Clinical trials: Crohn's Diseases
Crohn Disease (CD)
Concordance Between Inflammatory Activity Assessed by Enteric MRI With and Without Intestinal Distension Product in Patients With Ileal Crohn's Disease.
Crohn's disease (CD) is a chronic inflammatory bowel disease (IBD) that can significantly impair patients' quality of life. Due to its transmural nature (affecting the entire thickness of the intestinal wall), it naturally…
- Trial name
- CONFORT (NCT07471438)
- Testing
- MRI
- Where
- 2 sites in France
- Volunteers
- 60 people
- Sponsor
- University Hospital, Clermont-Ferrand
CD - Crohn's Disease
The CURE - CD Trial
A prospective randomized three-arms controlled trial of Crohn's Disease (CD) patients in remission of <24 months duration. Patients will undergo screening by Magnetic Resonance Enterography (MRE) and patency capsule, and (if…
- Trial name
- NCT03555058
- Testing
- Treatment escalation
- Where
- Israel
- Volunteers
- 60 people
- Sponsor
- Sheba Medical Center
IBD
Intestinal Epithelial Fucosylation Affects the Efficacy of Ustekinumab in Crohn's Disease
The loss of response rate of ustekinumab(UST) is high, and the specific mechanism has not yet been elucidated. Molecular markers that can accurately predict the efficacy of UST are urgently needed to provide theoretical basis for…
- Trial name
- NCT06203158
- Where
- China
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital of Wenzhou Medical University
Crohn Disease
The Effects of Bifidobacterium Breve Bif195 for Small Intestinal Crohn's Disease
The purpose of this study is to investigate if the probiotic Bifidobacterium breve Bif195 (Bif195) will result in improvement in clinical outcome in patients with small intestinal Crohn's disease.
- Trial name
- NCT04842149
- Testing
- Bif195 capsules
- Where
- Denmark
- Volunteers
- 33 people
- Sponsor
- Hvidovre University Hospital
Crohn's Disease, Ankylosing Spondylitis
Post Marketing Surveillance of Remicade
The purpose of this study is to understand the safety and effectiveness of infliximab when used in clinical practice. This is a post-marketing surveillance study.
- Trial name
- NCT00724529
- Testing
- Infliximab
- Volunteers
- 938 people
- Sponsor
- Janssen Korea, Ltd., Korea
Crohn's Disease
The Efficacy of Open Label Infliximab for the Induction and Maintenance of Mucosal Healing in Small Bowel Crohn's Disease Assessed Through Wireless Camera Endoscopy
This is a pilot study to estimate the efficacy of infliximab in inducing and maintaining healing of lesions in the mucosa of subjects with Crohn's disease involving their small bowel.
- Trial name
- ICE (NCT01181765)
- Testing
- Infliximab 5 mg/kg body weight infused over 2 hours
- Where
- 2 sites in Canada
- Volunteers
- 1 people
- Sponsor
- Janssen Inc.
Crohn Disease
Study on the Long-Term Risk of Recurrence of Anoperineal Fistula in Crohn's Disease
This research aims to evaluate the long-term recurrence risk of perianal fistulas in Crohn's disease patients who have undergone treatment with anti-TNF therapy and seton drainage.The research seeks to identify factors…
- Trial name
- LT-SAFCD (NCT06514092)
- Testing
- anti-TNF therapy and seton drainage
- Where
- France
- Volunteers
- 63 people
- Sponsor
- University Hospital, Toulouse
Crohn Disease, Ulcerative Colitis
Occupational Insertion and Educational Level of Adult Patients With Pediatric Early Inflammatory Bowel Disease (IBD)
The main objective of this project is to assess the occupational insertion of these adult patients with pediatric-onset IBD and to compare it with the general population. The secondary objectives are: 1.
- Trial name
- PROMICI (NCT04887428)
- Where
- France
- Volunteers
- 343 people
- Sponsor
- University Hospital, Lille
Hypertension, Depression
Patient-Centred Innovations for Persons With Multimorbidity - Quebec
The aim of Patient-Centred Innovations for Persons With Multimorbidity (PACE in MM) study is to reorient the health care system from a single disease focus to a multimorbidity focus; centre on not only disease but also the…
- Conditions
- Hypertension, Depression, Anxiety, Musculoskeletal Pain
- Trial name
- PACEinMM-QC (NCT02789800)
- Testing
- DIMAC02
- Where
- 2 sites in Canada
- Volunteers
- 284 people
- Sponsor
- Université de Sherbrooke
Inflammatory Bowel Diseases, Crohn Disease
Assessment of Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of ATH-063 in Healthy Subjects
The goal of this clinical trial is to test the ATH-063 drug (single and multiple doses) in Healthy Subjects. The clinical trial aims to evaluate the below. 1. Safety of the drug 2. Tolerability of the drug 3.
- Conditions
- Inflammatory Bowel Diseases, Crohn Disease, Ulcerative Colitis, Autoimmune Diseases
- Trial name
- NCT05807971
- Testing
- ATH-063
- Where
- Australia
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- Athos Therapeutics Inc
Crohn's Disease
The Effect on Mucosal Healing With Pentasa Sachet in Mild to Moderate Active "Drug: Crohn's Disease"
The purpose of this study is to visualize the healing effect on mucosal lesions with Pentasa Sachet 4g in patients with mild to moderate active small bowel CD by video capsule endoscopy.
