Clinical trials: Crohn Disease of Intestine
Crohn's Disease
The Efficacy of Low Dose Naltrexone Therapy in Children With Crohn's Disease
It is hypothesized that oral naltrexone will improve inflammation of the bowel by increasing endogenous enkephalin levels in subjects with active Crohn's disease.
- Trial name
- LDN-Ped (NCT00715117)
- Testing
- Naltrexone
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Milton S. Hershey Medical Center
Irritable Bowel Syndrome, Colitis, Ulcerative
Advanced Metagenomic Analysis of Human Colonic Microbiota in Patients With Chronic GI Disorders
This clinical trial hypothesize that Gut Microbiota (bacteria, viruses, fungi)play a major role in the occurrence and progression of many chronic gastrointestinal diseases like Irritable Bowel Syndrome, Inflammatory Bowel…
- Conditions
- Irritable Bowel Syndrome, Colitis, Ulcerative, Crohn Disease, Colonic Neoplasms
- Trial name
- NCT01099111
- Where
- Saudi Arabia
- Volunteers
- 225 people, healthy volunteers welcome
- Sponsor
- King Fahad Medical City
Colonic Diseases, Rectal Diseases
Random Comparison of LigaSure and Disposable Staples for Laparoscopic Surgery
The purpose of this research is to compare two different standard of care surgical methods for the following large bowel (colon) procedures: laparoscopic right colectomy, total colectomy, and left colectomy.
- Trial name
- NCT00487409
- Testing
- Bipolar electrosurgical generator and instruments, Disposable stapling instruments
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University Hospitals Cleveland Medical Center
Crohn Disease
The Effects of Bifidobacterium Breve Bif195 for Small Intestinal Crohn's Disease
The purpose of this study is to investigate if the probiotic Bifidobacterium breve Bif195 (Bif195) will result in improvement in clinical outcome in patients with small intestinal Crohn's disease.
- Trial name
- NCT04842149
- Testing
- Bif195 capsules
- Where
- Denmark
- Volunteers
- 33 people
- Sponsor
- Hvidovre University Hospital
Crohn's Disease
A Study of Zasocitinib (TAK-279) in Adults With Active Crohn's Disease
Crohn's disease (CD) is a serious, long-term condition that can cause swelling (inflammation) and painful ulcers anywhere in the gut.
- Trial name
- NCT07403968
- Testing
- Zasocitinib
- Where
- United Kingdom
- Volunteers
- 20 people
- Sponsor
- Takeda
Crohn Disease
Management of Moderate POstoperative Recurrence in Crohn's Disease: a randoMizEd contROLled Trial of Therapeutic Escalation, the POMEROL Trial. (POMEROL)
Study type : A 30 months, multicentre, open-label strategic randomized controlled trial Population : Chron's Disease (CD) patients with an i2 endoscopic postoperative recurrence in the year following ileocolonic resection…
- Trial name
- POMEROL (NCT05072782)
- Testing
- Infliximab CT-P13, Immunosuppressors (Thiopurines or Methotrexate)
- Where
- France
- Volunteers
- 360 people
- Sponsor
- Groupe d'Etude Therapeutique des Affections Inflammatoires Digestives
Crohn's Disease
Extension Study of Semapimod 60 mg IV x 3 Days
Study CNI-1493-CD06 is an open, single-arm extension studies to CD03 and CD05. CDAI is the only efficacy measure assessed in this study.
- Trial name
- CD06 (NCT00741910)
- Testing
- Semapimod
- Where
- 8 sites in United States, Germany and 2 more
- Volunteers
- 15 people
- Sponsor
- Ferring Pharmaceuticals
Crohn's Disease
Behavioral Therapy for Crohn's Disease
People living with Crohn's disease (CD) experience psychological and emotional symptoms, in addition to known chronic and disabling physical symptoms, which prevent them from living their life to the fullest (flourishing).
- Trial name
- NCT06512597
- Testing
- Primary Intervention for Combination Therapy - IBD Coping Strategies Program, Time and Attention Control - IBD Support Program
- Where
- 2 sites in United States
- Volunteers
- 170 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Colo-rectal Cancer, Colo-rectal Surgery
Post Operative Hospital at Home After Colorectal Surgery
The goal of this feasibility study is to investigate whether a virtual Hospital at Home is safe and possible for patients undergoing planned minimally invasive colorectal surgery.
