- R2 Bundle
- Where
- 2 sites in United States
- Volunteers
- 56 people
- Sponsor
- University of Pennsylvania
Hemoglobin Results
Comparing Validity of Non-Invasive Hemoglobin Monitoring to Laboratory Results in Critically Ill Children
This is a prospective study to determine the accuracy of the Masimo Pronto Non-Invasive Hemoglobin Monitor and associated Rainbow® probes in the detection of hemoglobin concentration in critically ill children.
- Trial name
- NCT01750463
- Testing
- Masimo Pronto Rad 7 Non-Invasive hemoglobin monitor, Standard Laboratory Blood Draw and Hemoglobin Analysis
- Where
- United States
- Volunteers
- 65 people
- Sponsor
- University of North Carolina, Chapel Hill
Pediatric Acute Respiratory Distress Syndrome (PARDS), Pediatric Respiratory Diseases
IPV and Lung Compliance in Invasively Ventilated Children
The goal of this observational study is to determine if Intrapulmonary Percussive Ventilation (IPV) improves lung compliance in children receiving conventional invasive mechanical ventilation.
- Conditions
- Pediatric Acute Respiratory Distress Syndrome (PARDS), Pediatric Respiratory Diseases, Lung Compliance
- Trial name
- NCT06836050
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Northwell Health
Critical Illness, Child, Only
Epidemiological Study of the Microbiota in Critically Ill Children
Objectives: To study the composition of the microbiota in critically ill children, and to know the relationship of its microbiota with clinical complications and inflammation biomarkers.
- Conditions
- Critical Illness, Child, Only, Intensive Care Unit
- Trial name
- BIOUCIP (NCT04435470)
- Where
- Spain
- Volunteers
- 90 people
- Sponsor
- Universidad de Granada
Pediatric Critical Illness, Anxiety
Interactive Digital Art-Based Relaxation Program
This randomized controlled trial aims to evaluate the effects of an Interactive Digital Art-Based Relaxation Program on physiological parameters, anxiety levels, and emotional distress in children aged 7-12 years receiving care…
- Trial name
- NCT07388485
- Testing
- Interactive Digital Art-Based Relaxation Program
- Volunteers
- 60 people
- Sponsor
- Gazi University
ICU Length of Stay
Primary Intensivists and Primary Nurses to Decrease Pediatric ICU Length of Stay
This is a randomized control trial of PICU patients admitted for 7 days and expected to remain for at least another 3 days and who have a complex chronic condition.
- Trial name
- PIPRNs (NCT03364933)
- Testing
- Primary intensivist and nurses
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Columbia University
Acute Kidney Injury, Renal Replacement Therapy
FST Analysis Supporting Timely Therapy and Risk Assessment Via Clinical Decision Support for Kids
The goal of this study is to learn whether adding a clinical decision support tool to the electronic medical record helps clinicians use the furosemide stress test in critically ill children at high risk for severe acute kidney…
- Conditions
- Acute Kidney Injury, Renal Replacement Therapy, Pediatric Intensive Care Unit
- Trial name
- FAST TRACK (NCT07718464)
- Testing
- Furosemide Stress Test Clinical Decision Support Tool
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Pediatric Asthma, Critical Illness
Azithromycin for Critical Asthma - Pediatrics
The CR-AZI Study will assess the immunomodulatory effects of Azithromycin for pediatric Critical Asthma.
- Trial name
- CR-AZI Kids (NCT06223828)
- Testing
- Azithromycin
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Johns Hopkins All Children's Hospital
Infection, Bacterial, Antibiotic Side Effect
Medical Device (MD) Derived Pharmacokinetic (PK) Parameters for Vancomycin (MD-PK)
Getting the right dose of antibiotic promptly is an important part of treating infections. Unfortunately, when an infection is severe (sepsis) the body changes how it processes antibiotics.
- Conditions
- Infection, Bacterial, Antibiotic Side Effect, Antibiotic Resistant Infection, Sepsis
- Trial name
- MD-PK (NCT05950984)
- Testing
- Drug Infusion Pump Monitoring
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- St George's, University of London
Decision Making, Neonatal Critical Illness
Building Relationship, Improving Dialogue, and Growing Empathy (BRIDGE): An Intervention to Support Decision Making for Critically Ill Children
Parents of young children in the intensive care unit may be faced with decisions about their child's care. The Building Relationship, Improving Dialogue, and Growing Empathy (BRIDGE) intervention was designed to help support…
- Conditions
- Decision Making, Neonatal Critical Illness, Pediatric Critical Illness
- Trial name
- BRIDGE (NCT07390773)
- Testing
- BRIDGE intervention
- Where
- 3 sites in United States
- Volunteers
- 495 people
- Sponsor
- Duke University
Critical Illness
Early In-bed Cycling in Critically Ill Children
To evaluate the feasibility of conducting a randomized controlled trial (RCT) evaluating the efficacy of early in-bed cycling in addition to usual care physiotherapy, compared to usual care physiotherapy, on functional recovery…
- Trial name
- wEECycle (NCT02358577)
- Testing
- In-bed cycling, Usual Care
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- McMaster University
Fever
Fever Observational Study
To inform the feasibility of conducting a study to test different temperature thresholds at which clinicians deliver interventions to reduce fever (i.e.
- Trial name
- NCT03028818
- Where
- United Kingdom
- Volunteers
- 3,960 people
- Sponsor
- Intensive Care National Audit & Research Centre