Clinical trials: Crohn Disease of Intestine
Inflammatory Bowel Diseases
Individualized Infiximab Dosing-Proof of Concept Study
The purpose of this study is to determine which early infliximab pharmacokinetic level is most associated with clinical remission at weeks 30 and 54 in pediatric IBD patients.
- Trial name
- NCT02027727
- Testing
- No Intervention
- Where
- United States
- Volunteers
- 56 people
- Sponsor
- Cedars-Sinai Medical Center
Rheumatoid Arthritis, Inflammatory Arthritis
Safety and Effectiveness of Live Zoster Vaccine in Anti-Tumor Necrosis Factor (TNF) Users (VERVE Trial)
The VaricElla zosteR VaccinE (VERVE) trial evaluates the safety and effectiveness of the Herpes zoster (HZ) vaccine for shingles, Zostavax, in patients over 50 years old with arthritis and other diseases who are using anti-tumor…
- Conditions
- Rheumatoid Arthritis, Inflammatory Arthritis, Arthritis, Psoriatic Arthritis
- Trial name
- NCT02538341
- Testing
- Herpes Zoster (HZ) Vaccine
- Where
- 34 sites in United States
- Volunteers
- 617 people
- Sponsor
- University of Alabama at Birmingham
Inflammatory Bowel Diseases, Crohn Disease
Conventional vs Biologic Therapy in Pediatric IBD
This combined retrospective-prospective cohort study aims to evaluate the effectiveness, safety, and adverse events of conventional versus biologic therapy in children and adolescents with inflammatory bowel disease at Assiut…
- Conditions
- Inflammatory Bowel Diseases, Crohn Disease, Ulcerative Colitis
- Trial name
- NCT07818473
- Volunteers
- 100 people
- Sponsor
- Assiut University
Crohn's Disease
Efficacy Study of Targeted, Local Delivery of Drugs to Treat Crohn's Disease
The study is being undertaken to evaluate whether delayed-release medications, designed to begin to open in the lower intestinal tract, the main site of Crohn's Disease, are more effective than standard systemically delivered…
- Trial name
- NCT00287170
- Testing
- Delayed Release 6MP or Calcitriol vs. Purinethol
- Where
- Israel
- Volunteers
- 15 people
- Sponsor
- Teva GTC
Crohn's Disease
Safety and Efficacy of Treatment With Interferon Beta-1a Rebif® in Patients With Crohn's Disease
The purpose of this study is to determine the safety and efficacy of interferon beta-1a in maintaining remission in patients with Crohn's disease.
- Trial name
- NCT00304252
- Testing
- Interferon beta-1a
- Where
- 5 sites in Germany, Italy and 3 more
- Volunteers
- 192 people
- Sponsor
- EMD Serono
Ulcerative Colitis (UC), Crohn Disease (CD)
The Safety and Efficacy of Good Feeling Power® for IBD Patients
This open-label pilot study aims to evaluate the safety and efficacy of the dietary supplement Good Feeling Power® for patients with mild-to-moderate ulcerative colitis and colonic/ileal Crohn's disease.
- Trial name
- NCT07766733
- Testing
- Good Feeling Power®
- Where
- Spain
- Volunteers
- 36 people
- Sponsor
- Good Feeling Products GmbH
Ulcerative Colitis (Disorder), Crohn Disease (CD)
Incremental Value of Traditional Chinese Medicine Features in Two-Stage Pre-Endoscopic Prediction
This observational study evaluates whether adding Traditional Chinese Medicine (TCM)-related clinical features improves the performance of machine-learning models that estimate disease risk before colonoscopy.
- Conditions
- Ulcerative Colitis (Disorder), Crohn Disease (CD), Inflammatory Bowel Diseases, Colorectal Neoplasms
- Trial name
- NCT07784114
- Volunteers
- 1,500 people
- Sponsor
- Beijing University of Chinese Medicine
Crohn's Disease, Ulcerative Colitis
Study of Anti-glycan Antibodies Stability in Saint-Etienne IBD Cohort
Prognostic factors in Inflammatory Bowel Diseases (IBD) are currently mainly based on clinical factors (disease extension, perianal involvement, need for surgery, use of immunomodulators…).
- Conditions
- Crohn's Disease, Ulcerative Colitis, Inflammatory Bowel Disease
- Trial name
- NCT02502552
- Testing
- blood specimen
- Where
- France
- Volunteers
- 80 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Crohn Disease, Methylation
Comprehensive DNA Methylation Profiling in Crohn's Disease
Previous studies have indicated that abnormal DNA methylation frequently occurs in the mucosa in Crohn's disease. Comprehensive DNA methylation profiling of the inflamed and non-inflamed ileal mucosa of patients with Crohn's…
- Conditions
- Crohn Disease, Methylation, Illumina Human Methylation 850k BeadChip
- Trial name
- NCT03272152
- Testing
- Genome-wide DNA methylation
- Where
- China
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Jinling Hospital, China
Crohn's Disease
A Study of Safety and Effectiveness of Ustekinumab in Patients With Moderate to Severe Active Crohn's Disease Who Have Been Previously Treated With Anti-TNF Therapy
A medical research study in adult patients who have moderate to severe Crohn's disease designed to determine whether or not treatment with an experimental drug called ustekinumab (or CNTO1275) is safe or not and to determine if…
- Trial name
- NCT00771667
- Testing
- Ustekinumab 1mg/kg (IP), Ustekinumab 3 mg/kg (IP), Ustekinumab 6 mg/kg (IP)
- Where
- 174 sites in United States, Australia and 10 more
- Volunteers
- 526 people
- Sponsor
- Centocor, Inc.
