Clinical trials: Crohn Disease of Intestine
Inflammatory Bowel Diseases
Efficacy of LiveSpo COLON as a Supportive Treatment for Inflammatory Bowel Disease (IBD)
Inflammatory bowel disease (IBD) is a prevalent condition, comprising two major types: (1) Crohn disease (chronic enteritis characterized by abdominal pain, stool irregularities, fatigue, weight loss, and malnutrition) and (2)…
- Trial name
- NCT06637683
- Testing
- LiveSpo COLON, Routine treatment
- Where
- Vietnam
- Volunteers
- 60 people
- Sponsor
- Anabio R&D
Crohn's Disease
Pharmacodynamic and Clinical Outcome Study of Mongersen in Patients With Crohn's Disease
This study is designed to explore mechanism of action of mongersen (GED-0301) 160 mg once daily in patients with active Crohn's Disease
- Trial name
- NCT02685683
- Testing
- GED-0301
- Where
- 2 sites in Italy
- Volunteers
- 18 people
- Sponsor
- Celgene
Crohn Disease, Stenosis
Long-term Study of Endoscopic Treatment of Stenosis in Crohn´s Disease
Stenosis is one of the most frequent complications in patients with Crohn's disease (CD), causing greater morbidity and increasing the probability of repeated surgery and short bowel syndrome.
- Trial name
- Long-ProtDilat (NCT06036680)
- Where
- Spain
- Volunteers
- 80 people
- Sponsor
- Hospital Mutua de Terrassa
Crohn's Disease
Effectiveness and Safety in Patients With Crohn´s Disease in Clinical Routine
The purpose of this study was intended to evaluate the long-term safety and effectiveness of adalimumab in participants with Crohn's disease (CD) who are treated as recommended in the product label.
- Trial name
- NCT01083680
- Volunteers
- 4,107 people
- Sponsor
- AbbVie (prior sponsor, Abbott)
Crohn's Disease
A Study to Investigate Efficacy and Safety of SAR441566 in Patients With Crohn's Disease.
This is a phase 2, multinational, multicenter, randomized, double-blind, placebo-controlled, dose ranging study to evaluate the efficacy and safety of SAR441566 in adults with moderate to severe Crohn's Disease (CD).
- Trial name
- SPECIFI-CD (NCT06637631)
- Testing
- SAR441566
- Where
- 141 sites in United States, Argentina and 22 more
- Volunteers
- 105 people
- Sponsor
- Sanofi
Crohn's Disease, Oral Ulcer
The Efficacy of Topical Mesalazine Sustained-Release Tablets in Crohn's Disease Patients With Oral Ulcer
This study aims at evaluating efficacy and safety of topical using Mesalazine Sustained-Release Tablets in in the treatment of oral ulcers in patients with Crohn's disease.
- Trial name
- NCT02769494
- Testing
- Mesalazine Sustained-Release Tablets, Riboflavin Sodium Phosphate Injection
- Where
- China
- Sponsor
- Xijing Hospital of Digestive Diseases
Crohn Disease
Management of Moderate POstoperative Recurrence in Crohn's Disease: a randoMizEd contROLled Trial of Therapeutic Escalation, the POMEROL Trial. (POMEROL)
Study type : A 30 months, multicentre, open-label strategic randomized controlled trial Population : Chron's Disease (CD) patients with an i2 endoscopic postoperative recurrence in the year following ileocolonic resection…
- Trial name
- POMEROL (NCT05072782)
- Testing
- Infliximab CT-P13, Immunosuppressors (Thiopurines or Methotrexate)
- Where
- France
- Volunteers
- 360 people
- Sponsor
- Groupe d'Etude Therapeutique des Affections Inflammatoires Digestives
Inflammatory Bowel Diseases, Periodontitis
Oral Health-related Quality of Life (OHRQoL) in Patients With Inflammatory Bowel Disease (IBD)
IBD patients have a higher risk of oral diseases that affect the oral mucosa, the teeth and the tooth supporting tissues. These conditions are often associated with pain, bleeding and impaired masticatory function which may have…
- Conditions
- Inflammatory Bowel Diseases, Periodontitis, Dental Caries, Tooth Loss
- Trial name
- OQal-MICI (NCT05096897)
- Testing
- Self-administrated questionnaires
- Where
- France
- Volunteers
- 138 people
- Sponsor
- University Hospital, Lille
Inflammatory Bowel Diseases, Crohn Disease
Effect of a Probiotic Mixture on the Gut Microbiome and Fatigue in Patients With Quiescent Inflammatory Bowel Disease
The study is proposed as a single-site randomized double-blind placebo-controlled trial requiring 4 study visits, where two of the visits are combined with their appointment for routine clinical care.
