Clinical trials: Crohn Disease of Intestine
Inflammatory Bowel Diseases, Crohn Disease
Evaluation of Stricturing Crohn's Disease Using Digital Holographic Microscopy
Crohn's Disease (CD) patients, belonging to Inflammatory Bowel Disease (IBD), frequently suffer from uncontrolled intestinal inflammation. This can lead to severe disease complications requiring hospitalization.
- Trial name
- NCT03465215
- Testing
- Digital holographic microscopy
- Where
- Germany
- Volunteers
- 29 people
- Sponsor
- University Hospital Muenster
Crohn's Disease
A Comparative Study of Capsule Endoscopy, Magnetic Resonance Imaging and Computer Tomography Scanning of the Small Bowel in Crohn's Disease
The aim of this study is to evaluate three diagnostic methods for assessing small bowel disease in patients with suspected or known Crohn's disease.
- Trial name
- NCT01019460
- Testing
- Magnetic resonance imaging, computed tomography scanning and capsule endoscopy
- Volunteers
- 150 people
- Sponsor
- University of Southern Denmark
Crohn's Disease, Ulcerative Colitis
A Study Evaluating the Impact of an Educational Program (EDU-MICI) on Patients With Inflammatory Bowel Disease
This study has the objective to demonstrate that an education program could have a significant impact on Inflammatory Bowel Disease (IBD) patient's skills with regards to their disease.
- Trial name
- ECIPE (NCT02550158)
- Testing
- Educational program EDU-MICI
- Where
- 18 sites in France
- Volunteers
- 263 people
- Sponsor
- Groupe d'Etude Therapeutique des Affections Inflammatoires Digestives
Crohn's Disease
Study of Targeted Therapies for the Treatment of Adult Participants With Moderate to Severe Crohn's Disease
Crohn's disease (CD) is a long-lasting disease that causes severe inflammation (redness, swelling), in the digestive tract, most frequently affecting the bowels.
- Trial name
- Target CD (NCT06548542)
- Testing
- Risankizumab, Lutikizumab, Trosunilimab
- Where
- 255 sites in United States, Austria and 31 more
- Volunteers
- 590 people
- Sponsor
- AbbVie
Crohn's Disease
A Study to Test Efficacy, Safety, and Pharmacokinetics of Certolizumab Pegol in Children and Adolescents With Moderately to Severely Active Crohn's Disease
The purpose of the study is to assess efficacy, safety and tolerability of 2 dose regimens of certolizumab pegol
- Trial name
- NCT04643483
- Testing
- Certolizumab pegol, Adalimumab
- Sponsor
- UCB Biopharma SRL
Crohn Disease
Surgically Resected Crohn's Disease Patients: Prognostic Factors for Re-operation and New Score Building
The project will consist of a multicentre, prospective, observational study with a total duration of 24 months. Clinical, endoscopic and ultrasound data will be collected in a dedicated database (on IG-IBD Register), which will…
- Trial name
- POCD2017 (NCT03150238)
- Testing
- observation of prognostic factors for relapse
- Where
- Italy
- Volunteers
- 220 people
- Sponsor
- Istituto Clinico Humanitas
Inflammatory Bowel Diseases, Fatigue
The Effect of a Multimodal Lifestyle Intervention on Chronic Fatigue in Patients With Inflammatory Bowel Disease
Chronic fatigue is highly prevalent in patients with conditions characterized by chronic inflammation of the gastrointestinal tract, also known as Inflammatory Bowel Disease (IBD).
- Trial name
- Multi-IBD (NCT05374967)
- Testing
- Lifestyle intervention: Live with IBD, Control group
- Where
- Netherlands
- Volunteers
- 72 people
- Sponsor
- Leiden University Medical Center
Inflammatory Bowel Disease
An Epidemiological Study of the Incidence of Inflammatory Bowel Disease in Spain
This is a prospective, observational, multicenter, population-based incidence cohort study which will enroll cases of IBD (CD, UC, or indeterminate colitis) diagnosed in adults over 1 year in Spain.
- Trial name
- INCIDENCIA (NCT02686892)
- Where
- 16 sites in Spain
- Volunteers
- 4,000 people
- Sponsor
- Javier P. Gisbert
Crohn's Disease
Laquinimod Phase IIa Study in Active Crohn's Disease
The study aims to evaluate the safety and clinical effect of daily oral treatment of Laquinimod capsules in active moderate to severe Crohn's disease.
- Trial name
- NCT00737932
- Testing
- Laquinimod
- Where
- 34 sites in Belgium, France and 7 more
- Volunteers
- 180 people
- Sponsor
- Teva Branded Pharmaceutical Products R&D, Inc.
Crohn's Disease, Ulcerative Colitis
Decisional Influences and Inflammatory Bowel Disease (IBD) Patients' Medication Use
The primary purpose of this study is to pilot test an instrument that the investigators will develop to assess decision influences on inflammatory bowel disease patients' medication adherence decision-making.