- Conditions
- Colo-rectal Cancer, Colo-rectal Surgery, Colocolic and Ileocolic Anastomosis, Colon and/or Rectal Resection With Anastomosis for Cancer
- Trial name
- POPHaH (NCT07113717)
- Testing
- virtual Hospital at Home
- Where
- Denmark
- Volunteers
- 20 people
- Sponsor
- Nordsjaellands Hospital
IBD (Inflammatory Bowel Disease), IBS - Irritable Bowel Syndrome
ALPCO/Calprotectin CLIA Assay: Expected Values of Calprotectin in Healthy Subjects
This study is evaluating the levels of calprotectin, a protein found in stool, in healthy adults. Calprotectin is a marker of inflammation in the intestines and can help doctors tell the difference between inflammatory bowel…
- Conditions
- IBD (Inflammatory Bowel Disease), IBS - Irritable Bowel Syndrome, Crohn Disease (CD), UC - Ulcerative Colitis
- Trial name
- NCT07089420
- Testing
- ALPCO Calprotectin CLIA
- Where
- United States
- Volunteers
- 121 people, healthy volunteers welcome
- Sponsor
- American Laboratory Products Company
Inflammatory Bowel Diseases, Quality of Life
Effect of Probiotic Administration on Patients With Inflammatory Bowel Disease
The study is a single-center, randomized, single-blinded, controlled trial conducted at ZHUMC's endoscopy unit. It aims to assess the short-term effects of probiotic administration on disease course, quality of life, and…
- Conditions
- Inflammatory Bowel Diseases, Quality of Life, Food Intolerance, Flare Up
- Trial name
- NCT06392061
- Testing
- Trilac
- Where
- Lebanon
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Lebanese University
Crohn Disease, Infliximab
TDM-based Infliximab Treatment for Active Perianal Fistulizing Crohn's Disease
This study will compare the efficacy and safety of TDM (therapeutic drug monitoring)-based infliximab (CT-P13, RemsimaTM) intravenous therapy compared with the standard infliximab (RemsimaTM) intravenous therapy for patients with…
- Conditions
- Crohn Disease, Infliximab, Perianal Fistula Due to Crohn's Disease, Therapeutic Drug Monitoring
- Trial name
- NCT06051253
- Testing
- TDM-based infliximab intravenous therapy, Standard infliximab intravenous therapy
- Where
- South Korea
- Volunteers
- 86 people
- Sponsor
- Asan Medical Center
Crohn Disease, Ultrasound
Validation and Interobserver Reliability of a Simple Ultrasound Score for Crohn's Disease
Crohn's disease (CD) is a chronic inflammatory disease in the gastrointestinal (GI) tract. It is characterized by an alternating course between remission and relapse, which necessitates subsequent adjustments in medical therapy.
- Trial name
- NCT03481751
- Testing
- Diagnostic test: Ultrasound
- Where
- 3 sites in Norway
- Volunteers
- 124 people
- Sponsor
- Haukeland University Hospital
Crohn's Diseases
Washed Microbiota Transplantation Improves Nutritional Status of Patients With Crohn's Disease
Patients with Crohns' disease (CD) are always complicated with malnutrition. Exclusive enteral nutrition (EEN) is an effective treatment to improve nutritional status and induce remission in patients with CD however a reduction…
- Trial name
- NCT02897661
- Testing
- WMT, EEN
- Where
- China
- Volunteers
- 30 people
- Sponsor
- The Second Hospital of Nanjing Medical University
Crohn's Disease
Evaluation of Digestive Damage and Associated Predictive Factors in Crohn's Disease 5 to 10 Years After Diagnosis
The primary objective is to evaluate digestive damage in CD 5 to 10 years after diagnosis in the GETAID centers included in the RAPID study. Secondary objective is to identify predictive factors of the evolution digestive damage.
- Trial name
- DESTIN (NCT02549976)
- Testing
- Abdominal MRI, Upper endoscopy, Colonoscopy
- Where
- 9 sites in France
- Volunteers
- 54 people
- Sponsor
- Groupe d'Etude Therapeutique des Affections Inflammatoires Digestives
Inflammatory Bowel Disease, Crohn's Disease
FOCUS: The Future of Fecal Calprotectin Utility Study for the Diagnosis and Management of Inflammatory Bowel Disease (IBD)
Hypothesis: Fecal Calprotectin will be useful in guiding the diagnosis and management of patients with Inflammatory Bowel Disease.
- Conditions
- Inflammatory Bowel Disease, Crohn's Disease, Ulcerative Colitis
- Trial name
- FOCUS (NCT01676324)
- Where
- Canada
- Volunteers
- 289 people
- Sponsor
- University of British Columbia
Ulcerative Colitis, Crohn Disease
Efficacy of Fecal Microbiota Transplantation for Inflammatory Bowel Disease
The gut microbiota is determined to constitute a "microbial organ" which has pivotal roles in the intestinal diseases and body's metabolism.
- Conditions
- Ulcerative Colitis, Crohn Disease, Constipation (Excl Faecal Impaction)
- Trial name
- NCT02575040
- Testing
- Fecal microbiota transplantation
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Saglik Bilimleri Universitesi Gulhane Tip Fakultesi
Intestinal Disease, Inflammatory Bowel Diseases
Validation of CapsoVision CapsoCam® SV-3 Capsule Endoscopy System
To validate an updated version of CapsoCam® SV-3 Endoscopy System brand name CapsoCam Plus™) with respect to the reproducibility of the system to capture and download small bowel images in a manner consistent with the predicate…
- Conditions
- Intestinal Disease, Inflammatory Bowel Diseases, Crohn Disease, Ulcer
- Trial name
- NCT04573959
- Testing
- SV-3 Capsule Endoscopy
- Where
- United States
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Capso Vision, Inc.
Crohn's Disease, CAM
Efficacy of Acupuncture and Moxibustion Treatment in Patients With Quiescent Crohn's Disease:Evaluation With fMRI
The purpose of this study is to determine whether acupuncture or moxibustion therapies are effective in the treatment of Crohn's disease.
- Trial name
- NCT01696838
- Testing
- electroacupuncture, moxibustion
- Where
- China
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- Shanghai Institute of Acupuncture, Moxibustion and Meridian
Crohn Disease
Comparison of Quality of Life With or Without Automatic Seton Placement in Perianal Crohn's Fistula
In patients with Crohn's disease, anal fistulas are usually treated in three stages: 1) close examination of the fistula and drainage with a seton, 2) pharmacological treatment of the inflammatory component, and 3) closure of the…
- Trial name
- SOPA (NCT05330416)
- Testing
- Group Reference Strategy, Group Test Strategy
- Where
- France
- Volunteers
- 108 people
- Sponsor
- Fondation Hôpital Saint-Joseph
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