Clinical trials: Crohn Disease of Intestine
Inflammatory Bowel Disease, Intestinal Fistula
Safety and Efficacy of AST-120 in Mild to Moderate Crohn's Patients With Fistulas
The objective of this study is to evaluate the safety and effectiveness of the experimental drug AST-120 in treating patients with mild to moderately severe Crohn's disease who have fistulas.
- Trial name
- NCT00321412
- Testing
- AST-120
- Where
- 88 sites in United States, Austria and 10 more
- Volunteers
- 191 people
- Sponsor
- Ocera Therapeutics
Crohn Disease (CD), Intestinal Stricture
Endoscopic Stricturotomy Versus Balloon Dilation for Small Bowel Fibrotic Strictures in Crohn's Disease
This multicenter, open-label, randomized controlled trial aims to compare the safety and immediate effectiveness of endoscopic stricturotomy (ES) and endoscopic balloon dilation (EBD) for the treatment of small bowel fibrotic…
- Conditions
- Crohn Disease (CD), Intestinal Stricture, Intestinal Fibrosis
- Trial name
- NCT07833332
- Testing
- Endoscopic Stricturotomy, Endoscopic Balloon Dilation
- Where
- China
- Volunteers
- 244 people
- Sponsor
- Sixth Affiliated Hospital, Sun Yat-sen University
Crohn's Disease and Ulcerative Colitis
Interleukin-23 Monoclonal Antibody for Inflammatory Bowel Disease: Efficacy and Safety
Patients diagnosed with moderate to severe CD or UC by the end of the study period were selected. After obtaining informed consent, treatment with infliximab-based drugs was initiated.
- Trial name
- NCT07216014
- Testing
- Interleukin 23
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Sixth Affiliated Hospital, Sun Yat-sen University
Inflammatory Bowel Diseases, Crohn Disease
Effect of a Probiotic Mixture on the Gut Microbiome and Fatigue in Patients With Quiescent Inflammatory Bowel Disease
The study is proposed as a single-site randomized double-blind placebo-controlled trial requiring 4 study visits, where two of the visits are combined with their appointment for routine clinical care.
- Conditions
- Inflammatory Bowel Diseases, Crohn Disease, Ulcerative Colitis
- Trial name
- NCT03266484
- Testing
- Probiotic Mixture
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Massachusetts General Hospital
Complex Perianal Fistula, Crohn Disease
Safety and Efficacy of Adipose-Derived Stem Cells to Treat Complex Perianal Fistulas Patients With Crohn's Disease
The purpose of this study is to determine safety and efficacy of eASCs (expanded adult stem cells) for treatment of complex perianal fistulas in patients with Crohn's disease.
- Trial name
- FATT (NCT01378390)
- Testing
- Expanded autologous adipose-derived adult stem cells (eASCs)
- Where
- 12 sites in Austria, Netherlands and 1 more
- Volunteers
- 56 people
- Sponsor
- Tigenix S.A.U.
Anemia, Bowel Diseases, Inflammatory
Anemia in Inflammatory Bowel Disease
Anemia is a clinical manifestation, which is commonly observed in patients with inflammatory bowel disease, and it accounts for significant loss in the quality of life of these patients.
- Trial name
- IBD (NCT02760940)
- Testing
- oral liposomal iron
- Volunteers
- 200 people
- Sponsor
- Federal University of Juiz de Fora
Crohn Disease, Ulcerative Colitis
National Observational Study On The Use Of Inflectra™ An Infliximab Biosimilar In Real Life
National, prospective, multicentre observational study designed for eligible patients treated with Inflectra. Its objectives are to describe under real conditions of use, the profile of patients treated with Inflectra and the…
- Conditions
- Crohn Disease, Ulcerative Colitis, Rheumatoid Arthritis, Ankylosing Spondylitis
- Trial name
- ReFLECT (NCT02925338)
- Testing
- QOL questionaire
- Where
- 67 sites in France
- Volunteers
- 1,431 people
- Sponsor
- Pfizer
Crohn's Disease, Ulcerative Colitis
Cannabis for Inflammatory Bowel Disease
Background: The marijuana plant Cannabis has been used for centuries in the medicinal treatment of many disorders and is still the subject of medical research and public debate.
- Trial name
- NCT01040910
- Testing
- smoking of cannabis
- Where
- 2 sites in Israel
- Volunteers
- 20 people
- Sponsor
- Meir Medical Center
Lymphoma
An Observational Study of Lymphoma in Patients With Rheumatoid Arthritis or Crohn's Disease.
The purpose of this study is to examine the association with EBV infection, monitor the occurrence of lymphoma and assess lymphoma risk in patients with rheumatoid arthritis and/or Crohns disease and you have taken infliximab.
- Trial name
- NCT00440817
- Testing
- No intervention
- Where
- 3 sites in United States
- Volunteers
- 120 people
- Sponsor
- Centocor Ortho Biotech Services, L.L.C.
Colitis, Ulcerative, Crohn Disease
A Study of Vedolizumab in Adults in Real-World Practice
Vedolizumab is a medicine that is currently prescribed for adults with moderately to severely active ulcerative colitis or Crohn's disease.
- Trial name
- NCT04872491
- Where
- 40 sites in China
- Volunteers
- 500 people
- Sponsor
- Takeda
Ulcerative Colitis, Crohn Disease
A Multicentered Prospective Cohort Study of Chinese IBD Patients
Inflammatory bowel disease(IBD), including ulcerative colitis (UC) and Crohn's disease (CD), is characterized by chronic and recurrent nonspecific intestinal inflammation with high disability rate.
