Clinical trials: Crohn's Diseases
Crohn Disease, Colitis, Ulcerative
Home basEd faecaL calProtectin Measurements Predicting Adalimumab Induction Destiny
Recently a smartphone application IBDoc® was developed to enable patients to measure faecal calprotectin at home in an easy way.
- Trial name
- HELP-AID (NCT02634060)
- Testing
- Home Based Fecal Calprotectin
- Where
- Belgium
- Volunteers
- 140 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Crohn Disease, Adherent-invasive E. Coli
Evaluation of Adherent Invasive E. Coli Eradication in Adult Crohn Disease
The primary objective of this trial is to assess whether a 12-week treatment with Ciprofloxacin and Rifaximin is superior to placebo to obtain endoscopic remission in adherent-invasive E.
- Trial name
- TEOREM (NCT02620007)
- Testing
- Ciprofloxacin, Rifaximin
- Where
- 2 sites in France
- Volunteers
- 24 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Crohn Disease
Evaluate Efficacy of Certolizumab in Crohn's Patients With Draining Fistulas
To investigate the clinical efficacy of certolizumab pegol for fistula closure in Crohn's disease subjects with active draining fistulas.
- Trial name
- NCT00354367
- Testing
- Certolizumab pegol
- Sponsor
- UCB Pharma
Colitis, Ulcerative, Crohn Disease
A Study to Evaluate Disease Control and Treatment Pattern in Participants With Moderate to Severe Inflammatory Bowel Disease (IBD) in Real Life Practice
The purpose of this study is to characterize the treatment patterns associated with biologics agents use or non-biological therapy in participants with moderate to severe Ulcerative Colitis (UC) and Crohn's Disease (CD).
- Conditions
- Colitis, Ulcerative, Crohn Disease, Inflammatory Bowel Diseases
- Trial name
- INTENT (NCT03532932)
- Where
- 36 sites in Belarus, Kazakhstan and 1 more
- Volunteers
- 1,990 people
- Sponsor
- Takeda
Crohn's Disease, Genetic Predisposition
Abnormal Fecal Microbiota in Healthy Subjects at High Risk for Crohn's Disease
Transversal multicentric French study on the microbiota in patients with Crohn's disease and their first degree healthy relatives The primary objective is the comparison of microbiota between patients with CD, healthy controls…
- Trial name
- MAGIC (NCT02826330)
- Testing
- biomarkers
- Where
- 10 sites in France
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- University Hospital, Lille
Crohn Disease
Genomic/Epigenomic Biomarkers of Deregulation of Immune System in Inflammatory Bowel Diseases
The purpose is to search for enterocyte-specific or non-specific molecular signature of post-operating recurrence of Crohn's disease in transcriptome (measurement of gene expression through number of mRNA copies transcribed for…
- Trial name
- PREDIPOSTOP (NCT02878395)
- Testing
- Ileocolic resection
- Volunteers
- 30 people
- Sponsor
- Central Hospital, Nancy, France
Crohn Disease, Pediatric Crohns Disease
PediCRaFT: Pediatric Crohn's Disease Fecal Transplant Trial
The objective of this study is to assess the feasibility of a novel colonic and oral fecal microbiota transplantation protocol for the treatment of active pediatric Crohn's disease (CD).
- Conditions
- Crohn Disease, Pediatric Crohns Disease, Inflammatory Bowel Diseases, Colitis
- Trial name
- PediCRaFT (NCT03378167)
- Testing
- MICROBIOTA
- Where
- 2 sites in Canada
- Volunteers
- 17 people
- Sponsor
- McMaster Children's Hospital
Inflammatory Bowel Diseases
Correlation Between RISANKIZUMAB's Trough Levels, Clinical and Biological Remission in Moderate to Severe Crohn's Disease: a Retrospective Multicentric Study
The goal of this observational study is to determine if, as with other therapeutics such as anti-TNF, trough levels of Risankizumab are correlated with clinical and biological remission in patients with moderate to severe Crohn's…
- Trial name
- RISE-CD (NCT06589895)
- Where
- France
- Volunteers
- 40 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Crohn's Disease
Long-term Safety Study of Brodalumab in Adults With Crohn's Disease
The purpose of this study is to evaluate the safety and efficacy of long-term treatment with brodalumab in adults with Crohn's disease.
- Trial name
- NCT01199302
- Testing
- Brodalumab
- Where
- 34 sites in United States, Australia and 6 more
- Volunteers
- 67 people
- Sponsor
- Amgen
Crohn's Disease, Ulcerative Colitis
Body Composition in Children With Inflammatory Bowel Disease
Background: Growth impairment is commonly seen in children diagnosed with inflammatory bowel diseases (IBD), mainly those with Crohn's disease (CD).
- Trial name
- NCT02745457
- Where
- Israel
- Volunteers
- 72 people
- Sponsor
- Schneider Children's Medical Center, Israel
Colitis, Ulcerative, Crohn Disease
A Study to Assess Guselkumab in Participants With Moderate-to-Severe Inflammatory Bowel Disease in Real Life Italian Setting
The purpose of this study is to characterize participants with Crohn's Disease (CD) and Ulcerative Colitis (UC) receiving guselkumab in a real-world setting, and to evaluate treatment persistence (continuation) and clinical…
- Conditions
- Colitis, Ulcerative, Crohn Disease, Inflammatory Bowel Diseases
- Trial name
- GLAMOUR (NCT07851207)
- Volunteers
- 200 people
- Sponsor
- Janssen-Cilag Ltd.
