Clinical trials: Crohn Disease of Intestine
Inflammatory Bowel Diseases, Crohn Disease
Therapeutic Effect of New Biologics in Crohn's Disease
New types of biologics have brought advantages in therapy strategies for Crohn's disease. However, clinical data evaluating their efficacy and adverse in China is lacking.
- Conditions
- Inflammatory Bowel Diseases, Crohn Disease, Ulcerative Colitis, Treatment Side Effects
- Trial name
- NCT04923100
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Sixth Affiliated Hospital, Sun Yat-sen University
Crohn's Disease
Imuran Dosing in Crohn's Disease Study
This study will compare two different dosing methods of azathioprine (IMURAN) in participants with Crohn's disease who are currently taking steroids (e.g. prednisone or budesonide)or who have just started steroids.
- Trial name
- NCT00113503
- Testing
- Azathioprine weight-based dose, Azathioprine individualised dose
- Where
- 15 sites in United States, Canada
- Volunteers
- 50 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Crohn Disease, Drug Monitoring
TDM Guided Early Optimization of ADAL in Crohn's Disease
To investigate the influence of early therapeutic drug monitoring and dose optimization on disease outcome in Crohn's patients treated with Adalimumab.
- Conditions
- Crohn Disease, Drug Monitoring, Inflammatory Bowel Diseases
- Trial name
- NCT03261102
- Testing
- Adalimumab
- Where
- 6 sites in Canada
- Volunteers
- 200 people
- Sponsor
- waqqas.afif
Crohn Disease, Intestinal Tuberculosis
Validation of Scoring Systems for Differentiating Intestinal Tuberculosis from Crohn's Disease
Differentiating CD from intestinal tuberculosis (ITB) is difficult due to the low sensitivities of currently available diagnostic tests.
- Conditions
- Crohn Disease, Intestinal Tuberculosis, Differential Diagnosis
- Trial name
- NCT06629194
- Testing
- interferon gamma releasing assay (IGRA)
- Where
- 2 sites in Thailand
- Volunteers
- 84 people
- Sponsor
- Mahidol University
Crohn's Disease, Fistula
Mesenchymal Stem Cells for the Treatment of Pouch Fistulas in Crohn's
The purpose of this study is to determine the safety and feasibility of using allogeneic bone marrow derived mesenchymal stem cells (MSCs) to treat people with an ileal pouch anal anastomosis (IPAA) who develop a fistula in the…
- Conditions
- Crohn's Disease, Fistula, Anal Fistula, Pouch, Ileal
- Trial name
- IPAAF (NCT04073472)
- Testing
- mesenchymal stem cells (MSCs)
- Sponsor
- The Cleveland Clinic
Crohn's Disease, Ulcerative Colitis
An Assessment of Goal-Directed Intraoperative Fluid Management in Hand Assisted Laparoscopic Colectomy
The purpose of this study is to find out if guided fluid administration with the esophageal monitor is superior to standard fluid administration and whether use of the hetastarch or lactated ringers offers different benefits with…
- Conditions
- Crohn's Disease, Ulcerative Colitis, Rectal Cancer, Colon Cancer
- Trial name
- NCT00467922
- Testing
- Hextend, Lactated Ringers
- Where
- United States
- Volunteers
- 69 people
- Sponsor
- Corewell Health West
Crohn's Disease
Vedolizumab Intravenous (IV) Compared to Placebo in Chinese Participants With Crohn's Disease.
The purpose of this study is to assess the safety and efficacy of vedolizumab intravenous (IV) infusion as induction treatment in Chinese participants with moderately to severely active Crohn's disease (CD) at Week 10.
- Trial name
- NCT03234907
- Testing
- Vedolizumab IV
- Where
- 29 sites in China
- Volunteers
- 215 people
- Sponsor
- Takeda
Crohn's Disease, Fistula
The Role of MSC in the Treatment of Fistulas in Patients With Perianal Crohn's Disease
Here investigators will carry out this phase II clinical trial to explore a effective therapeutic regimen of MSC in the Crohn's perianal fistula.
- Trial name
- NCT03056664
- Testing
- Routine drainage surgery, MSC injection 01, MSC injection 02
- Volunteers
- 3 people
- Sponsor
- Sixth Affiliated Hospital, Sun Yat-sen University
Crohn's Disease
Vagus Nerve Stimulation in Crohn's Disease
This is an open label interventional study using an implantable vagus nerve stimulation device in patients with Crohn's disease who have active disease despite treatment with a tumor necrosis factor (TNF) antagonist drug.
- Trial name
- NCT02311660
- Testing
- Vagus Nerve Stimulation Device
- Where
- 4 sites in Croatia, Italy and 2 more
- Volunteers
- 15 people
- Sponsor
- SetPoint Medical Corporation
Crohn Disease (CD), Crohn Disease
Cranberry and Gut Health in Crohn's Disease
This study is investigating whether a cranberry-based dietary supplement, rich in polyphenols and fiber, can enhance gut health in individuals with Crohn's disease.
- Trial name
- NCT07170462
- Testing
- Cranberry powder
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- Ana Maldonado-Contreras
MASH, PSC
A Microdose Trial Investigating Binding of [68Ga]Ga-DOTA-CYS-ATH001 in Healthy Subjects and Different Patient Groups.