- Trial name
- NCT00968721
- Where
- United States
- Volunteers
- 55 people
- Sponsor
- Vanderbilt University
Crohn's Disease
PillCam® Platform With the PillCam Crohn's Disease Capsule
This is a prospective, multi-center (up to 6 sites) study which aims to To establish the effectiveness of the PillCam Platform with the PillCam Crohn's capsule as demonstrated by visualizing the small bowel and colon in patients…
- Trial name
- NCT01631435
- Testing
- Pillcam colon capsule and PillCam™ Prep Procedure, Ileocolonoscopy
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- Medtronic - MITG
Crohn Disease
QBECO SSI for Clinical and Endoscopic Remission in Moderate to Severe Crohn's Disease
The QBECO-CD-02 trial in subjects with moderate to severe Crohn's disease (CD) is intended to build on past experience with QBECO SSI and further establish the safety and efficacy of QBECO SSI for the induction of clinical and/or…
- Trial name
- NCT03472690
- Testing
- QBECO-SSI
- Where
- 3 sites in Canada
- Volunteers
- 20 people
- Sponsor
- Qu Biologics Inc.
Crohn's Disease
Efficacy and Safety of Anti-MAP Therapy in Adult Crohn's Disease
The investigators hypothesize that RHB-104 will have greater efficacy than placebo in Crohn's disease.
- Trial name
- MAPUS (NCT01951326)
- Testing
- RHB-104
- Where
- 103 sites in United States, Australia and 8 more
- Volunteers
- 331 people
- Sponsor
- RedHill Biopharma Limited
Crohn's Disease (CD)
Ultrasound-Guided Versus Standard Margin Selection in Ileocecal Resection of Terminal Ileal CD
This is a Phase II, single-center (Cleveland Clinic), two-arm, randomized, parallel-group superiority trial. The two arms will compare IOUS-guided margin selection against standard macroscopic margin selection in patients…
- Trial name
- SMILE-CD (NCT07680283)
- Testing
- IOUS-guided margin selection
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- The Cleveland Clinic
Crohn Disease (CD)
A Study on the Relationship of Interleukin-7 Receptor Gene Polymorphisms With the Risk of Crohn's Disease Onset and the Efficacy of Infliximab
From January 2020 to May 2025, 303 CD patients and 514 normal controls were retrospectively collected from Department of Gastroenterology, the Second Affiliated Hospital of Wenzhou Medical University.
- Trial name
- NCT07263477
- Testing
- Infliximab
- Where
- China
- Volunteers
- 900 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital of Wenzhou Medical University
Crohn's Disease
The Vitamin D in Pediatric Crohn's Disease
The purpose of this study is to determine if vitamin D as an adjuvant therapy can improve the outcome (i.e. fewer relapses) and the quality of life, including levels of physical activity, in children with newly diagnosed Crohn's…
- Trial name
- ViDiPeC (NCT02186275)
- Testing
- Vitamin D3: 3000 or 4000 UI/day then 2,000 UI/day, Vitamin D3 800 UI/day then 800 UI/day
- Where
- 10 sites in Canada
- Volunteers
- 25 people
- Sponsor
- St. Justine's Hospital
Inflammatory Bowel Diseases
Study to Evaluate the Epidemiology and the Characteristics "Omics" in Patients Recently Diagnosed of Inflammatory Bowel Disease in Spain
This is a prospective, observational, multicenter, population-based incidence cohort study which will enroll cases of inflammatory bowel disease IBD (Crohn´s disease CD, ulcerative colitis UC, or indeterminate colitis) diagnosed…
- Trial name
- IBDomics (NCT03689257)
- Where
- 16 sites in Spain
- Volunteers
- 376 people
- Sponsor
- Fundación de Investigación Biomédica - Hospital Universitario de La Princesa
Crohn's Disease
Evaluation of Efficacy and Safety of Brazikumab (MEDI2070) in Participants With Active, Moderate to Severe Crohn's Disease
A Phase 2b study to evaluate the efficacy and safety of brazikumab (MEDI2070) in participants with moderate to severe Crohn's disease who have failed or are intolerant to anti-tumor necrosis factor-alpha (anti-TNFα) therapy.
- Trial name
- NCT02574637
- Testing
- Brazikumab IV Infusion, Brazikumab SC Injection
- Where
- 97 sites in United States, Australia and 10 more
- Volunteers
- 29 people
- Sponsor
- AstraZeneca
Crohn's Disease
Phase 3 Study of Human TH-SC01 Cell Injection for Treating Perianal Fistulas in Patients With Crohn's Disease
The purpose of this study is to evaluate the efficacy of human TH-SC01 cell injection for the treatment of perianal fistulas in Crohn's Disease over 24 weeks.
- Trial name
- NCT06925594
- Testing
- Human TH-SC01 cell injection, Saline solution
- Where
- China
- Volunteers
- 228 people
- Sponsor
- Jiangsu Topcel-KH Pharmaceutical Co., Ltd.
Crohn's Disease
Azithromycin Based Therapy for Induction of Remission in Active Pediatric Crohn's Disease
The purpose of this study is to evaluate effectiveness of 2 months antibiotic course of Azithromycin combined with Metronidazole compared with 2 months antibiotic course of Metronidazole alone.
- Trial name
- NCT01596894
- Testing
- Azithromycin + Metronidazole, Metronidazole
- Where
- Israel
- Volunteers
- 73 people
- Sponsor
- Prof. Arie Levine