Clinical trials: Cross Infection
Ventilator-Associated Pneumonia
To Compare Safety and Efficacy of Doripenem Versus Imipenem-Cilastatin in Patients With Ventilator-Associated Pneumonia
The purpose of this study is to show that doripenem is as effective as imipenem-cilastatin in the treatment of patients with ventilator-associated pneumonia.
- Trial name
- NCT00589693
- Testing
- Doripenem, Imipenem-Cilastatin
- Where
- 100 sites in United States, Argentina and 19 more
- Volunteers
- 274 people
- Sponsor
- Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
HIV Infections
Quantitative and Qualitative Research for "mHealth Program to Support People Living With HIV Across the HIV Care Continuum"
The goal of this randomized control trial (RCT) is to assess the effectiveness of Amp, a mobile health (mHealth) app designed to improve outcomes along the HIV care continuum for young Black men who have sex with men (YBMSM)…
- Trial name
- VSS (NCT06181916)
- Testing
- Amp
- Where
- United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Sentient Research
COVID-19 Respiratory Infection, Covid19
COVID-19 Vaccine Hesitancy and Dental Faculty Staff Members in Egypt
Healthcare workers (HCWs) play a vital role in determining the success of vaccination programs. Patient acceptance and vaccination rely greatly on the utilization and attitude of HCWs towards the vaccine, their attitude also…
- Conditions
- COVID-19 Respiratory Infection, Covid19, Vaccine Refusal
- Trial name
- NCT05009043
- Where
- Egypt
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Mariam Ayman Amin Sharaf
Pressure Ulcer
Comparative Assessment of Effectiveness and Safety of Methods for Skin and Hair Care in Severe Intensive Care Unit Patients
Skin care for seriously ill patients in the intensive care unit (ICU) is one of the key components in the prevention of serious complications that affect the treatment outcome.
- Trial name
- NCT05112068
- Testing
- traditional skin care method, method using specialized gloves
- Where
- Russia
- Volunteers
- 60 people
- Sponsor
- State Budgetary Healthcare Institution, National Medical Surgical Center N.A. N.I. Pirogov, Ministry of Health of Russia
Acute Respiratory Infections, Critical Illness in Children
Serum Vitamin D Status in Critically Ill Children With Acute Respiratory Infections
Acute respiratory infections (ARIs) are among the leading causes of hospitalization, morbidity, and mortality in children worldwide, particularly among critically ill patients admitted to pediatric intensive care units (PICUs).
- Conditions
- Acute Respiratory Infections, Critical Illness in Children, Vitamin D Deficiency, Pediatric Respiratory Infections
- Trial name
- VITD-ARI (NCT06547749)
- Testing
- Serum 25-Hydroxyvitamin D Assessment
- Where
- Egypt
- Volunteers
- 63 people
- Sponsor
- Assiut University
Pneumonia, Ventilator-Associated
Biomarkers for Ventilator-associated Pneumonia
The purpose of this study is to evaluate different peptide biomarkers, variations in the microbiome and patterns in the bacterial transcriptome as prognostic or diagnostic biomarkers of VAP.
- Trial name
- VAPmarkers (NCT05117125)
- Testing
- Heparin-binding protein, Interleukin-26, Microbiome
- Where
- 5 sites in Norway, Portugal and 1 more
- Volunteers
- 1,000 people
- Sponsor
- Region Skane
Nosocomial Infections
Multi-center Observational Study to Evaluate Epidemiology and Resistance Patterns of Common ICU-Infections (MOSER)
Most literature on ICU infections and the resistant patterns comes from the western literature. This data may not truly reflect the incidence, epidemiology and resistance patterns in developing countries such as India.
- Trial name
- MOSER (NCT01346735)
- Testing
- No intervention
- Where
- India
- Volunteers
- 381 people
- Sponsor
- Indian Society of Critical Care Medicine
Pneumonia, Ventilator-associated
Early Detection of Ventilator-associated Pneumonia (VAP)
The study goal consists in the sequential collection of exhaled breath condensates (EBC) from patients receiving invasive ventilation.
- Trial name
- cheqVAP (NCT02753608)
- Testing
- Collection of exhaled breath condensate
- Where
- Germany
- Volunteers
- 80 people
- Sponsor
- Jena University Hospital
Pneumonia, Viral, Pneumonia, Ventilator-Associated
Umbilical Cord(UC)-Derived Mesenchymal Stem Cells(MSCs) Treatment for the 2019-novel Coronavirus(nCOV) Pneumonia
Serious Pneumonia and Critical Pneumonia caused by the 2019-nCOV infection greatly threats patients' life, UC-MSCs treatment has been proved to play a role in curing multiple diseases.
- Trial name
- NCT04269525
- Testing
- UC-MSCs
- Where
- China
- Volunteers
- 16 people
- Sponsor
- ZhiYong Peng
Facial Paralysis, Facial Palsy
Turkish Validation of the Synkinesis Assessment Questionnaire (SAQ)
Peripheral facial palsy may result in synkinesis, a condition characterized by involuntary facial muscle movements that occur during voluntary facial expressions.