The goal of this clinical trial is to use positron emission tomography (PET) to evaluate and compare the binding of the novel tracer [68Ga]Ga-DOTA-Cys-ATH001 in the liver and/or gastrointestinal tract between healthy volunteers…
- Conditions
- MASH, PSC, Fibrostenotic Crohn's Disease, Healthy Volunteers
- Trial name
- NCT06562361
- Testing
- [68Ga]Ga-DOTA-Cys-ATH001
- Where
- 3 sites in Sweden
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Antaros Medical
Crohn Disease (CD)
Tolerance of Local Administration of Cryopreserved Autologous Stromal Vascular Fraction Combined With Micrograft for the Treatment of Refractory Ano-perineal Fistulas in Crohn's Disease
The ADICROHN-3 study is a prospective, multicenter, open-label cohort study. Its design is supported by the following elements: The results of the ADICROHN pilot study (EudraCT No.
- Trial name
- ADICROHN3 (NCT07629245)
- Testing
- injection of thawed SVF
- Where
- France
- Volunteers
- 25 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Inflammatory Bowel Disease, Ulcerative Colitis
Efficacy of Energy Therapy in the Management of Chronic Pain Medical Condition in Children and Adolescents.
Paediatric and adolescent patients with chronic pain associated with their medical condition will be invited to participate in this study.
- Conditions
- Inflammatory Bowel Disease, Ulcerative Colitis, Crohn Disease, Chronic Pancreatitis
- Trial name
- ET&CP (NCT05394272)
- Testing
- Energy Therapy - Pranic Healing
- Where
- United Kingdom
- Volunteers
- 100 people
- Sponsor
- King's College Hospital NHS Trust
Autoimmune Disease, Crohn Disease
Fluorine F 18 Clofarabine PET/CT in Imaging Patients With Autoimmune or Inflammatory Diseases
This pilot trial studies how well fluorine F 18 clofarabine positron emission tomography (PET)/computed tomography (CT) works in imaging patients with autoimmune or inflammatory diseases.
- Conditions
- Autoimmune Disease, Crohn Disease, Inflammatory Disorder, Rheumatoid Arthritis
- Trial name
- NCT02925351
- Testing
- Computed Tomography, Fluorine F 18 Clofarabine, Positron Emission Tomography
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Jonsson Comprehensive Cancer Center
Inflammatory Bowel Diseases, Colitis, Ulcerative
Study of Relationship Between Vedolizumab Therapeutic Drug Monitoring, Biomarkers of Inflammation and Clinical Outcomes
The purpose of this study is to determine if a relationship exists between Week 6 vedolizumab therapeutic drug monitoring (TDM) and Week 30 Faecal calprotectin (FCP).
- Conditions
- Inflammatory Bowel Diseases, Colitis, Ulcerative, Crohn Disease
- Trial name
- VEDO TDM RWE (NCT04567628)
- Testing
- No Intervention
- Where
- Canada
- Volunteers
- 7,873 people
- Sponsor
- Takeda
Crohn's Disease
Bologna IBD Markers
Individuate possible predictive factors of anti-TNFalfa-induced deep remission in Crohn's disease.
- Trial name
- NCT02580864
- Where
- Italy
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Société des Produits Nestlé (SPN)
Inflammatory Bowel Diseases
IBD Disease Course of Infliximab-naïve IBD Patients Treated With Subcutaneous Infliximab CT-P13 Remsima®
CURRENT STATE OF KNOWLEDGE IN VIEW OF THE RESEARCH About the condition under investigation Inflammatory bowel diseases (IBD), including Crohn's disease and ulcerative colitis, are chronic diseases characterized by relapsing and…
- Trial name
- PRIME (NCT05722353)
- Testing
- Biocollection
- Where
- France
- Volunteers
- 120 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Crohn's Disease
Diet for Induction and Maintenance of Remission and Re-biosis in Crohn's Disease
The modified-Exclusive Enteral Nutrition (mEEN) is an open label randomized controlled trial in mild to severe Crohn's Disease patients.
- Trial name
- DIETOMICS-CD (NCT02843100)
- Testing
- Modified Exclusive Enteral Nutrition, Crohn's Disease Exclusion Diet, Partial Enteral Nutrition
- Where
- 7 sites in Canada, Ireland and 2 more
- Volunteers
- 63 people
- Sponsor
- Prof. Arie Levine
Inflammatory Bowel Disease, Colitis, Ulcerative
LMT503 First-in-human SAD, MAD, and FE Study
This is a double-blind, randomized, placebo-controlled study, consisting of a single ascending dose (SAD) part with integrated food effect (FE) arm, and a multiple ascending dose (MAD) part to assess the safety, tolerability, and…
- Conditions
- Inflammatory Bowel Disease, Colitis, Ulcerative, Crohn Disease
- Trial name
- NCT05659953
- Testing
- LMT503
- Where
- Netherlands
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Lmito Therapeutics Inc.
Inflammatory Bowel Disease, Ulcerative Colitis
Web-based Monitoring in Children and Adolescents With Inflammatory Bowel Disease
The investigators hypothesize that E-health - web based monitoring of disease and treatment - in young patients with chronic inflammatory disease (IBD) can improve the disease course and quality of life.
- Conditions
- Inflammatory Bowel Disease, Ulcerative Colitis, Crohn´s Disease
- Trial name
- NCT01860651
- Testing
- Web-monitoring
- Where
- Denmark
- Volunteers
- 103 people
- Sponsor
- Hvidovre University Hospital
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