Clinical trials: Crohns Disease, open to volunteers
Healthy
Safety, Pharmacodynamics, Pharmacokinetics, and Immunogenicity of Ascending Doses BCD-261 in Healthy Subjects
The goal of this clinical trial is to investigate the safety, tolerability, pharmacodynamics, pharmacokinetics, and immunogenicity of BCD-261 after single subcutaneous injection at ascending doses and proposed therapeutic doses…
- Trial name
- NCT06715540
- Testing
- BCD-261, dose 1, BCD-261, dose 2, BCD-261, dose 3
- Where
- Russia
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Biocad
Inflammatory Bowel Disease
The EDICT Trial - Therapy for Inflammatory Bowel Disease Flares
Inflammatory bowel disease (IBD), including Crohn's disease (CD) and ulcerative colitis (UC), are chronic inflammatory conditions of the gastrointestinal tract that affect millions of people in the United States of America.
- Trial name
- EDICT (NCT07143188)
- Testing
- elemental diet (ED)
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- Wake Forest University Health Sciences
Crohn Disease (CD)
The Microbial Impact on Intestinal Fibrosis and the Associated Immune Microenvironment in Crohn's Disease
The goal of this study is to find out if there is a direct connection between an imbalance of gut bacteria and the development of scar tissue in the gut by identifying important bacterial proteins found in scarred gut tissue.
- Trial name
- NCT06720961
- Testing
- Collection of surgical specimen, Collection of stool sample
- Where
- Italy
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- IRCCS San Raffaele
Crohn Disease (CD), Ulcerative Colitis (UC)
Food Limitations In Crohn's Disease and Ulcerative coliTis
The goal of this clinical trial is to increase the knowledge on what type of diet affects inflammation and how to better convay that information in patients with inflammatory bowel disease (IBD) and decrease selective eating in…
- Conditions
- Crohn Disease (CD), Ulcerative Colitis (UC), IBD (Inflammatory Bowel Disease)
- Trial name
- FLIT (NCT07289672)
- Testing
- Diet, education
- Where
- Sweden
- Volunteers
- 140 people
- Sponsor
- Region Skane
HELICOBACTER PYLORI INFECTIONS, Inflammatory Bowel Disease (Crohn's Disease and Ulcerative Colitis)
Prevalence of Helicobacter Pylori on Patients With Chronic Inflammatory Bowel Disease (IBD) at the CHU of Guadeloupe
Clinical and experimental data suggest that dysbiosis may play a pivotal role in the pathogenesis of intestinal bowel disease (IBD).
- Trial name
- HP-MICI (NCT07292454)
- Testing
- Biopsies
- Where
- Guadeloupe
- Volunteers
- 100 people
- Sponsor
- Centre Hospitalier Universitaire de la Guadeloupe
Crohn Disease (CD)
WAter Preparation in Crohn's Disease's Imagery
The goal of this clinical trial is to compare distension quality and patient experience of water and polyethylene glycol preparation as oral contrast media in Magnetic Resonance Enterography (MRE) in patients with Crohn's…
- Trial name
- WAM (NCT06690632)
- Testing
- water preparation, polyethylene glycol preparation
- Where
- France
- Volunteers
- 194 people
- Sponsor
- University Hospital, Toulouse
Crohn Disease (CD), Intensification
Optimal Care With Guselkumab in Crohn's Disease / OPTIM Study A Prospective Open Label Interventional, Multicenter Study
Crohn's disease (CD) is a chronic and destructive inflammatory disease of the gastrointestinal tract characterized by phases of relapse and remission.
- Trial name
- OPTIM (NCT07616687)
- Testing
- Guselkumab
- Where
- France
- Volunteers
- 210 people
- Sponsor
- Groupe d'Etude Therapeutique des Affections Inflammatoires Digestives
Anal Fistula, Rectal Fistula
Mechanical Bowel Preparation Prior To Sphincter-Sparing Surgery For Complex Anal Fistulae
The goal of this clinical trial is to learn whether bowel preparation with Plenvu before surgery improves healing of complex anal fistula in adults aged 18 to 64 years with a fistula of cryptoglandular origin or associated with…
- Conditions
- Anal Fistula, Rectal Fistula, Crohn Disease
- Trial name
- PLEN-SPARE (NCT07897539)
- Testing
- Mechanical bowel preparation
- Where
- Sweden
- Volunteers
- 116 people
- Sponsor
- Region Skane
Crohn Disease, Colitis, Ulcerative
A Study of Continued Use of Guselkumab in Participants With Crohn's Disease and Ulcerative Colitis in Real World Setting
The purpose of this study is to find out how long a participant keeps taking guselkumab or continues with their treatment plan without stopping (treatment persistence) in participants with moderate to severe Crohn's disease (CD)…
- Trial name
- GusTaCon (NCT07746765)
- Volunteers
- 35 people
- Sponsor
- Janssen Sciences Ireland UC
Digestive System Diseases, Inflammatory Bowel Disease, Ulcerative Colitis Type
Intestinal Organoids
Over the last decade, the use of mini-organ or organoids has been increasingly developed in fundamental research. Indeed, digestive organoids represent an essential advance compared to classical culture systems (epithelial cell…
- Conditions
- Digestive System Diseases, Inflammatory Bowel Disease, Ulcerative Colitis Type, Crohn Disease
- Trial name
- BIOÏDES (NCT05294107)
- Testing
- additional biopsies
- Where
- France
- Volunteers
- 90 people
- Sponsor
- Rennes University Hospital
Crohn Disease, Resection Margins
Cellvizio to Evaluate Margins in Crohn's Ileal Disease
Crohn disease is an inflammatory bowel disease. A surgical procedure is required in about 80% of cases. Surgery doesn't cure from Crohn's disease but the type of surgery remains important as there are several intraoperative risk…
- Conditions
- Crohn Disease, Resection Margins, Recurrence
- Trial name
- CELLVICROHN (NCT05805020)
- Testing
- cellvizio
- Where
- France
- Volunteers
- 41 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Inflammatory Bowel Disease (IBD), Crohn Disease
Hyperbaric Oxygen Therapy for Perianal Fistulizing Crohn's Disease Not Responsive or Intolerant to Conventional Care: HYPNOTIC Pilot Study
This study aims to test a new treatment called hyperbaric oxygen therapy (HBOT) for a severe type of inflammatory bowel disease called perianal Crohn's disease (PCD).