- Trial name
- NCT05386290
- Testing
- Infliximab, Vedolizumab, Ustekinumab
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Peking Union Medical College Hospital
IBD (Inflammatory Bowel Disease), IBS - Irritable Bowel Syndrome
ALPCO/Calprotectin CLIA Assay: Expected Values of Calprotectin in Healthy Subjects
This study is evaluating the levels of calprotectin, a protein found in stool, in healthy adults. Calprotectin is a marker of inflammation in the intestines and can help doctors tell the difference between inflammatory bowel…
- Conditions
- IBD (Inflammatory Bowel Disease), IBS - Irritable Bowel Syndrome, Crohn Disease (CD), UC - Ulcerative Colitis
- Trial name
- NCT07089420
- Testing
- ALPCO Calprotectin CLIA
- Where
- United States
- Volunteers
- 121 people, healthy volunteers welcome
- Sponsor
- American Laboratory Products Company
Inflammatory Bowel Disease, Crohn Disease
The Role of IGRA in Screening and Monitoring for TB During Anti TNF Therapy in Patients With IMID
Hong Kong is a region of intermediate TB burden, and the reactivation of latent TB in IMID patients treated with anti-TNF can be a serious problem.
- Conditions
- Inflammatory Bowel Disease, Crohn Disease, Ulcerative Colitis, Tuberculosis
- Trial name
- IGRA (NCT02135289)
- Where
- Hong Kong
- Volunteers
- 9,160 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
Inflammatory Bowel Diseases, Ulcerative Colitis
Improving Patient Outcomes Through the Implementation of an IBD Biologic Care Pathway
Inflammatory Bowel Disease (IBD) includes a group of chronic inflammatory conditions of the gastrointestinal system and is composed of Crohn's disease and ulcerative colitis.
- Conditions
- Inflammatory Bowel Diseases, Ulcerative Colitis, Crohn Disease
- Trial name
- NCT06030882
- Testing
- Biologic Care Pathway
- Where
- Canada
- Sponsor
- Jennifer Jones
Crohn Disease, Colitis, Ulcerative
A Study to Evaluate the Long-Term Effect of TEV-48574 in Moderate to Severe Ulcerative Colitis or Crohn's Disease
The primary objective of the study is to evaluate the efficacy of 2 different maintenance dose regimens of TEV-48574 subcutaneous (sc) administered every 4 weeks (Q4W) in adult participants with inflammatory bowel disease (IBD).
- Trial name
- NCT05668013
- Testing
- TEV-48574 Dose Regimen A, TEV-48574 Dose Regiment B
- Where
- 93 sites in United States, Austria and 14 more
- Volunteers
- 247 people
- Sponsor
- Teva Branded Pharmaceutical Products R&D LLC
Crohn's Disease
Top Down Versus Step Up Strategies in Crohn's Disease
The study prospectively compares two treatment algorithms for newly diagnosed Crohn's disease: one 'aggressive' treatment with early introduction of immunomodulators and biologicals and one 'standard treatment' with…
- Trial name
- NCT00554710
- Testing
- infliximab+azathioprine, methylprednisolone or budesonide
- Where
- Belgium
- Volunteers
- 129 people
- Sponsor
- Belgian Inflammatory Bowel Disease Research and Development (BIRD) VZW
Crohn's Disease
A Study of Vedolizumab With and Without Upadacitinib in Adults With Crohn's Disease
The main aim of this study is to learn whether vedolizumab and upadacitinib given together (also called dual targeted therapy or DTT) reduces bowel inflammation and ulcers in the bowel compared to vedolizumab only (also called…
- Trial name
- VICTRIVA (NCT06227910)
- Testing
- Vedolizumab, Upadacitinib
- Where
- 138 sites in United States, Austria and 24 more
- Volunteers
- 396 people
- Sponsor
- Takeda
Colitis Ulcerative, Crohn's Disease
A Study to Investigate the Long-term Safety, Tolerability and Efficacy of Balinatunfib in Participants With Crohn's Disease or Ulcerative Colitis (SPECIFI-IBD-LTS)
LTS19689 is a multinational, multicenter extension study to evaluate the long-term safety, tolerability and efficacy of balinatunfib in participants with Crohn's disease (CD) or ulcerative colitis (UC) who completed the 52-week…
- Trial name
- NCT07222189
- Testing
- balinatunfib
- Where
- 10 sites in United States, Argentina and 5 more
- Volunteers
- 7 people
- Sponsor
- Sanofi
Crohn's Disease, Vitamin D Deficiency
Exploring the Effects of Vitamin D Supplementation on the Chronic Course of Patients With Crohn's Disease With Vitamin D Deficiency
Aims:Prospectively observe the effects of Vitamin D drops supplementation on the chronic course of Crohn's disease patients, analyze whether the effect of Vitamin D drops on CD patients is affected by factors such as disease…
- Conditions
- Crohn's Disease, Vitamin D Deficiency, Vitamin D Supplement
- Trial name
- NCT04308850
- Testing
- Vitamin D drops
- Where
- China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital of Wenzhou Medical University
Anal Fistula, Crohn's Disease
Long-term Follow-up of Anal Fistulae in Crohn's Disease Treated With Anti-TNFalpha and Interest of New MRI Sequences
Main purposes of this study are : Analysis of relapse risk of anal fistulae with prospective follow-up of patients undergoing pelvic MRI every 6 months for one year.
- Trial name
- FISTULE (NCT02883296)
- Testing
- Pelvis Magnetic resonance imaging
- Volunteers
- 15 people
- Sponsor
- Central Hospital, Nancy, France
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