- Trial name
- NCT00245505
- Testing
- Mesalazine (Mesalamine)
- Where
- Sweden
- Volunteers
- 3 people
- Sponsor
- Ferring Pharmaceuticals
Crohn Disease
Contrast Enhanced Ultrasound in Human Crohn's Disease-Lumason
The investigators plan to compare contrast-enhanced ultrasound to CT and MRI for the detection and quantification of intestinal inflammation in the the setting of pediatric small bowel Crohns disease
- Trial name
- NCT03492944
- Testing
- Ultrasound Microbubble Contrast Agent, Ultrasound Imaging
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Crohn's Disease
Capsule Endoscopy Crohn's Disease Activity Index - Validation Multi Center Study
The Study 1. Prospective trial of the Niv score validating score against known activity indices - see addendum A for Niv score 2.
- Trial name
- NCT00596700
- Testing
- Given® Diagnostic System including PillCamTM SB Capsules
- Where
- 4 sites in Ireland, Israel
- Volunteers
- 100 people
- Sponsor
- Rabin Medical Center
Crohn Disease, Ulcerative Colitis
TARGET Registry A Project of the German Network for Intestinal Diseases in Cooperation With Other Corporate Partners
By capturing possible or known risk factors, it will be possible to recognize connections between these risk factors and the disease, thus obtaining valuable insights into the cause of the disease.
- Conditions
- Crohn Disease, Ulcerative Colitis, Indeterminate Colitis
- Trial name
- TARGET (NCT04031482)
- Testing
- No intervention, only standard care
- Volunteers
- 4,400 people
- Sponsor
- Ced Service GmbH
Crohn's Disease, Colitis
A Study to Evaluate the Safety and Efficacy of Ustekinumab Maintenance Therapy in Patients With Moderately to Severely Active Crohn's Disease (IM-UNITI)
The primary purpose of this study is to evaluate the efficacy and safety of 2 maintenance regimens of ustekinumab administered subcutaneously to patients with moderately to severely active Crohn's disease who responded to…
- Conditions
- Crohn's Disease, Colitis, IBD, Inflammatory Bowel Disease
- Trial name
- NCT01369355
- Testing
- Ustekinumab 90 mg SC q8w, Ustekinumab 130 mg IV, Ustekinumab 90 mg SC q12w
- Where
- 220 sites in United States, Australia and 24 more
- Volunteers
- 1,282 people
- Sponsor
- Janssen Research & Development, LLC
Crohn Disease, Inflammatory Bowel Diseases
Feasibility of a Wireless Thermal Capsule Endoscopy to Detect Gastrointestinal Thermal Variance
The goal of this research is to learn how a new device called the wireless thermal capsule (WTC) can collect thermal data to help see diseases that happen in the gastrointestinal (GI) tract, such as Crohn's Disease.
- Conditions
- Crohn Disease, Inflammatory Bowel Diseases, Healthy
- Trial name
- NCT07033208
- Testing
- Feasibility to obtain thermal variance measurements using a wireless thermal capsule
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Colitis, Ulcerative, Inflammatory Bowel Diseases
Patient Attitudes and Preferences for Outcomes of Inflammatory Bowel Disease Therapeutics
The investigators will test the hypothesis that that greater efficacy of anti-tumor necrosis factor (antiTNF) therapy results in reduced need for bowel resection surgery, fewer serious infections, and reduced short term mortality…
- Conditions
- Colitis, Ulcerative, Inflammatory Bowel Diseases, Crohn's Disease
- Trial name
- PPOD (NCT02316678)
- Testing
- No intervention
- Where
- United States
- Volunteers
- 9,573 people
- Sponsor
- University of Pennsylvania
Iron Deficiency Anaemia, Inflammatory Bowel Disease
Safety and Efficacy Study of Oral Ferric Iron To Treat Iron Deficiency Anaemia in Quiescent Crohn's Disease (AEGIS-2)
The purpose of this study is to determine whether ST10-021, an oral ferric iron preparation, is safe and effective in the treatment of iron deficiency anaemia (IDA) in subjects with non-active Crohn's Disease (CD).
- Conditions
- Iron Deficiency Anaemia, Inflammatory Bowel Disease, Crohn's Disease
- Trial name
- AEGIS-2 (NCT01352221)
- Testing
- ST10
- Volunteers
- 128 people
- Sponsor
- Shield Therapeutics
Ulcerative Colitis, Crohn's Disease
An Open-label Study of Vedolizumab (MLN0002) in Participants With Ulcerative Colitis and Crohn's Disease
The purpose of this multicenter, open-label study is to collect data on the occurrence of important clinical safety events resulting from chronic vedolizumab (MLN0002) administration.
- Trial name
- GEMINI LTS (NCT00790933)
- Testing
- Vedolizumab
- Where
- 41 sites in United States, Australia and 8 more
- Volunteers
- 2,243 people
- Sponsor
- Takeda
Crohn Disease, Ultrasound Therapy; Complications
Correlation of Cross Sectional Imaging and Small Intestinal Contrast Ultrasonography in Known Crohn's Disease
Small intestinal contrast ultrasound (SICUS) is a modality of intestinal ultrasound (IUS) which does not require any parenteral administration of contrast agent but requires ingestion of around 500 ml of polyethylene glycol…
- Conditions
- Crohn Disease, Ultrasound Therapy; Complications, Computed Tomography, Magnetic Resonance Imaging
- Trial name
- CACTUS-CD (NCT06125678)
- Testing
- Small intestinal contrast enhanced ultrasound followed by Computed tomography/Magnetic resonance enterography
- Where
- India
- Volunteers
- 407 people
- Sponsor
- Asian Institute of Gastroenterology, India
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