- Conditions
- Facial Paralysis, Facial Palsy, Bell Palsy
- Trial name
- NCT07750561
- Testing
- Synkinesis Assessment Questionnaire (SAQ)
- Where
- Turkey (Türkiye)
- Volunteers
- 49 people
- Sponsor
- Barış CELBEK
Burns
Massive Burns: Retrospective Analysis of Changes in Outcomes Across 18 Years
Burns treatment and management has evolved since the 90s, particularly for massive burns (≥ 50% of total body surface area (TBSA)).
- Trial name
- MassiveBurns (NCT04480944)
- Where
- Switzerland
- Volunteers
- 40 people
- Sponsor
- Mette M Berger
Eating Disorders
Implementing Virtual Parent Support Groups for Eating Disorders Across Canada
During the COVID-19 pandemic, Canada has experienced a surge in new pediatric eating disorder cases and hospitalizations and long treatment waitlists, with parents experiencing anxiety due to a lack of support.
- Trial name
- vPLPSG (NCT05151900)
- Testing
- Support Group for Caregivers
- Where
- 3 sites in Canada
- Volunteers
- 120 people
- Sponsor
- McMaster University
Critical Illness
Precision Modulation of Gut Microbiome Enteropathogen Colonization in Critical Illness
Patients requiring life support therapies in intensive care units are at very high risk of hospital-acquired infections. An important source of these infections is the accumulation of pathogenic bacteria in the microbiome of…
- Trial name
- MicroMod (NCT07813507)
- Testing
- Synbiotic, Standard of Care (SOC)
- Where
- Canada
- Volunteers
- 64 people
- Sponsor
- University of Calgary
Healthy
Drug-Drug Interaction Study: ASP2151 and Ciclosporin
ASP2151 is an experimental treatment for herpes. Patients undergoing organ and tissue transplantation may be prescribed ciclosporin to suppress their immune system to give the transplant an increased chance of not being rejected.
- Trial name
- NCT02280421
- Testing
- ASP2151 400mg + 100mg ciclosporin, ASP2151 1200mg + 100mg ciclosporin
- Where
- United Kingdom
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Maruho Europe Limited
Nosocomial Infection
Diagnostic of D-lactate in Cerebrospinal Fluid Level in Patients With Suspected Ventriculostomy-related Meningitis
The TOTEM study is a single-center study designed to evaluate the performance of the D-lactate assay in cerebrospinal fluid (CSF) for the diagnosis of ventriculostomy-related nosocomial meningitis.
- Trial name
- TOTEM (NCT06482463)
- Testing
- CSF sample
- Where
- France
- Volunteers
- 185 people
- Sponsor
- University Hospital, Toulouse
COVID-19, Lyme Disease
The Burden of Lyme Disease (BOLD) in a Pandemic - Insights From an Online Cross-sectional and Prospective Cohort Survey
A cross-sectional descriptive survey of the BOLD for individuals after having been ill with COVID-19 or have taken the COVID-19 vaccine will be compared with that of individuals who have neither been ill with COVID-19 nor taken…
- Conditions
- COVID-19, Lyme Disease, COVID-19 Vaccine
- Trial name
- NCT05312619
- Testing
- Cross sectional survey
- Where
- United States
- Volunteers
- 2,000 people
- Sponsor
- Dr. Daniel Cameron & Associates
Inflammation, Bacterial Infections and Mycoses
Iron Homoeostasis in Inflammation
The purpose of this study is to survey iron storage levels and their prognostic consequences in the context of acute inflammation. The impact of iron substitution in inflammatory states is controversial.
- Conditions
- Inflammation, Bacterial Infections and Mycoses, Anemia, Iron-Deficiency, Iron Overload
- Trial name
- NCT02155114
- Where
- Switzerland
- Volunteers
- 472 people
- Sponsor
- University Hospital, Basel, Switzerland
Nosocomial Infections
Potential Nosocomial Infection Prevention Via Modification of Anesthesia Intraoperative Aseptic Practice
We hypothesized that by improving hand hygiene compliance in the operative environment, we would reduce horizontal transmission of pathogenic bacteria to surgical patients.
- Trial name
- NCT00617006
- Where
- United States
- Volunteers
- 114 people
- Sponsor
- Dartmouth-Hitchcock Medical Center
Hospital-acquired Pneumonia, Antibiotic Resistant Infection
Chinese Hospital Acquired Pneumonia Collaboration Network: Epidemiology, Diagnosis and Treatment
The goal of this prospective and observatory study is to learn about the pathogen, clinical manifestations, prognosis, treatment and antibiotic resistance of bacteria in hospital-acquired pneumonia patients in China.
- Trial name
- CHAPTER (NCT06028217)
- Testing
- prognosis status
- Volunteers
- 4,000 people
- Sponsor
- Ruijin Hospital
COVID-19
LOng COvid Multidisciplinary Consortium: Optimising Treatments and servIces Across the NHS (LOCOMOTION)
Background: Long Covid (LC) affects over one million people in the UK, it has various symptoms and impacts daily life. Although there are 83 LC clinics in England, most people have not had access to them, and waiting times to be…
- Trial name
- LOCOMOTION (NCT05057260)
- Testing
- No drug invervention
- Where
- United Kingdom
- Volunteers
- 7,000 people
- Sponsor
- University of Leeds