Crohn Disease, Depression
The Effects of Intraoperative Esketamine on Postoperative Pain and Mood in Patients With Inflammatory Bowel Disease
Crohn's disease (CD) is a chronic inflammatory disease of the gastrointestinal tract with symptoms evolving in a relapsing and remitting manner.
- Conditions
- Crohn Disease, Depression, Esketamine
- Trial name
- NCT05506787
- Testing
- Esketamine
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Jinling Hospital, China
Crohn Disease (CD)
Health Benefits of Tart Cherry in Crohn's Disease
Crohn's disease (CD) is a long-term inflammatory condition of the digestive tract. People with CD often experience unpredictable and debilitating symptoms, including abdominal pain, diarrhea, and fatigue.
- Trial name
- NCT06901986
- Testing
- Montmorency tart cherry
- Volunteers
- 52 people
- Sponsor
- University of Central Lancashire
Ulcerative Colitis, Crohn's Disease
Study to Evaluate Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of AMG 181.
To assess the safety and tolerability of multiple subcutaneous doses of AMG 181 in healthy subjects, in subjects with active ulcerative colitis, and in subjects with active Crohn's disease.
- Trial name
- NCT01290042
- Testing
- AMG 181
- Where
- 8 sites in United States, Australia
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- Amgen
Crohn's Disease
A follow-on Safety Study of CDP870 in Subjects With Crohn's Disease (CD) Who Have Completed a 26-week Double Blind Study CDP870-031 [NCT00152490] or CDP870-032 [NCT00152425]
An open-label follow-on safety study of CDP870 (400 mg every 4 weeks) in patients with Crohn's Disease who have completed a 26-week blinded study (CDP870-031 [NCT00152490] or CDP870-032 [NCT00152425]).
- Trial name
- PRECiSE 3 (NCT00160524)
- Testing
- Certolizumab Pegol (CDP870)
- Where
- 206 sites in United States, Australia and 27 more
- Volunteers
- 596 people
- Sponsor
- UCB Pharma SA
Crohn's Disease
The Effect of Adalimumab on the Bone Microstructure in Crohn's Disease (CD) Patients
The investigators will study the effect of Adalimumab on the bone microstructure. Trial with medicinal product
- Trial name
- NCT01012570
- Testing
- Application of Adalimumab
- Where
- Switzerland
- Volunteers
- 34 people
- Sponsor
- Gerhard Rogler
Crohn Disease, Intestinal Tuberculosis
Validation of Scoring Systems for Differentiating Intestinal Tuberculosis from Crohn's Disease
Differentiating CD from intestinal tuberculosis (ITB) is difficult due to the low sensitivities of currently available diagnostic tests.
- Conditions
- Crohn Disease, Intestinal Tuberculosis, Differential Diagnosis
- Trial name
- NCT06629194
- Testing
- interferon gamma releasing assay (IGRA)
- Where
- 2 sites in Thailand
- Volunteers
- 84 people
- Sponsor
- Mahidol University
Crohn Disease
The Vitamin D in Pediatric Crohn's Disease ( ViDiPeC-2 )
The purpose of this study is to determine if vitamin D as an adjuvant therapy can improve the outcome (i.e. fewer relapses) and the quality of life, including levels of physical activity, in children diagnosed Crohn's disease…
- Trial name
- ViDiPeC-2 (NCT03999580)
- Testing
- vitamin D3
- Where
- 7 sites in Canada
- Volunteers
- 55 people
- Sponsor
- Jantchou Prevost
Crohn's Disease
Detecting Postoperative Recurrence in Crohn's Disease
Up to ¾ of patients who have been diagnosed with Crohn's disease (CD) will have to undergo bowel resection during their lifetime despite modern medical therapies.
- Trial name
- NCT00886327
- Testing
- Colonic capsule endoscopy
- Where
- 4 sites in Germany
- Volunteers
- 70 people
- Sponsor
- Johann Wolfgang Goethe University Hospital
Inflammatory Bowel Disease, Crohn Disease
Deep Endoscopic Remission Assessed by a Surrogate Biomarker in Patients With Inflammatory Bowel Disease
We hypothesize that the number of needed endoscopic procedure performed at IBD patients (adult and children), can be reduced by using an individualized algorithm of symptoms, blood and faecal biomarkers.
- Conditions
- Inflammatory Bowel Disease, Crohn Disease, Ulcerative Colitis
- Trial name
- NCT01861288
- Where
- Denmark
- Volunteers
- 157 people, healthy volunteers welcome
- Sponsor
- Herlev Hospital
Crohn's Disease, Osteopenia
Zoledronate for Osteopenia in Pediatric Crohn's
Background: Up to 30% of children and adolescents with Crohn's disease have decreased bone strength, or decrease bone density, called osteopenia.
- Conditions
- Crohn's Disease, Osteopenia, Osteoporosis
- Trial name
- NCT00798473
- Testing
- zoledronic acid, IV saline infusion
- Where
- Canada
- Volunteers
- 13 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
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