- Trial name
- HYPNOTIC (NCT06109961)
- Testing
- Oxygen Gas for Inhalation, Standard of care
- Volunteers
- 54 people
- Sponsor
- University of British Columbia
Clostridium Difficile, Inflammatory Bowel Disease
Fecal Microbiome Transplant
Fecal Microbiota Transplant (FMT) in pediatric patients with recurrent C. Difficile with or without Inflammatory Bowel Disease (IBD) The aims of this study are to determine the safety and efficacy of FMT treatment in pediatric…
- Conditions
- Clostridium Difficile, Inflammatory Bowel Disease, Crohn's Disease, Ulcerative Colitis
- Trial name
- NCT02636517
- Testing
- Fecal Microbiota Transplant
- Where
- United States
- Volunteers
- 250 people
- Sponsor
- Judith Kelsen
Crohn's Disease
An Observational Study to Assess Change in Disease Activity and Adverse Events in Adolescent and Adult Participants With Moderate to Severe Active Crohn's Disease (CD) in Japan
Crohn's disease (CD) is an incurable chronic inflammatory disorder of the gastrointestinal tract. This study will assess how safe and effective upadacitinib is in treating moderately to severely active CD in real world.
- Trial name
- NCT06023030
- Where
- 104 sites in Japan
- Volunteers
- 240 people
- Sponsor
- AbbVie
Chronic Inflammatory Bowel Diseases
Digestive Evolution of Children With Crohn's Disease or Ulcerative Colitis Whose Anti-TNFα Treatment Was Switched to Ustekinumab Due to Paradoxical Psoriasis,
Inflammatory bowel diseases (IBD) include Crohn's disease (CD) and ulcerative colitis (UC). They cause abdominal pain and chronic diarrhea and/or rectal bleeding, which can lead to weight loss and malnutrition.
- Trial name
- INFLISWITCH (NCT07529236)
- Testing
- switch of anti TNF for ustekinumab for paradoxical psoriasis.
- Where
- France
- Volunteers
- 40 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Inflammatory Bowel Diseases, Crohn Disease
Thermal Measurements of the Gut With a Colonoscope Compatible Thermal Probe
The goal of this clinical trial is to use a modified thermal probe to measure temperature rise in the colonic mucosa of participants with inflammatory bowel disease, Crohn's disease, and/or ulcerative colitis.
- Conditions
- Inflammatory Bowel Diseases, Crohn Disease, Ulcerative Colitis
- Trial name
- NCT07352995
- Testing
- Feasibility of using a thermal probe to measure temperature rise in colonic mucosa
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Massachusetts General Hospital
Crohn Disease (CD), Vedolizumab
Value of IUS in Predicting Vedolizumab Efficacy and Assessing Transmural Healing in Early Crohn's Disease: A Multicenter, Prospective Study
Crohn's disease(CD) is a chronic nonspecific inflammatory disease of the intestinal tract whose etiology is not yet fully understood,characterized by transmural inflammation , can present with serious complications such as…
- Conditions
- Crohn Disease (CD), Vedolizumab, Intestinal Ultrasound, Predictor
- Trial name
- NCT07093294
- Where
- China
- Volunteers
- 60 people
- Sponsor
- The Third Xiangya Hospital of Central South University
Ulcerative Colitis, Crohn's Disease
An Open-label, DDI Study to Investigate the Effects of Duvakitug on the PK of Selected Cytochrome P450 Substrates
This is an open-label, single group, 2-period, Phase 1, single-arm study. The primary purpose of this study is to investigate the effects of duvakitug on the pharmacokinetics of selected cytochrome P450 substrates in adult…
- Trial name
- NCT07923383
- Testing
- Duvakitug
- Volunteers
- 25 people
- Sponsor
- Sanofi
Crohn's Disease
A Study of Mirikizumab (LY3074828) in Pediatric Participants With Crohn's Disease
Study participants will be screened during the platform study and randomly assigned to receive mirikizumab or another intervention.
- Trial name
- AMAY (NCT05509777)
- Testing
- Mirikizumab
- Where
- 81 sites in United States, Austria and 14 more
- Volunteers
- 90 people
- Sponsor
- Eli Lilly and Company
Crohn Disease, Ulcerative Colitis
Safety and Efficacy of Fecal Microbiota Transplantation
The gut microbiota is critical to health and functions with a level of complexity comparable to that of an organ system. Dysbiosis, or alterations of this gut microbiota ecology, have been implicated in a number of disease…
- Conditions
- Crohn Disease, Ulcerative Colitis, Celiac Disease, Irritable Bowel Syndrome
- Trial name
- NCT04014413
- Testing
- Fecal Microbiota Transplantation
- Where
- Hong Kong
- Volunteers
- 450 people
- Sponsor
- Chinese University of Hong Kong