Crohn Disease
Effectiveness of Rifaximin Combined With Thiopurine on Preventing Postoperative Recurrence in Crohn's Disease
Some studies have shown that rifaximin is effective in the management of Crohn's Disease. Meanwhile, its adverse effect is tolerable. But no study has been conducted to assess its effect on preventing postoperative recurrence.
- Trial name
- NCT03185611
- Testing
- Rifaximin, Azathioprine
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Sixth Affiliated Hospital, Sun Yat-sen University
Inflammatory Bowel Diseases, Crohn Disease
Personalized Research on Diet in Ulcerative Colitis and Crohn's Disease
A series of N-of-1 trials will be used to determine the effectiveness of a specific carbohydrate diet (SCD) versus a modified SCD in patients in reducing symptoms and inflammatory burden at both the individual and population…
- Conditions
- Inflammatory Bowel Diseases, Crohn Disease, Ulcerative Colitis, Indeterminate Colitis
- Trial name
- PRODUCE (NCT03301311)
- Testing
- Specific Carbohydrate Diet (SCD), Modified Specific Carbohydrate Diet (MSCD)
- Where
- 20 sites in United States
- Volunteers
- 54 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Crohn's Disease
The Effect on Mucosal Healing With Pentasa Sachet in Mild to Moderate Active "Drug: Crohn's Disease"
The purpose of this study is to visualize the healing effect on mucosal lesions with Pentasa Sachet 4g in patients with mild to moderate active small bowel CD by video capsule endoscopy.
- Trial name
- NCT00245505
- Testing
- Mesalazine (Mesalamine)
- Where
- Sweden
- Volunteers
- 3 people
- Sponsor
- Ferring Pharmaceuticals
Crohn's Disease, Ulcerative Colitis
Cannabidiol for Inflammatory Bowel Disease
There are many anecdotal reports about improvement of Inflammatory bowel diseases (IBD) with cannabis smoking. The most effective anti inflammatory compound known today is cannabidiol.
- Trial name
- NCT01037322
- Testing
- cannabidiol
- Where
- Israel
- Volunteers
- 20 people
- Sponsor
- Meir Medical Center
Crohn's Disease
Infliximab Top-down in Pediatric Crohn
The purpose of this study is to determine whether a top-down treatment approach, prescribing infliximab and azathioprine at diagnose, yields better outcome in comparison to the usual step-up treatment approach, starting with…
- Trial name
- ITSKids (NCT01880307)
- Testing
- Azathioprine, Infliximab, Prednisolon
- Where
- 2 sites in Italy, Netherlands
- Volunteers
- 13 people
- Sponsor
- Erasmus Medical Center
Inflammatory Bowel Diseases, Ulcerative Colitis
IBD Strong Peer2Peer for Self-Management of Psychological Distress
Psychological distress (PD) as a result of inflammatory bowel disease (IBD) is prevalent and associated with worse disease-related outcomes.
- Conditions
- Inflammatory Bowel Diseases, Ulcerative Colitis, Crohn Disease
- Trial name
- NCT05722236
- Testing
- IBD Strong Peer2Peer, Waitlist control
- Where
- Canada
- Volunteers
- 120 people
- Sponsor
- Jennifer Jones
Crohn Disease
Microencapsulated Sodium Propionate in IBD Microbiota Modulation
The goal of this clinical trial is to evaluate whether microencapsulated sodium propionate can modulate the gut microbiota and improve inflammatory and immunological parameters in adult patients with inflammatory bowel disease…
- Trial name
- PSM_IBD (NCT07883044)
- Testing
- Microencapsulated sodium propiolate, Microencapsulated sodium Butyrate
- Where
- Italy
- Volunteers
- 50 people
- Sponsor
- University of Padova
Colitis, Ulcerative, Crohn's Disease
A Study of Long-term Effects of Vedolizumab Subcutaneous in Adults With Ulcerative Colitis and Crohn's Disease
The main aim of the study is to check for long-term side effects of Vedolizumab Subcutaneous (also known as Vedolizumab SC) in people with ulcerative colitis (UC) and Crohn's disease (CD).
- Trial name
- NCT02620046
- Testing
- Vedolizumab SC
- Where
- 301 sites in United States, Argentina and 31 more
- Volunteers
- 746 people
- Sponsor
- Takeda
Intestinal Diseases, Ulcerative Colitis
Anti-Inflammatory Effects of Mango Polyphenolics in Inflammatory Bowel Disease
Bioactive compounds from mango are bioavailable and their anti-inflammatory efficacy has been demonstrated in animals and humans.
- Conditions
- Intestinal Diseases, Ulcerative Colitis, Crohn Disease
- Trial name
- NCT02227602
- Testing
- Mango polyphenolics
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Texas A&M University
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