- Conditions
- Inflammatory Bowel Diseases, Crohn Disease, Ulcerative Colitis
- Trial name
- NCT03266484
- Testing
- Probiotic Mixture
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Massachusetts General Hospital
CD - Crohn's Disease
The CURE - CD Trial
A prospective randomized three-arms controlled trial of Crohn's Disease (CD) patients in remission of <24 months duration. Patients will undergo screening by Magnetic Resonance Enterography (MRE) and patency capsule, and (if…
- Trial name
- NCT03555058
- Testing
- Treatment escalation
- Where
- Israel
- Volunteers
- 60 people
- Sponsor
- Sheba Medical Center
Crohn Disease, Inflammatory Bowel Diseases
The IUSS Crohn's Study: A Feasibility Study
The aim of this study is to evaluate if an intraoperative protocol for Ultrasound scan (USS) is feasible and safe in patients undergoing elective surgery for ileocolic CD.
- Trial name
- NCT03939117
- Where
- United Kingdom
- Volunteers
- 6 people
- Sponsor
- Portsmouth Hospitals NHS Trust
Ulcerative Colitis (UC), Crohn Disease (CD)
Fluorescence Imaging of Adalimumab-680LT and Risankizumab-800CW in Inflammatory Bowel Disease
Inflammatory bowel diseases (IBD) are chronic relapsing inflammatory disorders of the gastrointestinal tract affecting 2.5 million patients in Europe alone.
- Trial name
- VOYAGER (NCT07258641)
- Testing
- 25mg adalimumab-680LT and 15/25 mg risankizumab-800CW, Adalimumab-680LT 25mg, Risankizumab-800CW 15 mg/25 mg
- Where
- Netherlands
- Volunteers
- 30 people
- Sponsor
- University Medical Center Groningen
Crohn's Disease
RED-FLAGS Index Validation in Crohn's Disease Patients
Observational prospective study to validate a new index for early diagnosis of Crohn's disease (CD)
- Trial name
- RED-FLAGS2 (NCT02940054)
- Testing
- Red-flags questionnaire
- Where
- Italy
- Volunteers
- 600 people
- Sponsor
- Istituto Clinico Humanitas
Crohn´s Disease, Ulcerative Colitis
Endomicroscopy for Assessment of Mucosal Healing
Inflammatory bowel disease (IBD) encompasses two major forms of chronic intestinal disorders, Crohn's disease and ulcerative colitis (UC).
- Trial name
- NCT01417715
- Testing
- Endomicroscopy
- Where
- Germany
- Volunteers
- 84 people
- Sponsor
- University of Erlangen-Nürnberg Medical School
Inflammatory Bowel Disease (Crohn's Disease; Ulcerative Colitis), Adherence, Patient
Treatment Adherence Among Patients With Inflammatory Bowel Disease Receiving Anti-TNF Therapy
Inflammatory bowel disease (IBD) is a chronic condition characterized by periods of remission and relapse, requiring long-term treatment adherence to maintain disease control and prevent complications.
- Conditions
- Inflammatory Bowel Disease (Crohn's Disease; Ulcerative Colitis), Adherence, Patient, Structured Education
- Trial name
- NCT07652840
- Testing
- Health Belief Model-Based Structured Patient Education, Standard Patient Education
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 140 people
- Sponsor
- Izmir Katip Celebi University
Crohn's Disease (CD)
Ultrasound-Guided Versus Standard Margin Selection in Ileocecal Resection of Terminal Ileal CD
This is a Phase II, single-center (Cleveland Clinic), two-arm, randomized, parallel-group superiority trial. The two arms will compare IOUS-guided margin selection against standard macroscopic margin selection in patients…
- Trial name
- SMILE-CD (NCT07680283)
- Testing
- IOUS-guided margin selection
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- The Cleveland Clinic
Crohn's Disease
Study of STA-5326 Mesylate in Patients With Moderate to Severe Crohn's Disease
STA-5326 is an oral experimental drug that has been shown to block the release of interleukin-12 from peripheral blood mononuclear cells.
- Trial name
- NCT00234741
- Testing
- STA-5326 mesylate
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Synta Pharmaceuticals Corp.
Major Depressive Disorder, Inflammatory Bowel Diseases
Trial of Mirtazapine for Depression in IBD
This study will test whether it is feasible to conduct a clinical trial of mirtazapine (an antidepressant tablet) in patients who have both depression and inflammatory bowel disease (IBD).
- Trial name
- MDIBD (NCT06309472)
- Testing
- Mirtazapine
- Where
- 4 sites in United Kingdom
- Volunteers
- 76 people
- Sponsor
- King's College London
Crohn Disease
Effectiveness and Safety of Ustekinumab Intensification in Crohn's Disease
The primary purpose of this study is to evaluate the efficacy and safety of intravenous administration at regular intervals of Ustekinumab in participants with loss of response to standard regimen or have evidence of high…
- Trial name
- NCT05705856
- Testing
- Ustekinumab
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Inflammatory Bowel Disease (IBD), Ulcerative Colitis
A Study of Vedolizumab and Biologic Agents in Participants With Inflammatory Bowel Disease (IBD)
This is a non-interventional, retrospective study of adult participants with IBD. IBD consists of either ulcerative colitis (UC) or Crohn's disease (CD).
- Conditions
- Inflammatory Bowel Disease (IBD), Ulcerative Colitis, Crohn's Disease
- Trial name
- NCT05596422
- Where
- 4 sites in Taiwan
- Volunteers
- 423 people
- Sponsor
- Takeda
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